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All Journal Martabe : Jurnal Pengabdian Kepada Masyarakat Vitek : Bidang Kedokteran Hewan IGKOJEI: Jurnal Pengabdian Masyarakat
Retina Yunani
Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Social Sciences Veterinary

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Journal : Vitek : Bidang Kedokteran Hewan

 1 
Kajian Peran Gen P53 dalam Tumorigenesis Retina Yunani
VITEK : Bidang Kedokteran Hewan Vol 6 (2016): VITEK - Bidang Kedokteran Hewan
Publisher : Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jv.v6i0.27

Abstract

Gene p53 is a tumor suppressor gene that in normal conditions is in ' standby ' mode , several studies show that pivotal point that lead to stimulation of p53 is DNA damage , heat shock , hypoxia, exposure of nitric oxide ( NO ) , the expression of oncogenes and some p53 pathways activation. p53 mechanism as a guardian of genome stability are cell cycle arrest, repair of DNA damaged, induce apoptosis, prevents angiogenesis , invasion and metastasis ability of the tumor. On many tumor , p53 is not loss , but mutated , the p53 mutant was expressed 70 % in lung cancer , and in different frequencies in other cancers . Then the role of p53 as a transcription factor that works to regulate genes involved in tumor suppression is indispensable .
PEMANFAATAN INFUSA DAUN SIRIH MERAH (Piper crocatum) SEBAGAI ANTI-OBESITAS PADA MENCIT (Mus musculus) Desty Apritya; Miarsono Sigit; Retina Yunani; Fuji Lestari
VITEK : Bidang Kedokteran Hewan Vol 10 (2020): VITEK - Bidang Kedokteran Hewan
Publisher : Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jv.v10i0.49

Abstract

The purpose of this research is to know the effectiveness of red betel leaf infusion (Piper crocatum) as anti-obesity in mice (Mus musculus). Other parameters of this study to know the relationship between changes in blood glucose levels to obesity in experimental animals. Experimental animals used were 24 male mice. The design of this research is completely randomized design (CRD) with 4 treatments 6 repetitions. There are four treatmens P0 (Control), P1 (6 mice by giving a betel leaf infusion with a concentration of 5%), P2 (6 mice by giving a betel leaf infusion with a concentration of 10%), and P3 (6 mice by giving a betel leaf infusion with a concentration of red 15%). The treatment is carried out once every day for 21 days. Before treatment, initial weight was weighed and blood glucose level examination continued on the 7th day, on the 14th day, and on the 21st day. Data obtained from the results of weighing and checking blood sugar levels were further analyzed using the ANOVA test which statistically showed no significant changes (P> 0.05) of body weight and blood glucose levels in mice (Mus musculus) given infusion red betel leaf (Piper crocatum).
Efektivitas salep ekstrak daun sirih merah (Pipercrocatum) terhadap luka insisi pada tikus putih (Rattus norvegicus) Ratna Widyawati; Ferrini Kasy; Retina Yunani; Junianto Wika Adi Pratama
VITEK : Bidang Kedokteran Hewan Vol 11 No 2 (2021): VITEK-Bidang Kedokteran Hewan
Publisher : Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jv.v11i2.82

Abstract

This study aims to see the effectiveness of red betel leaf extract ointment against incision wounds in white rats. The tannin and saponin compounds found in red betel leaf extract function to stimulate the formation of collagen which plays a role in the wound healing process. This study used an experimental research method with the test materials being 21 male white rats (Rattus norvegicus), red betel leaf extract on wound adhesions, the total number of erythrocytes and hemoglobin in white rats due to incision wounds, divided into 3 treatment groups with 7 samples. The results of the mean value of wound attachment in the groups P0 18 ± 0.5, P1 8.5 ± 0.4 and P2 6.5 ± 0.0. The mean results of erythrocyte values in the P0 group were 6.16 ± 0.90a, P1 6.46 ± 0.45a, and P2 6.20 ± 0.63a. and the results of the mean hemoglobin values in the P0 group 11.8 ± 1.1a , P1 12.3 ± 0.7a , and P2 12.1 ± 1.2a . The results of the study showed that the administration of red betel leaf extract ointment (Piper crocatum) on wound attachment had a significant effect at a concentration of 45%, because it was believed that red betel leaf extract ointment could increase peristaltic movements. While the total number of erythrocytes and hemoglobin due to incision wounds in white rats (Rattus norvegicus) there was no significant difference.
Co-Authors Adhitya Yoppy Ro Candra Asih Rahayu Bagus Uda Palgunadi, Bagus Uda Desty Apritya Desty Apritya Dian Ayu Kartika Sari Dyah Widhowati Era Hari Mudji Era Hari Mudji Restijono Ferrini Kasy Fuji Lestari Hana Cipka Pramuda Wardhani Intan Permatasari Hermawan Intan Permatasari Hermawan Junianto Wika Adi Pratama Kurnia Desiandura Kurnianto, Ady Lailia Dwi Kusuma Wardhani Miarsono Sigit Muhammad Noor Rahman Nurul Hidayah Palestin Palestin Palestin Palestin Ratna Widyawati