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All Journal Jurnal Kimia Riset Pharmacoscript
Purwaniati Purwaniati
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Chemistry Medicine & Pharmacology Public Health

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ANALISIS SENYAWA DALAM PARFUM ISI ULANG YANG BEREDAR DI KOTA BANDUNG DENGAN METODE KROMATOGRAFI GAS-SPEKTROMETRI MASSA (KG-SM) Purwaniati Purwaniati; Lisna Egisnawati; Emma Emawati
Pharmacoscript Vol. 4 No. 2 (2021): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v4i2.643

Abstract

Pewangi atau parfum merupakan produk yang sangat banyak ditemukan dalam kehidupan sehari-hari. Produk parfum tidak dilengkapi dengan informasi yang cukup mengenai senyawa-senyawa yang digunakan didalamnya. Hal ini menyebabkan masyarakat tidak mengetahui potensi bahaya yang terkandung dalam parfum tersebut. Penelitian ini bertujuan menganalisis senyawa yang terdapat dalam parfum isi ulang tersebut. Analisis ini dilakukan dengan metode kromatografi gas-spektrometri massa (KG-SM). Berdasarkan hasil analisis, parfum dengan aroma yang mirip menunjukkan mengandung senyawa-senyawa yang mirip pula. Dari lima sampel yang diuji, diketahui bahwa setiap sampel mengandung sekurang-kurangnya 24 senyawa. Dari semua senyawa tersebut, baru 5 senyawa yang telah ditentukan statusnya dalam Standard IFRA, yaitu limonene dan linalool yang statusnya spesificated, benzaldehyde dan citronellol yang statusnya restricted, dan lily aldehyde yang berstatus prohibited/restricted.
MOLECULAR DOCKING COMPOUNDS IN METHANOL EXTRACT OF MANGO LEAVES (Mangifera indica L.) AS ANTI-INFLAMMATORY AGENT Vina Juliana Anggraeni; Purwaniati Purwaniati; Wempi Budiana; Thoriq Nurdin
Jurnal Kimia Riset Vol. 7 No. 1 (2022): June
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v7i1.35950

Abstract

Previous studies have shown that mango has anti-inflammatory properties. Anti-inflammatory drugs are compounds or medicines used to treat diseases caused by inflammation. The most commonly used anti-inflammatory drug is a non-steroidal anti-inflammatory drug (NSAID). The drug works by inhibiting the enzyme cyclooxygenase (COX). The purpose of this study was to determine the profile metabolites present in the methanol extract of mango leaves and their interaction with the COX enzyme. This study includes an analysis of the compounds contained in the methanol extract of mango leaves using LCMS / MS and molecular docking studies of these compounds. Compounds detected by MS include C26H24O14, C45H84O14, Khellol-β-D-glucoside, Mangiferin, and Nevadensin-5-β-D-glucoside. Analysis of docking result was based on ΔG and Ki and the binding interactions that occur. Compounds that are compatible with COX1 and COX2 are Khellol βD glucoside with G and Ki values of 7.49 kcal/mol and 3.23 µM and 8.32 kcal/mol and 0.7919 µM, respectively. Through the molecular docking process, it was confirmed that khellol β-D-glucoside may be activated as an anti-inflammatory agent.  
Co-Authors Budiana, Wempi Emma Emawati Lisna Egisnawati Thoriq Nurdin Vina Juliana Anggraeni