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All Journal Biopropal Industri FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Farmamedika (Pharmamedica Journal) Jurnal Farmasi Sains dan Praktis Riset Informasi Kesehatan

Sitaresmi Yuningtyas

Program Studi Farmasi, Sekolah Tinggi Teknologi Industri Dan Farmasi Bogor

Author-ID : 3478077

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health

Published : 13 Documents Claim Missing Document

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AKTIVITAS INHIBISI α-GLUKOSIDASE DARI EKSTRAK AIR DAN ETANOL DAUN SIMPUR AIR (Dillenia suffruticosa (Griff.) Martelli) Sitaresmi Yuningtyas; Anna P. Roswiem; Erfina
Jurnal Farmamedika (Pharmamedika Journal) Vol 3 No 1 (2018): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Diabetes mellitus is a disorder of carbohydrate metabolism which characterized by hyperglycemia conditions. One of the mechanism from oral hypoglycemic drug is inhibition of α-glucosidase activity. Dillenia suffruticosa (Griff.) Martelli, known as "simpur air" has been used to treat diabetes mellitus. This study aims to determine the inhibition activity of α-glucosidase enzyme from water and ethanol extract simpur air leaves. Simpur air leaves extracted with water and ethanol 70% using maceration method. Parameter evaluated in this research were phytocemical screening and alpha glucosidase inhibiting (AGI) activity. The results showed that the active compounds in water and ethanol extracts were flavonoids, saponins and tannins. AGI activity in water extract from simpur air leaves at concentrations of 1%, 1.5% and 2% were 1.49%, 2.76% and 3.91%, respectively. AGI activity in ethanol extract from simpur air leaves at concentrations of 1%, 1.5% and 2% were 92.10%, 98.10% and 118.30%, respectively. While the AGI activity from glucobay were 99.50%. The optimum of AGI activity was in 1.5% ethanol extract. This AGI acivity which was not significantly different (α<0.05) from the 1% glucobay.

AKTIVITAS ANTIHIPERGLIKEMIA EKSTRAK AIR DAN HEKSANA DAUN PANDAN WANGI (Pandanus amaryllifolius) TERHADAP TIKUS PUTIH (Rattus novergicus) Sitaresmi Yuningtyas; Siti Mariam; Auliatun Nisa
Jurnal Farmamedika (Pharmamedika Journal) Vol 2 No 2 (2017): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Diabetes mellitus is a disorder of carbohydrate metabolism characterized by high blood glucose levels, or hyperglycemia. Hyperglycemia is a condition where the amount of glucose in the blood exceeds normal limits. Many plants that have the potential as the lowering of blood glucose levels, one of which pandan leaves (Pandanus amaryllifolius). The purpose this study were to identified class of chemicals compounds contained in extracts of water and hexane pandan leaves. Beside that, this study was conducted to determine the activity extracts of water and hexane pandan leaves to decrease blood glucose levels of white rats (Rattus novergicus) with hyperglycemia. Simplicia of pandan leaves extracted by maceration method. Condensed extract contains compounds defined and tested in vivo in rats induced by alloxan. Water extract of pandan leaves (EADP) contained alkaloids, flavonoids, saponins and tannins. Hexane extract of pandan leaves (EHDP) contained alkaloids and steroids. Measurement of blood glucose levels were measured by using a glucometer for 15 days with intervals in every 3 days. Negative control treatment with Na-CMC 1% was increased in blood glucose levels to 137.50%. Metfomin as positive control treatment with 9 mg could decrease the blood glucose levels to 66.41%. Treatment with EADP 300, EADP 600, EHDP 300 and EHDP 600 could decrease glucose levels 42.38, 60.25, 26.99 and 24.81% respectively. Therefore, water and hexane extracts of pandan leaves (Pandanus amaryllifolius) could decrease the blood glucose levels with in vivo.

POTENSI ENZIM TRANSGLUTAMINASE SEBAGAI GEL PENYEMBUH LUKA STADIUM II PADA AYAM RAS JANTAN Sitaresmi Yuningtyas; Winugroho; Abdul Ghoni
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 1 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

The transglutaminase (EC 2.3.2.13) is an enzyme that catalyses an acyl transfer reaction of the γ-carboxiamide groups glutamine residues in proteins, peptides and various primary amines. Enzyme transglutaminase helps to stabilized the fibrin monomer during the process of blood clotting. This research was to determine the activities of the wound healing process stage II in male broilers given the transglutaminase enzyme sample gels. In this researchgel formulationmadeenzymetransglutaminase1%, 3%, 5% and7%. Transglutaminaseenzymegelpreparationorganoleptictestandhomogeneity test. Furthermore,thegel formulationapplied to themalebroilersownwoundsstage II. Transglutaminaseenzymegel formulationhad ahomogeneoustexture, white, odorlesstypicalenzymetransglutaminase, andhad apH rangefrom 6.2 to 6.7. The percentagereduction inwoundlength ofstage IIinmalebroilersbyenzymetransglutaminaseperfomedgel1%, 3%, 5% , 7% and Bioplacenton® gel (positive control) were 80.54%, 99.00%, 99.67%, 87.25%, and 99.33% respectively. Based on analysis statisticsofANOVA, percentage reduction inwoundlength ofstage IIby treatment withtransglutaminasepreparationgel5% higher and significantly differentcompared totreatmentwithBioplacenton®(positive control). Hence, transglutaminaseenzymepreparations5% gelcanact as awound healerstage IIinmalebroilers.

PENENTUAN KADAR KAFEIN KOPI ROBUSTA TERFERMENTASIOLEH Enterococcus durans, Enterococcus sulfureus, DAN Lactococcus garvieae Sitaresmi Yuningtyas; Syahid Pratama Al-Wali; Winugroho
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Many people like to drink coffee because it has a unique flavor. Coffee also containscaffeine,which is not good for health. One of the most famous type of coffee is civet coffee (kopi luwak).This coffee is unique because lower caffeine and in the process of this coffee should be consumedfirst by civet. The issue is populations of civet who began to decrease and the process that makes itdifficult to be produced on a large scale in a short time. In this research, we tried to apply culture ofEnterococcus durans, Enterococcus sulfureus, and Lactococcusgarviea for processing robustacoffee that resembles the civet coffee. This study aims to determine the caffeine content offermented of robusta coffee and the results will be compared with the civet coffee. Bacteria foundin the digestive system of civet had isolated and added in fermentation process of robusta coffee.Caffeine levels measured by HPLC.From these results it can be concluded that the caffeine contentin fermented of robusta coffee whichfermented using bacterial suspension Enterococcus durans,Enterococcus sulfureus andLactococcusgarvieaehad not been able to equal the caffeine content incivet coffee.Amount of caffeine in fermented of robusta coffee had lower than amount of caffeinein robusta coffee. Percentage of caffeine in fermented of robusta coffee, robusta coffee, and civetcoffeewere 1,20%, 1,90%, and 0,59% respectively.

AKTIVITAS ANTIOKSIDAN, TOTAL FENOL, DAN KADAR VITAMIN C DARI KOMBUCHA DAUN SALAM (Syzygium polyanthum (Wight) Walp.) Sitaresmi Yuningtyas; Eem Masaenah; Murniwati Telaumbanua
Jurnal Farmamedika (Pharmamedika Journal) Vol 6 No 1 (2021): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v6i1.116

Kombucha adalah hasil fermentasi teh dan gula oleh SCOBY (symbiotic culture of bacteria and yeast). Kombucha dapat dibuat dari daun yang tinggi fenol salah satunya adalah daun salam. Penelitian ini bertujuan menentukan aktivitas antioksidan, total fenol, dan kadar vitamin C dari kombucha daun salam. Pada penelitian ini menggunakan kombucha daun salam dibuat dengan konsentrasi 12,5; 25; 37,5; dan 50 g/l. Kombucha daun salam yang diperoleh di uji karakteristik kombucha daun salam meliputi uji fitokimia, pH serta pengujian aktivitas antioksidan, total fenol dan kadar vitamin C secara in vitro. Aktivitas antioksidan kombucha daun salam pada penelitian ini diperoleh 38,58%-75,05% dengan nilai IC50 sebesar 27 g/l, total fenol kombucha daun salam berkisar 4,74-51,972 ppm, dan kadar vitamin C antara 16,426-30,506 mg/100g. Berdasarkan uji total fenol, kadar vitamin C dan uji antioksidan maka kombucha daun salam memiliki aktivitas antioksidan.

Co-Authors Abdul Ghoni Agustin, Lydia Ahmad Ben Anggraena Roesmiena Waty Anna P. Roswiem Auliatun Nisa Ben, Ahmad Citroreksoko, Padmono Devi Ratnasari Diah Ajeng Tri R Dian Setiawati Artianti Dwi Suwarni Eem Masaenah Erfina Harry Noviardi Lydia Agustin Meita Sari Mandiri Murniwati Telaumbanua Padmono Citroreksoko Setiawati Artianti, Dian Siti Mariam Syahid Pratama Al-Wali Tri R, Diah Ajeng Vira Yuniar Winugroho

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