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All Journal Berkala Penelitian Hayati
Syahida Ahmad
Faculty of Biotechnology and Biomolecular Sciences (FBBS), UPM, Malaysia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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EFEKTIVITAS KURKUMIN SEBAGAI ANTIOKSIDAN DAN INHIBITOR MELANIN PADA KULTUR SEL B16-F1 Sugiharto; Arbakariya Ariff; Syahida Ahmad; Muhajir Hamid
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 17 No 2 (2012): June 2012
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.789 KB) | DOI: 10.23869/211

Abstract

Melanin inhibitors have become increasingly important ingredients in medication and cosmetics for the prevention of hyperpigmentation. In the last few years, a huge number of natural herbal extracts have been tested as inhibitors of melanin synthesis and some of these effects are related to the antioxidant properties. The objectives of this study were to determine of curcumin properties as antioxidant activity and melanin inhibitors. In this study, our data indicated that antioxidant assay with DPPH showed IC50 was 16,05 μg/ml. In the absence of α-MSH (α-Melanocyte Stimulating Hormone), melanin content assay in cell B16-F1 indicated that the highest activity of curcumin to reduce melanin content of 45,67% at 25 μg/ml. Meanwhile, in the presence of α-MSH at the same concentration indicated that the highest activity was 53,87%. Based on the data, curcumin has potential properties as antioxidant activity and melanin inhibitor.
Co-Authors Arbakariya Ariff Muhajir Hamid Sugiharto