Berkala Penelitian Hayati
Vol 17 No 2 (2012): June 2012

EFEKTIVITAS KURKUMIN SEBAGAI ANTIOKSIDAN DAN INHIBITOR MELANIN PADA KULTUR SEL B16-F1

Sugiharto (Fakultas Sains dan Teknologi (FST), Universitas Airlangga – Indonesia)
Arbakariya Ariff (Faculty of Biotechnology and Biomolecular Sciences (FBBS), UPM, Malaysia)
Syahida Ahmad (Faculty of Biotechnology and Biomolecular Sciences (FBBS), UPM, Malaysia)
Muhajir Hamid (Faculty of Biotechnology and Biomolecular Sciences (FBBS), UPM, Malaysia)

Article Info

Publish Date
15 Mar 2013

Abstract

Melanin inhibitors have become increasingly important ingredients in medication and cosmetics for the prevention of hyperpigmentation. In the last few years, a huge number of natural herbal extracts have been tested as inhibitors of melanin synthesis and some of these effects are related to the antioxidant properties. The objectives of this study were to determine of curcumin properties as antioxidant activity and melanin inhibitors. In this study, our data indicated that antioxidant assay with DPPH showed IC50 was 16,05 μg/ml. In the absence of α-MSH (α-Melanocyte Stimulating Hormone), melanin content assay in cell B16-F1 indicated that the highest activity of curcumin to reduce melanin content of 45,67% at 25 μg/ml. Meanwhile, in the presence of α-MSH at the same concentration indicated that the highest activity was 53,87%. Based on the data, curcumin has potential properties as antioxidant activity and melanin inhibitor.

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Journal Info
Berkala Penelitian Hayati
Website

Abbrev

jurnal

Publisher

Perhimpunan Biologi Indonesia Cabang Jawa Timur

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

Description

Berkala Penelitian Hayati is a half yearly international peer reviewed, an open access life science journal. The journal was published by The East Java Biological Society and formerly used the Indonesian language. The first edition of this journal is Vol 1 No 1 in June 1995. It was accredited by ...