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Fitria Rahmi
prodi psikologi unand
Humanities Biochemistry, Genetics & Molecular Biology Education Medicine & Pharmacology Social Sciences

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Combination of Doxorubicin and Areca Ethanolic Extract Induces Apoptosis by Increasing Caspase-3 Level on Breast Cancer (T47D) Cells Rahmi, Fitria; Meiyanto, Edy; Susidarti, Ratna Asmah
Indonesian Journal of Cancer Chemoprevention Vol 3, No 1 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

Despite causing many side effects, doxorubicin (Dox) is still one of breast cancer drug of choice. Thus, combination of chemotherapy is developed in order to decrease doxorubicin regimen dose. The aim of this research is to examine the combination effect of doxorubicin (dox) and areca extract (AE) on T47D human breast cancer cells. The cytotoxic activity was determined using MTT assay. The combination index (Cl) of the combination treatment was calculated to determine the effects (synergistic, additive or antagonistic). The combination application of dox (6-22nM) and AE (8-30μg/ml) on T47D cells showed synergistic (Cl<0.9) or addictive effect )Cl =0.9-I.I). The effective combincation of dox-AE was 6nM-8μg/ml on Cl<0.5. Apoptosis induction of AE solely and its combination with dox was the observed using double staining method. Moreover, expression of Bax and caspase-3 protein which mediated apoptosis, were observed using immunocytochemistry. Combination of AE and Dox increased expression of Caspase-3 but did not increase expression of Bax. This result showed AE increase the effectiveness of doxorubicin against T47D cells.Keyword : Breast cancer, doxorubicin, areca extract, T47D cells
Ethanolic extract of Areca catechu seeds inhibit proliferation and induce apoptosis on MCF-7 cells Meiyanto, Edy; Susidarti, Ratna Asmah; Handayani, Sri; Rahmi, Fitria
INDONESIAN JOURNAL OF PHARMACY Vol 19 No 1, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.642 KB) | DOI: 10.14499/indonesianjpharm0iss0pp12-19

Abstract

Areca catechu seed contains antioxydant substances, supposed to have anticancer property. This research therefore addressed to examine the inhibitory effect of Areca catechu seed ethanolic extract (EP) on proliferating breast cancer cells, MCF-7. Areca catechu seed ethanolic extract (EP) standardization was done according to the standard of BPOM. Areca catechu seed powder extraction was done using ethanol 96%. Cytotoxic assay – to get the value of IC50 and to prevent the cell proliferation (using doubling time assay) – was carried out by using MTT assay. Apoptosis observation was done by acrydine orange- etidium bromide staining method (double staining). The result showed that treatment with Areca catechu seed ethanolic extract (25-100 µg/m) for 48 h caused 13-84% growth inhibition (IC 5077 µg/mL) of the cells, while arecoline (ARE) treatment (10-500 µg/mL) showed 8-73% inhibition (IC50 180 µg/mL). The extract also inhibited cell proliferation and induced apoptosis. These results conclude that Areca catechu seed ethanolic extract (EP) possesses antiproliferative effect through growth inhibition and apoptosis induction.Key words:MCF-7, Areca catechu, antiproliferative 
PENGAWASAN CAMAT DALAM PENATAAN PEMUKIMAN KUMUH DI KECAMATAN RUMBAI PESISIR KOTA PEKANBARU Rahmi, Fitria; ", Zulkarnaini
Jurnal Online Mahasiswa (JOM) Bidang Ilmu Sosial dan Ilmu Politik Vol 3, No 2: WISUDA OKTOBER 2016
Publisher : Fakultas Ilmu Sosial dan Ilmu Politik Universitas Riau

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Growth and development of an area of town is not always a positive affect. High population growth resulted in increased population density and an increased in the density of buildings for residential as well as an increased need of infrastructure to carry out activities in an effort to make ends meet. The increase in space requirements is almost always coupled with the growth and development of slums and squatter settlements in a region.Tassel coastal districts is one district that has slums, the residential area is located in one of the villages Meranti Pandak subdistrict coastal fringe. Villages that cannot escape the problem of untidiness. If it is left without treatment improvements will expand the existing slums. Efforts taken by the government to address this is through the implementation of the restructuring program of slums that have been implemented since the first approach taken by various coastal fringe districts, including mutual cooperation program of activities that include physical, environmental, and infrastructure there.One of the government programs in addressing the slum is a slum arrange evenly and thorough quality improvement in a very seedy area.This study aims to determine how much oversight arrangement slum districts on the fringe of society in the coastal city of Pekanbaru. The method used to achieve the purpose of the research is qualitative method.Keywords : Seedy, Structuring, Regulation, Supervision, Slums.
THE RELATIONSHIP BETWEEN CONSUMER INVOLVEMENT WITH BRAND AWARENESS IN THE PROCUREMENT OF SAMSUNG SMARTPHONE Rahmi, Fitria; Sarry, Septi Mayang; Boer, Novrizal Riady
Al-Qalb : Jurnal Psikologi Islam Vol 7, No 2 (2016)
Publisher : Universitas Islam Negeri Imam Bonjol Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15548/alqalb.v7i2.846

Abstract

A brand must be remembered by consumers for helping them when deciding to buy a product. This is related to brand awarenness which is owned by the consumer. Brand awareness is the ability for consumers to recognize and remember enough details of a brand in a given category to make it easier to buy. In this case the role of the process of storing information into the memory becomes important and one of the aspects associated with information processing is consumer involvement.This study describe the relationship between consumer involvement with the brand awareness in the purchase of Samsung Smartphone among teenagers in Padang City. The subject of this research were 150 teenagers in Padang City, the data obtained by using non-probability sampling with accidental sampling technique. Data was obtained using brand awareness scale with reliability coefficient on 0,904 and consumer involvement scale with reliability coefficient on 0,901. The data analyzed using correlationproduct moment pearson test.Data obtained by correlation analysis the result of this research showed the correlation coefficient (r) of 0.609 and a significant number which was 0.000 (p <0.05). The results of this analysis indicated that thereis a positive relationship between consumer involvement with the brand awareness in the purchase of Samsung Smartphone among teenagers in Padang City, it is means higher consumer involvement of a person, the higher brand awareness that one has,and when consumer involvement of a person is low, then the brand awareness of a person will be low.A brand must be remembered by consumers for helping them when deciding to buy a product. This is related to brand awarenness which is owned by the consumer. Brand awareness is the ability for consumers to recognize and remember enough details of a brand in a given category to make it easier to buy. In this case the role of the process of storing information into the memory becomes important and one of the aspects associated with information processing is consumer involvement.This study describe the relationship between consumer involvement with the brand awareness in the purchase of Samsung Smartphone among teenagers in Padang City. The subject of this research were 150 teenagers in Padang City, the data obtained by using non-probability sampling with accidental sampling technique. Data was obtained using brand awareness scale with reliability coefficient on 0,904 and consumer involvement scale with reliability coefficient on 0,901. The data analyzed using correlationproduct moment pearson test.Data obtained by correlation analysis the result of this research showed the correlation coefficient (r) of 0.609 and a significant number which was 0.000 (p <0.05). The results of this analysis indicated that thereis a positive relationship between consumer involvement with the brand awareness in the purchase of Samsung Smartphone among teenagers in Padang City, it is means higher consumer involvement of a person, the higher brand awareness that one has,and when consumer involvement of a person is low, then the brand awareness of a person will be low.
PENGARUH KARAKTERISTIK PEKERJAAN TERHADAP PERILAKU KEWARGAAN ORGANISASI DENGAN MEDIATOR NILAI-NILAI KUALITAS KEHIDUPAN KERJA Rahmi, Fitria; Riyono, Bagus
Jurnal Psikologi Vol 15, No 1 (2016): April 2016
Publisher : Faculty of Psychology, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (207.29 KB) | DOI: 10.14710/jpu.15.1.64-76

Abstract

Organizational Citizenship Behavior (OCB) can be formally defined as a discretionary work behaviour of the employees that is not recognized by the formal reward or the sanction system of their organization. OCB can be seen as a voluntary behavior of the employees, which is out of the job description of their obligation, it is not directly related to the formal reward, but useful in improving the efficiency and effectiveness of the organization.Previous research found four aspects of the job characteristic (variety skill, task identity, task significance and autonomy) positively effected on OCB of employee. The objective of this study was to look effect of job characteristic to OCB which mediated by values of Quality of Work Life (QWL). This values as a foundation to display OCB. The subjects of this research were 65 employees from PT. X. Regression analysis showed that job characteristic significant toward OCB through the mediating of QWL values. In another word QWL had a mediator role between job characteristic and OCB. This finding were usefull to improve the OCB in company, with more attention to job characteristic that promote employees’ QWL. The results and benefits of the research were further discussed in the discussion.
Co-Authors Bagus Riyono Boer, Novrizal Riady Dian Handayani Edy Meiyanto Ratna Asmah Susidarti Rustini Rustini Sarry, Septi Mayang Sri Handayani Zulkarnaini Zulkarnaini