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UJI EFEKTIVITAS ANTIOKSIDANT (IC50) DAN TOKSISITAS AKUT (LD50) FRAKSI ETANOL DAUN NANGKA (Artocarpus Heterophyllus Lam.) Recta Olivia Umboro; Dedent Eka Bimmaharyanto S; Ni Komang Wijiani Yanti
JUPE : Jurnal Pendidikan Mandala Vol 5, No 6 (2020)
Publisher : Lembaga Penelitian dan Pendidikan Mandala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jupe.v5i6.2349

Abstract

Antioxidants are needed by the body to ward of free radicals from internal and external factors. The presence of free radicals is related to human helath conditions. Back to nature lifestyle and the high cost of drugs therapy makes people preferring to use traditional medicine. Jackfruit (Artocarpus heterophyllus Lam) leaves is contain several secondary metabolites such a flavanoids, alkaloids, sapaonins, steroids and tannins. Flavanoid have an antioxidant effect.In this study, the antioxidant activity of ethanol jackfruit (Artocarpus heterophyllus Lam) leaves extract was tested using 1,1-diphenyl-2-picrylhidrazyl (DPPH) method by UV-Vis Spectrophotometry, wich Vitamin C as comparison standart. Acute toxicity test was carried out by giving oral doses of ethanol jackfruit leaf extract to 4 groups of male rats. Group I as a control (aquadest);II(100mg/30gBW);III (150mg/30gBW); IV (200mg/30gBW) were then observed for 7 days.The antioxidant activity test showed that ethanol jackfruit (Artocarpus heterophyllus Lam) leaves extract had effectiveness as an antioxidant with an IC50 value of 58.58 ppm. The data were analyzed using one-way ANOVA showing sig value 0.228, which means (P>0.005), then followed by post hoc test, an average value of 0.00,probability value is 1.000 (sig>0.005). It can be concluded that there is no significant difference between the control and the treatment dose of 100mg, and there is a significant difference in the 150mg/30gBW, 200mg/30gBW dose groups. LD50 value dosage range in 150mg and 200mg.
Evaluasi Waktu Tunggu Pelayanan Resep Obat Racikan dan Non Racikan pada Pasien Rawat Jalan di Apotek Depi Yuliana; Faizul Bayani; Dedent Eka Bimmaharyanto; Lelie Amalia Tusshaleha; Syamsul Rahmat; Meilynda Pomeistia; Recta Olivia Umboro
Bioscientist : Jurnal Ilmiah Biologi Vol 9, No 2 (2021): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v9i2.4950

Abstract

The quality of health services is still not optimal, especially in terms of patient dissatisfaction with drug services at pharmacies. A more efficient system can be built only if the waiting time evaluation has been carried out at pharmacies that provide drug prescriptions for patients. This study aims to evaluate the waiting time for prescription services at pharmacies to achieve patient satisfaction with drug services at pharmacies. In this study, Angkasa Farma's pharmacy became the subject of evaluation. The study was conducted with an observational design using descriptive analysis. The waiting time data obtained were then analyzed descriptively and compared with the minimum service standard of waiting time, this is for two types of drugs (prepared drugs and compound drugs). The results of the study based on a sample of 100 recipes and 100 non-concoction recipes are the number of recipes that meet the standards for prescription recipes as many as 37 recipes and for non-concoction recipes as many as 95 recipes. The average waiting time for concoction recipe services is 41.47 minutes and the average waiting time for non-concoction prescription services is 21.29 minutes. The average waiting time for non-concoction prescription services has met the standard, while the waiting time for blended prescription services has not met the standards according to the Regulation of the Minister of Health of the Republic of Indonesia.
PENINGKATAN PEMAHAMAN PENGGUNAAN VITAMIN DAN LONG COVID DI KOTA MATARAM DAN LOMBOK BARAT Fitri Apriliany; Recta Olivia Umboro; Dedent Eka Bimmaharyanto S.
SELAPARANG Jurnal Pengabdian Masyarakat Berkemajuan Vol 6, No 2 (2022): Juni
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v6i2.8421

Abstract

ABSTRAKPemerintah Kota Mataram dan Lombok Barat mengkonfirmasi jumlah kasus sembuh covid per 19 September 2021 6599 kasus dan 3113 kasus. Berdasarkan data tersebut akan ada sekitar enam ribuan orang di Kota Mataram dan tiga ribuan orang di Lombok Barat bisa mengalami gejala long covid-19. Minimnya pengetahuan mengenai penggunaan vitamin, long covid dan membantu program pemerintah untuk memberikan perhatian khusus pada pasien yang mengalami gejala long covid menjadi alasan dilakukan pengabdian ini. Tujuan pengabdian ini adalah memberikan pemahaman masyarakat mengenai long covid dan penggunaan vitamin pada masa pandemi covid-19. Metode pelaksanaan kegiatan ini adalah a) edukasi secara concurrent b) dialog interaktif c) diberikan pendampingan langsung memilih vitamin yang sesuai kebutuhan di Kota Mataram dan Lombok Barat yang dilakukan pada 29 - 30 Oktober 2021. Evaluasi kegiatan ini dilakukan dengan dialog interaktif dengan masyarakat secara singkat. Hasil kegiatan ini adalah telah berhasil meningkatkan pengetahuan masyarakat terhadap long covid dan penggunaan vitamin. Hal ini terlihat dari antusiasi masyarakat dengan diskusi singkat. Kata kunci: edukasi; long covid; vitamin ABSTRACTThe Mataram and West Lombok City Governments confirmed the number of recovered covid-19 cases as of September 19, 2021, with 6599 cases and 3113 cases. Based on this data, there will be six thousand people in Mataram City and three thousand people in West Lombok could experience the old symptoms of covid-19. The lack of knowledge about the use of vitamins, long covid, and assisting government programs to give special attention to patients who experience long-term symptoms of covid are the reasons for the activity. This activity aimed to determine the education about long covid and the use of vitamins during the covid-19 pandemic. This program was carried out by the following methods a) concurrent education b) interactive dialogue c) direct assistance in choosing the vitamins that are needed in Mataram City and West Lombok which be conducted on 29 - 30 October 2021. Evaluation of this activity is carried out by means of an interactive dialogue with the community. The results of this activity have succeeded in increasing public knowledge about long covid and the use of vitamins. This can be seen from the enthusiasm of the community during a short discussion. Keywords: education; long covid; vitamins
Identifikasi Penyebab ADR (Adverse Drug Reactions) pada Pasien CHF (Congestive Heart Failure) Depi Yuliana; Putri Ramdaniah; Faizul Bayani; Dedent Eka Bimmaharyanto S.; Dita Marina Lupitaningrum
Lensa: Jurnal Kependidikan Fisika Vol 9, No 1: June 2021
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (705.339 KB) | DOI: 10.33394/j-lkf.v9i1.4264

Abstract

Congestive Heart Failure (CHF) adalah salah satu masalah kesehatan yang progresif dengan angka mortalitas maupun morbiditas yang tinggi dan berpotensi terjadi ADRs (adverse drug reactions). Resiko ADRs pada pasien CHF berkaitan dengan regimen obat yang kompleks dan banyaknya komorbiditas pada pasien tersebut. Penelitian ini dilakukan untuk mengukur kausalitas dan menganalisis obat dan jenis ADRs yang paling sering terjadi. Penelitian ini termasuk retrospective study dengan data penelitian yang digunakan adalah data pasien CHF yang menjalani rawat inap RSUD Provinsi NTB dari tahun 2017 sampai 2019. Penilaian kausalitas ADRs menggunnakan skala WHO-UMC. Data pasien CHF yang digunakan dalam penelitian ini sebanyak 325 pasien. Sebanyak 223 pasien (68,6%) tercatat mengalami ADRs dengan hasil penilaian kausalitas menggunakan WHO-UMC antara lain 8 (1,8%) certain, 178 (39,9%) probable/likely, dan 260 (58,3%) possible. Obat yang paling banyak menimbulkan ADRs dengan status kausalitas certain adalah ramipril yang menimbulkan batuk. Kesimpulan: sebagian besar ADRs yang terjadi pada pasien CHF adalah possible dan jenis obat yang paling tinggi menimbulkan ADRs adalah ramipril sehingga penggunaan ramipril perlu lebih diperhatikan karena termasuk highly probable dalam menimbulkan ADRs.Identification of The Causality of ADR (Adverse Drug Reactions) in CHF (Congestive Heart Failure) PatientsAbstractCongestive Heart Failure (CHF) is a progressive health problem with high mortality and morbidity rates and the potential for ADRs (adverse drug reactions). The risk of ADRs in CHF patients is related to the complex drug regimen and the many comorbidities in these patients. This study was conducted to measure causality and analyze the most common drugs and types of ADRs. This study includes a retrospective study with the research data used is data on CHF patients who underwent hospitalization at the NTB Provincial Hospital from 2017 to 2019. The causality assessment of ADRs used the WHO-UMC scale. Data on CHF patients used in this study were 325 patients. A total of 223 patients (68.6%) were recorded to have ADRs with the results of a causality assessment using WHO-UMC including 8 (1.8%) certain, 178 (39.9%) probable/likely, and 260 (58.3%) possible. The drug that causes the most ADRs with certain causality status is ramipril which causes coughing. Conclusion: most of the ADRs that occur in CHF patients are possible and the type of drug that causes the highest ADRs is ramipril so that the use of ramipril needs to be paid more attention because it is highly probable in causing ADRs.
Sosialisasi Penyakit Skabies dan Edukasi Pembuatan Sabun Organik di Pondok Pesantren Nurul Qur’an di Desa Mertak Tombok Lalu Jupriadi; Dodiy Firmansyah; Dita Retno Pratiwi; Dedent Eka Bimaharyanto; Agung Suryawan; Dwi Ilham Abdika Putra; Putri Salindah Lestari; Winda Fitria; Azwar Hadi; Nurhasanah Nurhasanah; Weni Ari Wijayanti
Jurnal Abdimas Kesehatan (JAK) Vol 4, No 3 (2022): November
Publisher : Sekolah Tinggi Ilmu Kesehatan Baiturrahim Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (707.316 KB) | DOI: 10.36565/jak.v4i3.414

Abstract

Bath soap is a compound of sodium or potassium with fatty acids from vegetable oils and or animal fats in solid, soft or liquid form, used as a cleanser. The Nurul Qur'an Islamic boarding school is located in Mertak Tombok Village, Praya District, Central Lombok Regency, West Nusa Tenggara Province. The purpose of educational activities about scabies disease and training in making organic solid soap for the students and students of the Nurul Qur'an Islamic Boarding School was carried out to prevent and treat scabies disease. The method used is the distribution of questionnaires after socialization and education are carried out to students and female students. the activity showed that the students were very enthusiastic about the socialization of scabies disease and counseling on the manufacture of organic solid soap. The activity lasted for one month, namely in June 2022. The results of community service were obtained by increasing the ability of the students in soap making and understanding of the scabies disease. 
Studi Adverse Drug Reactions Penggunaan Obat Antiepilepsi Monoterapi Pada Anak di Rumah Sakit - Studi Farmakovigilans Putri Ramdaniah; Dwi Monika Ningrum; Depi Yuliana; Dedent Eka Bimmahariyanto S.; Recta Olivia Umboro
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 3, No 2 (2022): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v3i2.8384

Abstract

ABSTRAKPengobatan epilepsi membutuhkan waktu yang lama, penghentian terapi dilakukan secara bertahap apabila dicapai bebas kejang selama dua tahun. Pengobatan yang bersifat jangka panjang dikaitkan dengan peningkatan efek samping dan membutuhkan monitoring pengobatan. Pasien anak sering mengalami efek samping obat yang sama dengan pasien dewasa, namun reaksi obat yang tidak dikehendaki pada pasien anak lebih sulit karena perbedaan karakteristik antara pasien anak dan pasien dewasa juga mempengaruhi efikasi dan efek samping obat. Tujuan penelitian ini untuk menghitung angka kejadian ADRs dan Klasifikasi Jenis ADRs pada penggunaan obat antiepilepsi Monoterapi. Metode yang digunakan yaitu penelitian cross sectional dengan pengambilan data secara prospektif, penilaian kausalitas ADRs menggunakan algoritma naranjo, selama periode penelitian didapatkan 56 pasien yang mendapatkan terapi monoterapi dari total 86 pasien. jenis-jenis ADRs yang terjadi pada pasien yaitu gangguan gastrointestinal 32,35%, reaksi kulit gatal dan kemerahan terjadi 7,35%, gangguan metabolik sebanyak 10,29%, dan gangguan CNS (Central nervous system) sebanyak 10,29%. Kata kunci : Adverse drug reactions; Antiepilepsi; Anak-anak.ABSTRACTEpilepsy treatment takes a long time, discontinuation of therapy is carried out gradually if achieved without seizures for two years. Treatment is long-term treatment with increased side effects and requires medication monitoring. Pediatric patients often experience the same side effects of drugs as adults, but adverse drug reactions in pediatric patients are more difficult because differences in characteristics between patients and adult patients also affect the efficacy and side effects of drugs. The purpose of this study was to calculate the incidence of ADR and Classification of Types of ADR in the use of monotherapy antiepileptic drugs. The method used is a cross sectional study with prospective data collection, ADR Causality Assessment using the Naranjo Algorithm, during the study period 56 patients received monotherapy therapy from a total of 86 patients. The types of ADR that occur in patients are gastrointestinal disorders 32.35%, itching and skin reactions that occur 7.35%, metabolic disorders as much as 10.29%, and CNS (Central Nervous System) disorders as much as 10.29%.Keywords : Adverse drug reactions; Antiepileptic; Pediatric.
Peran Tenaga Kefarmasian dalam Proses Penanggulangan Wabah Covid-19 di Apotek Kota Mataram Tahun 2020 Dwi Monika Ningrum; Dedent Eka Bimma Haryanto; Depi Yuliana; Neneng Rachmalia Izzatul Mukhlishah; Denih Agus Setia Permana; Atri Sri Ulandari
Jurnal Kesehatan Qamarul Huda Vol. 10 No. 1 (2022): Juni 2022
Publisher : Universitas Qamarul Huda Badaruddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37824/jkqh.v10i1.2022.289

Abstract

Tenaga Teknis Kefarmasian (TTK), merupakan tenaga kesehatan yang berada di garda depan  pelayanan kefarmasian baik di apotek, puskesmas, rumah sakit dan sarana pelayanan kefarmasian lainnya.  Dalam penanggulangan Covid-19 ini, tenaga medis dan tenaga kesehatan lain berada di garis depan, membantu anggota masyarakat yang terserang tertular penyakit. Sebab itu, tenaga kesehatan terutama TTK harus mengerti dan paham betul apa yang mesti mereka lakukan pada masyarakat agar mendapat pencerahan, mereka harus memperoleh informasi yang benar dari tenaga kesehatan yang terpercaya. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan studi kasus. Pemilihan metode penelitian kualitatif dengan pendekatan studi kasus sesuai untuk meneliti tentang Peranan TTK Dalam Proses Penanggulangan Wabah Covid-19 dalam komunikasi informasi dan edukasi kesehatan kepada masyarakat. Observasi terhadap peran TTK dilakukan selama bulan April 2020 sampai dengan bulan Juli 2020 di beberapa Apotek di Kota Mataram. Subjek yang diamati terdiri dari TTK dengan kualifikasi pendidikan Sekolah Menengah Farmasi, Diploma-III dan Apoteker. Objek yang dikaji merupakan uraian tugas yang tertuang dalam dokumen disertai dengan pengamatan langsung berupa pelayanan yang diberikan oleh TTK di tempat kerja/sarana kefarmasian. Hasil yang  diperoleh dalam kegiatan ini menunjukkan bahwa TTK cukup berperan dalam proses penanggulangan wabah Covid-19 dengan prosentase sebesar 70,25%.
EDUKASI SISTEM REPRODUKSI SEBAGAI UPAYA PENCEGAHAN PENYAKIT INFEKSI MENULAR SEKSUAL PADA REMAJA Fitri Apriliany; Elis Cholisah; Recta Olivia Umboro; Dedent Eka Bimaharyanto
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 6, No 4 (2022): Desember
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v6i4.11435

Abstract

ABSTRAKMenurut Centers for Disease Control (CDC) tahun 2021 penyakit menular seksual yang paling banyak dilaporkan dari berbagai negara adalah sifilis, gonore, klamidia, chancroid, dan HIV. Berdasarkan data pemerintahan Provinsi Kalimantan Selatan pada tahun 2017 menunjukkan bahwa terdapat 3 Kota/Kabupaten yang memiliki kasus infeksi menular seksual tertinggi di Kalimantan Selatan yaitu Kota Banjarmasin (3.507 kasus), Kabupaten Hulu Sungai Utara (3.134 kasus), Kabupaten Banjar (1.715 kasus) dan data dari kemenkes RI menunjukkan persentase tertinggi terdapat pada kelompok usia 25-49 tahun (71,3%), usia 20-24 tahun (16,3%). Tujuan pengabdian ini adalah meningkatkan pemahaman terhadap sistem reproduksi sebagai upaya pencegahan penyakit infeksi menular pada remaja dan membantu program pemerintah mencapai eliminasi HIV-AIDS dan penyakit infeksi menular seksual (PIMS) pada tahun 2030. Metode pengabdian adalah sosialisasi sistem reproduksi dan PIMS serta dialog interaktif/tanya jawab. Evaluasi dilakukan dengan diskusi tanya jawab, pretest dan posttest dengan peserta. Hasil kegiatan ini menunjukkan bahwa terdapat peningkatan pengetahuan mahasiswa/i dengan hasil rata-rata pretest (38,5) dan posttest (85,7). Kesimpulan kegiatan ini adalah terjadi peningkatan pengetahuan rata-rata sebesar 47,2. Kata kunci: edukasi; sistem reproduksi; PIMS. ABSTRACTAccording to Centers for Disease Control (CDC) in 2021, the most reported sexually transmitted diseases from various countries are syphilis, gonorrhea, chlamydia, chancroid, and HIV. Based on data from South Kalimantan Provincial government in 2017 shows that there are 3 cities/districts that have the highest cases of sexually transmitted infections (STIs) in South Kalimantan, namely the city of Banjarmasin (3,507 cases), Kab. Hulu Sungai Utara (3,134 cases), Banjar Regency (1,715 cases) and data from kemenkes RI show that the highest percentage is in 25-49 year age group (71.3%), 20-24 years old (16.3%). This activity aimed to determine to increase understanding of reproductive system as an effort to prevent infectious diseases in adolescents and help government programs achieve elimination of HIV-AIDS and STIs by 2030. The program was carried out by following methods: the dissemination of reproductive system and STIs and interactive dialogue/ question and answer. Evaluation is done through question and answers discussion, pretest and posttest with participants. The results of this activity indicate that there is an increase in students knowledge with average results of pretest (38,5) and posttest (85,7). The conclusion is an increase in students knowledge with average increase 47.2. Keywords: education; reproduction system; STIs.
Aktivitas Antifungi Ekstrak Etanol Daun Parsley (Petroselinum Crispum) Terhadap Pertumbuhan Jamur Candida Albicans Secara Invitro Dedent Eka Bimmaharyanto S.; Recta Olivia Umboro; Fitri Apriliany
Jurnal Kesehatan Qamarul Huda Vol. 10 No. 2 (2022): Desember 2022
Publisher : Universitas Qamarul Huda Badaruddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37824/jkqh.v10i2.2022.411

Abstract

Candida albicans merupakan flora normal didalam tubuh manusia. Mikroorganisme  spesies jamur dari golongan deuteromycota ini pada kondisi tertentu dapat bersifat pathogen. Spesies ini adalah salah satu penyebab infeksi oportunistik kandidiasis pada kulit, mulut, organ kelamin. Parsley (Petroselinum crispum) merupakan tanaman aromatik berkhasiat obat. Kandungan senyawa flavanoid pada tanaman ini memiliki khasiat sebagai antifungi. Penelitian ini bertujuan untuk melihat efektivitas dan konsentrasi minimal ekstrak etanol daun parsley (Petroselinum crispum) dalam menghambat pertumbuhan  Candida albicans. Uji aktivitas antifungi dilakukan dengan metode disc diffusion test, menggunakan sampel uji ekstrak etanol 70% daun parsley (Petroselinum crispum) dengan konsentrasi 10%; 30%; 50%; 80% dan 100% (b/V). Kontrol positif menggunakan nystatin 100.000 IU dan kontrol negatif menggunakan aquadest steril. Hasil pengamatan dianalisis secara diskriptif dan diuji menggunakan analisisn statistik ANOVA Kruskal wallis. Hasil penelitian menunjukkan bahwa ekstrak etanol 70% daun parsley (Petroselinum crispum) signifikan efektif menghambat pertumbuhan Candida albicans. Konsentrasi 100% memiliki efek setara dengan kontrol positif. Sedangkan konsentrasi minimum yang mampu menghambat pertumbuhan Candida albicans adalah sebesar 10%.
UJI INVIVO AKTIVITAS DIURETIKA EKSTRAK ETANOL 70% DAUN UNGU (Graptophyllum pictum (L) Griff) PADA MENCIT PUTIH JANTAN GALUR WISTAR Recta Olivia Umboro; Dedent Eka Bimmaharyanto; Fitri Apriliany; Iva Rinia Dewi
Jurnal Insan Farmasi Indonesia Vol 5 No 2 (2022): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v5i2.1137

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Traditionally, daun ungu plant (Graptophyllum pictum (L) Griff) has been known to have pharmacological effects that can help with a variety of health issues. This plant’s flavonoid compounds content is thought to have diuretic activity in this plant is believed to have activity. The purpose of this study is to determine the diuretic activity and optimal dose of etanol extract of 70% daun ungu administered orally to male white mice. This is an experimental study with a completely randomized design (CRD) that includes 1 negative control group (Na.CMC 0.5%), 1 positive control group (furosemide 40 mg) and 3 test groups of 70% daun ungu ethanol extract doses of 10 mg/kg BW, 25 mg/kg BW and 40 mg/kg BW with urine volume test parameters. One-way ANOVA and Kruskal-Wallis statistical test were used to analyze the data. The results showed that one-way ANOVA revealed a P < 0.05 (0.012), and P ≤ 0.05 (0.051) for the Kruskal-Wallis test. It can be concluded that 70% daun ungu etahanol exctract has effective diuretics, with an optimal dose