Amira Permatasari Tarigan
Universitas Sumatera Utara

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The Relationship between Tyr113His Epoxidized Hydrolase Enzyme Gene Polymorphisms and the Incidence of Smoking Lung Cancer Lucia Aktalina; Amira Permatasari Tarigan; Noni Novisari Soeroso; Yahwardiah Siregar; Ozar Sanuddin
Jurnal Respirologi Indonesia Vol 38, No 2 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i2.163


Background: This study aims to determine the relationship between the gene polymorphism of the enzyme Epoxid Hydrolase (EPHX) Tyr113His and the tendency of smokers to suffer from lung cancer. The EPHX Tyr113His gene polymorphism is a change in one nucleotide base of the EPHX gene to produce enzymes with decreased function by 50%. EPHX plays a role in the metabolism of chemical compounds in cigarette smoke, especially Benzo (a) Pyren (BaP), which becomes a carcinogen in the body. Methods: This study is a case-control study design conducted from October 2016 to February 2017. Venous blood was taken from 35 people with lung cancer at RSUP H Adam Malik Medan and 35 healthy smokers. The genotype examination of the EPHX gene was carried out using the PCR-RFLP method in the USU FK Integrated Laboratory. Results: The genotype frequency of heterozygous variant T/C and homozygous variant C/C in case groups was 83.3% and 16.7%, respectively. The frequency of the T allele in the case group was 41.67% and the C allele was 58.33%. Whereas in the control, the frequency was heterozygous variant T/C (80%) and homozygous variant C/C (20%). The frequency of the T allele in the control group was 40% and the C allele was 60%. There were no homozygous wildtype T/T genotypes in the two groups. There was no significant difference in the genetic distribution and allele distribution of the EPHX enzyme between case and control groups. Conclusion: There is no relationship between EPHX Tyr113His enzyme gene polymorphisms and the incidence of lung cancer in smoking. J Respir Indo 2018; 38(2): 93-9)
Affect Decreasing Lung Function in Laundry Installation Worker At Rumah Sakit Umum Pusat H. Adam Malik, Medan Wina Elizabeth Octaria Saragih; Nuryunita Nainggolan; Amira Permatasari Tarigan
Jurnal Respirologi Indonesia Vol 38, No 2 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i2.165


Background: Data from International Labor Organization (ILO) at 2005 shows that there are 250 million case of diseases that related to occupation which can also cause 300.000 death in the world with annual incidence rate of work related lung disease around 1:1000 worker. Laundry worker was included as group that has risk of having occupational pneumoconiosis. Method: This is a descriptive study using total sampling with sample number 24 patient, this study was done in Laundry Installation of Rumah Sakit Umum Pusat Haji Adam Malik Medan on November 2016. Examination was done by using questionnaire, physical examination, daily PEF (before and after working) for 14 days, spirometry, total room dust, total room bacterial colonization. Factors (age, sex, working duration, smoking history, p.2,5 dust exposure, bacterial exposure, safety equipment usage, and nutritional status) that had potential of affecting the decreasing lung function was assessed. Result: From PEF examination, we found mean variability 3.1%. from all worker, there are 9 workers that had decreasing lung function ≥3, 1%. From examination result of 9 sample, decreasing lung function mostly caused by smoking (55%) and p.2,5 dust exposure (66%) Conclusion: Smoking and p.2,5 dust exposure is the most common factors that affected decreasing lung function in laundry worker. (J Respir Indo 2018; 38(2): 109-14)
Correlation of Ceramic Dust Content in Workplace with Lung Function in Ceramics Industry Workers of X Company, Mabar, Medan Endy Todo Sirait; Amira Permatasari Tarigan; Nuryunita Nainggolan; Putri Chairani Eyanoer
Jurnal Respirologi Indonesia Vol 41, No 3 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i3.187


Background: Workers in the ceramics industry are often exposed to silica content which is unwittingly inhaled and deposited in the lungs. Macrophages will release Interleukin 8 (IL-8), a chemoattractant that causes neutrophil recruitment to the alveoli and releases proteolytic enzymes that damage the lung parenchyma and cause a decrease in lung function. This study aimed to determine whether dust level correlate with IL-8 serum in ceramic industry workers. Method: This research is an analytic study with a cross-sectional design conducted in March–June 2019 in the X Ceramic Industry in Mabar, Medan. Personal Dust Sampler was used to measure dust level of the study subjects at work sites. Lung function was measured by spirometry. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) software. Results: A total of 35 male workers were divided into 3 working sections, 11 (31.4%) in the pre-compression section, 13 (37.1%) in the compression section and 11 (31.4%) in the sintering section. Dust levels at each working section were 24.8, 29.2, and 6.11, respectively. The lung function examination showed restrictive impairment in 21 subjects (60%). Statistical analysis showed that the higher the level of dust in the workplace, the lower the value of Forced Expiratory Volume 1 (FEV1) and Forced Vital Capacity (FVC) values, although this correlation was not statistically significant (r = -0.03 and -0.22 respectively; p> 0.05). Conclusion: There was no significant relationship between workplace dust levels and lung function in ceramic workers.
Correlation Between Wood Dust Levels with Interleukin-8 in Blood Serum Wood Processing Workers at X Company, Tanjung Morawa Jubilette Windy Hutabarat; Nuryunita Nainggolan; Amira Permatasari Tarigan; Putri Eyanoer
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i1.94


Backgrounds: Wood dust exposure can stimulate proinflammatory cytokines and increase IL-8 levels, which is a foreign body in the body will be phagocytosis by macrophages and excrete mediators such as chemokines, cytokines, and chemoattractants which can cause inflammation. Duration of exposure, number and size of wood dust in the respiratory tract of wood industry workers are associated with various pulmonary disorders such as, COPD, occupational asthma, allergic rhinitis, decreased pulmonary function and pulmonary fibrosis. The aim this study is determine correlation between wood dust levels with interleukin-8 in blood serum among wood processing workers at x company, Tanjung Morawa-North Sumatera. Methods: A cross-sectional study which involved 40 workers from 3 different locations namely cutting, sanding and drafting. Cumulative wood dust exposure was calculated by measuring the dust content at the work site using Dusttrak TSI. IL-8 serum levels were measured using the ELISA technique. The Spearman correlation test was used. Results: Out of 40 workers those who worked in the cutting section were 15 people (37,5%), sanding section were 15 people (37,5%) and drafting section were 10 people (25%). The average level of wood dust PM 2,5 was 5,23 mg/m3while PM10 was 8,24 mg/m3 and the mean level of IL-8 in serum was 163,3 ng/L. This study find that there is a strong correlation between wood dust and IL-8 serum (r = 0,683; p
The Effect of Two-Mile Jogging Training on Lung Function Values in TNI Soldier Kodam I/Bukit Barisan Rifda Hayati; Nuryunita Nainggolan; Amira Permatasari Tarigan; Putri Chairani Eyanoer
Respiratory Science Vol. 1 No. 1 (2020): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i1.8


Background: Military soldiers are army personnel who are required to have good physical endurance and optimal fitness, include. So, it's needed physical exercise, include to be able to improve lung function. One parameter that can reflect physical fitness are lung function and m VO2max. This study aims to determine whether there is a relationship between physical exercise in the form of 2-mile jogging with increased lung function and VO2max of military soldiers Kodam 1 Bukit Barisan Methods: This research is an experimental study carried out in February-April 2019 against the TNI soldiers of the Bukit Barisan Military District 1. The research subjects were divided into two groups, group 1 who underwent regular 2-mile jogging exercises 3-5 times a week with a duration of 25 minutes for 2 months, and group 2 who underwent non-routine jogging exercises (less than 3 times a week). Lung function was assessed by spirometry. Results: As many as 68 military soldiers were involved in this study which were divided into two groups, 38 people in the group 1 who routinely trained and 30 people in group 2 that did not routinely practice. Group 1 VEP1 values were higher than group 2 (p=0.03). No significant differences in terms of KVP, MVV and VO2max in both groups. Lung function of smokers were lower than non-smokers, but not statistically significant. Conclusion: There were significant differences in VEP1 values between military soldiers who routinely and did not routinely undergo 2-mile jogging exercises.