Article Per Year (5 Year)
p-Index From 2019 - 2024
0.983
P-Index
This Author published in this journals
All Journal Jurnal Respirologi Indonesia Respiratory Science
Bintang Yinke Magdalena Sinaga
Universitas Sumatera Utara
Health Professions Medicine & Pharmacology

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search
Journal : Jurnal Respirologi Indonesia

 1 
The Correlation of Body Mass Index with Sputum Conversion Time in MDR-TB Patients Undergoing Treatment with Short Term Regimen at H. Adam Malik Medan General Hospital Diana Santy; Parluhutan Siagian; Bintang Yinke Magdalena Sinaga; Putri C Eyanoer
Jurnal Respirologi Indonesia Vol 40, No 4 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i4.130

Abstract

Background: It was estimated about 10.4 million incidence of TB cases worldwide, of which 580,000 were MDR TB cases in 2015, however, only 125,000 were successfully found and treated. The World Health Organization (WHO) issued a recommendation of 9-11 month Short Term Regimen (STR) guideline that could provide satisfactory results in terms of successfull outcome, easier to control and also low-cost. The study aimed to analyze the correlation between Body Mass Index (BMI) and sputum conversion time in MDR TB patients undergoing treatment with STR and to determine the final treatment outcome using STR at H. Adam Malik Medan General Hospital, North Sumatra, Indonesia. Methods: This was a case series study of a total 76 MDR TB patients undergoing treatment using STR. Samples were obtained from medical record of the pulmonary isolation ward and MDR TB clinic at H. Adam Malik Medan General Hospital. Data were analyzed descriptively to identify the trend in sputum conversion from nine months of treatment. Results: The number of patients with normal BMI was 51.3% higher than those of low, very low and high BMI. The time to sputum conversion occured in the second month of treatment. All groups of BMI categories experienced conversions and normal BMI was higher in number. At the end of the treatment evaluation, the cure rate was 44.8%, the drop out was 28.9%, the regimen change was15.8%, died 9.2%, and moved 1.3%. Conclusion: There was a significant correlation between BMI and sputum conversion time in MDR TB patients. Good nutritional status was a predictor of treatment success.
Differences of Malondialdehyde (MDA) Levels in Blood of Pulmonary Tuberculosis Sufferers with Diabetes Mellitus, Pulmonary Tuberculosis without Diabetes Mellitus and Healthy People in Medan Eka Suhartika; Zainuddin Amir; Bintang Yinke Magdalena Sinaga; Putri C Eyanoer
Jurnal Respirologi Indonesia Vol 40, No 4 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i4.124

Abstract

Background: The imbalance between oxidants and antioxidants in the body can increase Malondialdehyde (MDA) in patients with pulmonary TB and type 2 DM, which causes cell damage and worsens the disease. The body has a protective mechanism from damage caused by increased MDA through enzymatic antioxidants such as SOD and vitamin E. This study aimed to examine the difference in MDA levels in the blood of pulmonary TB patients with type 2 DM, pulmonary tuberculosis without type 2 DM and healthy people in Medan, Indonesia. Methods: This was an analytical study using a case-control approach by measuring MDA levels in pulmonary TB with type 2 DM patients, pulmonary TB patients and healthy people who were treated at H. Adam Malik General Hospital, Community Health Centers, and GP’s practice in Medan for 4 months. Blood samples were taken and examined using the ELISA kit. Data were then analyzed using the Kruskal Wallis and Mann Whitney tests. Results: There were 75 patients recruited in the study in which 45 were males (60%) and 30 were females (40%). The age group found the most was 31-40 years with normal BMI (76%). The highest MDA level was found in the TB+DM group at 12.42 nmol/ml compared to the TB patients (3.75 nmol/ml) and healthy people (3.01 nmol/ml). Conclusion: There were no statistically significant differences in MDA levels although there was a difference found in the MDA levels among the three groups with MDA level in TB+DM group was shown to be the highest.
Comparison of Serum Vitamin C Levels Between Pulmonary Tuberculosis and Healthy Controls in Medan Rizka Helmi; Bintang Yinke Magdalena Sinaga; Parluhutan Siagian; Putri Eyenoer
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i3.364

Abstract

Background: Pulmonary tuberculosis infection is a high burden, especially in developing country. Vitamin C is a water-soluble micronutrient that contributes to immune defense by supporting avarietyof innate and adaptive immunity. Vitamin C protects the host from reactive oxygen and reactive nitrogen intermediates generated during Mycobacterial infection. Pulmonary tuberculosis patients have lower vitamin C levels because Mycobacterium tuberculosis infection produces reactive oxygen species for replication as well asmetabolism and also because of reduced nutrient intake. Vitamin C as an antioxidant also plays role in killing Mycobacterium tuberculosis by encouraging Fenton reaction.Methods: This is a case control study of serum vitamin C levels in pulmonary tuberculosis patients and healthy controls. Vitamin C levels were measured by ELISA (Enzyme Linked Immunosorbent Assay).Results: The number of subjects was 40 people, divided into 20 subjects of pulmonary tuberculosis as cases and 20 healthy controls, aged between 18–65 years old. Vitamin C levels according to age group were 99.03±38.60 ng/ml and 80.53±27.38 ng/mlfor18–30 years, 84.85±49.69 ng/ml and 82.70±14.93ng/ml for31–40 years, 61.34±25.36 ng/ml and 79.93±22.81 ng/ml for41–50 years, 71.43±18.36 ng/ml and 78.69±54.21 ng/ml for51–65 years. Vitamin C levels of male subjects based on case and control groups were 88.11±42.07 ng/ml and 78.36±28.95 ng/ml while for the female were 73.20±11.56 ng/ml and 83.16±23.77 ng/ml. Mean vitamin C levelin pulmonary tuberculosis patients was 83,64±35,99 ng/ml and in healthy controls was80,22±26,44 ng/ml.Conclusion: There was no significant difference in vitamin C levels between pulmonary tuberculosis patient and healthy people.
Co-Authors Diana Santy Dina Octafrida Marpaung Eka Suhartika Elok Ariyani Safitri Erna Mutiara Parluhutan Siagian Putri C Eyanoer Putri Chairani Eyanoer Putri Eyenoer Rizka Helmi Zainuddin Amir