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All Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran IJAAM (Indonesian Journal of Anti-Aging Medicine)
Ni Nyoman Ayu Dewi
Biochemistry Department, Faculty of Medicine, Universitas Udayana, Denpasar, Bali
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Macassar fruit extract (Brucea javanica (l.) merr) increased the level of superoxide dismutase (SOD) but had no effect on the level of malondialdehyde (mda) in paraquat-treated male swiss Webster mice Maria Eka Patri Yuliati; I Gusti Made Aman; Ni Nyoman Ayu Dewi
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 3 No 2 (2019): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (174.984 KB) | DOI: 10.36675/ijaam.v3i2.41

Abstract

Introduction: Paraquat exposure causes aging because it induces oxidative stress marked by decreased level of SOD and increased MDA serum level. Macassar fruit contains bioactive compounds such as vitamin C, flavonoids, tannins and polyphenol that have antioxidant activity. The purpose of this study was to prove that Macassar fruit extract increased the level of Superoxide Dismutase (SOD) enzyme and reduce the level of Malodialdehid (MDA) in male Swiss Webster mice treated by paraquat. Methods: A randomized pretest-posttest control group study was conducted using 14 male mice which were 2-3 months old, healthy and had 25-30 gram in weight. They divided into 2 groups namely P0 (control) and P1 (Treatment). Both groups were treated by paraquat but only group P1 received 20 mg Macassar fruit extract while the P0 only got 1 cc placebo for 14 days. Results: Our result showed that the level of SOD was increased in P1 group from 17.18±1.69 U/ml to 67.56±3.65 U/ml (p<0.01) while no change was observed in P0 group 16.97 ±1.45U/ml to 17.07±1.89 U/ml (p>0.05). However, no effect on MDA level was observed as the level of MDA tended to slightly decrease in both groups. Conclusion: It can be concluded that Macassar fruit extract 20 mg/kgBB significantly increased the level of SOD whilehave no effect on MDA level in male mice Swiss Webster treated by paraquat.
Level of awareness of alzheimer’s disease among elderly people in Denpasar, Bali Sabrina Annamma Philip; Desak Made Wihandani; Ni Nyoman Ayu Dewi
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.64 KB) | DOI: 10.15562/ism.v11i1.260

Abstract

Background: Alzheimer’s disease (AD) is a chronic, irreversible, progressive, neurodegenerative that slowly impair memory and thinking skills especially in elderly people. This study aims to determine the level of awareness of AD among elderly people in Denpasar, Bali.Methods: A descriptive cross-sectional study was conducted by using self–administered validated questionnaire to determine the level of awareness of Alzheimer’s disease among the elderly people in Denpasar, Bali. The level of awareness could be classified into high awareness (>80%), moderate awareness (50-79%) and low awareness (<50%)Results: There were 50 subjects with 50 years old or above enrolled in this study. Most of the respondents had low awareness (82%) to the AD. About 38% of elderly people knew about AD and 58% of respondents said losing memory is a common thing in old age. Low education was said responsible increasing the risk of AD (30%). Only about 24% answered depression was prone to AD. In addition, about 34% said there was no cure for Alzheimer’s disease.Conclusion: Level of awareness among elderly people towards Alzheimer’s disease was low and needed improvement. Development and execution of educational programs should be carried out to the public to expand knowledge and understanding about Alzheimer’s disease.
Co-Authors Desak Made Wihandani I Gusti Made Aman Maria Eka Patri Yuliati Sabrina Annamma Philip