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All Journal Pharmacology and Clinical Pharmacy Research Jurnal Politikom Indonesiana
Mally G. Sholih
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Languange, Linguistic, Communication & Media Medicine & Pharmacology Social Sciences

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Potential Nephrotoxicity of Lisinopril and Valsartan on Patients with Congestive Heart Failure Sarini Pani; Melisa I. Barliana; Eli Halimah; Venice Chaeriadi; Mally G. Sholih
Pharmacology and Clinical Pharmacy Research Vol 2, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.357 KB) | DOI: 10.15416/pcpr.v2i1.16192

Abstract

Lisinopril (angiotensin converting enzyme inhibitor) and valsartan (angiotensin II receptorblocker) are the first-line treatment for patients with congestive heart failure (CHF). Thesetwo drugs potentially cause side effects on renal functions. However, limited informationwas available regarding the comparison of potential nephrotoxicity of these drugs in IndonesianCHF patients. This research was aimed to compare the potential nephrotoxicitybetween lisinopril and valsartan in outpatients with CHF at a hospital in Palu, Indonesia.This was an observational study conducted during April-May 2015. Potential nephrotoxicitywere assessed by measuring serum creatinin (SCr) and blood urea nitrogen (BUN). Datawere obtained from Cardiology Unit from a hospital in Palu, Indonesia. Statistical analysiswas conducted using T-test and Mann-Whitney test. The increasing trend of SCr and BUNwere observed in lisinopril-treated patients with the mean of increase were 21% and 59%,respectively. Relatively higher increase was observed in valsartan treatment group with 47%and 51% in SCr and BUN, respectively. The analysis showed that there were significant differencesin SCr level between lisinopril and valsartan groups (p=0.001), but the oppositeresults observed in BUN parameter (p=0.697). Therefore, valsartan was potentially morenephrotoxic than lisinopril based on the increase of SCr parameter. Thus, lisinopril is recommendedfor CHF patients who are particularly at high risks of having renal impairment.Keywords: lisinopril, valsartan, nephrotoxicity, congestive heart failure
Pengaruh Peringatan Visual Iklan Kemasan Rokok: Pengukuran Tingkatan Perasaan Takut yang Dibedakan Berdasarkan Jenis Kelamin dan Usia Mayasari Mayasari; Hadi Sudarjat; Mally G. Sholih
Jurnal Politikom Indonesiana Vol 3 No 2 (2018): Jurnal Politikom Indonesiana
Publisher : Fakultas Ilmu Sosial dan Ilmu Politik Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (589.105 KB) | DOI: 10.35706/jpi.v3i2.1667

Abstract

Cigarettes kill nearly seven million people every year throughout the world. Changes in cigarette packaging design is one way to reduce the number of smokers in the community. Some studies suggest that the threat to cigarette packaging in the form of Threatening Visual Warnings (TVWs) only has a slight effect and does not have any effect at all on the reaction and character of people who smoke. In contrast, several studies have shown that TVWs have a positive effect on smokers' desire to smoke or reduce smoking consumption. Because of these conflicting results, further research is needed. The main objective of this study was to assess the effectiveness of cigarette packaging images in terms ofemotional and behavioral reactions, namely TVWs at moderate vs. very high levels of cigarette packaging for active smokers by age and sex category. The age group is divided into adolescents (12-17 years) and adults (> 18 years). Thesex group is divided into two, namely male and female. From the results of chi-square statistical analysis, it was obtained a significant correlation or influence between the threat level of moderate level and high level on cigarette packaging to the feeling of fear or disgust among smokers, namely in the category of adolescent girls, adolescent boys and men (p- value <0.05). Whereas in adult women there is no significant effect (p-value> 0.05).Keywords: Threatening Visual Warnings, Smokers, Ads, Health
Co-Authors Eli Halimah Hadi Sudarjat Mayasari Mayasari Melisa I. Barliana Sarini Pani Venice Chaeriadi