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All Journal Farmaka Jurnal Farmasi Klinik Indonesia Pharmacology and Clinical Pharmacy Research
Melisa I. Barliana
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Monitoring Penggunaan Antibiotik dengan Metode ATC/DDD dan DU 90%: Studi Observasional di Seluruh Puskesmas Kabupaten Gorontalo Utara Sarini Pani; Melisa I. Barliana; Eli Halimah; Ivan S. Pradipta; Nurul Annisa
Indonesian Journal of Clinical Pharmacy Vol 4, No 4 (2015)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2722.634 KB) | DOI: 10.15416/ijcp.2015.4.4.280

Abstract

Penggunaan antibiotik yang tidak rasional dapat menyebabkan peningkatan morbiditas dan mortalitas. Monitoring penggunaan antibiotik diperlukan dalam mendukung program pemerintah khususnya Dinas Kesehatan yang menyatakan penggunaan antibiotik untuk penyakit ISPA non-pneumonia adalah kurang dari 20%. Evaluasi penggunaan antibiotik ini menggunakan metode ATC/DDD dan DU 90%. Antibiotik yang digunakan untuk ISPA non-pneumonia adalah sebanyak 9 jenis dan antibiotik yang masuk dalam DU90% sebanyak 3 jenis yaitu amoksisilin 500 mg (2,723 DDD/1000 pasien-hari), siprofloksasin (0,378 DDD/1000 pasien-hari) dan sefadroksil (0,202 DDD/1000 pasien-hari). Analisis data secara kuantitatif menggunakan ATC/DDD menunjukkan bahwa antibiotik yang banyak digunakan adalah amoksisilin (500 mg) 2723 DDD/1000 pasien-hari dan yang paling sedikit yaitu amoksisilin (125 mg/5 ml) 1,5 DDD/1000 pasien-hari. Efek peresepan penggunaan antibiotik jangka pendek pada pelayanan pengobatan dasar dapat meningkatkan kejadian resistensi. Diperlukan studi kualitatif untuk mengetahui pola ketidakrasionalan penggunaan antibiotik di pusat pelayanan kesehatan masyarakat tersebut dan mengembangkan model intervensinya.Kata kunci: ATC/DDD, DU 90%, ISPA non-pneumonia antibiotikMonitoring the Use of Antibiotics by the ATC/DDD Method and DU 90%: Observational Studies in Community Health Service Centers in North Gorontalo DistrictIrrational use of antibiotics may lead to increase morbidity and mortality. Monitoring of antibiotics was required to support government programs, especially The Department of Health stating the use of antibiotics for non-respiratory diseases pneumonia was less than 20%. The evaluation of antibiotics use in this research applied ATC / DDD methods and DU 90%. The antibiotic used for non-pneumonia ARI were 9 types and the antibiotics contained DU 90% were three types namely amoxicillin 500 mg (2,723 DDD/1000 patients-year), ciprofloxacin (0,378 DDD/1000 patients-day) and cefadroxil (0,202 DDD/1000 patients-day). Quantitative data analysis using the ATC / DDD indicated that the most used antibiotic was amoxicillin (500 mg) 2723 DDD / 1000 patients-day and the least was amoxicillin (125 mg / 5 ml) 1.5 DDD / 1000 patients-day. The effects of short-term use of antibiotic prescribing in primary medical care could increase the resistance. Qualitative studies were needed to determine the pattern of irrational antibiotic use in community health service center and to develop the intervention model.Keywords: ARI non-pneumonia antibiotics, ATC/DDD, DU 90%
Anti-proliferative Activity of Crotalaria pallida Aiton on MCF-7 Breast Cancer Cells Erladys M. Rumondor; Moelyono Moektiwardoyo; Melisa I. Barliana
Pharmacology and Clinical Pharmacy Research Vol 2, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (145.873 KB) | DOI: 10.15416/pcpr.v2i3.16218

Abstract

 Crotalaria pallida Aiton (C. pallida Aiton) is empirically used as dietary supplement to treat cancer by the people of North Sulawesi. However, its scientific pharmacology activity has not been explored yet. Therefore, this study was conducted to evaluate anti-proliferative activity of C. pallida Aiton on MCF-7 breast cancer cells. The extraction of leaves and seeds were performed using ethanol, ethyl acetate, n-hexane, and water. Phytochemical screening was then performed to identify secondary metabolites in this extract. Anti-proliferative activity was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results indicated that ethyl acetate fraction of C. pallida Aiton has the lowest IC50 (29,67). In conclusion, ethyl acetate fraction of C. pallida Aiton is potential to be developed as anti cancer agent.Keywords: Crotalaria pallida Aiton, WST assay, MCF-7 cell line
Potential Nephrotoxicity of Lisinopril and Valsartan on Patients with Congestive Heart Failure Sarini Pani; Melisa I. Barliana; Eli Halimah; Venice Chaeriadi; Mally G. Sholih
Pharmacology and Clinical Pharmacy Research Vol 2, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.357 KB) | DOI: 10.15416/pcpr.v2i1.16192

Abstract

Lisinopril (angiotensin converting enzyme inhibitor) and valsartan (angiotensin II receptorblocker) are the first-line treatment for patients with congestive heart failure (CHF). Thesetwo drugs potentially cause side effects on renal functions. However, limited informationwas available regarding the comparison of potential nephrotoxicity of these drugs in IndonesianCHF patients. This research was aimed to compare the potential nephrotoxicitybetween lisinopril and valsartan in outpatients with CHF at a hospital in Palu, Indonesia.This was an observational study conducted during April-May 2015. Potential nephrotoxicitywere assessed by measuring serum creatinin (SCr) and blood urea nitrogen (BUN). Datawere obtained from Cardiology Unit from a hospital in Palu, Indonesia. Statistical analysiswas conducted using T-test and Mann-Whitney test. The increasing trend of SCr and BUNwere observed in lisinopril-treated patients with the mean of increase were 21% and 59%,respectively. Relatively higher increase was observed in valsartan treatment group with 47%and 51% in SCr and BUN, respectively. The analysis showed that there were significant differencesin SCr level between lisinopril and valsartan groups (p=0.001), but the oppositeresults observed in BUN parameter (p=0.697). Therefore, valsartan was potentially morenephrotoxic than lisinopril based on the increase of SCr parameter. Thus, lisinopril is recommendedfor CHF patients who are particularly at high risks of having renal impairment.Keywords: lisinopril, valsartan, nephrotoxicity, congestive heart failure
CATECHOL-O-METHYLTRANSFERASE VAL158MET GENE POLYMORPHISM IN SCHIZOPHRENIA RISPERIDONE-TREATED PATIENTS Fitri N. Ramadhani; Ajeng Diantini; Shelly Iskandar; Melisa I. Barliana
Farmaka Vol 18, No 4 (2020): Farmaka (Suplemen)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v18i4.42482

Abstract

Catechol-O-Methyltransferase (COMT) gene is located at chromosome 22q11 on a location with a high risk of the occurrence of schizophrenia that has a role in the degradation and inactivation of dopamine neurotransmitters. The COMT Val158Met gene polymorphism has enzymatic activity variation that can affect the availability of COMT enzyme, balance of dopamine level, and availability of dopamine receptors so it can influence the effectiveness of risperidone therapy that varies. The aim of this study was to observe the genetic profile of COMT Val158Met gene polymorphism and its correlation with effectiveness of risperidone therapy either single or combination in schizophrenia patients at Mental Hospital of Prof. Dr. Soerojo Magelang. This study was an observational descriptive study with a cross-sectional plan. Data collection was carried out prospectively through assessment of risperidone therapy effectiveness based on PANSS-EC scores in medical record, whole blood sampling, and identification of COMT Val158Met gene polymorphism using Polymerase Chain Reaction-Amplification Refractory Mutation System (PCR-ARMS) method. The result of study showed that all schizophrenia patients at Mental Hospital of Prof. Dr. Soerojo Magelang had heterozygote Val/Met (GA) genotype. Combination risperidone therapy was the most widely used (90.79%) rather than single with the result that 44 patients of 69 patients (63.77%) responded to the combination risperidone. Combined risperidone clozapine therapy was the most widely used (57.97%) with the result that 23 patients out of 40 (57.50%) responded to the combination therapy.
VALIDITAS DAN RELIABILITAS KUESIONER LIVING WITH MEDICINES QUESTIONNAIRE (LMQ) VERSION 3 TERHADAP PASIEN LUPUS ERITEMATOSUS SISTEMIK Aulia Nurlatifah; Melisa I. Barliana; Laniyati Hamijoyo; Rizky Abdullah
Farmaka Vol 18, No 4 (2020): Farmaka (Suplemen)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v18i4.42349

Abstract

Berbagai jenis obat harus diminum selama hidupnya oleh setiap Odapus (Orang Lupus), yang bertujuan untuk meningkatkan kualitas hidup. Berbagai jenis obat dengan jumlah banyak menghasilkan beban pengobatan yang akan menurunkan kepatuhan pasien. Ketika kepatuhan pasien menurun, maka luaran yang dihasilkan juga tidak maksimal. Beban yang terkait dengan pengelolaan penyakit kronis, termasuk pada penyakit Lupus Eritematosus Sistemik (LES), akan berdampak pada kesejahteraan pasien dan risiko terjadinya efek samping obat. Penelitian ini merupakan studi potong lintang, pengambilan data secara prospektif di Poliklinik rawat jalan Reumatologi disalah satu Rumah Sakit kota Bandung periode Februari – Maret 2019, dan menggunakan kuisioner LMQ (Living with Medicine Questionnaire) versi 3. Jumlah pasien dalam penelitian ini sebanyak 30 pasien dengan kriteria inklusi adalah pasien dengan diagnosa LES, usia minimal 18 tahun, pasien rawat jalan di Poliklinik Reumatologi, sedang meminum obat terkait pengobatan LES, dan bersedia mengikuti penelitian dengan menandatangani informed consent. Kriteria ekslusi sampel penelitian adalah pasien ibu hamil, pasien dengan gangguan pendengaran dan pasien yang tidak bisa berbicara. Uji validasi kuesioner pada penelitian ini menggunakan uji korelasi Pearson Product Moment, sedangkan uji reliabilitas kuesioner menggunakan uji Cronbach alpha coefficient. Hasil penelitian ini menunjukan bahwa nilai Koefisien Validitas (r hitung) lebih besar dari pada r tabel yaitu sebesar 0,361 (n = 30). Sedangkan koefisien reliabilitas hasil perhitungan tidak ada nilai reliabilitas yang sangat rendah (kurang dari 0,200) sehingga untuk keseluruhan item pada variabel dan domain dalam penelitian ini dapat digunakan untuk analisis variabel lebih lanjut.
FGF-21: THE HOMEOSTASIS GUARDIAN. A NEW OPTIMISM FOR OBESITY? Gianni Yosephine; Anna Meiliana; Melisa I. Barliana
Farmaka Vol 18, No 4 (2020): Farmaka (Suplemen)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v18i4.42478

Abstract

The prevalence of obesity is increasing worldwide. Current obesity treatment is not suitable for all patients, hence the novel treatment are needed. Fibroblast Growth Factor 21 (FGF21) is a protein that consisting 210 amino acids. This protein is predominantly produced by the liver. In contrast to other FGF family members, FGF21 has a metabolic effect compared to cell proliferation and differentiation. It appears to be prospect treatment for metabolic syndrome, including obesity. Studies on FGF21 continue to develop and it is found that this protein has a beneficial role in the metabolism of lipids as well as glucose in vitro and in vivo. Interestingly, this protein also has the ability in energy homeostasis and has recently emerged as an intriguing therapeutic agent for obesity care. Because of its role as energy homeostasis, this protein can increase under certain conditions for example when fasting or on the ketogenic diet. Recombinant FGF21 administration in mice has been shown to reduce lipid levels. Assembling evidence from animal studies indicates that FGF21 is a potent metabolic regulator with many beneficial effects on obesity, even though the underlying mechanism of this effect is not fully understood. In the future it has potential to use FGF21 as treatment for obesity in human.
KORELASI POLIMORFISME GEN ERCC1 RS11615 DENGAN EFEKTIVITAS KEMOTERAPI BERBASIS-PLATINUM PADA PASIEN KANKER PARU JENIS KARSINOMA BUKAN SEL KECIL Muhammad F. Effendi; Nadiya N. Afifah; Ajeng Diantini; Ruri Intania; Melisa I. Barliana
Farmaka Vol 18, No 4 (2020): Farmaka (Suplemen)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v18i4.42350

Abstract

Kemoterapi berbasis platinum merupakan regimen kemoterapi lini pertama untuk pasien kanker paru jenis karsinoma bukan sel kecil (KPKBSK) pada stadium lanjut dan non-operasi tanpa mutasi gen Epidermal growth factor receptor (EGFR). Excision repair cross-complementation group 1 (ERCC1) adalah enzim yang mengeksekusi insisi dari untai DNA yang rusak dan menghilangkan aduksi DNA yang diinduksi oleh platinum. Tujuan penelitian ini adalah untuk mengetahui korelasi polimorfisme gen ERCC1 rs11615 dengan efektivitas kemoterapi berbasis-platinum pada pasien KPKBSK di RS Paru dr. H. A. Rotinsulu Bandung pada bulan November 2019 sampai dengan Maret 2020. Penelitian ini merupakan observasional analitik dengan desain penelitian kohort prospektif terhadap 28 pasien. Polimorfisme gen ERCC1 rs11615 diidentifikasi dengan metode DNA squencing, sedangkan untuk efektivitas kemoterapi menggunakan metode response evaluation criteria in solid tumour (RECIST) dan analisis Cytokeratin 19 fragments (CYFRA 21-1). Hasil penelitian menunjukkan adanya frekuensi alel gen ERCC1 rs11615 masing-masing 50% (C/C), 35,7% (C/T), dan 14,3% (T/T). Tidak terdapat hubungan yang signifikan antara polimorfisme gen ERCC1 rs11615 dengan nilai RECIST (OR = 0,417; 95% confidence interval (CI): 0,091-1,908, P=0,256) atau dengan nilai CYFRA 21-1 (OR = 0,417; 95% confidence interval (CI): 0,063-2,768, P=0,357). Kami tidak menemukan bukti yang mendukung penggunaan gen ERCC1 rs11615 sebagai prediktor untuk menentukan efektivitas kemoterapi berbasis platinum. Dibutuhkan sampel yang memadai untuk mengkonfirmasi secara statistik korelasi polimorfisme gen ERCC1 rs11615 terhadap efektivitas kemoterapi.
THE IMPACT OF ATP-BINDING CASSETTE SUBFAMILY B MEMBER 1 (ABCB1) POLYMORPHISMS ON STANDARD TREATMENTS FOR SYSTEMIC LUPUS ERYTHEMATOSUS Muhammad Syawal Pratama; Laniyati Hamijoyo; Melisa I. Barliana
Farmaka Vol 18, No 4 (2020): Farmaka (Suplemen)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v18i4.42489

Abstract

The ATP-Binding Cassette Subfamily B Member 1 (ABCB1) gene encodes for P-glycoprotein (P-gp) which is an efflux pump used to transport a variety of xenobiotics. The role of ABCB1 polymorphisms in Systemic Lupus Erythematosus (SLE) affect outcomes of standard therapy (hydroxychloroquine, glucocorticoid (GC), azathioprine (AZA), mycophenolate mofetil (MMF), and cyclophosphamide (CYC)). We conducted an investigation assessing affiliations between the ABCB1 polymorphisms, G1199A, C1236T, G2677T/A, and C3454 and effectiveness variables. Although ABCB1 polymorphisms do not cause SLE, they exert a significant impact on therapy effectiveness. These polymorphisms significantly influenced GCs and AZA, had less effects on methotrexate (MTX), MMF, and CYC, and no impact on antimalarials. The four most influential polymorphisms were, rs1045642 (C3454), rs1128503 (C1236T), rs2032582 (G2677T/A), and rs2229109 (1199A).
Co-Authors AJENG DIANTINI Anna Meiliana Aulia Nurlatifah Eli Halimah ELI HALIMAH Erladys M. Rumondor Fitri N. Ramadhani Gianni Yosephine Ivan S. Pradipta Laniyati Hamijoyo Mally G. Sholih Moelyono Moektiwardoyo Muhammad F. Effendi Muhammad Syawal Pratama Nadiya N. Afifah Nurul Annisa Rizky Abdullah Ruri Intania Sarini Pani Sarini Pani Shelly Iskandar Venice Chaeriadi