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All Journal Medica Hospitalia Diponegoro International Medical Journal (DIMJ) Ophthalmologica Indonesiana
Maharani Cahyono
Department Of Ophthalmology, Faculty Of Medicine, Diponegoro University, Semarang, Indonesia
Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Effect Of Topical DLBS 1425 On Tissue Plasminogen Activator (tPA) Expression In Trabecular Meshwork Of Wistar Rats Utami Widijanto; Trilaksana Nugroho; Maharani Cahyono
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (403.767 KB) | DOI: 10.36408/mhjcm.v8i1.553

Abstract

Introduction: Tissue plasminogen activator (tPA) in the trabecular meshwork (TM) is a serine protease that important to maintain the aquos outflow resistance by activating the matrix metalloproteinase (MMP). It can cause a degradation of the extracellular matrix, which can maintain the normal flow of aquos humor. However, the use of anti-inflammatory drugs has been shown to reduce the expression of tPA, leading to an increase in the outflow resistance. Therefore, we propose the use of DLBS 1425, an extract of Phaleria macrocarpa which has been proven to have anti-inflammatory effects. Aim : This study aims to determine the expression of tPA in Wistar rats’ TM. Methods : An experimental laboratory study with post-test only randomized controlled group design was performed. Twenty-two Wistar rats were divided into two groups, the control and the experimental. The experimental group was given topical DLBS 1425 at a dose of 6 times / day, for 4 weeks. The control group was given drops of Hyalub Minidose® 6 times / day, for 4 weeks. tPA expression on TM was examined by immunohistochemical staining. Data were collected and processed using the SPSS 15.0 for Windows. Results : The mean tPA expression in TM with Allred scores in the experimental group (0.18 ± 0.60) was significantly lower (p <0.001) than the control group (6.27 ± 0.91). Conclusion : Topical DLBS 1425 suppresses the expression of tPA on the trabecular meshwork of Wistar rats. Key words: tissue plasminogen activator, trabecular meshwork, DLBS 1425, Phaleria macrocarpa.
The Effect of Using Blue Light Filter Feature on Smartphones with Asthenopia Occurrence Arnan Victor Wiryawan; Maharani Maharani; Tanti Ajoe Kesoema; Riski Prihatningtias
Diponegoro International Medical Journal Vol 2, No 1 (2021): July
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i1.9761

Abstract

Background: Smartphone users can be found in almost every class society in Indonesia. Excessive use of smartphones and the blue light emitted by smartphones play an important role in causing asthenopia symptoms. Smartphone development companies have developed a blue light filter feature, which is expected to reduce the incidence of Asthenopia symptoms.Objective: To evaluate the Asthenopia questionnaire's comparison results before and after smartphone use with various levels of opacity in the blue light filter.Methods: This study used a quasi-experimental pre-posttest study. The research subjects were students of the Faculty of Medicine, Diponegoro University (n = 30), selected by purposive sampling. In this study, research subjects saw an hour-long smartphone with a predetermined opacity level for the blue light filter, with the same room lighting. Before and after the treatment, the subjects were asked to fill out the Asthenopia questionnaire. Data were analyzed using the Wilcoxon test, Mann Whitney U test, and Kruskal Wallis test.Results: The results of the Asthenopia questionnaire before and after using a smartphone with a blue light filter opacity level of 0% and 100% showed a significant difference in results (p <0.05), and there was no significant difference for the pre-posttest using a smartphone with a blue light filter with 50% opacity level. The comparison results of the Asthenopia questionnaire between smartphone use with the opacity level of the blue light filter 0% and 50% only showed a significant difference in sore/aching eye symptoms. The comparison results of the Asthenopia questionnaire between smartphone use with the opacity level of the blue light filter 50% and 100% only showed a significant difference in sleepy eye symptoms. The comparison results of the Asthenopia questionnaire between smartphone use with the opacity level of the blue light filter 0%, 50%, and 100%, did not show a significant difference.Conclusion: There were no significant differences between the Asthenopia questionnaire results with 0%, 50%, and 100% opacity blue light filters after one hour of smartphone use.
Difference of Schirmer Test Results Before and After Using Smartphones with Various Screen Brightness Levels Dodik Dumadi; Maharani Maharani; Tanti Ajoe Kesoema; Riski Prihatningtias
Diponegoro International Medical Journal Vol 2, No 2 (2021): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i2.9763

Abstract

Background : The use of smartphones and other digital devices such as laptops and tablets is familiar in Indonesian society. Excessive uses of the devices are associated with dry eye syndrome and tear film dysfunction. The intensity of blue light when penetrating the eye is believed to affect tear film stability. Thus it will encourage tear evaporation which proved by Schirmer test.Objective : To find out the difference of Schirmer test results before and after using a smartphone with  various screen brightness levels.Methods : This study used pretest-posttest quasi-experimental study. The research subjects were students of the Faculty of Medicine, Diponegoro University (n = 30) who were selected by purposive sampling. In this study, the research subjects used smartphones for an hour with a predetermined screen brightness level, with the same room lighting. Before and after treatment the subject was measured the quantity of tears using the Schirmer test. Data were analyzed using the Wilcoxon test, Mann Whitney U test, and Kruskal Wallis test.Results : The average pretest result on low brightness was 25,60 ± 9,44 and the post-test result was 17,60 ± 8,45. The pre-test result on medium brightness was 27,90 ± 9,46 and the post-test result was 24,80 ± 10,46. The pre-test result on high brightness was 23,60 ± 6,80 and the post-test result was 19,10 ± 7,95. The Schirmer test results before and after using smartphones with low brightness showed a significant different (P<0.05) and there was no significant difference for the pre-post test using smartphones with medium and high brightness. Comparison of Schirmer test results on low, medium and high screen brightness did not show a significant difference.Conclusion : There is no significant difference between the Schirmer test results among low, medium and high screen brightness after one hour of smartphone usage.
Correlation of Intraocular Pressure Reduction and Frequency of Exercise Sara Listyani Koentjoro; Maharani Cahyono; Fifin Luthfia Rahmi
Majalah Oftalmologi Indonesia Vol 42 No 1 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i1.70

Abstract

Background: Intraocular pressure (IOP) is one of the primary risk factors of glaucoma. It is a modifiablerisk factor and can be affected by exercise. Some studies reported that physical exercise produced IOPreduction. The purpose of this study is to analyze the correlation between IOP reduction and frequencyof exercise.Methods: Thirty seven healthy subjects underwent IOP measurement on both eyes before andimmediately after 5 km of running. The frequency of exercise in a week was recorded and classifiedinto three groups: less than 2 times a week (group 1), 2-3 times a week (group 2), and more than 3times a week (group 3). IOP reductions were calculated and compared between groups. The data wereanalyzed with T-test for each group and ANOVA test for multivariate analysis.Results: There were 30 males and 7 females participated in this study. The mean age was 23.8±6.7years. After running up to 5 km, there was IOP reduction in each group frequency of exercise. Themean IOP reduction in group 1 was 0.20±2.5 mmHg (1.01%), in group 2 was 1.58±2.6 mmHg (8.60%),in group 3 was 1.31±3.0 mmHg (6.82%). IOP reductions in group 2 was statistically significant (p=0.019),compared to the other group. The multivariate analysis of three groups resulted in not significantcorrelation of IOP reduction and frequency of exercise (p=0.431).Conclusion: There was IOP reduction after running up to 5 km in each group frequency of exercise.However, there was no significant correlation of IOP reduction and frequency of exercise. Keywords: intraocular pressure, IOP, exercise
Intraocular Pressure Changes After Selective Laser Trabeculoplasty (SLT) in Open-Angle Glaucoma Amalia Mayasari; Maharani Cahyono
Majalah Oftalmologi Indonesia Vol 42 No 2 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i2.85

Abstract

Background: Selective laser trabeculoplasty (SLT) use laser to selectively target pigmented trabecularmeshwork without producing collateral damage to adjacent non-pigmented cells or structures. A previousdata suggests that SLT is effective at every stage of open-angle glaucoma (OAG). SLT can be used asa first-line therapy, alternative to medical therapy, or as an adjunctive therapy to topical glaucomadrops. The aim of this study was to determine the changes in intraocular pressure (IOP) after SLT inpatients with OAG.Methods: Design of this research was cohort-prospective study. Twenty-six eyes of 18 patients withOAG were participated in this study. All the patients were treated with 180o SLT to the temporaltrabecular meshwork and followed by 180o SLT to the nasal trabecular meshwork 1 week after the firsttreatment. A frequency-doubled (532 nm) Q-switched Nd:YAG laser with a 400 μm spot size wasused to deliver 0.4-1.0 mJ of energy for 0.3 ns to perform the procedure. Additionally, IOP in thetreated eye was assessed and measured with Goldman applanation before SLT, and 1 hour, 1 week,and 2 weeks following complete SLT. All patientes were given corticosteroid (prednisolone acetat 1%eyedrop) 4 times a day for 7 days after SLT to prevent elevation of IOP caused by inflammation.Results: The average pre-SLT IOP were 19.94 mmHg. The mean IOP 1 hour post-SLT was slightlyincrease. IOP 2 weeks after complete SLT showed a significant decrease compared to before SLT(Wilcoxon-test, before: p=0.033; 1 hour: p=0.915; 1 week: p=0.098; 2 weeks: p=0.009)Conclusion: Intraocular pressure lowering effect was significant at 2 weeks after SLT treatment. SLTeffectively reduces IOP in open-angle glaucoma. It can be used as a primary or adjunctive therapy inpatient with open-angle glaucoma.Keywords: obstructive MGD, quality of meibum, ocular surface damage
Co-Authors Amalia Mayasari Arnan Victor Wiryawan Dodik Dumadi Fifin Luthfia Rahmi Riski Prihatningtias Sara Listyani Koentjoro Tanti Ajoe Kesoema, Tanti Ajoe Trilaksana Nugroho Utami Widijanto