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All Journal Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Medica Hospitalia Diponegoro International Medical Journal (DIMJ) Ophthalmologica Indonesiana
Fifin Luthfia Rahmi
Department Of Ophthalmology, Faculty Of Medicine, Universitas Diponegoro Kariadi Hospital, Semarang, Central Java
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Comparison of Intraocular Pressure (IOP) Value Before and After Vitrectomy in Diabetic Retinopatic Patients Arnila Novitasari Saubig; Fifin Luthfia Rahmi; Hesti Triwahyu Hutami
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29943

Abstract

Background: Diabetic retinopathy is one of the second highest complications of microangiopathy in Indonesia due to diabetes mellitus in the form of damage to retina of the eye and can cause blindness in adults. The management of diabetic retinopathy is done by operative measure, one of which vitrectomy. However, this procedure can lead to an increase in the value of intraocular pressure after surgery. In this study, analysis of differences in intraocular pressure values before and after vitrectomy was carried out in patients with diabetic retinopathy.Research Purpose: To know, compare, and analyze the intraocular pressure values before and after vitrectomy in patients with diabetic retinopathy.Method: The study design was an analytic observation with a study design cross-sectional. Sampling using method consecutive sampling obtained from medical record of 45 diabetic retinopathy patients who underwent vitrectomy at the RSND for the period July-December 2019. After the data was collected, the data were analyzed using the difference Wilcoxon rank test.Result: A total of 45 diabetic retinopathy patients underwent vitrectomy from medical records were dominated by 24 people aged >69 years and 26 female patients. The mean values of intraocular pressure before and one week after vitrectomy were 20.32 + 2.57 mmHg and 23.89 + 9.24 mmHg. The results showed that there was a higher intraocular pressure value after vitrectomy than before vitrectomy in diabetic retinopathy patients (p=0.021) or p,0.05
Comparison of Prostaglandin Analogue and Selective Laser Trabeculoplasty Capability to Maintain Intraocular Pressure Fluctuation on Primary Open Angle Glaucoma Sara Listyani Koentjoro; Maharani Cahyono; Fifin Luthfia Rahmi
Journal of Biomedicine and Translational Research Vol 3, No 1 (2017): July 2017
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (65.279 KB) | DOI: 10.14710/jbtr.v3i1.1206

Abstract

Background: Glaucoma patients often come with intraocular pressure (IOP) that reach target pressure, but still have glaucoma progression due to IOP fluctuation. Water drinking test (WDT) can be used as a method to predict IOP fluctuation.Purpose: To compare prostaglandin analogue (PGA) and selective laser trabeculoplasty (SLT) capability to maintain IOP fluctuation on primary open angle glaucoma (POAG).Method: This clinical experimental research was conducted at Dr. Kariadi Hospital. Subjects were POAG patients selected with consecutive sampling. Intraocular pressure was measured before and after WDT. After WDT, IOP was measured every 15 minutes until 1 hour. Peak IOP and IOP fluctuation data were collected then analyzed with t-test.Results: Forty two eyes from 30 POAG patients were analyzed. Twenty six eyes in PGA group and 16 eyes in SLT group. Most of the subjects were male with mild glaucoma degree. WDT increased IOP significantly on both groups. Mean IOP pre WDT was 14.58 ± 2.580 mmHg and 16.94 ± 2.645 mmHg in PGA and SLT groups. Mean peak IOP post WDT was 22.73 ± 4.114 mmHg and 25.75 ± 5.859 mmHg in PGA and SLT groups. Mean IOP fluctuation was 8.15 ± 4.202 mmHg and 8.81 ± 5.344 mmHg in PGA and SLT groups. Peak IOP and IOP fluctuation result analysis on both groups were not significantly different.Conclusion: Prostaglandin analogue and SLT had equal capability to maintain IOP fluctuation but still higher than normal fluctuation (>6 mmHg) that affects glaucoma progression.
Perbedaan Skor OSDI Pre dan Post Senam "PERMATA-KU" pada Computer Vision Syndrome Fuadah Uyun; Fifin Luthfia Rahmi; Arnila Novitasari Saubig; Hari Peni Julianti
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (285.013 KB) | DOI: 10.36408/mhjcm.v8i2.543

Abstract

ABSTRACT DIFFERENCE OF OSDI SCORE BEFORE AND AFTER ‘SENAM PERMATA-KU’ IN COMPUTER VISION SYNDROME Background: Computer Vision Syndrome (CVS) is a group of symptoms that affects the eye and vision due to prolonged use of computer, cellphone, tablet, and e-reader. Dry eye is one of the symptoms that appear in CVS. In this study we did ‘senam PERMATA-KU’ (Pelihara Mata–Kendorkan Bahu) as additional exercise to reduce dry eye in CVS. Aim: Observe there is any improvement of OSDI (Ocular Surface Disease Index) score before and after doing “senam PERMATA-KU” in CVS. Methods: This was a Pre-Post with Control Design quasi experimental study. The subjects were students of Faculty of Medicine of Diponegoro University who had CVS and met the inclusion and exclusion criteria that were divided randomly into control group and experimental group. The experimental group were given an education about using computer ergonomically and ‘senam PERMATA-KU’ for 14 days. The control group were given an education about using computer ergonomically. OSDI score were measured before and after intervention was given using Ocular Surface Disease Index questionnaire. Result: The subjects were 32 students with 16 students in the experimental group and 16 students in the control group. One student in the control group and one student in the experimental group dropped out because they could not complete the procedure so that only 30 subjects were analyzed. OSDI score after intervention in experimental group was decreased significantly (p<0.05). OSDI score after intervention in experimental group was better compared to control group (p<0.05). OSDI score improvement in experimental group was higher compared to control group but statistically is not significant (p=0.595). Conclusion: ‘senam PERMATA-KU’ that was done for 14 days can improve OSDI score in Computer Vision Syndrome. Keywords: Computer Vision Syndrome (CVS), Ocular Surface Disease Index (OSDI), dry eye, ‘senam PERMATA-KU’
Correlations between Severity of Disease with Anxiety Levels in Glaucoma Patients Maulida Zahra; Arief Wildan; Riski Prihatningtias; Fifin Luthfia Rahmi
Diponegoro International Medical Journal Vol 1, No 1 (2020): July
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v1i1.7926

Abstract

Background: Glaucoma is a group of diseases consisting of optic neuropathy characterized by damage to the retinal nerve fibers and narrowing of the visual field accompanied by increased intraocular pressure as a risk factor. Vision loss in glaucoma patients is considered as a separate stressor. Besides that, decrease visual function can also cause a person to lose his job and loss of social functions. This can trigger anxiety to depression.Objective: To analyze the correlations between the severity of disease with anxiety levels in glaucoma patients.Methods: This was an observational analytic study with a cross-sectional design. Subjects were taken by consecutive sampling with inclution criterias were patients with moderate or severe glaucoma, able to follow the interview process and 30-80 years old. The exclusion criteria of this study were patients who was taking anti-anxiety, antidepressant, or antipsychotic drugs and having other serious / chronic disease such as heart disease, diabetes, or hypertension. Anxiety level was assessed based on the Taylor Manifest Anxiety Scale (TMAS) questionnaire. Analysis of the data using the Spearman Correlation test.Results: Sixty five glaucoma patients who underwent treatment in out patients department dr. Kariadi hospital were involved in this study.  A significant correlation was obtained between the severity of glaucoma and the level of anxiety (p = 0.004). Strong statistical correlation between variables included in the weak category (0.357). The highest anxiety level in glaucoma patients was moderate anxiety level (64.6%), followed by mild anxiety level (23.1%) and severe anxiety level (12.3%).Conclusion: There were significant correlation between the severity of the disease and the level of anxiety in glaucoma patients.
The Discontinuation Effect of Topical Prednisolone on Extracellular Matrix Trabecular Meshwork in Wistar Rat Sekar Kumalasari; Liana Ekowati; Arief Wildan; Hermawan Istiadi; Arnila Novitasari Saubig; Fifin Luthfia Rahmi
Journal of Biomedicine and Translational Research Vol 8, No 1 (2022): April 2022
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v1i1.13440

Abstract

ABSTRACT Background:Intra ocular pressure (IOP) elevationis one of topical steroids’ side effects. Corticosteroid will initiate matrix metalloproteinase cascade that leads to extra cellular matrix (ECM)of trabecular meshwork (TM) turnover(remodeling) and its acumulationin TM. Objective: To analyze the reversibility of ECM TM in Wistar rat after discontinuation oftopical prednisolone1% at different periode(14 days and 28 days). Methods:This was an experimental study with post test only controlgroup design. Total samples of 28 rats were divided into 4 groups: Treatment groups 1 was treated with  topical prednisolone for 28 days, and was terminated 14 days after discontinuation of the drug.Treatment goups2 was treated topical prednisolone for 28 days and was terminated28 days after discontinuation of the drug. Control 1 was treated withtopical prednisolone for 28 days, and Control 2 was treated with topical saline for 28 days and terminated without periode of discontinuation. Histopathological grading score was used to evaluate ECM TM deposition. Mann-Whitney test and Kruskal-Wallis test were used to analyze the data. Result: Deposition of ECM in TM was not statistically different intreamentgroup 1 and treatment group 2 (p>0.05). Deposition of ECM in TM were statistically differentbetween treatment group 2 and control group 1 (p<0.05). Comparative test showed p<0.001,which means that there was a change in the  thickness of ECM after discontinuation of instillation. Conclusion: ECM TM was thinner in the experimental animals with a longer duration of topical prednisolondiscontinuation, which demonstrate that maintenance remodeling of ECM was happen.
Correlation of Intraocular Pressure Reduction and Frequency of Exercise Sara Listyani Koentjoro; Maharani Cahyono; Fifin Luthfia Rahmi
Majalah Oftalmologi Indonesia Vol 42 No 1 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i1.70

Abstract

Background: Intraocular pressure (IOP) is one of the primary risk factors of glaucoma. It is a modifiablerisk factor and can be affected by exercise. Some studies reported that physical exercise produced IOPreduction. The purpose of this study is to analyze the correlation between IOP reduction and frequencyof exercise.Methods: Thirty seven healthy subjects underwent IOP measurement on both eyes before andimmediately after 5 km of running. The frequency of exercise in a week was recorded and classifiedinto three groups: less than 2 times a week (group 1), 2-3 times a week (group 2), and more than 3times a week (group 3). IOP reductions were calculated and compared between groups. The data wereanalyzed with T-test for each group and ANOVA test for multivariate analysis.Results: There were 30 males and 7 females participated in this study. The mean age was 23.8±6.7years. After running up to 5 km, there was IOP reduction in each group frequency of exercise. Themean IOP reduction in group 1 was 0.20±2.5 mmHg (1.01%), in group 2 was 1.58±2.6 mmHg (8.60%),in group 3 was 1.31±3.0 mmHg (6.82%). IOP reductions in group 2 was statistically significant (p=0.019),compared to the other group. The multivariate analysis of three groups resulted in not significantcorrelation of IOP reduction and frequency of exercise (p=0.431).Conclusion: There was IOP reduction after running up to 5 km in each group frequency of exercise.However, there was no significant correlation of IOP reduction and frequency of exercise. Keywords: intraocular pressure, IOP, exercise
The Effect of Duration of Administration and Discontinuation of Fluorometholone Eye Drops on The Trabecular Meshwork Sandi Muslim; Arnila Novitasari Saubig; Riski Prihatningtias; A. Kentar Arimadyo Sulakso; Fifin Luthfia Rahmi
Journal of Biomedicine and Translational Research Vol 8, No 2 (2022): August 2022
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v8i2.13817

Abstract

Background: The extracellular matrix (ECM) in the trabecular meshwork (TM) may play a role in the steroid-induced aqueous humor outflow resistance pathophysiology. Topical steroids such as fluorometholone can cause elevated intraocular pressure. Increased synthesis and accumulation of TM ECM proteins due to steroids result in TM dysfunction and elevated intraocular pressure.Purpose: This study aims to analyze the effect of duration of administration and discontinuation of fluorometholone eye drops on the thickness of the TM ECM of Wistar rats.Methods: This study was an experimental study with a posttest-only control group design. The total sample of 25 rats was divided into 5 groups: Treatment 1 was given topical fluorometholone for 4 weeks and stopped for 4 weeks. Treatment 2 was given fluorometholone for 6 weeks and stopped for 4 weeks. Control 1 was given topical fluorometholone for 4 weeks, Control 2 was given topical fluorometholone for 6 weeks, and the negative control was used as a baseline. TM ECM examination was assessed using histopathological score grading. This study used the Mann-Whitney test and the Kruskal-Wallis comparative hypothesis test.Results: The difference in ECM thickness was not statistically significant either between treatment group 1 and treatment group 2 (p=1.000) or control group 1 (p=0,1000). There was a significant change in the thickness of the TM ECM in treatment group 1, treatment 2, control 1, control 2 compared to the negative control (p=0.003, p=0.003, p=0.003, p=0.004).Conclusion: TM ECM thickness did not return to normal thickness after administration of fluorometholone eye drops one drop 4 times a day for 4 weeks and 6 weeks followed by discontinuation of the drug for 4 weeks. The thickness of the TM ECM was thicker in experimental rats with a longer duration of administration of fluorometholone eye drops.
Co-Authors A. Kentar Arimadyo Sulakso Arief Wildan Arnila Novitasari Saubig Fuadah Uyun Hari Peni Julianti Hermawan Istiadi Hesti Triwahyu Hutami Liana Ekowati Maharani Cahyono Maharani Cahyono Maulida Zahra Riski Prihatningtias Riski Prihatningtias Sandi Muslim Sara Listyani Koentjoro Sara Listyani Koentjoro Sekar Kumalasari