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All Journal Journal of Biomedicine and Translational Research Jurnal Pengabdian Masyarakat Multidisiplin Diponegoro International Medical Journal (DIMJ) Ophthalmologica Indonesiana
Riski Prihatningtias
Department Of Ophthalmology, Faculty Of Medicine, Diponegoro University Kariadi Hospital, Semarang, Central Java
Aerospace Engineering Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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The Effect of Glutathione on Serum Malondialdehyde (MDA) Level in Retinopathy of Prematurity Rat Models Puspita Kusuma Dewi; Maharani Cahyono; Riski Prihatningtias; Liana Ekowati; Arief Wildan
Journal of Biomedicine and Translational Research Vol 6, No 3 (2020): December2020
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v6i3.9414

Abstract

Introduction Retinopathy of prematurity (ROP) is the leading cause of blindness in newborn babies worldwide. The benefit of anti-oxidant was investigated for ROP cases by assessing its effect on the oxidative stress of the tissues. Glutathione is a primary endogenous in human body and its supplementation has been discovered for its benefits towards some ocular diseases. This study aims to understand the effect of glutathione on oxidative stress marker, serum Malondialdehyde (MDA), in ROP rat models.Materials and methods This was an experimental study with post test only controlled group design. Sixteen Wistar rats that met our study criterias were divided into two groups, study group and control group. The study group were exposed to 95% oxygen for 4 hours / day followed by normoxic laboratory condition for 20 hours. Glutathione 1.5 mg / day were injected intramuscularly to rats in study group. The control group was exposed to 95% oxygen followed by normoxic laboratory condition with the same manner, and did not received glutathione. This cycle was repeated for 14 days. Both groups were settled in a room temperature settings on days 15-22. Serum sampel was collected from retroorbital vein. The malondialdehyde level was analyzed using MDA analyser kit.Results MDA level was found significantly higher in study group compared to control group (546.99 ng/ml vs 201.51 ng/ml, respectively, p 0,001).Conclusion Our study demonstrated a higher MDA levels in ROP rat models given glutathione injection compared to the control group.
PEMERIKSAAN MATA ANAK SD GULON 2 KECAMATAN SALAM UNTUK MENDUKUNG TUMBUH KEMBANG ANAK Edward Kurnia Setiawan Limijadi; Meita Hendrianingtyas; Maharani Maharani; Buwono Puruhito; Riski Prihatningtias
Jurnal Pengabdian Masyarakat Multidisiplin Vol 3 No 3 (2020): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.58 KB) | DOI: 10.36341/jpm.v3i3.1121

Abstract

Anak usia sekolah perlu mendapatkan perhatian dalam kesehatan tubuhnya untuk dapat menunjang proses tumbuh kembang yang optimal. Salah satu organ yang penting dalam menunjang proses tumbuh kembang adalah mata. Pemeriksaan kesehatan mata diperlukan untuk menapis dan mendiagnosis penyakit mata secara dini. Anak-anak SDN Gulon 2 mayoritas mempunyai orang tua yang bekerja sebagai petani dan memiliki tingkat pengetahuan tentang kesehatan yang rendah. Anak-anak SDN Gulon 2 tersebut belum pernah mendapatkan pemeriksaan kesehatan mata sebelumnya. Tujuan kegiatan pengabdian masyarakat ini adalah penemuan kasus penyakit mata pada anak SDN Gulon 2 dan pemberian edukasi kepada guru SD mengenai penyakit mata yang ditemukan serta pemeberian saran untuk penatalaksanaan penyakit yang ditemukan. Pemeriksaan kesehatan mata yang dilakukan meliputi pemeriksaan visus atau tajam penglihatan dengan Optotype Snellen, pemeriksaan segmen anterior mata dengan loop dan senter, serta pemeriksaan segmen posterior mata dengan oftalmoskop. Edukasi kepada guru dilakukan setelah pemeriksaan selesai dilakukan dan didapatkan suatu diagnosis penyakit mata. Kegiatan pengabdian masyarakat ini berhasil menemukan kelainan tajam penglihatan sebanyak 19 kasus, kelainan segmen anterior 1 kasus dan 1 kasus kelainan segmen posterior. Kegiatan pengabdian masyarakat seperti ini perlu dilakukan di sekolah-sekolah lain di Desa Gulon, dan tidak hanya pemeriksaan kesehatan mata namun kesehatan tubuh secara menyeluruh.
The Effect of Using Blue Light Filter Feature on Smartphones with Asthenopia Occurrence Arnan Victor Wiryawan; Maharani Maharani; Tanti Ajoe Kesoema; Riski Prihatningtias
Diponegoro International Medical Journal Vol 2, No 1 (2021): July
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i1.9761

Abstract

Background: Smartphone users can be found in almost every class society in Indonesia. Excessive use of smartphones and the blue light emitted by smartphones play an important role in causing asthenopia symptoms. Smartphone development companies have developed a blue light filter feature, which is expected to reduce the incidence of Asthenopia symptoms.Objective: To evaluate the Asthenopia questionnaire's comparison results before and after smartphone use with various levels of opacity in the blue light filter.Methods: This study used a quasi-experimental pre-posttest study. The research subjects were students of the Faculty of Medicine, Diponegoro University (n = 30), selected by purposive sampling. In this study, research subjects saw an hour-long smartphone with a predetermined opacity level for the blue light filter, with the same room lighting. Before and after the treatment, the subjects were asked to fill out the Asthenopia questionnaire. Data were analyzed using the Wilcoxon test, Mann Whitney U test, and Kruskal Wallis test.Results: The results of the Asthenopia questionnaire before and after using a smartphone with a blue light filter opacity level of 0% and 100% showed a significant difference in results (p <0.05), and there was no significant difference for the pre-posttest using a smartphone with a blue light filter with 50% opacity level. The comparison results of the Asthenopia questionnaire between smartphone use with the opacity level of the blue light filter 0% and 50% only showed a significant difference in sore/aching eye symptoms. The comparison results of the Asthenopia questionnaire between smartphone use with the opacity level of the blue light filter 50% and 100% only showed a significant difference in sleepy eye symptoms. The comparison results of the Asthenopia questionnaire between smartphone use with the opacity level of the blue light filter 0%, 50%, and 100%, did not show a significant difference.Conclusion: There were no significant differences between the Asthenopia questionnaire results with 0%, 50%, and 100% opacity blue light filters after one hour of smartphone use.
Correlations between Severity of Disease with Anxiety Levels in Glaucoma Patients Maulida Zahra; Arief Wildan; Riski Prihatningtias; Fifin Luthfia Rahmi
Diponegoro International Medical Journal Vol 1, No 1 (2020): July
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v1i1.7926

Abstract

Background: Glaucoma is a group of diseases consisting of optic neuropathy characterized by damage to the retinal nerve fibers and narrowing of the visual field accompanied by increased intraocular pressure as a risk factor. Vision loss in glaucoma patients is considered as a separate stressor. Besides that, decrease visual function can also cause a person to lose his job and loss of social functions. This can trigger anxiety to depression.Objective: To analyze the correlations between the severity of disease with anxiety levels in glaucoma patients.Methods: This was an observational analytic study with a cross-sectional design. Subjects were taken by consecutive sampling with inclution criterias were patients with moderate or severe glaucoma, able to follow the interview process and 30-80 years old. The exclusion criteria of this study were patients who was taking anti-anxiety, antidepressant, or antipsychotic drugs and having other serious / chronic disease such as heart disease, diabetes, or hypertension. Anxiety level was assessed based on the Taylor Manifest Anxiety Scale (TMAS) questionnaire. Analysis of the data using the Spearman Correlation test.Results: Sixty five glaucoma patients who underwent treatment in out patients department dr. Kariadi hospital were involved in this study.  A significant correlation was obtained between the severity of glaucoma and the level of anxiety (p = 0.004). Strong statistical correlation between variables included in the weak category (0.357). The highest anxiety level in glaucoma patients was moderate anxiety level (64.6%), followed by mild anxiety level (23.1%) and severe anxiety level (12.3%).Conclusion: There were significant correlation between the severity of the disease and the level of anxiety in glaucoma patients.
Difference of Schirmer Test Results Before and After Using Smartphones with Various Screen Brightness Levels Dodik Dumadi; Maharani Maharani; Tanti Ajoe Kesoema; Riski Prihatningtias
Diponegoro International Medical Journal Vol 2, No 2 (2021): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i2.9763

Abstract

Background : The use of smartphones and other digital devices such as laptops and tablets is familiar in Indonesian society. Excessive uses of the devices are associated with dry eye syndrome and tear film dysfunction. The intensity of blue light when penetrating the eye is believed to affect tear film stability. Thus it will encourage tear evaporation which proved by Schirmer test.Objective : To find out the difference of Schirmer test results before and after using a smartphone with  various screen brightness levels.Methods : This study used pretest-posttest quasi-experimental study. The research subjects were students of the Faculty of Medicine, Diponegoro University (n = 30) who were selected by purposive sampling. In this study, the research subjects used smartphones for an hour with a predetermined screen brightness level, with the same room lighting. Before and after treatment the subject was measured the quantity of tears using the Schirmer test. Data were analyzed using the Wilcoxon test, Mann Whitney U test, and Kruskal Wallis test.Results : The average pretest result on low brightness was 25,60 ± 9,44 and the post-test result was 17,60 ± 8,45. The pre-test result on medium brightness was 27,90 ± 9,46 and the post-test result was 24,80 ± 10,46. The pre-test result on high brightness was 23,60 ± 6,80 and the post-test result was 19,10 ± 7,95. The Schirmer test results before and after using smartphones with low brightness showed a significant different (P<0.05) and there was no significant difference for the pre-post test using smartphones with medium and high brightness. Comparison of Schirmer test results on low, medium and high screen brightness did not show a significant difference.Conclusion : There is no significant difference between the Schirmer test results among low, medium and high screen brightness after one hour of smartphone usage.
The Analysis of Vasculopathy Risk Factors to the Incidence of N-AION Intan Oktaviana; Riski Prihatningtias
Majalah Oftalmologi Indonesia Vol 41 No 3 (2015): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.753 KB) | DOI: 10.35749/journal.v41i3.47

Abstract

Background: Nonarteritic Anterior Ischemic Optic Neuropathy (N-AION) is an optic disc oedem caused by ischemic process. The disease often occured at old age population and threatening the vision. Vasculopathy was assumed to accelerate the ischemic process in the incidence of N-AION. The purpose of this study is to analyze the vasculopathy risk factors that play a role to the incidence of N-AION in Kariadi Hospital Semarang. Methods: This was an analytic observational study with chi square test. Samples were obtained from patient’s medical record who were diagnosed as N-AION in Kariadi Hospital eye’s clinic from January 2012 to June 2014. The data included vasculopathy risk factors consisting of hypertension (blood pressure >140/80 mmHg), diabetic Mellitus (blood sugar >200mg/dl) and dislypidemia, including hypercholesterolemia (>200 mg/dl), hypertriglyceride (>150 mg/dl) and the increase of LDL level (>140 mg/dl). All the data was analysed by SPSS 15.0. Results: A total of 31 patients of N-AION were reviewed, 20 patients (64,5 %) had risk factors of hypertension and those with diabetic mellitus. Twenty five patients (80.6%) were hypercholesterolemia, 15 patients (48.4%) were hypertriglyceride and 11 patients (25.5%) had increasing LDL level. The statistical testing using chi square test (α = 0,05) resulted only hypercholesterolemia (p=0.001) which had a significant correlation with the incidence of N-AION, meanwhile hypertension (p=0.106), diabetic mellitus (p=0,106) and hypertriglyceride (p=0.857) had no significant correlation. Conclusion: Statistic analysis of vasculopathy risk factors to the incidence of N-AION indicates that hypercholesterolemia is the most influence risk factor. Keywords: N-AION, risk factor, vasculopathy
Co-Authors Arief Wildan Arnan Victor Wiryawan Buwono Puruhito Dodik Dumadi Edward Kurnia Setiawan Limijadi Fifin Luthfia Rahmi Intan Oktaviana Liana Ekowati Maharani Cahyono Maharani Cahyono Maharani Maharani Maulida Zahra Meita Hendrianingtyas Puspita Kusuma Dewi Tanti Ajoe Kesoema, Tanti Ajoe