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ANALISIS EFEKTIVITAS BIAYA KEMOTERAPI PADA PASIEN KANKER PAYUDARA DI RSPAD GATOT SOEBROTO JAKARTA Musnelina, Lili; Pontoan, Jenny; Martin, Clara Jesica
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Breast cancer is a disease of malignant neoplasm which is an abnormal growth of tissue that is different from the surrounding tissue. Various used of chemotherapy in the process of achieving management in cancer that causes the use of benefits and costs. This study aims to determine a more effective therapy in breast cancer patients at RSPAD Gatot Soebroto in 2017. This study was non experimental with comparative study into two group chemotherapy is single group (chemotherapy bondronat) and combination group (chemotherapy doxorubicin-paclitaxel). This study use secondary data from medical records patients on retrospectively. The results showed a decrease in the scale of single chemotherapy (Bondronat) was 82,61% with an average direct medical cost of IDR 9,3 million where as in combination chemotherapy (Doxorubicin-Paclitaxel) 95,65% with an average direct medical cost of IDR 7,6 million. The ACER value in single chemotherapy was IDR 11,3 million and combination chemotherapy was IDR 7,9 million. The ICER value in the two treatment groups was IDR 13,5 million. The conclusion is the combination of chemotherapy of Doxorubicin-Paclitaxel is the most cost-effective than Bondronate single chemotherapy.

Profil Kesesuaian Terapi Obat Dispepsia Terhadap Formularium Pada Pasien Rawat Jalan Rumah Sakit Tk. IV Cijantung Jakarta, Jakarta Timur, Periode Januari – Desember 2016 Lili Musnelina; Dewa Gede Agung AR
SAINSTECH FARMA Vol 12 No 2 (2019): Sainstech Farma Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Dispepsia merupakan suatu sindroma atau kumpulan gejala/keluhan berupa nyeri atau rasa tidak nyaman pada ulu hati, mual, kembung, muntah, sendawa, rasa cepat kenyang, dan perut merasa penuh. Tujuan penelitian ini untuk mengetahui profil karakteristik terapi obat dispepsia dan kesesuaian terapi obat dispepsia terhadap formularium. Penelitian ini merupakan bersifat deskriptif non eksperimental. Pengumpulan data dilakukan secara retrospektif terhadap 100 pasien yang menjalani rawat jalan di Rumah Sakit Tk. IV Cijantung selama periode Januari sampai dengan Desember 2016. Hasil penelitian menunjukkan bahwa pasien dengan jenis kelamin terbanyak adalah perempuan (73%), jumlah pasien yang terbanyak terdapat pada usia 45 – 56 tahun (27%), jenis terapi yang banyak digunakan adalah omeprazole (17,19%), kombinasi obat yang banyak digunakan adalah kombinasi antagonis H2+Prokinetik+kelompok obat lain (14%), ketepatan dosis dan frekuensi yang paling tepat (85,3%), lama terapi obat yang terbesar adalah 1-7 hari diperoleh (89,4%), kesesuaian jenis terapi yang terbanyak diresepkan sesuai terhadap formularium adalah ranitidine (14,4%) dan kesesuaian terapi obat dispepsia terhadap formularium diperoleh (85,9%), yang artinya sudah >80%, bahwa penerapan formularium pada penggunaan terapi obat dispepsia di rumah sakit Tk.IV Cijantung Jakarta Timur sudah dilaksanakan dengan baik dan sesuai dengan formularium rumah sakit.

Evaluasi Terapi Antiretroviral Terhadap Perkembangan Jumlah Limfosit CD4+ dan Perkembangan Berat Badan Pada Pasien HIV/AIDS Rawat Jalan di Rumah Sakit PELNI Jakarta Periode Januari-Juni 2013 Lili Musnelina; Tyas Kusumaningrum Ganis
SAINSTECH FARMA Vol 7 No 1 (2014): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v7i1.770

Angka kejadian HIV/AIDS dari tahun ke tahun terus meningkat. Terapi antiretroviral memiliki mekanisme kerja mencegah replikasi virus secara bertahap menurunkan jumlah virus dalam darah. Evaluasi terapi antiretroviral dinilai dari hasil pemeriksaan jumlah limfosit CD4+ yang merupakan status imunitas pasien HIV/AIDS. Sistem imunitas tubuh menurun menyebabkan turunnya berat badan secara bertahap. Penelitian ini bertujuan untuk mengetahui sejauh mana perkembangan jumlah limfosit CD4+ (Normal 1500 sel/mm3) dan berat badan setelah mendapatkan terapi antiretroviral di Rumah Sakit PELNI Jakarta. Jenis penelitian yang digunakan adalah metode penelitian non-eksperimental dan bersifat deskriptif analitik. Pengumpulan data menggunakan pendekatan retrospective dari berkas data rekam medik dan analisis data menggunakan uji statistik paired sample T-Test dengan sampel yang didapatkan sebanyak 52 rekam medik yang telah memenuhi kriteria inklusi pada periode Januari-Juni 2013. Hasil penelitian menunjukkan bahwa penderita HIV/AIDS paling banyak pada pasien laki-laki sebanyak 34 pasien (65,4%) berusia antara 30-39 tahun sebanyak 23 pasien (46,2%) dengan faktor risiko NON IDU sebesar 35 pasien (67,3%). Gejala klinis yang dirasakan pasien paling banyak adalah batuk sebanyak 21 pasien (40,0%) dengan kejadian infeksi oportunistik TB paru 24 pasien (46,0%) dan menggunakan regimen lini-pertama substitusi sebanyak 31 pasien (59,6%) dengan kombinasi jenis obat yang digunakan adalah stavudin + lamivudin + efvirenz dan tenofovir + lamivudin + efvirenz sebanyak 30 pasien (58,0%). Perkembangan pasien HIV/AIDS setelah mendapatkan terapi antiretroviral mengalami peningkatan jumlah limfosit CD4+ sebanyak 51 pasien (98,1%) dengan peningkatan rata-rata sebanyak 2,01 sel/mm3 dan peningkatan berat badan sebanyak 47 pasien (90,4%) dengan rata-rata sebesar 7,35 kg setelah 6 bulan mendapatkan terapi antiretroviral.

Evaluasi Penggunaan Obat Antihipertensi Pada Pasien Hipertensi Primer di Rumah Sakit Umum Daerah Kota Depok Lili Musnelina; Sri Eka Yanti NK
SAINSTECH FARMA Vol 10 No 1 (2017): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v10i1.797

Hipertensi primer atau hipertensi esensial adalah jenis hipertensi yang tidak diketahui penyebab pastinya. Tujuan dari penelitian ini adalah untuk mengetahui evaluasi penggunaan obat antihipertensi pada pasien hipertensi primer di Instalasi Rawat Jalan RSUD Kota Depok periode Januari 2015 - Desember 2015. Penelitian ini dilakukan secara retrospektif menggunakan data rekam medik pasien. Data yang diperoleh dievaluasi kesesuaiannya dengan JNC8 Tahun 2013. Dari 65 data rekam medik pasien berdasarkan jenis kelamin tertinggi terdapat pada wanita yaitu 81,54% dengan rentang usia tertinggi pada 36-45 tahun, dengan tekanan darah tertinggi pada Hipertensi Derajat 2 yaitu 35,38%, Jenis obat Antihipertensi yang digunakan untuk hipertensi primer di RSUD Kota Depok periode Januari 2015 – Desember 2015 yaitu : ARB + CCB (Valsartan + Nifedipin, Valsartan + Amlodipin, Valsartan +Candesartan) 43,08% , jenis ACE Inhibitor (Captopril) 15,38%, ARB (Valsartan) 12,31%, CCB (Amlodipin, Nifedipin) 15,38%, CCB+Diuretik tiazid (Nifedipin + HCT) 3,08%, CCB+ACE (Amlodipin + Captopril, Nifedipin + Captopril) 4,61%, Diuretik tiazid (HCT) 1,54%, ARB + Diuretik Tiazid (Valsartan + HCT), ACE Inhibitor + Diuretik Tiazid (Captopril + HCT) dan ARB + CCB + Diuretik Tiazid (Valsartan + Nifedipin + HCT) 1,54%. Pengobatan jenis kombinasi 56,92% dan pengobatan tunggal 43,08%. Dari 65 data rekam medik pasien yang telah di evaluasi kesesuaiannya dengan JNC8 tahun 2013 diperoleh tepat indikasi 100%, tepat pasien 100%, tepat dosis dan tepat frekuensi pemberian 55,38%.

Pengukuran Kualitas Hidup Pasien Diabetes Melitus Tipe 2 dengan Penyakit Penyerta Hipertensi Menggunakan SF-36 Lili Musnelina; Widia Mutiara; Alfina Rianti
SAINSTECH FARMA Vol 14 No 2 (2021): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v14i2.832

Diabetes melitus dan hipertensi termasuk penyakit kronik yang dapat menimbulkan efek mendalam pada kualitas hidup pasien baik aspek fisik, sosial, maupun psikologis. Kualitas hidup merupakan salah satu indikator yang sangat penting dalam menilai keberhasilan pelayanan kesehatan, baik dari segi pencegahan maupun pengobatan. Pengukuran kualitas hidup pada pasien diabetes melitus tipe 2 dengan penyakit penyerta hipertensi dapat menggunakan instrumen baku Short Form-36 (SF-36). Tujuan penelitian untuk mengetahui kualitas hidup pasien diabetes melitus tipe 2 dengan penyakit penyerta hipertensi di RSUP Fatmawati. Jenis penelitian berupa observasi non-eksperimen dengan mengambil 75 data pasien secara prospektif. Hasil menunjukkan bahwa nilai rata-rata dimensi kesehatan mental pada pasien diabetes melitus tipe 2 dengan penyakit penyerta hipertensi lebih tinggi dibandingkan dengan dimensi kesehatan fisik, dan sebanyak 58,7 % pasien mempunyai nilai rata-rata ≥ 70. Kesimpulan penelitian ini adalah sebagian besar pasien DMT2 dengan penyakit penyerta hipertensi mempunyai kualitas hidup yang baik.

Relationship between Dose and Retention of Methadon Maintenance Therapy to Drug Dependence Patients in Primary Health Care Lili Musnelina; Jenny Pontoan; Bagus Atmana Prasetya
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 11, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.57922

Methadon maintenance therapy is one of the substitution therapies needed as an approach to harm reduction or the reduction of the adverse effects of drug abuse. This study aims to fix the infinitive relationship doses with retention of drug dependence patients on methadon maintenance therapies program (PTRM) in Kramat Jati Primary Health Care in 2009-2018. A cross-sectional study is conducted using secondary data from medical records subsequently significance analysis. This research involves 136 patients who were included in the inclusion criteria. Results shown mean initial doses received is 27,65 mg (10-40 mg), after 2 weeks of therapy mean doses received are 51,6 mg (range 22,5 – 85 mg). Average lowest and highest maintenance dose which received is 30,9 mg (range 0,25-115 mg) dan 84,39 mg (range 7,77-126,92 mg). This research shows the retention value 1 year or more reaches 64,71%. Maintenance doses 2 weeks (P=0,005), lowest maintenance doses (P=0,000), average maintenance doses (P=0,004), and history misses doses (P=0,000) have significance with retention. The conclusion that the more optimal maintenance doses received, even more in methadone maintenance therapies. Otherwise, lower missed doses frequency better to patients retention in methadon maintenance therapies.

GAMBARAN TERAPI DIABETES DENGAN PENYAKIT PENYERTA HIPERLIPIDEMIA DI RUMAH SAKIT Refdanita Refdanita; Lili Musnelina; Teodhora Teodhora; Hirim Hotma Uli Aprianis
Jurnal Endurance Vol. 6 No. 1 (2021): Jurnal Endurance : Kajian Ilmiah Problema Kesehatan
Publisher : LLDIKTI Wilayah X

Diabetes mellitus and cholesterol disorders are a lethal combination that places patients with diabetes 2-4 times more at risk for developing macrovascular and microvascular complications. Risk factors for Diabetes with Hyperlipidemia include age, sex, lifestyle, metabolic conditions that affect the metabolism of plasma lipoproteins, insulin deficiency. This study aims to know determine demographic data (age, sex, and length of stay), to know results of the laboratory tests and to know description of the therapy. The study was conducted descriptive with a cross sectional design, retrospective data collection methods from patients medical records of diabetic with hyperlipidemia at the hospital inpatient installation in January-December 2019, with 130 sample patients medical record. Result presented as a percentage table. The mean results of the study based on the highest patients demographics were at age 51-60 years as 40%, the highest gender was females 56%, based on the highest length of stay was 3 days 54%. Initial fasting glucose examination with the highest percentage >126 mg / dl of 78.5%. Total cholesterol examination with the highest percentage >200 mg / dl was 84.6%, triglycerides with the highest percentage >150 mg / dl was 15.4%, LDL with the highest percentage >100 mg / dl 79.3%. The highest use of oral antidiabetic was 52.30%, long-acting insulin was 40.70% and oral antihyperlipidemia was 77.60%. The statin class has been shown to have an effect in preventing complications in patients with type 2 diabetes mellitus

Perbedaan Kualitas Hidup antara Terapi Hemodialisis dengan Terapi Continuous Ambulatory Peritoneal Dialysis (CAPD) pada Pasien Gagal Ginjal Kronik Lili Musnelina; Ditha Kurniati; Del Ferdinal
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar

Chronic Kidney Disease (CKD) is a progressive and irreversible disorder of kidney function. CKD patients who enter the final stage must immediately get renal replacement therapy to maintain their life. The most widely used kidney replacement therapy hemodialysis (HD) and peritonial dialysis (CAPD). Therapies performed either HD or CAPD cause various side effects such as physical fatigue, impaired concentration, disruption of social life and risk of infection. Side effects affect the quality of life of CKD patients. The purpose of this study was to the determine the differences quality of life chronic kidney failure patients between HD and CAPD. This research was an analytic observational research using the SF- 36 questionnaire. The results have shown that the average value of quality of life was significally different, the average score in the CAPD therapy group was 71.06 ± 13.92 and the HD therapy group the average score was 48.08 ± 14.37. The study found a that the majority of the CAPD therapy group have a good quality of life than the HD therapy group.

GAMBARAN TERAPI DIABETES DENGAN PENYAKIT PENYERTA HIPERLIPIDEMIA DI RUMAH SAKIT Refdanita Refdanita; Lili Musnelina; Teodhora Teodhora; Hirim Hotma Uli Aprianis
Jurnal Endurance Vol. 6 No. 1 (2021): Jurnal Endurance : Kajian Ilmiah Problema Kesehatan
Publisher : LLDIKTI Wilayah X

Diabetes mellitus and cholesterol disorders are a lethal combination that places patients with diabetes 2-4 times more at risk for developing macrovascular and microvascular complications. Risk factors for Diabetes with Hyperlipidemia include age, sex, lifestyle, metabolic conditions that affect the metabolism of plasma lipoproteins, insulin deficiency. This study aims to know determine demographic data (age, sex, and length of stay), to know results of the laboratory tests and to know description of the therapy. The study was conducted descriptive with a cross sectional design, retrospective data collection methods from patients medical records of diabetic with hyperlipidemia at the hospital inpatient installation in January-December 2019, with 130 sample patients medical record. Result presented as a percentage table. The mean results of the study based on the highest patients demographics were at age 51-60 years as 40%, the highest gender was females 56%, based on the highest length of stay was 3 days 54%. Initial fasting glucose examination with the highest percentage >126 mg / dl of 78.5%. Total cholesterol examination with the highest percentage >200 mg / dl was 84.6%, triglycerides with the highest percentage >150 mg / dl was 15.4%, LDL with the highest percentage >100 mg / dl 79.3%. The highest use of oral antidiabetic was 52.30%, long-acting insulin was 40.70% and oral antihyperlipidemia was 77.60%. The statin class has been shown to have an effect in preventing complications in patients with type 2 diabetes mellitus

Tren Penggunaan Antikoagulan Oral Direk dan Warfarin pada Pasien Fibrilasi Atrium Lili Musnelina; Fitri Handayani; Thanh - Hoa Vo; Jenny Pontoan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1475

Treatments used in atrial fibrillation therapy, such as those of anticoagulants, consist of vitamin K antagonists (warfarin) and direct oral anticoagulants (dabigatran, apixaban, rivaroxaban, and edoxaban). The use of warfarin requires regular monitoring of prothrombin time (PT) and international normalized ratio (INR), the therapeutic dose range is narrow, but the price is cheaper. Oral anticoagulants are directed, the incidence of major bleeding is lower, ease of use, food and drug interactions are minor, the half-life is shorter, and the lack of laboratory monitoring needs. Based on this problem, researchers conducted a study to determine the trend of using warfarin and oral anticoagulants in patients with atrial fibrillation at public hospital in Jakarta. This study uses a qualitative approach, with longitudinal methods and retrospective data using outpatient medical records for the period 2014 to 2018. The trend of using warfarin anticoagulants decreased from 82.3% in 2014 to 62% in 2016, while oral anticoagulants were reduced. Direct oral anticoagulants are rivaroxaban and dabigatran which are more widely used than apixaban, and edoxaban no data on their use are obtained. The opposite was true in 2017 to 2018, when the use of warfarin increased and caused a decrease in the use of direct oral anticoagulants. This research is expected to contribute to various parties, both health practitioners and academics in terms of selecting therapies for atrial fibrillation.

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