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All Journal Meditory : The Journal of Medical Laboratory Jurnal Ilmu dan Teknologi Kesehatan Jurnal Riset Kesehatan Poltekkes Depkes Bandung Anakes: Jurnal Ilmiah Analis Kesehatan
Dewi Astuti
Poltekkes Kemenkes Jakarta III
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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IDENTIFIKASI BAKTERI YANG MENGONTAMINASI KONSENTRAT TROMBOSIT Dewi Astuti; Eva Ayu Maharani
Jurnal Ilmu dan Teknologi Kesehatan Vol 2 No 1 (2014): September
Publisher : Poltekkes Kemenkes Jakarta III

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (48.559 KB)

Abstract

Indonesian Red Cross (IRC) is an organization that received an assignment to provide blood for transfusion therapy. Blood for transfusion should free from infectious disease. Several studies have shown that viruses, bacteria and protozoa can be transmitted by transfusion. Clinical features due to bacterial contamination varies from asymptomatic, mild fever, acute sepsis, hypotension and can even cause death. Components of platelet concentrates can be a good place for the growth of Gram positive and Gram negative bacteria, because it is stored at a temperature of 20O-24OC with the addition of dextrose that can be used as an energy source for bacteria. Bacteria identification performed by culturing the component of platelet concentrates on BPA tube of Bact / ALERT. Tube with contaminated bacteria is subcultured onto blood agar media. Bacterial colonies from blood agar stained with Gram staining and further identified using API20E, API 20NE, API 20STREP, MSA media or staphilase test using reagents Staphaurex*, according to the type of bacteria detected on Gram stain. The results shown a component of platelet concentrates is contaminated by bacteria., The bacteria is Gram positive cocci clusters. MSA and staphilase test have a negative result, so it can be concluded that the bacteria that had contaminated platelet concentrates is Staphylococcus epidermidis.
PENGHITUNGAN INDEKS FORMULA ERITROSIT PADA UJI SARING THALASEMIA MINOR Eva Ayu Maharani; Dewi Astuti Astuti
Jurnal Ilmu dan Teknologi Kesehatan Vol 2 No 1 (2014): September
Publisher : Poltekkes Kemenkes Jakarta III

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Abstract

Thalassemia is a genetic disorder caused by impaired synthesis of globin chains in hemoglobin (Hb) molecule which can be partial or total. Since thalassemia is inherited from parents to their children, screening is compulsory to prevent newborn at risk from major thalassemia. The incidence thalassemia cases can be found around the world but majority cases emerge among Mediterranean, easter, and Asian. Thalassemia minor is diagnosed based on erythrocyte indices and confirmed by molecular analysis of Hb and DNA. Currently, several formulas are developed to identify the existence of thalassemia. This cross sectional study was aimed to know how good the formulas is. Thalassemia screening was done to 138 donors with minimum of Hb 12,5 g/dL. Detection and identification proses was conducted by the use of calculation index formulas for erythrocytes namely Mentzer index, Srivastava, Shine & Lal, and England & Fraser. The results showed that all of four indexes can detect ? thalassemia minor. The highest degree of sensitivity is Mentzer and Shine & Lal indexs (100%), whereas the highest specificity is Srivastava index (100%). In addition, ? thalassemia and Hb variant (HbE) can also be detected, although not 100%. This result shows that the formulas can be used as a screening of thalassemia, especially in areas those have no accessto molecular laboratory.
NILAI INDEKS TROMBOSIT SEBAGAI KONTROL KUALITAS KOMPONEN KONSENTRAT TROMBOSIT Dewi Astuti
Meditory : The Journal of Medical Laboratory Vol 8, No 2 (2020): Meditory, Volume 8, No 2, Tahun 2020
Publisher : Jurusan Analisis Kesehatan, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/m.v8i2.1238

Abstract

Platelet component therapy is given to patients who have thrombocytopenia and platelet dysfunction, therefore an assessment of the quality of platelet components is necessary. The platelet component evaluation in UTDD PMI DKI Jakarta was carried out on the parameters of blood type test, volume, platelet count, pH and macroscopic examination of platelets (swirling) once on days 1, 2 or 3. This study aims to determine the value of the platelet index during the shelf life of the platelet concentrate component as a quality control. The research method uses a cross sectional experimental approach. Platelet index analysis was performed using Sysmex SN 350 hematology analyzer on five platelet component samples. The quality of platelet components is assessed based on the presence or absence of the difference between the platelet index values during the shelf life. Statistical results show that there are significant differences in the values of MPV, PDW and PCT from the shelf life of the 2nd day until the 5th day, but the examination results are still within normal limits. Platelet index results show an increasing trend. This indicates an increase in platelet volume and variations in platelet form. The conclusion of this study, the platelet component has good quality until the 5th day, and the platelet index value can be used as a platelet quality control parameter.
PENGGUNAAN SIX SIGMA SEBAGAI EVALUASI KONTROL KUALITAS PADA HEMATOLOGY ANALYZER SYSMEX XN-1000 Eva Ayu Maharani; Rika Erviani; Rizana Fajruni'mah; Dewi Astuti
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 14 No 2 (2022): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v14i2.2106

Abstract

Saat ini metode otomatisasi menggunakan hematology analyzer banyak dipilih dibandingkan metode manual dengan keutamaan mempunyai presisi yang lebih baik. Kontrol kualitas pada hematology analyzer umumnya hanya menggunakan aturan Westgard, dan belum digunakannya analisis six sigma di laboratorium RSUD Budhi Asih, walaupun analisis six sigma juga diperlukan untuk melihat tingkat akurasi dan presisi suatu metode. Penelitian ini bertujuan untuk menganalisis penggunaan six sigma sebagai evaluasi kontrol kualitas hematology analyzer Sysmex XN-1000 di laboratorium klinik RSUD Budhi Asih pada parameter HGB, RBC, WBC, HCT dan PLT. Penelitian ini merupakan penelitian deskriptif menggunakan data hasil kontrol kualitas internal laboratorium klinik RSUD Budhi Asih periode Januari s/d Februari 2022 dengan bahan kontrol level low, normal dan high. Analisis six sigma melibatkan CV dan bias. Perhitungan CV dibandingkan dengan nilai target kit insert dan nilai bias dibandingkan dengan standar Rico’s biological variation. Hasil menunjukkan, bahan kontrol masuk dalam kategori ‘in control’, nilai CV di bawah batas yang ditetapkan dan nilai bias umumnya berada di bawah standar, kecuali parameter HCT. Nilai sigma berada pada kategori world class performance sampai marginal performance. Kesimpulan penelitian ini analisis kontrol kualitas cukup digunakan dua level bahan kontrol setiap hari, yang disertai dengan analisis kurva Levey Jenning’s melalui aturan Westgard. Kata kunci: Kontrol Kualitas, Six Sigma, CV, Bias
Perbandingan Hasil Laju Endap Darah Metode Otomatis dan Manual pada Pasien Anemia Dewi Astuti; Jumi Astuti; Liza Liza; Eva Ayu Maharani
Anakes : Jurnal Ilmiah Analis Kesehatan Vol 9, No 1 (2023): Anakes: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v9i1.1254

Abstract

Pemeriksaan Laju Endap Darah (LED) adalah pemeriksaan darah yang menggambarkan kecepatan mengendapnya eritrosit dalam plasma darah yang dinyatakan dalam satuan mm/jam. Pemeriksaan metode manual yang disarankan ICSH adalah metode Westergren, dimana sampel diencerkan dan pembacaan dilakukan setelah satu jam. Prosedur pemeriksaan metode otomatis dilakukan tanpa pengenceran sampel dan hasil dibaca setelah 20 menit. Penelitian ini bertujuan  untuk mengetahui apakah ada perbedaan hasil LED antara metode otomatis dengan metode manual pada pasien anemia. Penelitian ini merupakan penelitian observative menggunakan data primer dengan desain studi potong lintang. Subyek penelitian ini adalah 51 pasien dengan kadar hemoglobin kurang dari 10 g/dL. Bahan pemeriksaan yang digunakan adalah whole blood dengan antikoagulan EDTA. Uji beda bermakna dilakukan setelah uji normalitas data (nilai α 0,05). Data penelitian diuji menggunakan uji statistik paired T-test.Simpulan penelitian ini terdapat perbedaan yang signifikan antara hasil pembacaan LED metode otomatis dan metode manual. Kata kunci: Laju Endap Darah; LED metode otomatis; LED metode Westergren
Co-Authors Eva Ayu Maharani Jumi Astuti Liza Liza Rika Erviani Rizana Fajrunni’mah