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Efficacy of NETDC (New England Trophoblastic Disease Center) prognostic index score to predict gestational trophoblastic tumor from hydatidiform mole Khrismawan, Khrismawan; Saleh, Agustria Z.; Sanif, Rizal; Theodorus, Theodorus
Medical Journal of Indonesia Vol 13, No 1 (2004): January-March
Publisher : Faculty of Medicine Universitas Indonesia

A prospective longitudinal analytic study assessing the efficacy of NETDC (New England Trophoblastic Disease Center) prognostic index score in predicting malignancy after hydatidiform mole had been performed. Of the parameter evaluated; age of patients, type of hydatidiform mole, uterine enlargement, serum hCG level, lutein cyst, and presence of complicating factors were significant risk factors for malignancy after hydatidiform mole were evacuated (p<0.032). The study were done on 50 women diagnosed with hydatidiform mole with 1 year observation (January 2001-December 2002) at the Department of Obstetrics and Gynecology, Mohammad Hoesin Hospital, Palembang. The results showed that the NETDC prognostic index score predicted malignancy in 50% of high risk group and 10% in low risk group (p<0.05). This showed a higher number than that found by the WHO (19%-30%). The risk for incidence ofÂ malignancy after hydatidiform mole in the high risk group is 9.0 times higher compared to that of the low risk group (CI: 1.769-45.786). (Med J Indones 2004; 13: 40-6)Â Keywords: New England Trophoblastic Disease Center (NETDC), gestational trophoblastic tumor, hydatidiform mole, high and low risk

Survival of borderline tumors of the ovary and its prognostic factors at Dr. Cipto Mangunkusumo hospital from 1990 to 1999 Sanif, Rizal; Nuranna, Laila; Sutrisna, Bambang
Medical Journal of Indonesia Vol 11, No 4 (2002): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Sixty-two patients with borderline tumors of ovary were historical cohort analyzed for survival characteristics. There were 9 patients with FIGO stage IA, 9 with stage IC, 3 with stage IIIA, 2 with stage IIIB, 4 with stage IIIC, 1 with stage IV and 34 with inadequate stage tumors. Twenty one patients had surgical staging with radical surgery, 10 patient had at least a total abdominal hysterectomy and bilateral salpingo-oophorectomy, 6 patient had surgical staging with conservative surgery, 24 patient had at least a unilateral salphingo-oophorectomy or ovarian cystectomy and 1 patient had biopsy. Sixteen patients received cisplatin-based combination chemotherapy, that were 8 with inadequate stage tumors, 7 with stage III tumors and 1 with stage IV tumor. Follow-up range from 0.02 to 10.48 years, with a median of 3.5 years. Fifty nine patient were alive. Three patients died, all of disease. Recurrence were found in 4 patients. The overall 2-years survival rate was 96% and 10-years survival rate was 94%. In log rank test, residual disease and histology type were significant predictor of survival. (Med J Indones 2002; 11:222-9)Keywords: borderline tumors of ovary, survival

Clinical Evaluation of Neoadjuvant Chemotherapy Followed by Radical Hysterectomy in the Management of Cervical Cancer Stage IIB Sanif, Rizal
Indonesian Journal of Obstetrics and Gynecology Volume. 3, no. 2, April 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate the clinical efficacy, operability, radicality, toxicity, and incidence of recurrences of neoadjuvant chemotherapy (NAC) followed by radical hysterectomy (RH) among patients with stage IIB cervical cancer. Method: This is an observational clinical study at Dr. Moh. Hoesin Hospital, Palembang. Data were analyzed from 27 patients who matched the inclusion criteria and underwent 3 cycles of neoadjuvant chemotherapy (NAC) with Paclitaxel (75 mg/m2) in combination with Cisplatin (50 mg/m2) and Docetaxel (75 mg/m2) combined with Carboplatin (300 mg/m2) according to AUC 6, followed by radical hysterectomy from January 2012 until December 2013. Result: The operability rate after NAC was 96.4%. Lymph node metastases were negative in 75% of patients, and we found bilateral lymph node metastases in 14.3% of patients. Parametric infiltrations were negative in 85.7% of the patients, and positive in 14.3% of patients. No vaginal infiltrations were found. As much as 89.3% of the patients did not experience any side effect, while anemia and thrombocytopenia were found in 10.8% of the patients. We found that 7.1% of patients had recurrences within 6 months interval. Conclusion: NAC followed by radical hysterectomy showed significant advantages for patients with stage IIB cervical cancer, with fewer side effects. However, long-term evaluation and a larger number of patients are required to confirm this result. Keywords: cervical cancer, neoadjuvant chemotherapy, radical hysterectomy

BRCA1 Gene Q356R (1186A=G) Polymorphism and Epithelial Ovarian Cancer Incidence Rakhmatsyah, Benyamin; Saleh, Agustria Z; Sanif, Rizal; Yuwono, Yuwono
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 4, October 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the association between BRCA1 gene Q356R (1186A=G) polymorphism and epithelial ovarian cancer incidence. Methods: This study is an observational analytic study with casecontrol study design. All patients diagnosed with epithelial ovarian cancer that were treated in the outpatient clinic and inpatient ward of the Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin Hospital, Palembang who met the inclusion criteria were included in this study. DNA extraction was performed on blood samples, followed by PCR-RFLP process. Results: We obtained the genotype distribution of BRCA1 Q356R (1186A=G) polymorphisms to be QQ genotype (wild-type) on all 50 subjects in the case group (100%) and 50 control subjects (100%). Similarly, all BRCA1 alleles have the Q allele. The results of this study found no polymorphism of the BRCA1 Q356R (1186A=G) in the ovarian cancer and control groups. Conclusion: Polymorphism of BRCA1 gene Q356R (1186A=G) was not significantly associated with epithelial ovarian cancer incidence. [Indones J Obstet Gynecol 2015; 3-4: 206-211] Keywords: BRCA1 gene, epithelial ovarian cancer, polymorphism

Clinical Evaluation of Neoadjuvant Chemotherapy Followed by Radical Hysterectomy in the Management of Cervical Cancer Stage IIB Sanif, Rizal
Indonesian Journal of Obstetrics and Gynecology Volume. 3, no. 2, April 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate the clinical efficacy, operability, radicality, toxicity, and incidence of recurrences of neoadjuvant chemotherapy (NAC) followed by radical hysterectomy (RH) among patients with stage IIB cervical cancer. Method: This is an observational clinical study at Dr. Moh. Hoesin Hospital, Palembang. Data were analyzed from 27 patients who matched the inclusion criteria and underwent 3 cycles of neoadjuvant chemotherapy (NAC) with Paclitaxel (75 mg/m2) in combination with Cisplatin (50 mg/m2) and Docetaxel (75 mg/m2) combined with Carboplatin (300 mg/m2) according to AUC 6, followed by radical hysterectomy from January 2012 until December 2013. Result: The operability rate after NAC was 96.4%. Lymph node metastases were negative in 75% of patients, and we found bilateral lymph node metastases in 14.3% of patients. Parametric infiltrations were negative in 85.7% of the patients, and positive in 14.3% of patients. No vaginal infiltrations were found. As much as 89.3% of the patients did not experience any side effect, while anemia and thrombocytopenia were found in 10.8% of the patients. We found that 7.1% of patients had recurrences within 6 months interval. Conclusion: NAC followed by radical hysterectomy showed significant advantages for patients with stage IIB cervical cancer, with fewer side effects. However, long-term evaluation and a larger number of patients are required to confirm this result. Keywords: cervical cancer, neoadjuvant chemotherapy, radical hysterectomy

BRCA1 Gene Q356R (1186A=G) Polymorphism and Epithelial Ovarian Cancer Incidence Rakhmatsyah, Benyamin; Saleh, Agustria Z; Sanif, Rizal; Yuwono, Yuwono
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 4, October 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the association between BRCA1 gene Q356R (1186A=G) polymorphism and epithelial ovarian cancer incidence. Methods: This study is an observational analytic study with casecontrol study design. All patients diagnosed with epithelial ovarian cancer that were treated in the outpatient clinic and inpatient ward of the Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin Hospital, Palembang who met the inclusion criteria were included in this study. DNA extraction was performed on blood samples, followed by PCR-RFLP process. Results: We obtained the genotype distribution of BRCA1 Q356R (1186A=G) polymorphisms to be QQ genotype (wild-type) on all 50 subjects in the case group (100%) and 50 control subjects (100%). Similarly, all BRCA1 alleles have the Q allele. The results of this study found no polymorphism of the BRCA1 Q356R (1186A=G) in the ovarian cancer and control groups. Conclusion: Polymorphism of BRCA1 gene Q356R (1186A=G) was not significantly associated with epithelial ovarian cancer incidence. [Indones J Obstet Gynecol 2015; 3-4: 206-211] Keywords: BRCA1 gene, epithelial ovarian cancer, polymorphism

Faktor Risiko Kanker Serviks Pada Pasien Rawat Jalan dan Rawat Inap Di Departemen Obstetri dan Ginekologi RSUP Dr. Mohammad Hoesin Palembang trifitriana, Monica; Sanif, Rizal; Husin, Syarif
Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya Vol 3, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Kanker serviks adalah tumor ganas primer yang berasal dari sel epitel skuamosa merupakan salah satu penyakit kanker yang paling banyak terjadi bagi kaum wanita.. Penelitian ini menggunakan jenis penelitian deskriptif analitik dengan case-control. Sampel penelitian adalah 52 pasien yang terbagi menjadi 26 pasien kanker serviks dan 26 pasien non-kanker serviks baik yang dirawat jalan maupun rawat inap di Departemen Obstetri dan Ginekologi RSUP Dr. Mohammad Hoesin Palembang selama periode September-November 2016. Penelitian ini menggunakan data primer berupa wawancara. Data dianalisis secara univariat dan disajikan dalam bentuk tabel distribusi frekuensi. Selanjutnya, dianalisis secara bivariat untuk mengetahui hubungan dan nilai OR. Dari 8 faktor risiko yang diteliti, terdapat hubungan yang bermakna antara riwayat keputihan patologis (p= 0,0005 OR= ?), paritas (p= 0,0005 OR= 22,7), usia (p= 0,0005 OR= 19,2), penggunaan kontrasepsi oral jangka panjang (p= 0,0005, OR= 12,4), usia pertama kali melakukan hubungan seksual (p= 0,006, OR= 6,1 ), dan pekerjaan suami (p= 0,05 OR= 3,6), dengan kejadian kanker serviks. Sedangkan Terdapat 2 faktor risiko yang tidak memiliki hubungan yang bermakna antara merokok (p= 1,0) dan berganti-ganti pasangan seksual (p= 1,0) dengan kejadian kanker serviks. Hasil penelitian mengidentifikasi faktor-faktor risiko dengan hubungan terhadap kejadian kanker serviks yang signifikan, yaitu usia, usia pertama kali melakukan hubungan seksual, paritas, penggunaan kontrasepsi oral jangka panjang, riwayat keputihan, dan pekerjaan suami.

Faktor Risiko Kanker Serviks Pada Pasien Rawat Jalan dan Rawat Inap Di Departemen Obstetri dan Ginekologi RSUP Dr. Mohammad Hoesin Palembang Monica Trifitriana; Rizal Sanif; Syarif Husin
Biomedical Journal of Indonesia Vol. 3 No. 1 (2017): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

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Kanker serviks adalah tumor ganas primer yang berasal dari sel epitel skuamosa merupakan salah satu penyakitkanker yang paling banyak terjadi bagi kaum wanita.. Penelitian ini menggunakan jenis penelitian deskriptif analitikdengan case-control. Sampel penelitian adalah 52 pasien yang terbagi menjadi 26 pasien kanker serviks dan 26pasien non-kanker serviks baik yang dirawat jalan maupun rawat inap di Departemen Obstetri dan Ginekologi RSUPDr. Mohammad Hoesin Palembang selama periode September-November 2016. Penelitian ini menggunakan dataprimer berupa wawancara. Data dianalisis secara univariat dan disajikan dalam bentuk tabel distribusi frekuensi.Selanjutnya, dianalisis secara bivariat untuk mengetahui hubungan dan nilai OR. Dari 8 faktor risiko yang diteliti,terdapat hubungan yang bermakna antara riwayat keputihan patologis (p= 0,0005 OR= âˆž), paritas (p= 0,0005 OR=22,7), usia (p= 0,0005 OR= 19,2), penggunaan kontrasepsi oral jangka panjang (p= 0,0005, OR= 12,4), usia pertamakali melakukan hubungan seksual (p= 0,006, OR= 6,1 ), dan pekerjaan suami (p= 0,05 OR= 3,6), dengan kejadiankanker serviks. Sedangkan Terdapat 2 faktor risiko yang tidak memiliki hubungan yang bermakna antara merokok(p= 1,0) dan berganti-ganti pasangan seksual (p= 1,0) dengan kejadian kanker serviks. Hasil penelitianmengidentifikasi faktor-faktor risiko dengan hubungan terhadap kejadian kanker serviks yang signifikan, yaitu usia,usia pertama kali melakukan hubungan seksual, paritas, penggunaan kontrasepsi oral jangka panjang, riwayatkeputihan, dan pekerjaan suami.

POLIMORFISME GEN P21 CODON 31 RS 1801270 DENGAN KEJADIAN KANKER SERVIKS PADA ETNIS MELAYU DI SUMATERA SELATAN Diana Polania; Legiran Legiran; Rizal Sanif
JURNAL KEDOKTERAN DAN KESEHATAN Vol 8, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/V8I2.13787

Kanker servik adalah tumor ganas primer yang berasal dari sel epitel skuamosa.lebih dari 90% penyebab kanker leher rahim saat ini akibat Human Papiloma Virus (HPV) Gen yang terlibat dalam kanker servik adalah Gen P21 Codon 31 rs 1801270.Gen P21 Codon 31 rs 1801270 terletak pada kromosom 6p21.1 terdiri dari 3 ekson dan 2 intron dan mengkode protein 21-kd. Polimorfisme gen p21 dapat mempengaruhi ekspresi dan aktivitas protein berperan dalam ketahanan terhadap kanker serviks. Tujuan penelitian ini menganalisis hubungan polimorfisme gen p21 codon 31 dengan kejadian kanker serviks pada etnis melayu di sumatra selatan. Penelitian ini merupakan penelitian analitik observasional dengan desain Kasus Kontrol ( Case - Control ).Penelitian ini dilaksanakan pada bulan maret 2019 di Biologimolekuler Fakultas Kedokteran Universitas Sriwijaya.Uji statistik menggunakan uji Chi - Square.Sampel penelitian ini menggunakan sampel darah yang diambil pada 70 sampel yang terdiri dari 35 dari kelompok kasus dan 35 dari kelompok kontrol.Polimorfisme Gen P21 Codon 31 rs1801270 dilakukan dengan metode PCR-RFLP. Tidak ditemukan adanya polimorfisme genotif dan alotif Gen P21 Codon 31 rs1801270 terhadap kejadian kanker serviks pada etnis Melayu di Sumatra Selatan.

Vitamin A dan perannya dalam siklus sel Rizal Sanif; Raissa Nurwany
JURNAL KEDOKTERAN DAN KESEHATAN Vol 4, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Mekanisme normal pengatur proliferasi sel melalui siklus sel, dimana sebagai pengontrolnya adalah pada chech point yaitu fase G1 dan S. Tumor supresor gen sangat berperan dalam mengatur mekanisme sel untuk istirahat atau memperbaikinya apabila terjadi abnormal, dimana bila tidak bisa diperbaiki akan terjadi proses kematian atau apoptosis. Vitamin A merupakan sebagai salah satu substrat yang ikut berperan didalam pengatur mekanisme siklus sel, utamanya pada fase G1 dan S istirahat.Vitamin A didapatkan dari konsumsi makan yang berasal dari hewan atau provitamin A dari tumbuh-tumbuhan. Vitamin A diabsorbsi dari usus masuk ke aliran linfe atau darah dan dengan mekanismenya akan masuk kedalam inti sel yang berikatan dengan reseptornya untuk memberikan sinyal sinyal didalam proses pengaturan siklus sel.

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