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All Journal Medali Jurnal : Media Dental Intelektual
Oediani Santoso
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Dentistry Health Professions Public Health

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PENGARUH PEMBERIAN EKSTRAK JINTAN HITAM (Nigella Sativa) 50% DAN 100% TERHADAP PENYEMBUHAN ULKUS TRAUMATIKUS PADA TIKUS WISTAR Ayuda Nur Sukmawati; Endah Aryati E; Rahmawati Sri P; Oediani Santoso
Jurnal Medali Vol 1, No 1 (2013): Media Dental Intelektual
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.1.1.1-5

Abstract

Traumatic ulcer is the most common lesion in the oral mucosa. Nigella sativa has been known and proven for its therapeutical effects, such as antibacterial, antiinflammation, and analgesic. This study aimed to find out the effect of Nigella sativa extract 50% and 100% towards traumatic ulcer healing visually and histologically on wistar rats.This experimental research was done using post test design. There were 3 groups in this study, consisted of 2 treatment groups and 1 control group. Rats were ulcerated using scalpel on the tip of the lip with 5 mm diameter, then betadine was applied on the control group, and Nigella sativa extract 50% and 100% on the treatment groups with 12 hours interval. This treatment was done for 10 days. Ulcer then measured at day 0, 3rd , 7th, and 10th. The rats were sacrificed for histological examination.Result from traumatic ulcer measuring was analyzed statistically using Kruskal-Wallis test and continued with post-hoc Mann-Whitney. There was significant differences with p value < 0,05. Result from histology observation was tabulated according to categories and then analyzed.In conclusion, Nigella sativa extract has an effect towards traumatic ulcer healing visually and histologically. Keywords: Nigella sativa extract, traumatic ulcer, in vivo
PENGARUH EKSTRAK DAUN SAGA PADA PROSES PENYEMBUHAN ULKUS TRAUMATIKUS MUKOSA MULUT TIKUS PUTIH JANTAN (Rattus Novegicus) (in vivo) Ong Jonathan; Siti Chumaeroh; Moh Baehaqi; Oediani Santoso
Jurnal Medali Vol 1, No 1 (2013): Media Dental Intelektual
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.v1i1.82

Abstract

Traumaticus ulcer or often called thrush is an issue that often comes up in society as it causes pain. People believe that the saga leaves can heal the ulcer. Previous research mentions saga leaves have anti-inflammatory substances.This research aims to determine the effect of Saga leaf (Abrus precatorius) against ulcerative traumatikus in vivo to Rattus Novegicus. This is experimental research which design randomized post test only control group, with Rattus Novegicus. In this research there were four group treatments. Data used to calculate the number of fibroblasts in 4 each visual field preparate. The research used statistical analysis Independent T test.The results of the average number of fibroblasts in each group were K3, K7, P3, P7 is 23.34, 18.83, 47.00, 23.83. Independent T Test obtained value of p <0.05 on day 3 but not on day 7. This means there was inhibition effect produced by extracts of saga leaves on day 3 but not on day 7.From the results, it can be concluded that the leaf extract Saga (Abrus precatorius) has an influence on ulcer healing traumatikus on Rattus Novegicus which have been shown number of fibroblasts. Key Words : Saga Leaf extract, traumatic ulcer
Co-Authors Ayuda Nur Sukmawati Endah Aryati Eko Ningtyas Moh Baehaqi Ong Jonathan Rahmawati Sri P Siti Chumaeroh