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All Journal Indonesian Journal of Pharmaceutical Science and Technology Pharmacoscript Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Hestiary Ratih
Universitas Jenderal Achmad Yani
Chemistry Computer Science & IT Medicine & Pharmacology Public Health

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Isoniazid Microencapsulation With HPMCP HP-50 and HPMCP HP- 55 (2:3) Coating Using Solvent Evaporation Method Hestiary Ratih; Gladdis Kamilah Pratiwi; Fikri Alatas; Mia Agustin; Bella Dewinta Saraswati
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.36678

Abstract

The combination formulation of tuberculosis drugs may cause interactions if these drugs are givensimultaneously. Rifampin (RIF) decomposes in the stomach when given concurrently with isoniazid(INH), which results in a decrease in the bioavailability of RIF. The purpose of this study is to makeINH microcapsules using HPMCP HP-50 and HP-55 coatings to prevent these interactions. Theprocess of making INH: HPMCP HP-50 and HP-55 (2:3) microcapsules was done by using solventevaporation method. The entrapment efficiency of INH: HPMCP HP-50 and HP-55 (2:3) were 83.21%and 91.57%, respectively. The dissolution test of INH: HPMCP HP-50 and HP-55 microcapsules metthe requirements of the Indonesian Pharmacopoeia Edition V. The FTIR results showed that there wasno change either in the chemical composition of isoniazid or in the coating of the microencapsulation.Scanning Electron Microscopy (SEM) showed the active substance was well coated. This studyproduces microcapsules that can provide a delayed release effect, so it is expected that INH: HPMCPHP-50 and HP-55 (2:3) microcapsules can be released in the intestines without interacting with RIF.Keywords: HPMCP HP 50, HPMCP HP-55, isoniazid, microcapsules, solvent evaporation method
Isoniazid Microencapsulation With HPMCP HP-50 and HPMCP HP-55 (2:3) Coating Using Solvent Evaporation Method Hestiary Ratih; Gladdis Kamilah Pratiwi; Fikri Alatas; Mia Agustin; Bella Dewinta Saraswati
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.36513

Abstract

The combination formulation of TB drugs may cause interactions if these drugs are given simultaneously. Rifampin (RIF) decomposes in the stomach when given concurrently with isoniazid (INH), which results in a decrease in the bioavailability of RIF. The purpose of this study is to make INH microcapsules using HPMCP HP-50 and HP-55 coatings to prevent these interactions. The process of making INH: HPMCP HP-50 and HP-55 (2:3) microcapsules was done by using solvent evaporation method. The entrapment efficiency of INH: HPMCP HP-50 and HP-55 (2:3) were 83.21% and 91.57%, respectively. The dissolution test of INH: HPMCP HP-50 and HP-55 microcapsules met the requirements of the Indonesian Pharmacopoeia Edition V. The FTIR test showed that the microcapsules didn’t change the chemical composition of isoniazid or the coating on the microencapsulation so that it was concluded that no chemical reaction or decomposition occurred before and after the formation of the microcapsules. Scanning Electron Microscopy (SEM) showed a spherical microcapsule surface morphology and the active substance was well coated for INH: HPMCP HP-50 (2:3), while for INH: HPMCP HP-55 (2:3) the surface of the microcapsules was round but hollow. This study produces microcapsules that can provide a delayed release effect, so it is expected that INH: HPMCP HP-50 and HP-55 (2:3) microcapsules can be released in the intestines without interacting with RIF.
PENGARUH PENAMBAHAN CROSPOVIDONE DALAM PEMBUATAN TABLET ORALLY DISINTEGRATING TABLET LORATADIN SECARA GRANULASI BASAH DAN KEMPA LANGSUNG Wulan Anggraeni; Nira Purnamasari; Fikri Alatas; Hestiary Ratih; Rachmadian Aulia Fitri
Pharmacoscript Vol. 6 No. 1 (2023): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v6i1.1188

Abstract

Sediaan Orally Disintegrating Tablet (ODT) merupakan sistem penghantaran obat dengan disintegrasi yang cepat dalam waktu kurang dari 60 detik. ODT umumnya menggunakan bahan penghancur yang dapat mempercepat hancurnya tablet dalam rongga mulut tanpa melalui proses pembentukan gel, antara lain crospovidone. Penelitian ini bertujuan mengetahui pengaruh penambahan crospovidone dalam pembuatan ODT loratadin dengan metode granulasi basah dan kempa langsung terhadap sifat fisik tablet, seperti kerapuhan, kekerasan, waktu pembasahan, waktu hancur serta profil disolusi tablet. Penambahan crospovidone dengan metode granulasi basah dilakukan secara intragranular dan ekstragranular. Secara intragranular crospovidone dicampurkan dengan eksipien lain untuk membentuk granul, sedangkan secara ekstragranular, crospovidone dicampurkan dengan granul kering. Berbeda dengan metode granulasi basah, pada metode kempa langsung, crospovidone dicampurkan langsung dengan bahan-bahan lainnya. Hasil penelitian menunjukan bahwa penambahan crospovidone dalam pembuatan ODT loratadin secara intragranular, ekstragranular dan kempa langsung mempengaruhi sifat fisik tablet seperti kerapuhan, kekerasan, waktu pembasahan, waktu hancur serta profil disolusi tablet. Penambahan crospovidone secara kempa langsung merupakan metode yang paling efektif dalam menghasilkan Orally Disintegrating Tablet loratadine dengan waktu hancur yang paling singkat yaitu 57 detik.
Identification of Candesartan Cilexetil-L-Arginine Co-amorphous Formation and Its Solubility Test Fikri Alatas; Erina Sifa Mutmainah; Hestiary Ratih; Titta Hartyana Sutarna; Sundani Nurono Soewandhi
Borneo Journal of Pharmacy Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i1.2942

Abstract

The formation of co-amorphous is one alternative that can be attempted to enhance the solubility of drugs. The study aimed to identify the co-amorphous formation between candesartan cilexetil (CAN) and l-arginine (ARG) and to know its effect on the solubility and dissolution rate of candesartan cilexetil. Initial prediction of co-crystal formation was undertaken by observing differences in crystal morphology between the candesartan cilexetil-l-arginine (CAN-ARG) mixture and each of its initial components due to crystallization in ethanol. The CAN-ARG co-amorphous was produced by the liquid-assisted grinding (LAG) method with the same molar ratio of the CAN and ARG mixture using ethanol as solvent. The co-amorphous formation of CAN-ARG was identified by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) methods. The solubility and dissolution test was performed to know the impact of the co-amorphous CAN-ARG formation. The PXRD pattern of CAN-ARG of LAG result showed a very low peak intensity compared to pure CAN and ARG. The DSC thermogram of the CAN-ARG LAG result does not show any sharp endothermic peaks. The PXRD and DSC results reveal that CAN and ARG can form co-amorphous. The solubility and dissolution rate of candesartan cilexetil in co-amorphous CAN-ARG was better than that of pure CAN. It can be concluded, liquid-assisted grinding of CAN-ARG mixture is identified to form co-amorphous which has an impact on increasing the solubility and dissolution rate of candesartan cilexetil.
PERBAIKAN FLOWABILITY DAN TABLETABILITY FUROSEMID MELALUI KO-KRISTALISASI DENGAN KAFEIN : FLOWABILITY AND TABLETABILITY IMPROVEMENT OF FUROSEMID THROUGH CO-CRYSTALIZATION WITH CAFFEINE Ine Rosmala Dewi; Fikri Alatas; Nadira Cantika Putri Ananda; Diamona Ayu Lestari; Alisha Ramadhanty Ludin; Endah Wahyuni; Hestiary Ratih
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 3 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i3.414

Abstract

Furosemid (FUR) adalah obat diuretik kuat yang umum dipakai untuk pengobatan tekanan darah tinggi dan lemah jantung. Bahan baku FUR memiliki kemampuan mengalir (flowability) dan kemampuan untuk dikempa menjadi tablet (tabletability) yang buruk. Pada penelitian memperbaiki flowability dan tabletability furosemid diperbaiki melalui pembentukkan ko-kristal dengan kafein (CAF). Metode Ultrasound Assisted Solution Co-Crystalization (USSC) digunakan untuk menyiapkan ko-kristal FUR-CAF. Morfologi kristal produk USSC diamati dengan mikroskop polarisasi. Karakterisasi produk USSC juga dilakukan dengan metode difraksi sinar-X serbuk dan Differential Scanning Calorimetry (DSC). Pengujian flowability yang dilakukan terdiri dari laju alir, sudut istirahat, dan indeks kompresibilitas, sedangkan pengujian tabletability yang dilakukan terdiri dari tensile strength dan elastic recovery. Produk USSC dari FUR-CAF menunjukkan habit kristal yang berbentuk batang, pola difraktogram khas, dan titik lebur di 223,0°C yang terletak di antara titik lebur FUR dan CAF. Hasil pengujian flowability menunjukkan laju alir, sudut istirahat, dan indeks kompresibilitas ko-kristal FUR-CAF lebih baik daripada FUR murni. Tensile strength dan elastic recovery ko-kristal FUR-CAF juga lebih baik daripada FUR murni. Hasil-hasil ini  menunjukkan flowability dan tabletability furosemid bisa diperbaiki melalui ko-kristalisasi dengan kafein menggunakan metode USSC.
Co-Authors Alisha Ramadhanty Ludin Bella Dewinta Saraswati Diamona Ayu Lestari Endah Wahyuni Erina Sifa Mutmainah Fikri Alatas Gladdis Kamilah Pratiwi Ine Rosmala Dewi Mia Agustin Nadira Cantika Putri Ananda Nira Purnamasari Rachmadian Aulia Fitri Sundani Nurono Soewandhi Titta Hartyana Sutarna, Titta Hartyana Wulan Anggraeni