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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Brawijaya Universa Medicina Media Farmasi Indonesia
Hadi Sarosa
Bagian Ilmu Fisiologi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA)
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Formula Jamu Antihipertensi and captopril are equally effective in patients with hypertension Hussaana, Atina; Sarosa, Hadi; Indrayani, Ulfah Dian; Chodidjah, Chodidjah; Widiyanto, Bagas; Pertiwi, Danis
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.81-88

Abstract

BACKGROUNDHypertension is the main cause of morbidity and mortality associated with cardiovascular diseases. Many herbs/spices appear to have significant effects in favorably modulating high blood pressure. A jamu formulation containing 6 plant extracts, Formula Jamu Antihipertensi (FJA), has been described previously. This research study aimed to evaluate the effect of FJA as antihypertensive agent in mild to moderate hypertensive patients. METHODSThis double-blind experimental study was conducted in 40 hypertensive patients, who were randomized into two groups. The first group was treated with oral administration of 2 g FJA and the second group 25 mg captopril daily for 4 weeks. Systolic and diastolic blood pressure as well as liver and kidney function were followed up every week. Independent- t test and two-way ANOVA were used to analyze the data with a level of significance of 0.05.RESULTSThe results showed that after the treatment, FJA and captopril were capable of significantly decreasing systolic and diastolic blood pressure (p <0.05). The decrease in systolic blood pressure between the two groups was identical (p>0.05), while the decrease in diastolic blood pressure was greater in the FJA group than in the captopril group (p <0.05). CONCLUSIONFrom this study it may be concluded that administration of FJA for 4 weeks is equally effective as captopril in reducing systolic and diastolic blood pressure in patients with mild and moderate hypertension. Thus, natural plants and herbs can be our source of drugs, with fewer side effects and better bioavailability for treatment of hypertension in the future.
PENGARUH PEMBERIAN DEKAMETHASONE TOPIKAL TERHADAP TEKANAN INTRAOKULER Pritasari, A. M. Sita; Sarosa, Hadi; Apriani, Erina Widya
Media Farmasi Indonesia Vol 9 No 2 (2014): Media Farmasi Indonesia
Publisher : STIFAR "YAYASAN PHARMASI SEMARANG"

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Abstract

ABSTRAK   Penyebab utama (50%) kebutaan di Indonesia adalah katarak. Katarak merupakan salah satu masalah kesehatan utama pada usia lanjut. Satu-satunya cara untuk mengatasi kebutaan akibat katarak adalah melakukan bedah katarak. Salah satu obat yang diberikan pasca bedah katarak adalah anti inflamasi yaitu dexamethasone topikal untuk mengobati peradangannya. Namun, pemakaian steroid topikal lebih dari 2 minggu dapat mengakibatkan peningkatan tekanan intraokuler (TIO). Penelitian ini bertujuan untuk mengetahui pengaruh pemberian dexamethasone topikal terhadap tekanan intraokuler pada pasien pasca bedah katarak. Penelitian observasional analitik dengan rancangan riset cohort study ini menggunakan sampel 21 mata pasien pasca bedah katarak di Rumah Sakit Islam Sultan Agung Semarang periode 1 Februari ? 2 Maret 2013 yang telah memenuhi kriteria inklusi. Pemeriksaan TIO dengan tonometer non kontak dilakukan pada sebelum operasi, minggu I, dan minggu III pasca operasi dengan melihat rekam medis pasien. Data penelitian dianalisis dengan uji Friedman. Dari hasil penelitian didapatkan rata-rata TIO sebelum operasi 12,48±2,94 mmHg, minggu I 11,02±2,45 mmHg, dan minggu III 13,04±4,62 mmHg. Minggu III setelah pemberian dexamethasone, terdapat 4 mata (19%) mengalami peningkatan selisih tekanan intraokuler >3 mmHg. Hasil uji Friedman menunjukkan tidak ada pengaruh pemberian dexamethasone topikal terhadap tekanan intraokuler pada pasien pasca bedah katarak, nilai p = 0,067. Berdasarkan hasil tersebut dapat disimpulkan bahwa tidak ada pengaruh pemberian dexamethasone topikal terhadap tekanan intraokuler pada pasien pasca bedah katarak.
Physical Activity Correlates to Body Mass Index among Medical Students Vikawati, Nura Eky; Sarosa, Hadi; Makarim, Fadli Rizal; Fasitasari, Minidian
Jurnal Kedokteran Brawijaya Vol 31, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2020.031.02.8

Abstract

Physical activity (PA) has a positive effect on preventing risk on cardiovascular and metabolic syndrome, including obesity. Learning behavior that tends to be sedentary causes medical students to tend to be physically inactive. This present study aimed to associate the physical activity (PA) level with blood pressure, body mass index, and non-fasting blood glucose level (NFBG) among medical students. This cross-sectional study was conducted from February to March in 2019 on the first-year medical students at Sultan Agung Islamic University (UNISSULA). A total of 167 medical students (64.7% female and 35.3% male) were enrolled in this study. The international physical activity questionnaire (IPAQ)-short form was used to measure the PA level. The activity level was classified into low, moderate, and high. Blood pressure and glucose level were measured using a digital sphygmomanometer and NFBG dipstick. The association between PA level and Body Mass Index (BMI), Blood Pressure (BP), and NFBG level were analyzed using Spearman's correlation test. Chi square test was done to analyse the difference of PA level between male and female groups. The majority of the respondents had a low PA level (64.7%). A positive association was shown between PA level and BMI (p<0.05, r=0.192). Female medical students tend to be physically inactive than males (OR 2.004, 95% CI (1.038-3.8690)). Female students need to be encouraged to do more physical activity. The university's policies that promote physical outdoor activity need to be suggested.  
Relationship between Family History of Hypertention and Autonomic Nervous System Activity Ambasari, Rika Putri; Sarosa, Hadi; Muhtarom, Muhtarom
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 5, No 1 (2013): January-June 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.992 KB) | DOI: 10.30659/sainsmed.v5i1.357

Abstract

The most common hypertension is essential hypertention influenced by genetic factors. Autonomicic nervous activity is influenced by several factors including genetic. This study aimed to determine the relationship between family history of hypertension and autonomic nervous system activity. In this observational analytic cross sectional study, out of 124 a students of the Medical Faculty, University Islam Sultan Agung Semarang 44 students were included using simple stratified method consisting of 22 men and 22 women aged over 20 years. The subjects were asked for family history of hypertension, orthostatic and valsalva examination. 25 students (56.8%) had a family history of hypertension and experienced imbalance of autonomic nervous activity. Out of 19 students (43.2%) without a history of hypertension, 10 people (22.7%) had a balance of autonomic nervous system activity and 9 people (20.5%) experienced imbalance of autonomic nervous system activity. Fisher correlation test results showed a significant association (p < 0.05) and correlation test of Lamda resulted in p value of 0.100, indicating a very week positive correlation. The study concludes that there was a correlation between a family history of hypertension and on autonomic nervous system activity with a very weak relationship.
The Effect of Tempeh on the Ability of Macrophage Phagocytosis An experimental study in male Balb/c mice Afiyata, Noven; Sarosa, Hadi; Sumarawati, Titiek
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.904 KB) | DOI: 10.30659/sainsmed.v3i1.409

Abstract

Background: Consuming tempeh regularly increases the levels of isoflavones in the our body influencing the IFNã and macrophage activating factor (MAF) that lead to the in increase in the ability of macrophage phagocytosis. Macrophage phagocytosis gives an illustration of the macrophages ability as the first line of phagocytic cells to digest foreign particles. This study aims at finding out the influence of tempeh on the ability of macrophage phagocytosis.Design and Methods: In an experimental study using post test only control group design, 15 mice Balb/c were divided into 3 groups of 5 mice each. Gp1: 0.5 gr of tempeh juice, Gp2: 1 mg tablet imboost in 1 cc of water (positive control), Gp3: 1 cc of 1 times (negative control). Treatment was given daily for 12 days. On day 13, Phagocytic ability of macrophages were examined using latex beads method. Data were analyzed using one Kruskal Wallis test followed by Independent T-Test.Results: The phagocytic ability for the three groups were 760,6 -----± 109,898 ; 244.2 ± 70.159; 9.6 ± 2.839 respectively. Independent t- test resulted in the significance difference (p = 0.008) between treated groups and control groups, both positive and negative ones (p<0,05).Conclusion: There is a difference in phagocytic ability between treatment and control groups (Sains Medika, 3(1):54-62).
The Difference in The Effect Between The Oxygenated and Mineral Water on The O2 Saturation And Urine pH Ellyana, Naila Shulya; Sarosa, Hadi; Hussaana, Atina
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 2 (2011): Juli-Desember 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.232 KB) | DOI: 10.30659/sainsmed.v3i2.399

Abstract

Background: During exercise, oxygen decreases due to acidosis leading the production acid urine by kidney. Oxygenated water having capability to absorb more oxygen compared to mineral water is used to meet the oxygen need during exercise. This study investigated the effect of oxygenated water and mineral water on the O2 saturation and urine pH.Design and method: In this crossover study, 46 subjects were randomly assigned to either oxygenated water or mineral water for 24 hours followed by a crossover to the other regimen for an additional 24 hours of treatment. After 100 m sprint running for 20 minutes, the oxygen saturation and urine pH of the subjects were assessed.Result:The mean oxygen saturation before and after the treatment of oxygenated water were 96.78±1.32 and 97.61±0.93 respectively. The mean oxygen saturation before and after the mineral water treatment was 97.35±0.85 and 97.01±1.04 respectively. The urine pH after the administration of oxygenated water and mineral water were 6.643±0.69 and 6.585±0,58 respectively. Wilcoxon test resulted in no significant difference in pH after the treatment of oxygenated water and mineral water (p=0.498). Urine pH after the treatment of oxygenated water was found to be higher compared to that of mineral water.Conclusion: the oxygenated water increases the O2 saturation and urine pH compared to mineral water (Sains Medika, 3(2):162-167).
Co-Authors Apriani, Erina Widya Atina Hussaana Bagas Widiyanto, Bagas Chodidjah Chodidjah Danis Pertiwi Makarim, Fadli Rizal Minidian Fasitasari Muhtarom Muhtarom, Muhtarom Naila Shulya Ellyana noven afiyata Pritasari, A. M. Sita Rika Putri Ambasari Titiek Sumarawati Ulfah Dian Indrayani Vikawati, Nura Eky