Ulfah Dian Indrayani
Departement Of Histology, Universitas Islam Sultan Agung, Semarang, Indonesia

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Formula Jamu Antihipertensi and captopril are equally effective in patients with hypertension Hussaana, Atina; Sarosa, Hadi; Indrayani, Ulfah Dian; Chodidjah, Chodidjah; Widiyanto, Bagas; Pertiwi, Danis
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.81-88

Abstract

BACKGROUNDHypertension is the main cause of morbidity and mortality associated with cardiovascular diseases. Many herbs/spices appear to have significant effects in favorably modulating high blood pressure. A jamu formulation containing 6 plant extracts, Formula Jamu Antihipertensi (FJA), has been described previously. This research study aimed to evaluate the effect of FJA as antihypertensive agent in mild to moderate hypertensive patients. METHODSThis double-blind experimental study was conducted in 40 hypertensive patients, who were randomized into two groups. The first group was treated with oral administration of 2 g FJA and the second group 25 mg captopril daily for 4 weeks. Systolic and diastolic blood pressure as well as liver and kidney function were followed up every week. Independent- t test and two-way ANOVA were used to analyze the data with a level of significance of 0.05.RESULTSThe results showed that after the treatment, FJA and captopril were capable of significantly decreasing systolic and diastolic blood pressure (p <0.05). The decrease in systolic blood pressure between the two groups was identical (p>0.05), while the decrease in diastolic blood pressure was greater in the FJA group than in the captopril group (p <0.05). CONCLUSIONFrom this study it may be concluded that administration of FJA for 4 weeks is equally effective as captopril in reducing systolic and diastolic blood pressure in patients with mild and moderate hypertension. Thus, natural plants and herbs can be our source of drugs, with fewer side effects and better bioavailability for treatment of hypertension in the future.
Plasma DNA as a potential biomarker for breast cancer detection Dewajani Purnomosari; Ulfah Dian Indrayani; . Irianiwati; Dian Caturini Sulistyoningrum
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 48, No 4 (2016)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (545.141 KB) | DOI: 10.19106//JMedSci004804201603

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Breast cancer is a major malignancy among Indonesian women. It is often diagnosed inthe later stages of cancer, which leads to poor prognosis and survival of the patients.This study investigated plasma DNA concentration as a potential biomarker for breastcancer. The benefit of using this detection is the cost-effectiveness and the samples canbe collected from patients using non-invasive methods. Plasma samples were obtainedfrom healthy controls (n=18) and cancer patients (n=22). Each sample was split intotwo equal portions for DNA isolation using two different methods for the NaI methodand a commercially available kit (Qiagen/ QA) method. The DNA concentration wasdetermined by using a GeneQuant spectrophotometer (Pharmacia). The t-test was usedfor statistical analysis, which was performed using the SPSS 17.0 software. Compared tothe commercial method, extraction using NaI yielded higher DNA concentration, both fromsamples of healthy controls and cancer patients (p=0,008 and p=0.000, respectively).Furthermore, regardless of the isolation method used, the plasma DNA concentrationwas higher in healthy controls than in cancer cases (p=0,032 and p=0.005, for NaIand QA methods, respectively). In conclusion, isolation methods significantly affect DNAconcentrations. The plasma DNA concentration of healthy controls is significantly higherthan those of the cancer cases, suggesting that plasma DNA concentration might be apotential biomarker for breast cancer detection with less invasive sampling method thantissue biopsies.
Deteksi Dini Penyakit Ginjal Kronis pada Pasien Hipertensi dan Diabetes Melitus di Puskesmas Srondol Ulfah Dian Indrayani; Kamilia Dwi Utami
Jurnal ABDIMAS-KU: Jurnal Pengabdian Masyarakat Kedokteran Vol 1, No 1 (2022): Januari
Publisher : Fakultas Kedokteran, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (361.24 KB) | DOI: 10.30659/abdimasku.1.1.34-38

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Penyakit Ginjal Kronis (PGK) adalah komplikasi yang sangat sering terjadi pada pasien dengan diabetes mellitus dan hipertensi. PGK sangat berpengaruh terhadap kualitas hidup penderita dan meningkatkan beban ekonomi kesehatan karena penatalaksanaan PGK stadium akhir memerlukan pembiayaan yang besar. Berdasarkan data profil Kesehatan Kota Semarang 2019 menunjukkan jumlah kasus hipertensi dan diabetes melitus meningkat tajam dibandingkan tahun 2015.  Kondisi ini berpotensi untuk meningkatkan jumlah penderita PGK di kota Semarang. Namun demikian, perkembangan PGK pada pasien dengan hipertensi dan diabetes mellitus dapat dicegah atau diperlambat dengan pengendalian gula darah dan tekanan darah serta deteksi dini PGK. Tujuan kegiatan ini adalah untuk deteksi dini terhadap gangguan fungsi ginjal, meningkatkan pengetahuan tentang pengendalian tekanan darah dan gula darah untuk mencegah PGK, serta mengetahui faktor-faktor penghambat kepatuhan minum obat pasien hipertensi dan diabetes. Mitra pada pengabdian masyarakat ini adalah Puskesmas Srondol. Metode pengabdian berupa penyuluhan, pengisian kuesioner, serta pemeriksaan kreatinin dan Hb untuk deteksi dini PGK. Indikator keberhasilan program ini adalah tersedianya data pemeriksaan penunjang fungsi ginjal sebagai acuan pengelolaan lanjutan dan data faktor penghambat kepatuhan minum obat.  Chronic Kidney Disease (CKD) is a very common complication in patients with diabetes mellitus and hypertension. CKD is very influential on the quality of life of patients and increases the economic burden on health because the management of end-stage CKD requires large funding. Based on data from the health profile of the City of Semarang in 2019 shows that the number of cases of hypertension and diabetes mellitus increased sharply compared to 2015. This condition could potentially increase the number of CKD sufferers in the city of Semarang. However, the development of CKD in patients with hypertension and diabetes mellitus can be prevented or slowed by controlling blood sugar and blood pressure and early detection of CKD. The purpose of this program is to carry out early detection of impaired kidney function, increase knowledge about controlling blood pressure and blood sugar to prevent CKD, as well as determine the factors inhibiting drug adherence in patients with hypertension and diabetes. The partner in this community service is the Srondol Health Center. The method of this service program is in the form of counseling, filling out questionnaires, and checking creatinine and Hb for early detection of CKD. An indicator of the success of this program is the availability of data on supporting examinations of kidney function as a reference for further management and data on factors inhibiting drug adherence.
EKOENZIMM FOR AGRICULTURAL WASTE TREATMENT IN SELODUWUR HAMLET, BATUR VILLAGE, GETASAN DISTRICT Susilorini Susilorini; Ulfah Dian Indrayani; Kamilia Utami; Achmad Syafii
Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Vol 6 No 3 (2022): September 2022
Publisher : LPPM Univ. Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (435.741 KB) | DOI: 10.32832/abdidos.v6i3.1261

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Organic farming is one of the proponents of food resistance, economic resilience and human health especially during the COVID 19 pandemic. The sustainability of organic farming must be supported by the availability of fertilizer, pesticides and sufficient financial capital. Ecoenzym is one of the easy and inexpensive agricultural waste fermentation products. Ecoenzyme can be one of the solutions to increase the availability of fertilizer, pesticides and can be used to reduce the economic burden due to financial spending on soap, shampoo and household hygiene. In addition, ecoenzymes are also beneficial in restoring fertility and repairing the quality of soil damaged by conventional agriculture using chemical fertilizers and pesticides. Batur Village is one of the villages with an organic farming community that is affiliated in the Minang Bangkit Merbabu farming group. Currently, the organic fertilizer used is the fertilizer and compost that comes from agricultural waste only. Its availability is highly dependent on the limited number of livestock, and not all farmers have livestock. Ecoenzyme training is one of the activities that is expected to be a solution for farmers to jointly produce fertilizer and pesticides, thus increasing the economic level of agricultural waste that is processed into ecoenzymes.
Pengaruh Pemberian Kombinasi Madu dan Habbatussauda Terhadap Fungsi dan Fibrosis Ginjal Tikus Kamilia Dwi Utami; Ulfah Dian Indrayani; Israhnanto Isradji; Hanifah Tiara Putri; Hilwa Qonita Almazia; Yusri Apriliani Karyono
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 13, No 4 (2022): Oktober 2022
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf13420

Abstract

Honey has ingredients that can provide antioxidant effects, while Black Seed contains thymoquinone which has antioxidant, anti-inflammatory and anti-microbial effects. This study aims to determine the effect of giving a combination of honey and Black Seed on urea levels in rats induced by Unilateral Ureteral Obstruction (UUO). This study used a pretest-posttest randomized controlled group design for urea and creatinine and a posttest only controlled group design for the percentage fraction of areas of renal fibrosis. The test subjects were 30 Rattus Wistar male white rats randomized into 5 groups namely group 1 (Sham Operation), group 2 (irbesartan 13.5 mg/kgBW/day), group 3 (combination of honey 0.675 mL/200 g/day and Black Seed 0.5 mL/kgBW), group 4 (combination of honey 1.35 mL/200 g/day and Black Seed 1.0 mL/kgBW), and group 5 (combination of honey 2.025 mL/200 g/day and Black Seed 2.0 mL/kgBW). Urea levels were examined using enzymatic methods. Analysis of urea levels pretest-posttest using One Way Anova followed by Post Hoc test. The results of measuring urea levels in the pretest showed an increase in urea levels in all UUO-induced groups, while measurements of urea levels in the posttest showed a decrease in urea levels compared to the pretest. Analysis of creatinine levels pretest using One Way Anova followed by Post Hoc test while posttest analysis using Kruskal Wallis followed by Mann Whitney test. The results of measuring creatinine levels in the pretest showed an increase in creatinine levels in all UUO-induced groups, while measurements of creatinine levels in the posttest showed a decrease in creatinine levels compared to the pre test. The percentage of kidney fibrosis area fraction in groups 1, 2, 3, 4, and 5 were as follows: 0%, 2%, 7%, 5.5%, and 1.5%, respectively. Analysis of the results of the area fraction of renal fibrosis using Kruskal Wallis followed by the Mann Whitney test. The results of measuring the area fraction of fibrosis showed a decrease in the percentage of area fraction in the test group. Administration of a combination of honey reduced urea and creatinine levels and the percentage of fibrous area fraction of rats induced by unilateral ureteral obstruction.Keywords: Unilateral Ureteral Obstruction; honey; Black Seed; urea; creatinine; area fraction; kidney fibrosisABSTRAK Madu memiliki kandungan yang dapat memberikan efek antioksidan, sedangkan habbatussauda mengandung thymoquinone yang memiliki efek antioksidan, anti inflamasi, dan anti mikroba. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kombinasi madu dan habbatussauda terhadap kadar ureum pada tikus yang di induksi Unilateral Ureter Obstruction (UUO). Penelitian ini menggunakan rancangan pretest-posttest randomized controlled group untuk ureum dan kreatinin serta posttest only controlled group design untuk persentase fraksi area fibrosis ginjal. Subjek uji adalah 30 ekor tikus putih jantan Rattus Wistar dirandomisasi menjadi 5 kelompok yaitu kelompok 1 (Sham Operation), kelompok 2 (irbesartan 13,5 mg/kgBB/hari), kelompok 3 (kombinasi madu 0,675 mL/200 g/hari dan habbatussauda 0,5 mL/KgBB), kelompok 4 (kombinasi madu 1,35 mL/200 g/hari dan habbatussauda 1,0 mL/KgBB), dan kelompok 5 (kombinasi madu 2,025 mL/200 g/hari dan habbatussauda 2,0 mL/KgBB). Kadar ureum diperiksa dengan menggunakan metode enzimatik. Analisis kadar ureum pretest-posttest menggunakan One Way Anova dilanjutkan uji Post Hoc. Hasil pengukuran kadar ureum pretest menunjukkan peningkatan kadar ureum pada semua kelompok yang diinduksi UUO, sedangkan pengukuran kadar ureum posttest menunjukkan penurunan kadar ureum dibandingkan pretest. Analisis kadar kreatinin pretest menggunakan One Way Anova dilanjutkan uji Post Hoc sementara analisis posttest menggunakan Kruskal Wallis dilanjutkan uji Mann Whitney. Hasil pengukuran kadar kreatinin pretest menunjukkan peningkatan kadar kreatinin pada semua kelompok yang diinduksi UUO, sedangkan pengukuran kadar kreatinin posttest menunjukkan penurunan kadar kreatinin dibandingkan pre test. Persentase fraksi area fibrosis ginjal pada kelompok 1, 2, 3, 4, dan 5 masing-masing sebagai berikut: 0%, 2%, 7%, 5,5%, dan 1,5%. Analisis hasil fraksi area fibrosis ginjal menggunakan Kruskal Wallis dilanjutkan uji Mann Whitney. Hasil pengukuran fraksi area fibrosis terdapat penurunan persentase fraksi area pada kelompok uji. Pemberian kombinasi madu menurunkan kadar ureum dan kreatinin serta persentase fraksi area fibrosis tikus yang diinduksi obstruksi ureter unilateral.Kata kunci: Unilateral Ureter Obstruction; madu; habbatussauda; urea; kreatinin; fraksi area; fibrosis ginjal
Pengaruh Mendengarkan Murottal Al-Qur’an Surah AR-Rahman Terhadap Tingkat Depresi Elly Noerhidajati; Ulfah Dian Indrayani; Lusito Lusito; Reza Adityas Trisnadi
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 13, No 4 (2022): Oktober 2022
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf.v13i4.1941

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Chronic kidney failure patients with hemodialysis therapy often experience psychological problems, namely depression. Depression can be treated with pharmacological and non-pharmacological therapy, one of which is by listening to the murottal Al-Qur'an which will give the patient a feeling of calm. This study aims to determine the effect of listening to murottal Al-Qur'an surah Ar-Rahman on the level of depression in chronic kidney failure patients undergoing hemodialysis therapy. The research design used was a pretest-posttest without control group, involving 50 patients with hemodialysis therapy which were then divided into 2 groups, namely the control group and the treatment group which was exposed to listening to murottal Al-Qur'an for 2 weeks. The level of depression was measured using the BDI II questionnaire (Back Depression Inventory II). In the treatment group, 18 patients did not experience depression and 7 patients experienced mild depression. In the control group, 10 patients did not experience depression, 10 patients experienced mild depression and 5 patients experienced moderate depression. Wilcoxon test results showed p <0.05. It was concluded that murottal Al-Qur'an surah Ar-Rahman can reduce the level of depression in chronic kidney failure patients undergoing hemodialysis therapy.Keywords: hemodialysis; depression; murottal Al-Qur'an; chronic kidney failure; hemodialysis therapyABSTRAK Pasien gagal ginjal kronik dengan terapi hemodialisa sering mengalami masalah psikologi yaitu depresi. Depresi bisa ditangani dengan terapi farmakologi maupun non farmakologi, yang salah satunya adalah dengan mendengarkan murottal Al-Qur’an yang akan memberikan perasaan tenang pada pasien. Penelitian ini bertujuan untuk mengetahui pengaruh mendengarkan murottal Al-Qur’an surah Ar-Rahman terhadap tingkat depresi pada pasien gagal ginjal kronik yang menjalani terapi hemodialisa. Rancangan penelitian yang digunakan adalah pretest-postest without control group, dengan melibatkan 50 pasien dengan terapi hemodialisa yang kemudian dibagi menjadi 2 kelompok, yakni kelompok kontrol dan kelompok perlakuan yang diberikan pajanan dengan mendengarkan murottal Al-Qur’an selama 2 minggu. Tingkat depresi diukur menggunakan kuesioner BDI II (Back Depression Inventory II). Pada kelompok perlakuan, 18 pasien tidak mengalami depresi dan 7 pasien mengalami depresi ringan. Pada kelompok kontrol, 10 pasien tidak mengalami depresi, 10 pasien mengalami depresi ringan dan 5 pasien mengalami depresi sedang. Hasil uji Wilcoxon menunjukkan p <0,05. Disimpulkan bahwa murottal Al-Qur’an surah Ar-Rahman dapat menurunkan tingkat depresi pada pasien gagal ginjal kronik yang menjalani terapi hemodialisa.Kata kunci: hemodialisa; depresi; murottal Al-Qur’an; gagal ginjal kronik; terapi hemodilisa 
The Effect of Alium Satium Extract on the Glomerular Diameter of STZ -induced Sprague dawley Rats Susilorini, Susilorini; Indrayani, Ulfah Dian; Soffan, Moch.
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 5, No 1 (2013): January-June 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (525.371 KB) | DOI: 10.30659/sainsmed.v5i1.358

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Hyperglycemia exert toxic effect in kidney.The aim of this study was to investigate the short term effect of ethanolic extract of garlic in preventing nephropathy following streptozotocin (STZ) induced rats. Twenty male Sprague dawley rats were randomly divided into 4 group, all group induced induced by single dose intraperitoneal injection of 40 mg kg-1 of streptozotocin (STZ). Treatment with 3 doses ethanolic extract of garlic (0,1; 0,25; 0,5 mg kg-1 day-1) was followed for 14 days, then the left kidneys were excised and histhopathological studies were carried out using scanner 3D Hitech and Panoramic view software. Statistical analysis have been done using non parametric analysis Kruskall Wallis. The study revealed that glomerular diameter of the treatment rats was significantly different from the control group (p=0,0001). Increasing doses didn’t make difference. The ethanolic extract of garlic (Allium sativum) influences the diameter glomeruli but increasing doses has no effect on the glomerular diameter.
The Effect of Honey on Plasma Malondialdehyde (MDA) Level onAlloxan-Induced hyperglycemic Rats An Experimental studies in rats Galur Wistar White Males Fajrilah, Bela Risqiyani; Indrayani, Ulfah Dian; Djam’an, Qathrunnada
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 5, No 2 (2013): July-December 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (456.746 KB) | DOI: 10.30659/sainsmed.v5i2.348

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Malondialdehyde (MDA) is the end product of lipid peroxidation and a marker of free radicals. Honey is a safe sweetener proven to lower blood glucose level and contains flavonoids, vitamin A, C, E as a source of antioxidant that can capture free radicals. This study aims to determine the effect of honey on plasma MDA level ionalloxan-induced hyperglycemicrats. This was an experimental study with post-test only control group design conducted for 25 days using 18 white male Wistar rats divided into 3 groups randomly. A negative control group, group B were given honey orally at the dose of 0.54 ml/mice/day, and group C were given honey orally at the of dose 0.9 ml/head/day. Each group consisted of 6 rats. Blood plasma MDA was evaluated by Thiobarbituric Acid Reactive Substance (TBARS) test assay. One way ANOVA analysis test followed post hoc were applied for data analysis. The results showed that mean levels of MDA in group A, B, and C were 6.02 mmol/l ± 0.36, 4.37 mmol/± 0.30, and 1.12 mmol/l ± 0.11 respectively. Bivariate analysis One way ANOVA test showed a significant difference (p<0,05). Post hoc tests showed a significant differences between the study groups (p<0,05). It can be concluded that honey had an effect on the levels of malondialdehyde (MDA) in the blood plasma of alloxan-induced hyperglycemic rats.
The Correlation between Duration of Employment, Body Posture and Smoking Habit on Low Back Pain Incidence An Analytic Observational Study Among Taxi Driver in Semarang Municipality Firmanita, Syifa Dian; Rosdiana, Ika; Indrayani, Ulfah Dian
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 6, No 1 (2015): January-June 2015
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (684.612 KB) | DOI: 10.30659/sainsmed.v6i1.339

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Introduction: Low back pain ((LBP) ranks as number two of neurological disease’s highest prevalence after cephalgia and migraine in Indonesia. Objective: This study aim to determine the relationship between duration of employment, body posture and smoking habit on the incidence of low back pain on taxi driver. Method: This research is an observational analytic cross sectional design. Seventyfour taxi drivers in Semarang municipality was screened with Beck’s Depression Inventory Scale to meet the inclusion and exclusion criteria. Respondents were then given Risk Factor of LBP questionnaire. Data were analyzed with a bivariate correlation test contingency coefficient to see the relationship between duration of employment, body posture, smoking habit and low back pain.Result: the taxi driver with duration of employment >10 years were moderate smokers and having astenis body posture. The analysis of correlation coefficients contingency test showed a significance relationship between duration of employment (p = 0,000), body posture (p = 0,000), and moderate smokers (p=0.010) with the incidence of LBP. Conclusion: the taxi driver with duration of employment >10 years with astenis body posture, and moderate smokers were posstively correlated with LBP.
Sinergitas Penguatan Dakwah Dan Kemandirian Perekonomian Melalui Perencanaan Gedung Serbaguna Sebagai Pengembangan Amal Usaha PCM Sawit Boyolali Guntur Nugroho; As'at Pujianto; Chusnul Azhar; Fathurrahman Kamal; Ghoffar Ismail; Gita Danu Pranata; Arini Hidayah; Ulfah Dian Indrayani
NUSANTARA Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 2 (2023): Mei : Jurnal Pengabdian Kepada Masyarakat
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/nusantara.v3i2.1644

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Community service programs have been implemented at the head of the Muhammadiyah Sawit Boyolali branch. The purpose of the community service program is to plan the development of da'wah through the development of Muhammadiyah business charity within the PCM Sawit Boyolali company. From the results of discussions held by the service team and management of the PCM Branch Leadership, it was agreed that the development of Muhammadiyah business charity was realized by planning the PCM Multipurpose Building. The problem that arises is that the land that will be used as the location for the construction of the Multipurpose Building is not yet available. The effort made is to invite all company residents to participate in the construction building. From the joint efforts of the Muhammadiyah Sawit branch leader, Boyolali received waqf land from company residents in the PCM Sawit environment. With the waqf land from the company's residents, the problems faced related to the location of the building placement have been solved.