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All Journal JURNAL KIMIA SAINS DAN APLIKASI INDONESIAN JOURNAL OF PHARMACY
Hardjono Sastrohamidjojo
Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada Yogyakarta
Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Medicine & Pharmacology

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Chemical composition and antibacterial properties of the essential oil of Pogostemon cablin Aisyah, Yuliani; Hastuti, Pudji; Sastrohamidjojo, Hardjono; Hidayat, Chusnul
INDONESIAN JOURNAL OF PHARMACY Vol 19 No 3, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.325 KB) | DOI: 10.14499/indonesianjpharm0iss0pp151-156

Abstract

The aim of this research were to evaluate the chemical compositions and antibacterial activities of patchouli. The identification of patchouli oil was carried out by using gas chromatography-mass spectrophotometer, fractionation of patchouli oil was done by vacuum fractionational distillation method. The gas chromatography mass spectra showed that the patchouli oil consisted of 15 components. It was found that the five major components were patchouli alcohol, Δ-guaiene, α-guaiene, seychellene and α-patchoulene. Patchouli oil and high boiling point fraction exhibited antibacterial activity, while the low boiling point fractions did not show the antibacterial properties. The antibacterial properties found to be more effective for the Gram-positive bacteria than that the Gram-negative bacteria.Key words : patchouli oil, patchouli alcohol, fractinational distillation, antibacterial
Dimerisasi Metilisoeugenol dengan Katalis HCl Ngadiwiyana, Ngadiwiyana; Soelistyowati, Retno Dwi; Sastrohamidjojo, Hardjono
Jurnal Kimia Sains dan Aplikasi Vol 5, No 3 (2002): Volume 5 Issue 3 Year 2002
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6810.571 KB) | DOI: 10.14710/jksa.5.3.1-6

Abstract

Telah dilakukan reaksi adisi terhadap metilisoeugenol dengan HCl dalam pelarut CCl4, CH2Cl2, CH3OH, CH3CH2OH dan tanpa pelarut. Metilisoeugenol merupakan hasil isomerisasi metileugenol. Reaksi adisi metilisoeugenol dengan HCl dilakukan dengan mengalirkan gas HCl ke dalam metilisoeugenol sambil diaduk selama 3 jam. Reaksi adisi dilakukan pada suhu 15 oC. Pemurnian terhadap hasil reaksi menghasilkan endapan putih kecoklatan. Analisis menggunakan spektrofotometer IR, spektrometer 1H-NMR dan kromatografi gas-spektrometer massa terhadap hasil tersebut memberikan keterangan bahwa senyawa utama yang dihasilkan adalah senyawa dimer metilisoeugenol yaitu 9,10-dietil-2,3,6,7-tetrametoksi-9,10-dihidroantrasena.
Co-Authors Chusnul Hidayat Ferdayanti, Marlia Ngadiwiyana M.Si. S.Si. Pudji Hastuti Retno Dwi Soelistyowati Riyanto Riyanto Yuliani Aisyah