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All Journal BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains
Syalfinaf Manaf
Universitas Bengkulu
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Efektivitas Ekstrak Batang Arcangelisia flava Merr. sebagai Afrodisiaka pada Mencit Jantan dan Betina Santi Nurul Kamilah; Eka Fitri Siti Andriyani; Dea Ananda Putri; Sri Astuti; Syalfinaf Manaf; Hari Marta Saputra
BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Vol 5 No 1 (2022): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (459.038 KB) | DOI: 10.31539/bioedusains.v5i1.2426

Abstract

This study aimed to analyze the effect of the stem extract of the yellow root plant (Arcangelisia flava Merr.) from Enggano Island on the introduction and locomotor activity of male and female mice (Mus musculus L.). The method used is an experiment with a completely randomized design. The treatment variations were extracted at a dose of 150 mg/kgBW, 200 mg/kgBW and 250 mg/kgBW, Neo Hormoviton capsules at a 200 mg/kgBW dose as a positive control, and without extract or strong drug as a negative control. The results showed that the administration of the extract caused an increase in the introduction activity, but the activity decreased with the increase in the dose of the given extract. Meanwhile, an increase in locomotor activity occurred at a dose of 250 mg/kgBW, while the doses of 150 mg/kgBW and 200 mg/kgBW tended to cause a decrease. Duncan's further test showed that a dose of 250 mg/kgBW increased locomotor activity which was more significant in female mice but not significantly in male mice. In conclusion, the extract at a dose of 250 mg/kgBW can increase locomotor activity, higher than Neo Hormoviton capsules at 200 mg/kgBW in both male and female mice. Keywords: Aphrodisiac, Sexual Activity, Arcangelisia flava, Fitness
Efek Ekstrak Jintan Hitam (Nigella sativa L.) terhadap Gambaran Histopatologi Hepar Tikus Putih (Rattus norvegicus) yang Diinduksi Isoniazid Kartika Sari; Rizki Muharani; Syalfinaf Manaf; Hilda Taurina; Liya Agustin Umar; Novriantika Lestari
BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Vol 4 No 2 (2021): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (759.928 KB) | DOI: 10.31539/bioedusains.v4i2.2636

Abstract

This study aimed to examine the effect of giving black cumin extract to changes in the histopathological picture of the liver of white rats induced by isoniazid. The method used is experimental with posttest only control group design pattern. The research subjects used 25 Rattus norvegicus, which were divided into negative control group (P1), positive control (P2) isoniazid orally with a dose of 5.4 - 6.75 mg/day for six weeks, treatment 1 (P3), treatment 2 (P4 ), and treatment 3 (P5) which was given isoniazid at a dose of 5.4 - 6.75 mg/day orally and followed by oral black cumin with stratified amounts of 2000, 2500 and 3000 mg/kgBW. The results showed that there was a significant increase in liver cell damage after administration of isoniazid (p < 0.05) and liver cell recovery after administration of black cumin extract for 42 days (p < 0.05). In conclusion, the administration of black cumin extract can restore isoniazid-induced liver cell damage. Keywords: Liver Histopathology, Isoniazid, Black Cumin
Co-Authors Dea Ananda Putri Eka Fitri Siti Andriyani Hari Marta Saputra Hilda Taurina Kartika Sari Liya Agustin Umar Novriantika Lestari R R. Sri Astuti Rizki Muharani Santi Nurul Kamilah