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All Journal Proceeding Seminar LPPM UMP Tahun 2014 Pharmaceutical Sciences and Research (PSR)
Sundani Nurono Soewandhi
Sekolah Farmasi ITB Bandung
Education

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Pengembangan Inovasi Kesehatan dan Teknologi Menuju Masyarakat Madanis Soewandhi, Sundani Nurono
Proceeding Seminar LPPM UMP Tahun 2014 2014: Proceeding Seminar Nasional LPPM 2014, 20 Desember 2014
Publisher : Proceeding Seminar LPPM UMP Tahun 2014

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Persoalan aktual yang dihadapi seluruh industri farmasi di dunia disebabkan karena; (1) sifat hidrofobik bahan aktif farmasi (BAF) yang menyebabkan kelarutannya rendah di dalam air dan berakibat pada rendahnya laju disolusi serta bioavailabilitasnya; (2) sifat polimorfisme yang ditunjukkan 70-80% BAF dengan segala konsekuensinya; (3) antaraksi antarmolekular sistem biner yang terdiri dari minimal dua BAF atau kombinasi BAF dan eksipien atau Non BAF; (4) transformasi polimorfik BAF yang berpengaruh pada masa kadaluwarsa sediaan.  Untuk mengatasi persoalan-persoalan tersebut, akhir-akhir ini di dunia farmasi mulai diterapkan metode kristalografik yang terdiri dari difraksi sinar-X serbuk, difraksi sinar-X kristal tunggal, analisis termal, spektroskopi inframerah, spektroskopi Raman, mikrokop polarisasi dan mikroskop elektron. Melalui penggunaan instrumen-intrumen ini dapat diketahui habit, dimensi, kondisi permukaan partikel, sistem kristal, indeks kristalinitas, enthalpi, suhu lebur, suhu transisi dan perubahan-perubahannya akibat perlakukan tribomekanik, termal, hidrotermal ataupun kompresi. Dengan demikian, peristiwa transformasi polimorfik BAF teridentifikasi, kebenaran informasi dalam Certificate of Analysis BAF, CoA terjamin dan antaraksi antarmolekular kombinasi BAF terdeteksi sejak dini. Jika metode-metode tersebut digunakan untuk tujuan kuantitatif, maka kinetika reaksi transformasi polimorfik dapat ditentukan. Dengan demikian, batas waktu kadaluwarsa sediaan farmasi yang disebabkan perubahan fisika dapat ditetapkan. Prinsip rekayasa kristal atau crystal engineering yang mulai berkembang pesat sejak tahun 2005 diterapkan dengan tujuan mengubah sementara karakter fisika BAF yang semula sukar menjadi mudah larut di dalam air, semula higroskopis menjadi tidak higroskopis, semula sukar dikompresi menjadi mudah dikompresi dan sebagainya. Rekayasa kristal melibatkan BAF dan koformer membentuk ko-kristal atau molekul super melalui adanya ikatan hidrogen atau van der Waals. Pada dasarnya baik BAF maupun koformer harus memiliki gugus-gugus penerima dan penyuplai proton (sinton) yang dapat berikatan melalui homosinton (karboksilat-karboksilat atau amida-amida), atau heterosinton (seperti karboksilat-amida, karboksilat-piridin).Kata kunci: molekul super (ko-kristal), metode kristalografik, rekayasa kristal
Pengaruh Milling Terhadap Laju Disolusi Campuran Metampiron-Fenilbutason (7:3) Soewandhi, Sundani Nurono; Haryana, Aris
Majalah Ilmu Kefarmasian Vol. 4, No. 2
Publisher : UI Scholars Hub

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In pharmaceutical process, milling is a common process to produce particle in certain expectation size. Impact of milling process could lead to physical interaction. Dissolution rate will change as an impact of physical interaction. To observe physical interaction between methampyrone and phenylbutazone during milling process, is needed to analyze its X-ray diffractogram, DSC thermogram and dissolution rate. Data of X-ray diffractogram, differential scanning calorimetry and dissolution test, showed that physical interaction occurred after 5,5 hours and 18 hours of milling and cause enhancement of dissolution rate of phenylbutazone. Dissolution rate of methampyrone was constant after 5,5 hours of milling. Decreasing dissolution rate of methampyrone occured after 18 hours of milling.
Pengamatan Visual Tahap-Tahap Pembentukan Kristal Sistem Eutektikum Asetaminofen-Pseudoefedrin Hidroklorida Nugrahani, Ilma; Asyarie, Sukmadjaja; Soewandhi, Sundani Nurono; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

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The aim of this research was to observe the recrystallization process of two component, acetaminophen-pseudoephedrine hydrochloride in ethanol and the thermal profiles. The visual data resulted from polarization microscope observation confirmed with thermograph DSC showed that the crystal habit was represented to the intrinsic character representative by thermodynamic properties of the binary system.The visualization process proved that in different molar ratios, the binary system formed crystals habit with different and step by step showed inhibit, to form polycrystalline until at molar ratio 6:4 formed the fines single crystals mixture which was smaller than before co-recrystallization. Acetaminophen was observed as monoclinic hexagonal crystals while pseudoephedrine hydrochloride was observed monoclinic/orthorombic forms.
Polimorfisasi dan Solvatomorfi Amoksisilina Trihidrat setelah Proses beku Kering Nugrahani, Ilma; Asyarie, Sukmadjaja; Soewandhi, Sundani Nurono; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 7, No. 2
Publisher : UI Scholars Hub

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The polymorphismof amoxicillin has been identified after freeze drying process. The freeze dried amoxicillin have some specific physical properties different from their raw material, that was proved by DSC, XRD, and polarize microscope. Exothermal curve from DSC thermogram changes to endothermal curve, diffractogram XRD changes to different profile, and the crystal shows different habit. All of data showed that freeze drying process improve amoxicillin to different crystal form which has higher melting oxidation point and lower hydrate. The improvement of the crystal structure might be impact to change physical-pharmaceutical properties like dissolution, absorption, and change it antibiotic potency.
Co-Authors Aris Haryana, Aris Ilma Nugrahani Slamet Ibrahim Sukmadjaja Asyarie