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All Journal JURNAL FARMASIMED (JFM) Best Journal (Biology Education, Sains and Technology) JURNAL PENELITIAN FARMASI & HERBAL
Firdaus Fahdi
Institut Kesehatan Deli Husada Deli Tua
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health

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UJI EFEKTIVITAS ANTIKOLESTEROL KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalina Del.) DENGAN EKSTRAK ETANOL DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) PADA TIKUS HIPERKOLESTEROL Herviani Sari; Nurmaulia Nurmaulia; Wahyudi Wahyudi; Firdaus Fahdi
Jurnal Penelitian Farmasi & Herbal Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i2.206

Abstract

African leaves (Gymnanthemum amygdalina Del.) and palm leaves (Elaeis guineensis Jacq.) which is contain flavonoid, saponin, alkaloid, and tannin can be used to decrease cholesterol levels and reduced the risk of cardiovascular disease. This study aims to determine the effect of EEDA dan EEDKS combination on blood cholesterol levels in hypercholesterolemic mice. Sample in this study was African leaves and palm leaves which were taken purposively without comparing samples from other regions, then extracted by maceration using ethanol 96%. The results of data analysis from the three EEDA and EEDKS groups effected cholesterol reduction due to the sig value <0.05. Based on ANOVA one way analysis of the five most effective treatments is simvastatin then dose 400-600mg/kgBB, dose 200-300mg/kgBB, dose 100-150mg/kgBB and CMC Na 1%. The combination of EEDA and EEDKS has an antihypercholesterol effect, the combination of EEDA and EEDKS has an antihypercholesterol effect that is comparable to the positive control, and the finding from this study that the most effective dosage of EEDA and EEDKS as antihypercholesterol is at dosage 400-600 mg/kgBB.
UJI EFEKTIVITAS ANTI BAKTERI EKSTRAK DAUN LEUNCA (SOLANUM NIGRUM) TERHADAP DAYA HAMBAT BAKTERI ESCHERICHIA COLI Firdaus Fahdi; Herviani Sari; Lisbet Saulina Lubis
Jurnal FARMASIMED (JFM) Vol 3 No 1 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i1.472

Abstract

Antibacterial is a compound that can inhibit the growth of bacteria that can be used for the treatment of infections in humans. One of the bacteria that can cause interference with the system is the Escherichia coli bacteria, where the Escherichia coli bacteria is widely spread around us. The spread of the Escherichia coli bacteria can occur by direct contact (shaking hands, touching). Then passed on by mouth. Leunca leaves have chemical contents including alkaloids, flavonoids, saponins, tanins. The purpose of this study was to determine whether Leunca's leaf extract (Solanum nigrum) has antibacterial effects against the inhibitory power of Escherichia coli bacteria with a concentration of 50 mg/ml, 100 mg/ml, 150 mg/ml, 200 mg/ml, 250 mg/ml. The method of this study was the sample of Leunca leaf obtained from West Lumban Rau Village, Habinsaran Subdistrict, Toba Samosir Regency. Sample preparation was done by making thick extract with the maceration method. An anti-bacterial effectiveness test is done by the disk diffusion method. The results showed Leunca's leaf extract containing alkaloid compounds, flavonoids, saponins, tannins. As well as having antibacterial effectiveness against the inhibition of Escherichia coli bacteria. Average inhibition zone area concentration of 50 mg/ml = 6.1 mm, concentration of 100 mg/ml = 7.3, concentration of 150 mg/ml = 8.8 mm, concentration of 200 mg/ml = 10.8 mm, concentration of 250 mg/ml = 12.6 mm. Conclusion: Leunca (Solanum nigrum) Leaf Extract has antibacterial effects against the inhibitory power of Escherichia coli bacteria with a strong category.
Aktivitas Antibakteri Ekstrak Etanol Rumput Laut Israel (Asystasiagangetica L.) Terhadap Pertumbuhan Bakteri Eschericia coli Herviani Sari; Firdaus Fahdi
BEST Journal (Biology Education, Sains and Technology) Vol 6, No 2 (2023): September 2023
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v6i2.7694

Abstract

Rumput israel (Asystasia gangetica) atau sering disebut dengan tanaman Ara sungsang merupakan salah satu tanaman budidaya yang berpotensi sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol rumput Israel dalam menghambat pertumbuhan bakteri Escherichia coli dan untuk mengetahui perbedaan aktivitas antibakteri ekstrak etanol rumput Israel pada berbagai konsentrasi. Metode : Ekstraksi dilakukan dengan metode maserasi menggunakan etanol 70%. Pengujian aktivitas antibakteri dilakukan dengan menggunakan metode difusi cakram kertas. Aktivitas ini ditandai dengan terbentuknya zona bening pada area paper disc. Penelitian ini dilakukan dengan menggunakan 4 perlakuan konsentrasi yaitu 25%, 50%, 75%, 100%, dan kontrol negatif aquades dan kontrol positif amoksisilin. Hasil : Berdasarkan hasil uji one way ANOVA menunjukkan adanya pengaruh aktivitas antibakteri terhadap Escherichia coli dengan nilai signifikansi (p0,05) dengan nilai F = 53.393. Hal ini menunjukkan bahwa terdapat perbedaan yang signifikan penggunaan berbagai konsentrasi ekstrak rumput Israel dalam menghambat pertumbuhan bakteri Escherichia coli. Penentuan diameter zona hambat sebelum perlakuan adalah 16mm dan sesudah perlakuan. Konsentrasi ekstrak lebih baik dalam menghambat pertumbuhan bakteri Escherichia coli yaitu konsentrasi 100% dengan diameter 20,4 mm
Co-Authors Herviani Sari Lisbet Saulina Lubis Nurmaulia Nurmaulia Wahyudi Wahyudi