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All Journal Media Ilmu Kesehatan Proceedings of the International Conference on Applied Science and Health
Tiar M Pratamawati
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Education Health Professions Medicine & Pharmacology Nursing Public Health

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THE EFFECT OF ORALLY ADMINISTERED CATFISH (Clarias gariepinus) SKIN AND MEAT ON EPITHELIALIZATION THICKNESS AND COLLAGEN DENSITY IN INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Muhammad Irsyad Baihaqi; Muhammad Duddy Satrianugraha; Tiar M Pratamawati; Donny Nauphar
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Alternative medicine using animal is still rare whereas Indonesia have a lot of potential natural resources. Catfish is easily found animal in Indonesia and is common consumed as nutriment sources contains albumin, amino acid and fatty acids which plays an essential role of wound healing process. This study will determine effect of orally administered catfish (Clarias gariepinus) skin and meat on epithelialization thickness and collagen density in incision wound of white male rat (Rattus norvegicus).Methods: This experimental post-test only group design used 30 white male rat (Rattus norvegicus), that randomly divided into 4 tratment goup and one control group. The treatment group was given 12,5 mg/g W, 25 mg/g W, 37,5 mg/g W and 50 mg/g W dose of catfish (Clarias gariepinus) skin and meat flour, in the other hand the contol group were given aquades. Non-parametric analyses using Kruscall-Wallis and Mann Whitney test were used to compare epithelization thickness and collagen density.Result: The comparison results of epithelialization thickness between group C with TGI, C with TG2, C with TG3 and C with TG4 showed significant differences (p<0.05). TG4 was the thickest of all groups. Significant differences were also observed in collagen density result between C with TGI, C with TG2, C with TG3 and C with TG4 (p <0,05) TG4 showed the highest density of all groups.Conclusion: Catfish (Clarias gariepinus) skin and meat flour with 50 mg/200g W dose is effective for wound healing and increasing epithelial thickness and collagen density in Wistar rat (Rattus norvegicus) incision wounds.
EFFECTIVENESS OF ORALLY USE TILAPIA (Oreochromis niloticus) ON WOUND LENGTH AND FIBROBLAST DENSITY ON INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Sayyidah Vina Syauqia; A Fariz Malvi Zamzam Zein; Tiar M Pratamawati; Donny Nauphar
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: The incidence of a wound in Indonesia has increased from 7.5 percent in 2007 to 8.2 percent in 2013 according to Riskesdas. Wound care that widely used is povidone-iodine, but in case, it has a toxic effect on healthy cells around the wound. The albumin, amino acids, and fatty acids in Tilapia  (Oreochromis niloticus) are the potential substances to accelerate the wound healing process. This study aims to investigate the efficacy of Tilapia (Oreochromis niloticus) on wound length and fibroblast density on the incision wound of Wistar rat (Rattus norvegicus).Methods: The study was conducted in the Food and Nutrition PAU Laboratory and Pathology Anatomy Laboratory of Universitas Gadjah Mada, Yogyakarta. This post-test only control group design experimental study used 30 male white rats that randomly divided into five groups, i.e. control group K, and treatment group P1, P2, P3 and P4 that were each given Tilapia with a dose of 12.5 mg/200gBW, 25 mg/200gBW, 37.5 mg/200gBW dan 50 mg/200gBW. The length of the wound was measured by a ruler each day. The rats were terminated on the 10th day to obtain wound tissue for H&E stained histopathological sections to observe fibroblast density. One Way ANOVA, Tamhane, Kruskal-Wallis and Mann Whitney tests were used to compare the wound length and fibroblasts density.Results: Incision wounds in this study showed the best wound healing on the 10th day. Based on the theory, on the 10th day, a proliferation and remodeling phase occurs. There is an effect of giving Tilapia (Oreochromis niloticus) orally at a different dose. Tilapia at dose 37.5mg/200gBW is more effective compared with the dose of 12.5mg/200gBW, 25mg/200gBW, and 50mg/200gBW to accelerate wound healing for wound length and fibroblast density in Wistar rat (Rattus norvegicus).Conclusion: Consuming Tilapia (Oreochromis niloticus) could be a new alternative for wound healing treatment. The antimicrobial ability of Tilapia should be analyzed.
EFFECTIVENESS OF ORALLY USE CATFISH (Clarias gariepinus) SKIN AND MEAT ON WOUND LENGTH AND FIBROBLAST DENSITY IN INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Sri Utami Fauziah; Risnandya Primanagara; Tiar M Pratamawati; Donny Nauphar
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Abstract

Background: Treatment for wounds that are currently often given is use povidone-iodine. But, this antiseptics also kills fibroblast tissue which is useful for forming new tissue. One of the other ways to treatment for wounds is use catfish. The contents found in catfish (Clarias gariepinus) is albumin which is a globular protein that is useful in the formation of body tissues, such as postoperative wounds and burns. This study aims to determine the effect of skin and meat of catfish (Clarias gariepinus) on wound length and fibroblast density in incision wounds of Wistar rat (Rattus norvegicus).Methodology: This study is an experimental study with Post Test Only Control Group Design using Wistar rats which are divided into five groups. The control group (aquadest) and treatment groups 1, 2, 3 and 4 are given the skin and meat of catfish (Clarias gariepinus) orally at a dose of 12.5 mg / 200 g BW, 25 mg / 200 g BW, 37.5 mg / 200 g BW, and 50 mg / 200 g BW. After 10 days, the rats are killed to take the wound tissue for histological preparations to observe fibroblast density. Then, it is analyzed by ANOVA test or the alternative.Results: There is an effect of giving catfish skin and meat (Clarias gariepinus) orally at different dose. The administration of catfish skin and meat (Clarias gariepinus) at a dose of 37.5 mg / 200 g BW and 50 mg / 200 g BW is better than other doses assessed from wound length and fibroblast density in Wistar rat incision wounds (Rattus norvegicus).Conclusion: The use of catfish for wound healing can be applied. This method can reduce wound length and increase fibroblast density at certain doses.
FAKTOR – FAKTOR YANG BERHUBUNGAN DENGAN PERILAKU PEMBELIAN ANTIBIOTIK Uswatun Khasanah; Witri Pratiwi; Tiar M Pratamawati; Tridaya P Handayani; Mateus Sakundarno Adi
MEDIA ILMU KESEHATAN Vol 9 No 2 (2020): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v10i2.768

Abstract

Background: Antibiotics are a group of drugs used to treat infectious diseases. Consumption of antibiotics must be adhere to the indications and dosages, so they must be prescribed by a doctor. However, in daily practice antibiotics can be purchased freely by the public without using prescription. Objective: This study aims to analyse the factors associated with purchasing antibiotics without prescription in the city of Cirebon. Method: This study was an observational study with a cross-sectional approach. Primary data was collected through a validated questionnaire against people who bought antibiotics without prescription at five pharmacies in the city of Cirebon. Samples recruited using consecutive sampling method with a total of 299 respondents. The Spearman rank test was used to analyse the data. Results: 246 out of 299 (82.3%) respondents purchased antibiotics without prescription. Results showed that level of education (r=0.267, p=0.001), socioeconomic status (r=0.217, p=0.001), and profession (r=0.132, p=0.022) are significant, while sex (r=0.068, p=0.239) and distance to facility (r=0.102, p=0.054) are not. Conclusion: Level of education, socioeconomic status, and profession are significantly related to purchase of antibiotics without prescription in the city of Cirebon.
Co-Authors A Fariz Malvi Zamzam Zein Donny Nauphar Mateus Sakundarno Adi, Mateus Sakundarno Muhammad Irsyad Baihaqi Risnandya Primanagara Satrianugraha, Muhammad Duddy Sayyidah Vina Syauqia Sri Utami Fauziah Tridaya P Handayani USWATUN KHASANAH Witri Pratiwi