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All Journal Jurnal Matematika & Sains Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Sukrasno Sukrasno
Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, ITB
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Mathematics Medicine & Pharmacology Public Health

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 1 
Antimicrobial Activities of the Ethanol Extracts of Capsicum Fruits with Different Levels of Pungency Soediro Soetarno; Sukrasno Sukrasno; Elin Yulinah; Sylvia Sylvia
Jurnal Matematika & Sains Vol 2, No 2 (1997)
Publisher : Institut Teknologi Bandung

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Abstract

Ethanol extracts of the fruits of three kinds of Capsicum showed similar potencies in their antimicrobial activities against Gram (+) and Gram (-) bacterias, and fungi, although they contained different level of capsaicin. Bioautographic tests demonstrated that capsaicin was the main antimicrobial component. At least two other non-polar components of ethanol extract also contributed in the antimicrobial activity and very likely that these compounds were responsible for the activity toward Pseudomonas aeruginosa.
Kandungan Kapsaisin dan Dihidrokapsaisin Pada Berbagai Buah Capsicum Sukrasno Sukrasno; Siti Kusmardiyani
Jurnal Matematika & Sains Vol 2, No 1 (1997)
Publisher : Institut Teknologi Bandung

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Search for the hotest chilli pepper (Capsicum) fruits which was based on their capsaisinoid contents has been conducted. Chilli pepper fruits were collected from various places in Indonesia and two of them from Japan. From the 25 kinds of chilli pepper analysed, it was found that all C. frutescens contained capsaicinoids while in some C. annuum these compounds were not detected. Capsaicinoid content in chilli pepper fruits is affected by the their age and the highest content found in mature fruits before ripening which is indicated by the change of colour from green or pale yellow to red.
Aktivitas Antidiabetika Ekstrak Etanol Herba Sambiloto (Andrographis paniculata Nees (Acanthaceae)) Elin Yulinah; Sukrasno Sukrasno; Muna Anom Fitri
Jurnal Matematika & Sains Vol 6, No 1 (2001)
Publisher : Institut Teknologi Bandung

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Antidiabetic activity of the ethanol extract of Andrographis paniculata Nees herbs had been tested using glucose tolerance test in rat and alloxan induced diabetic mice. The extract reduced rat blood glucose at the dose of 2.0 g/kg bw but there was no effect observed at dose of 0.50 g/kg bw and 1.0 g/kg bw. It is interesting that the extract at doses 2.1 g/kg bw and 2.8 g/kg bw, and the effect was much lower at 3.5 g/kg bw also showed the capacity to reduce blood glucose level of alloxane induced diabetic mice.
Aktivitas Hipoglisemik Ekstrak Herba Sambiloto (Andrographis paniculata Nees, Acanthaceae) Soediro Soetarno; Elin Yulinah Sukandar; Sukrasno Sukrasno; Agung Yuwono
Jurnal Matematika & Sains Vol 4, No 2 (1999)
Publisher : Institut Teknologi Bandung

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Abstract

Hypoglycemic activity of hexane, ethylacetate, ethanol and aqueous extract of Andrographis paniculata herbs had been tested using glucose tolerance test. Extraction was conducted consecutively using hexane, ethylacetate and ethanol. Aqueous extract was obtained directly from the crude drug similar to the traditional use. At the dose level of 0.5 g/kg bw, hexane and ethylacetate extract did not show the hypoglycemic effect. Significant activity was shown by ethanol and aqueous extract and the activity of the latter was higher than the former.
Kajian Penerapan Cara Pembuatan Obat Tradisional yang Baik pada Industri Ekstrak Bahan Alam di Indonesia Purnama Dwi Tistiyanto; Sukrasno Sukrasno; Budiastuti Budiastuti; Lydia Prima
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.32090

Abstract

 Good Manufacturing Practices for Traditional Medicine (GMP for TM) must be applied by Traditional Medicine Businesses in Indonesia, namely Traditional Medicine Small Businesses (TMSB), Traditional Medicine Micro Businesses (TMMB), Traditional Medicine Industry (TMI) and Active Traditional Medicine Ingredients Industries (ATMII), to ensure the quality of the products produced. At the end of 2021, the Indonesian FDA established the most recent GMP for TM standards, which follow the PIC / PE 009-015 standard that must be applied by TMI and ATMII, with an appendix related to GMP for Active Ingredients Traditional Medicine (ATMI) for ATMII. This study aims to determine the GMP profile for TM implementation, specifically in 17 ATMII in Indonesia, and to provide recommendations to the Indonesian FDA in supervising and assisting ATMII. The method was carried out by creating a list of questions from 17 aspects of GMP for Active Ingredients TM, including aspects of product development and technology transfer, to be filled out independently by 17 IEBA, followed by verification and assessment of compliance with the implementation of GMP for TM with the conclusion of the assessment results of the categories are very good, good, sufficient, and poor. According to the findings of the current GMP for TM application, 6 ATMII (35.3%) received a very good assessment result, 6 ATMII (35.3%) received a good assessment result, 3 ATMII (17.6%) received sufficient assessment results, and 2 ATMII (11.8%) received poor assessment results. The current GMP for TM implementation by ATMII that requires attention are Contract Manufacturers (Including Laboratories), product development and technology transfer, personnel, quality control, and validation, whose average level of fulfilment is still less than 80%. These aspects are critical because they significantly influence the consistency of the quality.
Co-Authors Agung Yuwono Budiastuti Budiastuti Elin Yulinah Elin Yulinah Sukandar Lydia Prima Muna Anom Fitri Purnama Dwi Tistiyanto Siti Kusmardiyani Soediro Soetarno Sylvia Sylvia