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Clinical and Laboratory Features of COVID-19 in Ulin Referral Hospital of South Kalimantan: Predictors of Clinical Outcome Haryati, Haryati; Isa, Mohamad; Assagaf, Ali; Nurrasyidah, Ira; Kusumawardhani, Erna; Suhartono, Eko; Arganita, Fidya Rahmadhany
Journal of Tropical Life Science Vol 11, No 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.03.06

Abstract

Corona Virus Disease (COVID-19) is becoming a global pandemic. Indonesia, especially South Kalimantan had recorded increasing cases with a high fatality rate of 3.7%. Information about factors related to outcomes based on clinical and laboratory features in Indonesia is still limited. Identification of the risk is crucial to determine optimal management and reducing mortality. This retrospective study enrolled 455 adults COVID-19 patients, and data were extracted from medical records of Ulin General Hospital Banjarmasin. The latter is COVID-19 referral hospital in South Kalimantan between March-November 2020. Demographic data, comorbidities, and laboratory were all collected. Data were compared between survivors and non-survivors. Fisher’s exact test and chi-square were used to compare categorical variables. The Mann_Whitney U test was used to compare continuous variables. Analysis was continued by multivariate logistic regression then receiver operating characteristic (ROC) curve to determine cut-off value. The multivariate analysis showed that number of comorbidities [odds ratio (OR) 1,339 (95% confidence interval (CI): 1,064-1,685, P = 0,013) was a significant risk factor to the outcome. In laboratory, lactate dehydrogenase (LDH) [OR: 1.001, 95% CI: 1,000-1.002, P = 0.001], Ferritin (OR 1.000, CI: 1,000-1.001, P = 0.013), APTT (OR: 1.045, CI: 1.010-1.082, P = 0.012), and D-dimer (OR: 1.188, CI: 1.064 - 1.327, P = 0.002) were significant predictor factors but only LDH, ferritin, and D- dimer were obtained good AUC 0.731, 0.715, and 0.705, respectively. The cut of the value of LDH was 656.5 U/L, ferritin was 672.18 ng/ml, and D-dimer was 2.28 mg/L. Sensitivity and specificity were 66.7% and 68,0% for LDH, 83,2% and 56,3% for ferritin, and 62,8 and 70,8% for D-dimer. From this research, we revealed that the number of comorbidities was a risk factor for death. Elevated LDH, ferritin, and D-dimer could be good predictive factors for poor outcomes, thereby considering the accelerating management of COVID-19 patients.
Clinical Characteristics of Hospitalized Individuals Dying with COVID-19 in Ulin Regional Hospital Banjarmasin Haryati Haryati; Mohamad Isa; Ali Assagaf; Ira Nurrasyidah; Erna Kusumawardhani
Jurnal Respirasi Vol. 7 No. 1 (2021): January 2021
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (327.938 KB) | DOI: 10.20473/jr.v7-I.1.2021.1-7

Abstract

Background: Corona Virus Disease (COVID-19) has become a global pandemic and has spread to more than 200 countries including Indonesia. South Kalimantan is one of the provinces in Indonesia that has a high COVID-19 mortality rate (case fatality rate 4.1%). Information about characteristic of mortality patients with SARS-CoV-2 infection in Indonesia was limited. The objective of this study to describe clinical characteristics of COVID-19-confirmed deaths at Ulin Regional Hospital Banjarmasin, as a referral hospital in South KalimantanMethods: Medical records of 108 hospitalized patients dying with COVID-19 between March until August 2020 were collected. The recorded information included gender, age, onset and severity of disease, comorbidities, symptoms, signs, and laboratory findingsResults: The 108 confirmed cases of COVID-19 deaths were mostly male (73.1%) aged <65 years old (85.2%). About 84% of the cases had at least one comorbidity or more, like hypertension (44.4%), obesity (38%), and diabetes mellitus (32.4%). Common early symptoms were fever (91.7%) and shortness of breath (89.8%). Laboratory findings included lympocytopenia and eosinophilopenia (80.6% and 72.2%), increased neutrophil lymphocyte ratio (NLR; 86.1%), decreased absolute lymphocyte count (ALC; 72.2%), and hyponatremia (55.6%). Elevated C-reactive protein (CRP; 92.6%), lactate dehydrogenase (LDH; 91.7%), serum glutamic oxaloacetic transaminases (SGOT; 82.4%), and creatinine levels (57.4%). The majority of non survivors were severe-critical stage with severe acute respiratory distress syndrome (ARDS).Conclusion: In this depictive study, patients with comorbidities and severe-critical stage are at risk of death. Laboratory abnormalities were common in non survivors. Shortness of breath may indicate poor prognosis of COVID-19.
The Correlation of Rapid Antibody Results with SARS-CoV-2 PCR in COVID-19 Patients in Ulin General Hospital Banjarmasin Isa Ansori; Soraya Riefani; Ira Nurrasyidah
Jurnal Respirasi Vol. 7 No. 3 (2021): September 2021
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.435 KB) | DOI: 10.20473/jr.v7-I.3.2021.100-105

Abstract

Introduction: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of clinical disease, better known as COVID-19. The most common method to detect COVID-19 is serological testing of IgM and IgG in response to viral infections using rapid diagnostic test (RDT). Several other guidelines consider polymerase chain reaction (PCR) as the gold standard for diagnosis becausePCR has high sensitivity and specificity values in detecting SARS-CoV-2.Methods: This was a descriptive analytical study. The samples were taken from medical records of COVID-19 patients in Ulin General Hospital Banjarmasin from March to October 2020. Statistical Package for the Social Sciences (SPSS) 16.0 software and Chi-Square test were used for data analysis.Results: From 751 COVID-19 patients, 408 patients (54.32%) had rapid antibody with positive PCR, 132 patients (17.57%) had reactive rapid antibody with negative PCR, 152 patients (20.23%) had non-reactive rapid antibody with positive PCR, and 59 patients (7.85%) had non-reactive rapid antibody with negative PCR. The rapid antibody had sensitivity of 72.85% and specificity of 30.89%. From Chi-Square test, reactive rapid antibody was not correlated with PCR positive results; values of p = 0.320, odds ratio (OR) 1.20.Conclusion: The rapid test antibody could not be recommended as a diagnostic tool. In this study, it was also found that there was no relationship between reactive rapid test results and positive SARS-CoV PCR.
Seorang Laki-laki Usia 16 Tahun yang Mengalami Drowning dan Pneumotoraks Paska Pemasangan Ventilator Mekanik: [Pneumothorax in a Ventilated Young Man after Drowning: A Case Report] Ira Nurrasyidah; Winariani Koesoemoprodjo
Jurnal Respirasi Vol. 1 No. 1 (2015): Januari 2015
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (321.775 KB) | DOI: 10.20473/jr.v1-I.1.2015.15-21

Abstract

Background; Drowning is defined as respiratory impairment due to submersion/immersion in liquid. The liquid/air interface at the entrance of the airway prevents the victim from breathing air. According to the World Health Organization (WHO), 0.7% of all deaths worldwide - or more than 500,000 deaths each year - are due to unintentional drowning. Drowning is the second leading cause of unnatural death after road traffic injuries. Most of these deaths occur in countries with low or middle per capita income. Case; A16-years-old man rescued after drowning in the mud puddle for 15 minutes. He was unconscious, cyanosis, dyspnea and cough with blood and mud. After receiving oxygen in the nearest hospital he got conscious but still dyspnea. He came to our hospital and after undergone several examination we concluded that he had lung edema, ARDS and pneumonia aspiration. Patient immediately intubated and got mechanical ventilation. Five days later patient encounter pneumothorax on the right hemithorax, maybe due to barotrauma and we perfomed a chet tube insertion for three days. Patient had a good progression, there was no deficit neurologic and injury in the other organ. On follow up five months after patient hospitalized revealed normal condition on chest x ray.
Hubungan Komorbid dengan Kejadian Covid-19 di Puskesmas Pemurus Dalam Kota Banjarmasin Puspita Aisyiyah; Farida Heriyani; Ira Nurrasyidah; Meitria Syahadatina Noor; Siti Wasilah
Homeostasis Vol 5, No 1 (2022)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (225.975 KB)

Abstract

Abstract : In addition to major illnesses, there are cases when a person suffers from other illnesses. This is called comorbid or comorbidity. There are many risk factors for COVID-19, one of which is comorbidities. These comorbidities affect the prognosis for possible COVID-19 infection and disease severity. This study attempts to elucidate the relationship between comorbidities and the incidence of COVID-19 at Pemurus Dalam Urban Health Center in Banjarmasin. This study was designed as an analytical observation and used as a case control approach. A total of 30 subjects were found to meet the inclusion and exclusion criteria in each case and the control group as well as samples were taken using a simple random sampling technique. As a result of the univariate analysis, most of the case group (70%) had normal morbidity compared to the control group, and only a small number (23,33%) showed normal morbidity. Bivariate analysis showed that an OR value of 7,667 with a p value of 0,000 or <0,05 was associated with the incidence of COVID-19 and comorbidities. 7,667 OR value indicate that comorbidities is closely related to the incidence of COVID-19 in Banjarmasin. Keywords: comorbid, the incidence, COVID-19 Abstrak: Selain penyakit utama, terdapat kondisi dimana seseorang memiliki penyakit yang lain, hal ini disebut sebagai komorbid atau komorbiditas. COVID-19 memiliki berbagai faktor risiko, salah satunya adalah komorbid. Komorbid ini memengaruhi mudahnya terjadi infeksi COVID-19 serta prognosis dari beratnya derajat penyakit. Hubungan antara komorbid dengan kejadian COVID-19 di Puskesmas Pemurus Dalam Kota Banjarmasin berusaha dijelaskan pada penelitian ini. Penelitian didesain dengan observasional analitik, serta menggunakan case control sebagai teknik pendekatannya. Sebanyak 30 orang yang sesuai dengan kriteria inklusi maupun eksklusi didapatkan pada tiap kelompok kasus maupun kontrol, sampel tersebut diambil dengan menggunakan teknik simple random sampling. Hasil analisis univariat menunjukkan subjek pada kelompok kasus sebagian besar (70%) memiliki komorbid dibandingkan dengan kelompok kontrol hanya sedikit memiliki komorbid (23,33%). Nilai OR 7,667 dengan p value 0,000 atau < 0,05 pada analisis bivariat ditemukan pada hubungan komorbid dengan kejadian COVID-19. OR 7,667 menunjukkan bahwa komorbid memiliki hubungan yang signifikan dengan kejadian COVID-19 di Kota Banjarmasin. Kata-kata kunci: komorbid, kejadian, COVID-19
Literature Review: Hubungan Tingkat Pengetahuan Asma dengan Tingkat Kontrol Asma Khairunnisa Khairunnisa; Farida Heriyani; Ira Nurrasyidah
Homeostasis Vol 4, No 2 (2021)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.985 KB)

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Abstract: WHO estimates that the quantity of people with asthma in the world is around 235 million. Achieving controlled asthma in patients and maintaining control status in a controlled state are the goals of asthma management. Patients knowledge regarding asthma is one of the factors that influence asthma control. Asthma patients who have sufficient knowledge of asthma will have asthma under control. The purpose of writing this article is to find out how the relationship between the level of knowledge of asthma and the level of asthma control in asthma patients. Writing is done by analyzing related literature obtained from search results on electronic databases, namely: PubMed - MEDLINE, Google Schoolar, Science Direct, and official websites such as GINA, WHO and the Ministry of Health. The design used was a literature review, the articles included in Indonesian and English were published in 2010 - 2020. In this literature review, 20 articles were included. Of all the articles included in the literature review, the results showed a significant relationship between the level of knowledge of asthma and the level of asthma control in asthma patients. Keywords: asthma, asthma knowledge, and asthma control. Abstrak: WHO memperkirakan jumlah penderita asma di dunia sekitar 235 juta. Tercapainya asma yang terkontrol pada penderita serta mempertahankan status kontrolnya pada keadaan terkontrol merupakan tujuan dari penatalaksanaan asma. Pengetahuan pasien terkait asma merupakan salah satu faktor yang memengaruhi kontrol asma. Penderita asma yang mempunyai pengetahuan asma yang cukup akan memiliki asma yang terkontrol. Tujuan dari penulisan artikel ini adalah untuk mengetahuai bagaimana  hubungan terkait  tingkat pengetahuan asma dengan tingkat kontrol asma pada penderita asma. Penulisan dilakukan dengan menganalisis literatur terkait yang didapatkan dari hasil pencarian pada database elektronik yaitu: PubMed – MEDLINE, Google Schoolar, Science Direct, dan situs web resmi seperti GINA, WHO dan Kemenkes. Desain yang digunakan adalah literature review, artikel yang disertakan menggunakan bahasa Indonesia dan bahasa Inggris yang dipublikasikan pada tahun 2010 – 2020. Pada literature review ini disertakan 20 artikel. Dari semua artikel yang disertakan dalam literature review menunjukkan hasil adanya hubungan bermakna antara tingkat pengetahuan asma dengan tingkat kontrol asma pada penderita asma. Kata-kata kunci: asma, pengetahuan asma, dan kontrol asma.
Literatur Review: Pengaruh Diabetes Mellitus terhadap Konversi Apusan Sputum setelah Fase Intensif pada Pasien Tuberkulosis Paru Muhammad Ilham Fadillah; Ira Nurrasyidah; Nanang Miftah Fajari
Homeostasis Vol 4, No 1 (2021)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.058 KB)

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Abstract: The relationship between diabetes mellitus (DM) and tuberculosis (TB) infection has been reported in various studies. Hyperglycemia in DM will increase oxidative stress which will decrease the host's response to Mycobacterium tuberculosis (M. tb) infection. Poor glycemic control is associated with reduced treatment outcome in TB-DM patients. The sputum smear conversion in pulmonary TB patients is the most important indicator in evaluating the effectiveness of a given treatment. About 95% of converted sputum smears occurred after the intensive phase of ATD therapy. Time delay appears as an indication of treatment failure. This literature review aims to see the effect of DM on sputum smear conversion after intensive phase therapy in pulmonary tuberculosis patients. This study method is in the form of a review of the study of the effect of DM on the conversion of pulmonary tuberculosis sputum smear during the last 10 years (2010 – 2020).  The results of this literature review show that DM affects the delay in sputum smear conversion after intensive phase therapy. This effect is more significant in DM patients with poor glycemic control. Keywords: diabetes mellitus, tuberculosis, smear conversion Abstak: Hubungan antara diabetes mellitus (DM) dengan infeksi tuberkulosis (TB) telah dilaporkan pada berbagai studi. Kondisi hiperglikemia pada DM akan meningkatkan stres oksidatif yang akan menyebabkan penurunan respons host terhadap infeksi Mycobacterium tuberculosis (M. tb). Kontrol glikemik yang buruk dikaitkan dengan penurunan hasil pengobatan pada pasien TB-DM. Konversi apusan sputum pada pasien TB paru merupakan indikator yang paling penting dalam evaluasi efektifitas pengobatan yang diberikan.Sekitar 95% konversi apusan sputum terjadi setelah terapi OAT fase intensif. Keterlambatan waktu konversi dianggap sebagai indikasi kegagalan terapi. Literature review ini bertujuan untuk mengetahui pengaruh DM terhadap konversi apusan sputum setelah terapi fase intensif pada pasien tuberkulosis paru. Metode yang digunakan berupa review terhadap studi terkait pengaruh DM terhadap konversi apusan sputum TB paru selama 10 tahun terakhir (2010 – 2020). Hasil dari literature review ini menunjukkan bahwa DM berpengaruh terhadap keterlambatan konversi apusan sputum setelah terapi fase intensif. Pengaruh ini lebih signifikan pada pasien DM dengan kontrol glikemik yang buruk. Kata-kata kunci: diabetes mellitus, tuberkulosis, konversi apusan
Literature Review: Hubungan Tingkat Pengetahuan Asma dengan Kualitas Hidup Penderita Asma Ciendy Shintya Alhadi; Farida Heriyani; Ira Nurrasyidah
Homeostasis Vol 4, No 3 (2021)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.74 KB)

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Abstract: Asthma is one of the non-transmitted diseases that is still a global problem. Asthma is incurable. The treatment is only aimed to controlling the frequency of asthma attacks. Good knowledge will have an impact on better patient self management. If asthmatics know how to control asthma, then the frequency of asthma attacks and medication will decrease, so quality of life will improve. The literature review is intended to analyze how asthma knowledge affects asthma control levels and their effects on quality of life. The journals used in literature reviews obtained through databases include PubMed, DOAJ and Google Scholar. The journal used is a full text journal and published from 2010 to 2020. 22 literatures found, authors conclude that there is association between asthma knowledge levels and quality of life. Keywords: asthma, knowledge, quality of life Abstrak: Asma adalah salah satu penyakit tidak menular yang masih menjadi permasalahan global saat ini. Penyakit asma tidak dapat disembuhkan. Penatalaksanaan yang dilakukan hanya bertujuan untuk meringankan atau mengendalikan frekuensi serangan asma yang dialami. Pengetahuan asma yang baik pada penderita akan berpengaruh pada self management yang lebih baik, sehingga asma menjadi terkontrol. Jika asma terkontrol, frekuensi serangan asma menurun dan kebutuhan medikasi menurun, sehingga kualitas hidup meningkat. Literature review ini dibuat bertujuan untuk menganalisis  pengaruh dari tingkatan pengetahuan mengenai asma dengan  status kontrol asma dan pengaruhnya kepada kualitas hidup. Artikel yang digunakan dalam literature review diperoleh dari database PubMed, DOAJ dan Google Scholar. Artikel yang digunakan hanya jurnal berbentuk full text dan terbit dari tahun 2010 sampai dengan tahun 2020. 22 literatur yang ditemukan menunjukkan hasil dimana ada hubungan pengetahuan asma, status kontrol asma serta kualitas hidup penderita. Kata-kata kunci: pengetahuan, asma, kualitas hidup.
Literature Review: Hubungan Indeks Massa Tubuh (IMT) dengan Tingkat Kontrol Asma Ppada Penderita Asma Khairunisa Nurdin; Farida Heriyani; Ira Nurrasyidah
Homeostasis Vol 4, No 1 (2021)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.524 KB)

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Abstract: Asthma is more common in overweight and obesitas subjects, compared to normal weight and underweight subjects. The review summarizes the relationship between body mass index (BMI) with level of asthma control in asthma suffers. The writing was conducted by analyzing related literature obtained from the search results on medical journal databases, such as PubMed - MEDLINE, Scince Direct, Google Scholar, and official websites such GINA, WHO and the Ministry of Health. Articles included are in Indonesia amd English and published in 2009-2020. Several studies have shown that being overweight and obese can increase inflammation, increase gastroesophageal reflux, and decrease pulmonary function, which can worsen asthma symptoms compared to normal weight individuals. There is a significant relationship between BMI and the level of asthma control. Excess BMI and obesity have uncontrolled asthma compared to normal and underweight BMI. The higher the BMI, the lower the level of asthma control. Keywords: asthma, asthma control, body mass index. Abstrak: Asma lebih banyak didapatkan pada subjek berat badan lebih dan obesitas, dibandingkan dengan berat badan normal dan underweight. Penulisan literature review ini bertujuan untuk merangkum hubungan indeks massa tubuh (IMT) dengan tingkat kontrol asma. Penulisan dilakukan dengan menganalisis literatur terkait yang didapatkan dari hasil pencarian pada database jurnal kedokteran, yaitu PubMed – MEDLINE, Scince Direct, Google Scholar, dan situs web resmi seperti GINA, WHO dan Kemenkes . Artikel yang disertakan menggunakan bahasa Indonesia dan bahasa Inggris dan dipublikasikan pada tahun 2009-2020. Beberapa peneIitian menunjukkan bahwa keIebihan berat badan dan obesitas bisa  meningkatkan infIamasi, meningkatkan refIuks gastroesofagus, dan menurunnya fungsi pada paru yang bisa membuat buruknya gejaIa pada asma dibandingkan dengan individu dengan berat badan normaI. Terdapat hubungan yang signifikan antara IMT dengan tingkat kontrol asma. IMT berlebih dan obesitas memiliki asma yang tidak terkontrol dibandingkan dengan IMT normal dan kurus. Semakin tinggi IMT maka semakin rendah tingkat kontrol asma. Kata-kata kunci: asma, kontrol asma, indeks massa tubuh
Literature Review: Hubungan Paparan Asap Rokok dengan Tingkat Kontrol Asma pada Penderita Asma Nurlatifah Nurlatifah; Ira Nurrasyidah; Farida Heriyani
Homeostasis Vol 4, No 3 (2021)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.246 KB)

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Abstract: Asthma is include in the top 10 causes of morbidity and mortality, it is illustrated from the Household Health Survey Study (SKRT) data of various provinces in Indonesia. Cigarette smoke is one of the triggers for asthma. This study aims to analyze and collect articles related to cigarette smoke exposure and asthma control in asthma patients. The design used is literature review, national and international literature searches are carried out using the PubMed database, ScienceDirect, Google Scholar and official websites such as GINA, WHO, Ministry of Health. The criteria for the articles used are those published in 2011-2020. Based on the articles that have been collected, it is found that exposure to cigarette smoke can worsen asthma symptoms so that asthma is not well controlled. Asthma sufferers who are exposed to secondhand smoke will have a greater risk of having an asthma attack compared to asthmatics who have never been exposed to cigarette smoke. Keywords: asthma, asthma control, exposure to cigarettes. Abstrak: Asma termasuk 10 besar penyebab morbiditas dan mortalitas, hal itu digambarkan dari data Studi Survei Kesehatan Rumah Tangga (SKRT) dari berbagai provinsi yang ada di Indonesia. Asap rokok merupakan salah satu faktor pencetus asma. Penelitian memiliki tujuan untuk menganalisa dan mengumpulkan artikel yang berhubungan dengan paparan asap rokok dan kontrol asma pada pasien asma. Desain yang digunakan adalah literature review pencarian literatur nasional maupun internasional dilakukan dengan menggunakan database PubMed, ScienceDirect, Google Scholar dan situs web resmi seperti, GINA, WHO, Kemenkes. Kriteria artikel yang digunakan adalah artikel yang diterbitkan dari tahun 2011-2020. Berdasarkan artikel yang telah dikumpulkan didapatkan hasil bahwa paparan asap rokok dapat memperburuk gejala asma sehingga asma tidak terkontrol dengan baik. Penderita asma yang terpapar asap rokok  mempunyai risiko lebih besar terjadinya serangan asma dibandingkan dengan penderita asma yang tidak pernah terpapar oleh asap rokok. Kata-kata kunci : asma, kontrol asma, paparan rokok.