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All Journal Jurnal Ilmiah Farmasi Majalah Farmaseutik Media Ilmu Kesehatan Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN) Journal of Fundamental and Applied Pharmaceutical Science Sasambo Journal of Pharmacy Journal of Pharmaceutical (JOP)
Nofran Putra Pratama
Program Studi Farmasi (S-1) Fakultas Kesehatan Universitas Jenderal Achmad Yani Yogyakarta
Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Acute toxicity study of Andrographis paniculata (Burm.f) Ness herbs and Gynura procumbens (Merr) leaves extracts combination Kurnia Rahayu Purnomo Sari; Nofran Putra Pratama; Nadia Husna
Jurnal Ilmiah Farmasi Vol. 16 No. 1 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss1.art5

Abstract

AbstractBackground: Development of medical plants as an alternative treatment needs support in terms of scientific evidence to increase public confidence to ensure the safety of its use. Recent research on Andrographis paniculata (Burm. f) Ness and Gynura procumbens (Lour.) Merr showed that the combination of these extracts has a potential to be developed into antihyperglycemic agent and there’s no any potential toxicity for each extract.Objective: The aim of this study was to evaluate the acute toxicity level of these two extracts combination. From this research, it is expected that information can be obtained regarding the safety of extracts to support the further development of the extract combination.  Method: The method that used in this research is based on OECD 423. Observation was intensively done to animal behavior 4 h after acute exposure and continued up to 14 days after acute exposure to evaluate whether there were animal died. After the 15 days, all the animals were sacrificed and the vital organ was isolated for histological study.Results: The results showed that the exposure of these combination didn’t caused any to toxicity symptoms and there’s no animals died. Histological study on hepar showed that there’s no mayor damage in the hepar even after exposure of 2000 mg/kgBW dose.Conclusion: The combination of ethanol extract of A. paniculata herbs and G. procumbens leaves was categorized as unclassified (>2000 mg/kgBW) in term of toxicity levels based on Globally Harmonized Classification System.Keywords: Andrographis paniculata (Burm.f) Ness, Gynura procumbens (Lour.) Merr, acute toxicityIntisariLatar belakang: Pengembangan tanaman obat sebagai alternatif pengobatan perlu dukungan dari segi scientific evidence untuk meningkatkan kepercayaan masyarakat dan menjamin keamanan penggunaannya. Penelitian terbaru tentang sambiloto dan sambung nyawa menunjukkan bahwa kombinasi ekstrak tersebut berpotensi untuk dikembangkan menjadi agen antihiperglikemia dan dibutuhkan pemastian keamanannya.Tujuan: Penelitian bertujuan untuk mengevaluasi potensi ketoksikan secara akut kombinasi ekstrak larut etanol herba sambiloto dan daun sambung nyawa.Metode: Metode yang digunakan pada penelitian ini mengacu pada panduan OECD 423. Pengamatan yang dilakukan termasuk pada tingkah laku hewan uji tikus betina galur Wistar berjumlah 15 ekor, secara intensif terhadap gejala toksisitas selama 4 jam awal setelah paparan sediaan uji kemudian dilanjutkan hingga 14 hari pasca paparan untuk melihat ada/tidaknya hewan uji yang mati. Pada hari ke-15, seluruh hewan uji dikorbankan dan dibedah untuk diisolasi, ditimbang organ vitalnya dan dilakukan pengamatan histologi. Hasil: Hasil penelitian menunjukkan bahwa kombinasi ekstrak tersebut tidak menyebabkan gejala toksik terhadap hewan uji dan tidak ada satupun hewan uji yang mati. Hasil histopatologi organ hepar menunjukkan bahwa kombinasi ekstrak ini tidak menunjukkan efek berbahaya pada organ hepar hewan uji yang telah diberi paparan akut dengan dosis 2000 mg/kgBB. Kesimpulan: Ketoksikan kombinasi ekstrak larut etanol herba sambiloto dan daun sambung nyawa masuk dalam kategori unclassified (>2000mg/kgBB) menurut Globally Harmonized Classification System.Kata kunci : Andrographis paniculata (Burm.f) Ness, Gynura procumbens (Lour.) Merr, toksisitas akut 
PENGARUH PEMBERIAN GEL BINAHONG TERHADAP PENYEMBUHAN LUKA SAYAT Deby Zulkarnain Rahadian Syah; Nofran Putra Pratama
MEDIA ILMU KESEHATAN Vol 9 No 3 (2020): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v9i3.699

Abstract

Background: Effective wound healing will reduce the costs incurred for treatment. Wound assessment, action and selection of treatment are carried out based on conditions and problems. Today's society prefers to do treatment by utilizing natural resources only on incision wounds given binahong leaves. Objective: Produces a binahong gel composition that heals cuts and minimizes infection in the incision. Methods: This research is included in inferential quantitative with parametric data. The mean difference test was then performed, followed by a paired t-test. Results: Administration of Na CMC On day 10 the mean wound closed was 18.83 cm with a standard deviation of 1.15. The administration of 1% binahong gel obtained an average wound healing area of 19.54 cm with a standard deviation of 0.18. The administration of 5% binahomg gel on the 6th day only showed wound healing with a T test value of 0.004 but on day 8 there was no additional wound closure with an average wound healing area of 6.36. The administration of 7.5% gel was known until the 10th day indicating that there was no wound healing. Giving Povidone iodine is known to be on the 8th day showing wound healing with an average wound healing of 6.65 cm. Conclusion: The 1% binahong gel was more effective in accelerating the healing of cuts in rats compared to the 5% and 7.5% binahong gel.
Effect of Andrographis paniculata (Burm.f) Ness Herbs and Gynura Procumbens (Merr) Leaves Extracts Combination in Free-Radical Scavenging Activity Kurnia Rahayu Purnomo Sari; Nofran Putra Pratama; Margaretha Kurniasari
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.772 KB) | DOI: 10.22146/farmaseutik.v15i1.45012

Abstract

Development of medical plants as an alternative treatment needs support in terms of scientific evidence to increase public confidence in its efficacy and to ensure the safety of its use. Recent research on Andrographis paniculata (Burm.f) Ness dan Gynura procumbens (Lour.) Merr show that the combination of these two extracts has a potential to be developed into antihyperglycemic agent, through the mechanism of action as an antioxidant. The aim of this study was to evaluate the antioxidant effect of these two extracts combination. Extraction was done by maceration method. Testing of free radical capture activity was carried out by the DPPH method. The results of the antioxidant activity test showed that the combination of soluble ethanol extract of A. paniculata herbs and G. procumbens leaves 50:50 had the best IC50 value of 91.418 µg/mL, the combination of soluble ethanol extract 75:25 had IC50 value 117,059 µg/mL, and the combination combination of soluble ethanol extract 25:75 had the weakest IC50 of 142,277 µg/mL. The three comparisons of the combination were weaker in antioxidant activity compared to the standard vitamin C which had IC50 3,546 µg/mL. Statistical analysis using one-way ANOVA obtained significant differences in antioxidant activity of the three comparison groups.
Acute Toxicity Study of the Combination of Azadirachta indica A. Juss. and Gynura procumbens (Lour.) Merr. Leave Extracts Nofran Putra Pratama; Kurnia Rahayu Purnomo Sari; Ririn Irma Marliana
Journal of Fundamental and Applied Pharmaceutical Science Vol 1, No 2 (2021): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v1i2.9868

Abstract

Azadirachta indica A.Juss. and Gynura procumbens (Merr.) are medicinal herbs widely used in traditional medicine. Recent research on the combination of these two plants showed aggressive antioxidant activity. The combination results can improve insulin and beta-cell morphology and can increase insulin expression. The variety of activities performed is the basis for conducting acute toxicity tests on the ethanol extract of Azadirachta Indica A. Juss. and Gynura procumbens (Lour.) Merr. to increase public confidence in its efficacy and ensure the safety of its use. The acute toxicity test on the ethanol extract of Azadirachta Indica A. Juss. and Gynura procumbens (Lour.) Merr. was carried out on female Wistar rats by following the 423 procedures of OECD (Organization for Economic Cooperation and Development) Guideline with five groups of experimental animals, namely normal treatment, aquadest solvent treatment and 0.5 Na-CMC 0.5%, a separate treatment of the ethanol extract of Azadirachta Indica A. Juss., a separate treatment of the ethanol extract of Gynura procumbens (Lour.) Merr., and combination treatment of the ethanol extract of Azadirachta Indica A. Juss. and leaves of Gynura procumbens (Lour.) Merr. Furthermore, it was proceeded by observing the liver of the experimental animals histopathologically. The acute toxicity test results utilizing the 423 procedures of the OECD did not confirm any death or signs of toxicity in the experimental animals, and histopathological observations did not show any major histopathological damage. Based on these results, according to Globally Harmonized Classification System (GHS), the combination of the ethanol extract of Azadirachta Indica A. Juss. and Gynura procumbens (Lour.) Merr. is included in the unclassified category 2,000 mg/kg BW.
Analisis fitokimia dan kromatografi lapis tipis ekstrak etanol daun rosella (Hibiscus sabdariffa L.) Tira Risa Oktapiya; Nofran Putra Pratama; Nur'aini Purnamaningsih
Sasambo Journal of Pharmacy Vol. 3 No. 2 (2022): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i2.181

Abstract

Rosella (Hibiscus sabdariffa L) is a plant belonging to the Malvaceae family. This plant is widely used as herbal medicine. Rosella leaves have many compounds that can function as antioxidants and antibacterials. As a crude material for traditional medicine, it is necessary to know the content of secondary metabolites contained in rosella leaves both quantitatively and qualitatively as one of the standardization parameters. The objective of this study was to determine the content of secondary metabolites contained in the ethanolic extract of rosella leaves through phytochemical analysis and Thin Layer Chromatography. Rosella leaf extraction was carried out by maceration method using 70% ethanol as solvent. Testing the content of secondary metabolites in the ethanolic extract of rosella leaves was carried out by phytochemical screening. Furthermore, the TLC test was carried out to confirm the presence of a positive group of compounds on phytochemical screening. Phytochemical screening from rosella leaves extract revealed the presence of alkaloids, flavonoids, saponins and tannins. The TLC system used in this study was able to separate the phytochemical content and gave positive results confirming the phytochemical screening results. The eluent used was chloroform:methanol:acetic acid with a ratio of 14:2:1 obtained spots with an Rf of 0.737 which is similar to the Rf standard of quercetin which is 0.762.
Daya Hambat Fraksi n-heksan, Etil Asetat, dan Air dari Ekstrak Etanol Bunga Cengkeh (Syzygium aromaticum (L.) Merrill & Perry) Terhadap Bakteri Staphylococcus epidermidis Ratih Armay Gustari; Nofran Putra Pratama; Kurnia Rahayu Purnomo Sari
JOURNAL OF PHARMACEUTICAL (JOP) Vol 1 No 1 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v1i1.865

Abstract

Background: Clove flower plants are known as traditional plants that can be used in food, drink and medicine. Clove flower ethanol extract (Syzygium aromaticum (L.) Merrill & Perry) has antibacterial activity. Antibacterial is a substance that can interfere with the growth or kill bacteria by interfering with the metabolism of harmful microbes.Objective: This study was conducted to determine how effective the n-hexane, ethyl acetate, and water fractions from clove the ethanol extract of clove flower (Syzygium aromaticum (L.) Merrill &Perry) in inhibiting the growth of Staphylococcus epidermidis bacteria.Method: Extract were made by the maceration method with 70% ethanol as a solvent. Then proceed with the fractionation process using a liquid-liquid extraction method using three solvents, namely n-hexane solvent (non-polar), ethyl acetate solvent (semi-polar), and water solvent (polar). Identification of clove flower extract and fraction flower was carried out by organoleptic test, phytochemical screening test, and thin layer chromatography test. A Bacterial inhibition test was carried out using the Kirby-Bauer disc diffusion method using concentrations of 20%, 40%, 60%, 80% and 100% with positive control used chloramphenicol while the negative control used distilled water.Result: The results of the n-hexane and ethyl acetate fraction had bacterial inhibition at concentrations of 60%, 80%, and 100%. The water fraction had a zone of bacterial inhibition at 100% concentration.Conclusion: Based on the results of the study was found that the n-hexane, ethyl acetate, and water fractions had effectiveness in inhibiting the growth of Staphylococcus epidermidis bacteria.
Peredaman Radikal Bebas Ekstrak Etanol Daun Rosella (Hibiscus sabdariffa L) Dengan Metode Frap (Ferric Reducing Antioxidant Power) Vina Farah Fauziah; Devika Nurhasanah; Nofran Putra Pratama
JOURNAL OF PHARMACEUTICAL (JOP) Vol 1 No 1 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v1i1.866

Abstract

Background: Antioxidant are chemical compounds that can donate electrons to unpaired free radicals, thereby reducing the effects of free radical oxidation. One of the plants that have antioxidants activity is the rosella plant, for example in the leaves. Rosella leaves contain phytochemical compounds that are useful as antioxidant, namely flavonoids, alkaloids, saponins, tanin.Objective: Determine the antioxidant activity of the ethanol extract of rosella leave (Hibiscus sabdariffa L) by FRAP method.Method: Rosella leaf was macerated using 70% ethanol as solvent. Then filtered and thicken using a frying pan on an electric stove over medium heat of approximately 300 watt. Phytochemical screening was carried out, namely flavonoids, alkaloids, saponins, tanin and TLC test to indicate the presence of flavonoid compounds as antioxidants. Quantitative analysis was carried out to determine antioxidant activity with the FRAP method measured using a UV-Vis spectrophotometer.Result: The antioxidant activity test of the ethanol extract of rosella leaves has FRAP value of 1,749 mmol FeSO4/mg. Based on statistical analysis T-test, shows that there is a difference between the sample and the standard with a significant value (p<0,05) is 0,001.Conclusion: The antioxidant activity test on rosella leaves with the FRAP method proved that the ethanol extract of rosella leaves had antioxidant content with a FRAP value of 1,749 mmol FeSO4/mg.
Sosialisasi Dan Pengenalan Gerakan Yoga Untuk Mengurangi Kecemasan Pada Ibu Hamil Dan Cara Meminum Fe Secara Tepat Budi Rahayu; Nur Rahmawati S.; Nofran Putra Pratama
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 5 No. 2 (2024): Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN) Edisi April - Juni
Publisher : Sistem Informasi dan Teknologi (Sisfokomtek)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v5i2.3014

Abstract

Permasalahan utama yang di hadapi ibu hamil terutama ibu hamil primigravida adalah masalah kecemasan terhadap kehamilan dan persalinan serta kehamilan yang sisertai dengan kondisi anemia. Kecemasan akan menimbulkan perasaan tidak nyaman bagi ibu hamil dan juga ibu di masa persalinan. Kecemasan dalam persalinan dapat menimbulkan ketegangan otot-otot polos dan pembuluh darah, sehingga terjadi kekakuan serviks dan hipoksia pada rahim yang menyebabkan impuls nyeri bertambah banyak, impuls nyeri melalui thaloma limbic ke korteks serebri dari akibat menambah rasa takut, sehingga kontraksi Rahim berkurang. Persalinan disertai dengan anemia apabila tidak ditangani secara efektif menyebabkan perdarahan dan infeksi menjadi lebih berat, dan meningkatkan kondisi morbiditas dan mortalitas baik pada ibu dan juga bayinya. Pengabdian masyarakat ini dilaksanakan di tempat praktik mandiri Bidan yang diikuti oleh ibu hamil TM III yang dilaksanakan dalam dua hari yaitu hari pertama pelaksanaan yoga dan hari kedua pemberian edukasi mengenai cara meminum Fe secara tepat, diikuti oleh 10 peserta ibu hamil. Tujuan dari pengabdian kepada masyarakat ini adalah untuk meningkatan pengetahuan ibu hamil TM III tentang pengetahuan cara meminum tablet Fe secara benar dan mengurangi kecemasan dalam proses persalinan melalui yoga. Metode penelitian ini menggunakan Pre experiment dengan rancangan one group pretest dan posttest design dan analisa data menggunakan uji statistic non parametris dengan uji Wilcoxon. Hasil ada peningkatan pengetahuan ibu hamil mengenai konsumsi tablet Fe dan ibu bisa melakukan gerakan dasar yoga terhadap keluhan ketidaknyamanan kehamilan.
Co-Authors Budi Rahayu Deby Zulkarnain Rahadian Syah, Deby Zulkarnain Rahadian Devika Nurhasanah Kurnia Rahayu Purnomo Sari Kurnia Rahayu Purnomo Sari Kurnia Rahayu Purnomo Sari Margaretha Kurniasari Nadia Husna Nur Rahmawati S. Nur’Aini Purnamaningsih Ratih Armay Gustari Ririn Irma Marliana Tira Risa Oktapiya Vina Farah Fauziah