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All Journal B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah ISM (Intisari Sains Medis) : Jurnal Kedokteran Interdental Jurnal Kedokteran Gigi (IJKG) Journal of Health and Dental Sciences
Putu Sulistiawati Dewi
Bagian Bedah Mulut, Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar
Biochemistry, Genetics & Molecular Biology Dentistry Medicine & Pharmacology Public Health

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RED GINGER RHIZOME EXTRACT GEL IMPROVES COLLAGEN DENSITY POST EXTRACTION OF GUINEA PIG TEETH Putu Dewi, Sulistiawati; Ma’ruf, Mochammad Taha
Interdental: Jurnal Kedokteran Gigi Vol 17 No 1 (2021): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Faculty of Dentistry, Mahasaraswati Denpasar University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v17i1.1190

Abstract

Introduction: tooth extraction can cause injury involving the bone structure and soft tissue of the oral cavity. Tooth extraction can cause various complications, one of which is bleeding. Red ginger is a type of spice that ismost widely used in various food and beverage recipes. Red ginger is commonly used by the public as a cold, digestive, antipyretic, anti-inflammatory, and analgesic drug. Various studies have shown that ginger has antioxidant properties, flavonoids, and oleoresins found in the rhizome. The purpose of this study was to determine the effect of the concentration of red ginger extract (Zingiber Officinale Varr. Rubrum) on collagen density after extraction of guinea pig teeth (Cavia porcellus). Materials and method: the method of this research is an experimental in vivo laboratory with a post-test-only control group design. The hypothesis test was carried out by the One Way Anova test and was carried out on 24 male guinea pigs. The experimental animals were divided into 4 groups which were distinguished by concentration, 10%, 20%, 30%, and the control group was given 2% CMC-Na gel respectively. Results and discussions: The results showed that red ginger extract gel concentrations of 10%, 20%, and 30% can increase collagen density compared to CMC-Na 2%. Conclusion: the red ginger extract gel with a concentration of 30% was most effective at increasing collagen density compared to concentrations of 10% and 20%.
Management of Cleft Lip and Palate (Literature Review) Dewi, Putu Sulistiawati
Interdental: Jurnal Kedokteran Gigi Vol 15 No 1 (2019): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Faculty of Dentistry, Mahasaraswati Denpasar University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v15i1.340

Abstract

Cleft lip and cleft palate (orofacial cleft) are facial and oral malformations that occur very early in pregnancy. A cleft lip and cleft palate, known technically as an orofacial cleft, is actually a group of various conditions that involve a ‘cleft” on the patient’s face. Clefting results when there is not enough tissue in the mouth or lip area, and the tissue that is available does not join together properly. Cleft lip and cleft palate can occur on one or both sides of the mouth. Because the lip and the palate develop separately, it is possible to have a cleft lip without a cleft palate, a cleft palate without a cleft lip, or both together. Children with a cleft lip with or without a cleft palate or a cleft palate alone often have problems with feeding and speaking clearly and can have ear infections. They also might have hearing problems and problems with their teeth. Cleft lip with or without cleft palate, can be diagnosed during pregnancy by a routine ultrasound. They can also be diagnosed after the baby is born, especially cleft palate. Treatment with orofacial clefts can vary depending on the severity of the cleft; the child’s age and needs; and the presence of associated syndromes or other birth defects, or both.
LENDIR BEKICOT MENINGKATKAN JUMLAH SEL MAKROFAG PADA PENYEMBUHAN LUKA PASCA PENCABUTAN GIGI MARMUT Dewi, Putu Sulistiawati; DS, Setiawan
Interdental: Jurnal Kedokteran Gigi Vol 16 No 1 (2020): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Faculty of Dentistry, Mahasaraswati Denpasar University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v16i1.686

Abstract

Tooth extraction is a common practice in dentistry. Tooth extraction will cause injuries that need healing before they can return to the physiological state of the oral cavity. Snail mucus contains beta agglutinin (antibodies) in plasma (serum), achasin protein, glycoconjugate and sulfate levels which can accelerate wound healing by increasing the mobilization of macrophage cells on day 5 after tooth extraction. The purpose of this study was to determine the effectiveness of snail mucus on the number of macrophage cells in wound healing after extraction of guinea pigs. The research method used was pure experimental research using 32 guinea pigs as samples. Guinea pigs were divided into 2 (two) groups: the control group was given 2% CMC-Na gel and the treatment group was given snail mucus after having been extracted. Calculation of the number of macrophages is done on the 5th day. The results showed the mean number of macrophage cells in the control group was 13.06 cells, and the treatment group was 17.44 cells. After being analyzed using the Independent t-test with significance ρ <0.05, it was found that there were significant differences in the number of macrophage cells in the test group and the control group. From this study it can be concluded that snail mucus is effective in increasing the number of macrophage cells in the process of wound healing after tooth extraction. Keywords : snail mucus, macrophage cell, tooth extraction
Management of Cleft Lip and Palate (Literature Review) Putu Sulistiawati Dewi
Interdental: Jurnal Kedokteran Gigi Vol. 15 No. 1 (2019): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Faculty of Dentistry, Mahasaraswati Denpasar University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v15i1.340

Abstract

Cleft lip and cleft palate (orofacial cleft) are facial and oral malformations that occur very early in pregnancy. A cleft lip and cleft palate, known technically as an orofacial cleft, is actually a group of various conditions that involve a ‘cleft” on the patient’s face. Clefting results when there is not enough tissue in the mouth or lip area, and the tissue that is available does not join together properly. Cleft lip and cleft palate can occur on one or both sides of the mouth. Because the lip and the palate develop separately, it is possible to have a cleft lip without a cleft palate, a cleft palate without a cleft lip, or both together. Children with a cleft lip with or without a cleft palate or a cleft palate alone often have problems with feeding and speaking clearly and can have ear infections. They also might have hearing problems and problems with their teeth. Cleft lip with or without cleft palate, can be diagnosed during pregnancy by a routine ultrasound. They can also be diagnosed after the baby is born, especially cleft palate. Treatment with orofacial clefts can vary depending on the severity of the cleft; the child’s age and needs; and the presence of associated syndromes or other birth defects, or both.
LENDIR BEKICOT MENINGKATKAN JUMLAH SEL MAKROFAG PADA PENYEMBUHAN LUKA PASCA PENCABUTAN GIGI MARMUT Putu Sulistiawati Dewi; Setiawan DS
Interdental: Jurnal Kedokteran Gigi Vol. 16 No. 1 (2020): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Faculty of Dentistry, Mahasaraswati Denpasar University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v16i1.686

Abstract

Tooth extraction is a common practice in dentistry. Tooth extraction will cause injuries that need healing before they can return to the physiological state of the oral cavity. Snail mucus contains beta agglutinin (antibodies) in plasma (serum), achasin protein, glycoconjugate and sulfate levels which can accelerate wound healing by increasing the mobilization of macrophage cells on day 5 after tooth extraction. The purpose of this study was to determine the effectiveness of snail mucus on the number of macrophage cells in wound healing after extraction of guinea pigs. The research method used was pure experimental research using 32 guinea pigs as samples. Guinea pigs were divided into 2 (two) groups: the control group was given 2% CMC-Na gel and the treatment group was given snail mucus after having been extracted. Calculation of the number of macrophages is done on the 5th day. The results showed the mean number of macrophage cells in the control group was 13.06 cells, and the treatment group was 17.44 cells. After being analyzed using the Independent t-test with significance ρ <0.05, it was found that there were significant differences in the number of macrophage cells in the test group and the control group. From this study it can be concluded that snail mucus is effective in increasing the number of macrophage cells in the process of wound healing after tooth extraction. Keywords : snail mucus, macrophage cell, tooth extraction
EFEKTIFITAS GEL EKSTRAK DAUN BINAHONG TERHADAP JUMLAH MAKROFAG PADA PENYEMBUHAN LUKA INSISI MENCIT YANG DIINDUKSI ALOKSAN Putu Sulistiawati Dewi; Setiawan Setiawan
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 8, Nomor 3, Desember 2021
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v8i3.862

Abstract

Introduction: diabetes mellitus is a disorder of carbohydrate, fat, and protein metabolism which is characterized by an increase in blood glucose levels (hyperglycemia) due to secretion and insulin, or decreased insulin action. The amount of costs incurred and the difficulty of handling diabetic wounds, it is necessary to find alternative medicines that are cheaper, one of them is herbal plants. One of the herbs is binahong leaf (Anredera cordifolia). Binahong leaves have active compounds alkaloids, saponins, flavonoids, and terpenoids. Objectives: the purpose of this study was to determine the effectiveness of binahong leaf extract gel against decreasing the number of macrophage cells in incision wound healing of alloxan induced mice (Mus musculus). Materials and methods: 24 mice induced with alloxan were then divided into four groups, such as application of binahong leaf extract gel concentration of 25%, 30%, 35% and application of CMC-Na 2% gel as a control group. All treatment given within 4 days. The data obtained were analyzed using One Way Anova and continued with LSD (Least Significant Differences). Result: from the results of this study indicate that the treatment of binahong leaf extract gel concentrations of 25%, 30%, and 35% effectively decreased the number of macrophage cells compared to the control group. Conclusion: this study concluded that binahong leaf extract gel concentration of 35% was more effective on decreasing the number of macrophage cells in incision wound healing of alloxan induced mice.
RED GINGER RHIZOME EXTRACT GEL IMPROVES COLLAGEN DENSITY POST EXTRACTION OF GUINEA PIG TEETH : GEL EKSTRAK RIMPANG JAHE MERAH MENINGKATKAN KEPADATAN KOLAGEN PASCA EKSTRAKSI GIGI MARMUT Sulistiawati Putu Dewi; Mochammad Taha Ma’ruf
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 17 No. 1 (2021): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v17i1.1190

Abstract

Introduction: tooth extraction can cause injury involving the bone structure and soft tissue of the oral cavity. Tooth extraction can cause various complications, one of which is bleeding. Red ginger is a type of spice that ismost widely used in various food and beverage recipes. Red ginger is commonly used by the public as a cold, digestive, antipyretic, anti-inflammatory, and analgesic drug. Various studies have shown that ginger has antioxidant properties, flavonoids, and oleoresins found in the rhizome. The purpose of this study was to determine the effect of the concentration of red ginger extract (Zingiber Officinale Varr. Rubrum) on collagen density after extraction of guinea pig teeth (Cavia porcellus). Materials and method: the method of this research is an experimental in vivo laboratory with a post-test-only control group design. The hypothesis test was carried out by the One Way Anova test and was carried out on 24 male guinea pigs. The experimental animals were divided into 4 groups which were distinguished by concentration, 10%, 20%, 30%, and the control group was given 2% CMC-Na gel respectively. Results and discussions: The results showed that red ginger extract gel concentrations of 10%, 20%, and 30% can increase collagen density compared to CMC-Na 2%. Conclusion: the red ginger extract gel with a concentration of 30% was most effective at increasing collagen density compared to concentrations of 10% and 20%.
RHIZOME BANGLE EXTRACT INHIBITION GROWTH TEST AGAINST Staphylococcus aureus FOR ORAL ABSCESSS HERBAL TREATMENT (UJI DAYA HAMBAT EKSTRAK RIMPANG BANGLE TERHADAP PERTUMBUHAN Staphylococcus aureus SEBAGAI PERAWATAN HERBAL ABSES ORAL) Putu Sulistiawati Dewi; Setiawan
Journal of Health and Dental Sciences Vol. 1 No. 3 (2022): Journal of Health and Dental Sciences
Publisher : Fakultas Kedokteran Gigi Unjani

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (158.434 KB)

Abstract

An abscess is a typical infection caused by Staphylococcus aureus bacteria. Resistance of bacteria occurs due to improper antibiotics dosage, inaccurate diagnosis, and improper bacterial causes. Rhizome Bangle contains saponins, flavonoids and essential oils, alkaloids, tannins, and glycosides that have antibacterial. The purpose of this study is to determine the inhibitory effect of rhizome Bangle extract (Zingiber purpureum Roxb.) on the growth of Staphylococcus aureus bacteria in Vitro. The study was an experimental laboratory study with group design post-test in vitro. The method used as the antibacterial test was the Kirby Bauer diffusion method. Concentration of rhizome Bangle extract were 8%, 16%, 32%, and negative control of ethanol and positive control of chlorhexidine 0,2%. The culture medium used Mueller Hinton agar (MHA). Data  analyzed by Krusskal wallis (p <0.05). The result of this study shows Rhizome Bangle extract 32% concentration inhibit Staphylococcus aureus bacteria growth significant with p= 0.001. The conclusion is that rhizome Bangle extract (Zingiber purpureum Roxb.) inhibits the growth of Staphylococcus aureus bacteria at 32% concentration. DOI : 10.54052/jhds.v1n3.p225-232
Efektifitas ekstrak lidah buaya terhadap jumlah sel fibroblast pada proses penyembuhan luka incisi marmut Putu Sulistiawati Dewi
Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (203.836 KB) | DOI: 10.15562/ism.v9i3.272

Abstract

Latar belakang : Proses pembedahan seringkali melibatkan tindakan insisi yang dapat menyebabkan kerusakan jaringan, dimana kerusakan jaringan ini akan menstimulasi terjadinya proses pemulihan atau yang biasa disebut dengan proses penyembuhan luka. Penyembuhan luka merupakan proses yang dinamis dan terdiri dari fase inflamasi, fase proliferasi dan fase maturasi. Sel fibroblas mulai muncul pada fase proliferasi. Salah satu tanaman herbal  yang berperan dalam penyembuhan luka adalah lidah buaya yang berkhasiat membantu proses regenerasi sel, anti bakteri, anti jamur dan anti inflamasi Tujuan : Penelitian ini dilakukan untuk mengetahui efektifitas ekstrak lidah buaya terhadap jumlah sel fibroblas dalam proses penyembuhan luka insisi pada hewan marmut. Metode : Penelitian ini menggunakan 9 ekor marmut jantan dewasa berumur 5-6 bulan dengan berat sekitar 700-800 gram. Dua buah luka insisi dibuat pada punggung masing-masing marmut dengan panjang insisi kurang lebih 1,5 cm, kedalaman 2 mm dan dengan jarak antar insisi kurang lebih 3 cm, insisi dibuat vertikal pada daerah punggung marmut. Luka insisi pertama kemudian diberi perlakuan dengan ekstrak lidah buaya 75% sebagai kelompok uji, sedangkan luka insisi kedua diberi aquades sebagai kelompok kontrol. Perlakuan diberikan selama 4 hari, pada hari ke-5 semua hewan uji didekapitasi dan dilakukan pemeriksaan histologi untuk menghitung jumlah sel fibroblas kemudian dianalisis menggunakan uji Independent t-test. Hasil penelitian : terdapat perbedaan yang signifikan antara jumlah sel fibroblas kelompok uji dengan jumlah sel fibroblas kelompok kontrol (sig < 0,05). Kesimpulan : pemberian ekstrak lidah buaya 75% dapat meningkatkan jumlah sel fibroblas dalam proses penyembuhan luka insisi pada marmut.
SUB-ACUTE TOXICITY TEST OF RED GINGER EXTRACT (Zingiber officinale var. Rubrum) ON MICE (Mus musculus): UJI TOKSISITAS SUB-AKUT EKSTRAK JAHE MERAH (Zingiber officinale var. Rubrum) TERHADAP MENCIT (Mus musculus) Sulistiawati Putu Dewi; Mochammad Taha Ma’ruf
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 19 No. 1 (2023): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v19i1.6289

Abstract

Introduction: Red ginger (Zingiber officinale var. rubrum) is one of the herbal plants used as a wound healing drug because it contains high oleoresin and essential oil. Red ginger also has antioxidant, anti-inflammatory, and antibacterial properties that can strengthen the immune system and prevent infection. For the safety of using herbal plants, it is necessary to do a toxicity test. Subacute toxicity test is a test to detect toxic effects after administration of test preparations with repeated doses given orally to test animals for 28 days. Objectives: the aim of the study is to determine whether red ginger extract has a toxic effect on the liver of mice. Materials and Methods: This is a laboratory experimental study using in vivo laboratory experimental methods using The Post Test Only Control Group design with sample grouping using a Completely Randomized Design. The 25 mice were divided into 5 groups, namely group I as control, group II to group V given the test extract at doses of 100, 200, 400, and 800mg/KgBW with one oral administration. On day 28, the mice were autopsied, and histopathological observations of the liver were performed. The data obtained were analyzed using the Kruskall Wallis test and continued with the Mann Whitney U test. Results and Discussions: in the control group tended to be in normal conditions, in treatment P1 parenchymal degeneration occurred, in treatment P2 hydropic degeneration occurred, in 55 treatment P3 hydropic degeneration and necrosis occurred, while in treatment P4 necrosis occurred. Conclusions: Red ginger extract had a subacute toxic effect on the liver of mice at a dose of 400 mg/kg BW, which was a score of 3 (hydropic degeneration) and a dose of 800mg/kg BW showed a score of 4 (necrosis).
Co-Authors DS, Setiawan Mochammad Taha Ma’ruf Setiawan Setiawan DS Setiawan Setiawan