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All Journal International Journal of Public Health Science (IJPHS) Jurnal Kesehatan Masyarakat Jurnal Penelitian Kesehatan Health Notions Amerta Nutrition Medical Technology and Public Health Journal Jurnal Pengabdian Masyarakat IPTEKS Nusantara Science and Technology Proceedings Aloha International Journal of Multidisciplinary Advancement (AIJMU) Jurnal Pengbdian Teknik Mesin JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Jurnal Sosial dan Sains Journal of Business, Social and Technology
Yunita Satya Pratiwi
Program Studi Teknologi Pangan, Fakultas Teknik, Universitas Pembangunan Nasional “Veteran” Jawa Timur
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : International Journal of Public Health Science (IJPHS)

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Hepatoprotective Effect of Mangosteen Peel Extract on Borax-Induced Male Rats Yunita Satya Pratiwi; Bambang Wirjatmadi; Mangestuti Agil; Merryana Adriyani; Supriyadi Supriyadi
International Journal of Public Health Science (IJPHS) Vol 5, No 3: September 2016
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (343.05 KB) | DOI: 10.11591/ijphs.v5i3.4798

Abstract

The aim of this study was to determine the hepatoprotective effect of mangosteen peel extract (MPE) on borax-induced male rats. Hepatoprotective effect is represented by the variables of liver weight, SGOT (Serum Glutamic oxaloacetic transaminase) and SGPT (Serum Glutamic Pyruvate Transaminase). The true experimental study used randomized separated pretest-posttest control group design. MPE was made with 50% ethanol and 0.5% carboxymethyl cellulose-sodium (CMC-Na) stabilizer solutions. Studied groups included three control groups (positive, negative pretest and posttest) and three experimental groups (MPE dose of 200 mg/kg, 400 mg/kg and 600 mg/kg rats body weight (BW)). Samples consisted 36 male rats. The length of intervention was 16 days by providing borax, and then MPE was started on day 3 (in 3 experimental groups). Results showed that up to 16th day the SGOT tended to decrease (α <0.05), while the SGPT levels was stable, and so was the liver weight. Thus, up to day 16 the MPE was generally able to provide hepatoprotective effects mainly based on the variable SGOT in doses of 200 and 400 mg/kg. It has been proved that liver function of the rats was still relatively normal. This is in relations to the antioxidant potential of the MPE polyphenols.
Co-Authors Abdul Azis Akbar Abdul Azis Akbar Asrotul Hikmah Avita Amalina Bambang Wirjatmadi Cahya Tri Bagus Hidayat Didiek Tranggono Dina Mustika Rini Doni Waluyo Erlambang Budi Darmanto Erman Arif Erwan Widiyatmoko Fadiatul Ismaniah Farida Wahyu Ningtyias Farida Wahyu Ningtyias, Farida Wahyu Firjoun Ali Muhammad Gideon Setyo Budiwitjaksono Hadi Munarko Hadi Prayitno, Hadi Haris Ahmadi Heru Santoso Wahito Nugroho Ifwarisan Defri Ifwarisan Defri Ifwarisan Defri Kaleem Ahmad Karera Aryatika Lirista Dyah Ayu Oktafiani Lirista Dyah Ayu Oktafiani Luh Putu Ratna Sundari Luh Putu Suciati Mangestuti Agil Manik Nur Hidayati Merryana Adriyani Mohammad Adenan Muhammad Anshari, Muhammad Muhammad Rizqi Ansori Nadia Shoukat Nadia Shoukat Nurullia Arisandy Pardi Sampe Tola Pardi Tola Rahmawati Rahmawati Ristya Widi Endah Yani Roiful Fatah Ruli Bahyu Antika Septi Nur Rachmawati Septi Nur Rachmawati Septy Handayan Septy Handayani Supriyadi Supriyadi Supriyadi Supriyadi Supriyadi Supriyadi Suzuki , Takuya Syahnia Wasilatul Jannah Yushinta Aristina Sanjaya Zainul Fatmah Zidni Imanial Bathista