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All Journal International Journal of Public Health Science (IJPHS) Farmasains : Jurnal Farmasi dan Ilmu Kesehatan BALI MEDICAL JOURNAL (BMJ) Media Penelitian dan Pengembangan Kesehatan Jurnal Tumbuhan Obat Indonesia Majalah Obat Tradisional JURNAL PENGABDIAN KEPADA MASYARAKAT UNEJ e-Proceeding Journal of Islamic Pharmacy Journal Of Vocational Health Studies Journal of Tropical Pharmacy and Chemistry Madaniya Jurnal Sains dan Kesehatan Farmasis: Jurnal Sains Farmasi Pharmaceutical Sciences and Research (PSR)

Mangestuti Agil

Faculty Of Pharmacy, Universitas Airlangga

Author-ID : 221082

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Public Health Social Sciences

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EFEK PEMBERIAN SPILANTHES ACMELLA DAN LATIHAN FISIK TERHADAP JUMLAH SEL OSTEOBLAS FEMUR MENCIT YANG DIINDUKSI DEKSAMETASON Laswati, Hening; Agil, Mangestuti; Widyowati, Retno
Media Penelitian dan Pengembangan Kesehatan Vol 25, No 1 Mar (2015)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (483.348 KB)

AbstrakTelah dilakukan penelitian untuk mengetahui uji aktivitas anti-osteoporosis secara in vivo dari tanaman Spilanthes acmella terhadap sel osteoblas tulang trabekula proksimal femur mencit jantan model osteoporosis induksi deksametason. Penelitian ini dilakukan dengan rancangan penelitian posttest only control group, 60 ekor mencit jantan sehat (usia >5 bulan) dikelompokkan secara random menjadi 10 kelompok yaitu kelompok sehat tanpa induksi deksametason dan kelompok osteoporosis induksi deksametason. Kontrol positif mendapat suspensi alendronat dan kelompok latihan fiik menggunakantreadmill mencit berjalan 10m/menit bertahap selama 5 -12 menit, 3 kali dalam satu minggu, kelompok kombinasi ekstrak etanol 70% dan latihan fiik serta kelompok uji fraksi butanol, heksan, etil asetat dan air. Penelitian ini dilakukan selama 4 minggu. Osteoporosis akibat pemakaian glukokortikoid menjadi penyebab osteoporosis sekunder yang meningkatkan risiko fraktur. Telah banyak bukti klinik tentang peran fioestrogen dalam pengobatan osteoporosis pada pascamenopause. Spilanthes acmella, atau yang dikenal masyarakat dengan sebutan Legetan, termasuk famili Asteracea merupakan satu tanaman obat di Indonesia yang mempunyai kandungan senyawa polifenol dan flvonoid. Dari hasil penelitian sebelumnya diketahui bahwa baik fraksi butanol dan air dari tanaman tersebut mampu meningkatkan aktivitas enzim alkalin fosfatase yang merupakan marker pembentukan tulang. Hasil menunjukkan bahwa ekstrak etanol 70% Spilanthes acmella dikombinasikan dengan latihan fiik meningkatkan jumlah sel osteoblas secara bermakna bila dibandingkan dengan hanya ekstrak etanol atau latihan fiik. Ini membuktikan bahwa ekstrak etanol 70% Spilanthes acmella mempunyai efek additive terhadap efek latihan pembebanan aksial pada kondisi osteoporosis. Fraksi heksana, etil asetat dan air juga meningkatkan secara bermakna jumlah sel osteoblas. Fraksi non polar merupakan fraksi yang lebih potensial untuk pembentukan tulang karena fraksi tersebut banyak mengandung senyawa turunan amida dan sesquiterpena. Kesimpulan penilitian ini menunjukan adanya efek additive ekstrak etanol 70% dari Spilanthes Acmella pada latihan fiik dengan meningkatkan jumlah sel osteoblas.Kata kunci: Spilanthes acmella, osteoporosis sekunder, osteoblasAbstractStudy was conducted to analyse the anti-osteoporosis effect of Spilanthes acmella plant in vivo on osteoblast cell trabecular bone of femur male mice with dexamethasone- induced osteoporosis. This study using a post test control group design, 60 male healthy mice (>5 months old) were randomizely devided into 10 groups, there are healthy control group (without induction dexamethaxone), and osteoporosis groups (induction with dexamethaxone). The positive control receive suspension alendronat suspension and the exercise group walking using mice treadmill 10m/minute, 5-12 minutes 3 times a week,the combination group of 70% extract ethanol and exercise, the butanol, hexane, etil asetat and water fraction group. The study conducted for 4 weeks. Glucocorticoid-induced osteoporosis is leading cause of secondary osteoporosis and an increase in fracture risk. There were clinical evidence suggest a role for phytoestrogen in the treatment of post-menopausal osteoporosis. Spilanthes acmella, or already known by public society as Legetan, include in Asteracea family, is one of Indonesia medicinal plants that contain of polyphenol and flvonoids. Previously in vitro study showed that buthanol and water fraction from this plant have increased alkaline phosphatase that known as marker of bone formation.The results showed that 70% ethanol extract of Spilanthes acmella that combined by physical exercise increasing osteoblast cells signifiantly than only 70% ethanol extract or physical exercise. Additionally hexane, ethyl acetate and water fractions from Spilanthes acmella also increasing osteoblast cells signifiantly. Non-polar fraction is a potential fraction of bone formation because it contains many nonpolar compounds such as amides derivatives and sesquiterpene. The study concluded that 70% ethanol extract of Spilanthes acmella have an additive effect to weight bearing exercise in osteoporotic condition.Keywords : Spilanthes acmella, secondary osteoporosis, osteoblast

SPILANTHES ACMELLA AND PHYSICAL EXERCISE INCREASED TESTOSTERONE LEVELS AND OSTEOBLAST CELLS IN GLUCOCORTICOID-INDUCED OSTEOPOROSIS MALE MICE Laswati, Hening; Subadi, Imam; Widyowati, Retno; Agil, Mangestuti; Pangkahila, Jahya Alex
BALI MEDICAL JOURNAL Vol 4 No 2 (2015)
Publisher : BALI MEDICAL JOURNAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (469.999 KB)

Background: Glucocorticoid-induced osteoporosis is leading cause of secondary osteoporosis by decreasing formation activity and increasing resorption activity. Spilanthes acmella, is one of Indonesia medicinal plants that contain of polyphenol and flavonoids. Previously in vitro study showed that buthanol and water fraction from this plant have increased alkaline phosphatase that known as marker of bone formation. The objective of this study to analyze the effect of Spilanthes acmella and physical exercise in increasing testosterone and osteoblast cells of femoral’s trabecular glucocorticoid-induced osteoporosis male mice. Method: This study using a posttest control group design, 36 male healthy mice (5 months old) were randomizely devided into 6 groups, there are : 1.Healthy control group (without induction dexamethaxone), 2.Osteoporosis groups (induction with dexamethaxone without treatment), 3.Positive control receive suspension alendronat, 4.70% Ethanol extract of Spilanthes acmella group, 5.Combination group of 70% extract ethanol of Spilanthes acmella and exercise, and 6.Exercise group (walking using mice treadmill 10m/minute, 5-12 minutes 3 times a week). All of the intervention were given for 4 weeks. The serum levels of testosterone were determined using immunoserology (ELISA) and osteoblast cells were determined histomorphometry by light microscopy. All statistical test were carried out using SPSS 23 and statistical significance was set at p

Isolation of terpenoid compound of n-hexane extract of Marsilea crenata Presl.. Ma'arif, Burhan; Agil, Mangestuti; Widyowati, Retno
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Isolation, identification, and structure elucidation of terpenoid compounds fromÂ an n-hexane extract ofÂ Marsilea crenataÂ Presl., had been done. The leaves of M. crenata was extracted using n-hexane solvent. The extract then separated with vacuum column chromatography and open column chromatography to obtain the isolate. Furthermore, the isolate was identified and elucidated using UV-Vis, FT-IR, 1H-NMR, 13C- NMR, and 2D-NMR (COSY, HMQC, and HMBC). The identification and elucidation of the isolated structure fromÂ an n-hexane extract of M. crenata leaves indicate the isolate was a pentacyclic triterpenoid.Â

Analisis in Silico Senyawa Fitokimia dari Fraksi n-Heksana Daun Semanggi (Marsilea crenata Presl.) sebagai Agen Neuroprotektif Ma'arif, Burhan; Jatmiko, Ricky Arie; Megawati, Dewi Sinta; Annisa, Rahmi; Sugihantoro, Hajar; Muchlisin, Muhammad Artabah; Laswati, Hening; Agil, Mangestuti
Journal of Islamic Pharmacy Vol 5, No 1 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i1.9180

Estrogen deficiency causes various health problems in postmenopausal women, including neurodegenerative disease. Phytoestrogens emerged as a group of compounds that can replace the estrogen function in the body, and prevent the neurodegenerative disease to occur. Semanggi (Marsilea crenata Presl.) is a typical plant in Surabaya, Indonesia, that contain phytoestrogens. The aim of this research was to determine the metabolite profile of n-hexane fraction of Semanggi leaves using UPLC-QToF-MS/MS, and then to predict the neuroprotective activity of compounds with in silico study using PyRX 0.8 software. The 100 ppm of n-hexane fraction of Semanggi leaves in DCM and methanol were injected 5 Âµl each into the UPLC-QToF-MS/MS, and then analyzed by Masslynx 4.1 software to determine the compounds. The compounds from metabolite profiling then prepared with SwissADME webtool and Avogadro 1.90.0 software, molecular docking was done using Autodock Vina and Biovia Discovery Studio Visualizer 2016 to 3OLS protein. Metabolite profiling process shows a total of 34 predictable compounds and 28 unknown compounds. From in silico study, it shows a total of 7 compounds that are predicted to have activities similar to estrogen. This result indicate that n-hexane fraction of Semanggi leaves has potential as a neuroprotective agent for treatment for postmenopausal women who experience estrogen deficiency.Keywords: Marsilea crenata Presl., phytoestrogens, metabolite profiling, in silico, neuroprotective

A literature review of complementary and alternative medicine used among diabetes mellitus patients Anita Joeliantina; Oedojo Soedirham; Mangestuti Agil; M. Bagus Qomaruddin; Kusnanto Kusnanto
International Journal of Public Health Science (IJPHS) Vol 8, No 2: June 2019
Publisher : Intelektual Pustaka Media Utama

Diabetes is a chronic disease that requires regular and sustainable health management that involves proper treatment. Some diabetic patients use CAM, as well as conventional medicine, to maintain their health and control their blood sugar. This literature review aimed to 1) determine the prevalence of CAM used by patients with diabetes, summarize and evaluate the CAM use that includes: characteristics, patterns, types and reasons, 2) propose a conceptual model associated with CAM used by patients with diabetes. Systematic reviews were searched using an electronic database. The systematic reviews were published between 2005 and 2015 by using specific keywords. The number of systematic reviews obtained as a search result is 14 articles from 14 countries. The prevalence of CAM used by patients with diabetes ranged from 16.6% to 76%. Determinants associated with the CAM use were age, gender, family income, occupation, residence, and the characteristics of the disease, such as the length of time since diagnosed and complications. Most patients used CAM, along with the conventional treatment, and did not inform health professionals about the CAM use. The CAM use by patients with diabetes was relatively high and the confidence of patients believed the benefits of CAM. Therefore, integration with health professionals to develop CAM management is highly required.

Hepatoprotective Effect of Mangosteen Peel Extract on Borax-Induced Male Rats Yunita Satya Pratiwi; Bambang Wirjatmadi; Mangestuti Agil; Merryana Adriyani; Supriyadi Supriyadi
International Journal of Public Health Science (IJPHS) Vol 5, No 3: September 2016
Publisher : Intelektual Pustaka Media Utama

The aim of this study was to determine the hepatoprotective effect of mangosteen peel extract (MPE) on borax-induced male rats. Hepatoprotective effect is represented by the variables of liver weight, SGOT (Serum Glutamic oxaloacetic transaminase) and SGPT (Serum Glutamic Pyruvate Transaminase). The true experimental study used randomized separated pretest-posttest control group design. MPE was made with 50% ethanol and 0.5% carboxymethyl cellulose-sodium (CMC-Na) stabilizer solutions. Studied groups included three control groups (positive, negative pretest and posttest) and three experimental groups (MPE dose of 200 mg/kg, 400 mg/kg and 600 mg/kg rats body weight (BW)). Samples consisted 36 male rats. The length of intervention was 16 days by providing borax, and then MPE was started on day 3 (in 3 experimental groups). Results showed that up to 16th day the SGOT tended to decrease (α <0.05), while the SGPT levels was stable, and so was the liver weight. Thus, up to day 16 the MPE was generally able to provide hepatoprotective effects mainly based on the variable SGOT in doses of 200 and 400 mg/kg. It has been proved that liver function of the rats was still relatively normal. This is in relations to the antioxidant potential of the MPE polyphenols.

Responses of Diabetes Mellitus Patients Who Used Complementary Medicine Anita Joeliantina; Mangestuti Agil; M. Bagus Qomaruddin; Arijanto Jonosewojo; Kusnanto Kusnanto
International Journal of Public Health Science (IJPHS) Vol 5, No 4: December 2016
Publisher : Intelektual Pustaka Media Utama

Diabetes Mellitus as a chronic disease tend to seek appropriate medical treatment to heal the condition. Health-seek searched can be either medical treatment or Complementary and Alternative Medicine. This study explored deeply on the response of diabetes mellituspatients who visited to Indonesian Traditional Medicine Polyclinic on Regional Public Hospital dr. Soetomo Surabaya in using complementary medicine. This study used qualitative study with phenomenological method approach. The focus of this study was diabetes mellitus patients who use complementary medicine. Nine participants were selected based on purposive sampling method with certain criteria. Data collection used was in-depth interview and field note. Data analysis used thematic content analysis. Determining five themes that correspond with the purpose of study and a new theme. Some themes were psychological response after being diagnosed diabetes mellitus, opinion on the diabetes mellitus disease, complementary medicine usage patterns, reasons, the response after the use of complementary medicine, and family support. As a chronic disease, patients need proper treatment and conduct it continuously. Healer shopping was often taken by diabetes mellituspatients. It was required cooperation between patients and health professionals to monitor the behavior in order to achieve the effectiveness of medical treatment.

Isolation of terpenoid compound of n-hexane extract of Marsilea crenata Presl.. Burhan Ma'arif; Mangestuti Agil; Retno Widyowati
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 4 No. 2 (2019)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v4i2.10717

Isolation, identification, and structure elucidation of terpenoid compounds from an n-hexane extract of Marsilea crenata Presl., had been done. The leaves of M. crenata was extracted using n-hexane solvent. The extract then separated with vacuum column chromatography and open column chromatography to obtain the isolate. Furthermore, the isolate was identified and elucidated using UV-Vis, FT-IR, 1H-NMR, 13C- NMR, and 2D-NMR (COSY, HMQC, and HMBC). The identification and elucidation of the isolated structure from an n-hexane extract of M. crenata leaves indicate the isolate was a pentacyclic triterpenoid.

ANALISIS FITOKIMIA EKSTRAK N-HEKSANA DAN FRAKSI DAUN Marsilea crenata Presl. DENGAN GC-MS Burhan Ma'arif; Mangestuti Agil; Hening Laswati
Majalah Obat Tradisional Vol 21, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Estrogen deficiency causes various health problems in postmenopausal women, including osteoporosis. Phytoestrogen emerged as a potential alternative of estrogen with minimum side effects. Green clover (Marsilea crenata Presl.) is a typical plant in East Java which suspected contains estrogen-like substances. The aim of this research was to report the phytochemical properties of M. crenata using GC-MS as a preliminary study. M. crenata leaves were dried and extracted with n-hexane, then separated using vacuum column chromatography to get four fractions, after that the n-hexane extract and four fractions were identified with GC-MS. The results of GC-MS analysis showed some compounds contained in M. crenata leaves like monoterpenoid, diterpenoid, fatty acid compounds, and other unknown compounds. The results obtained in this research indicated a promising potential of M. crenata as medicinal plants, especially as antiosteoporotic agent.

AKTIVITAS ANTIOSTEOPOROSIS EKSTRAK ETANOL 96 % DAUN Abelmoschus manihot L. MEDIK SECARA IN VITRO MENGGUNAKAN SEL PREOSTEOBLAS MC3T3-E1 Agnis Pondinekaria Aditama; Mangestuti Agil; Hening Laswati
Majalah Obat Tradisional Vol 21, No 3 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue. Estrogen deficiency causes loss of bone mineral density which causes osteoporosis. Phytoestrogen is a potential alternative of estrogen that can be used as Hormone Replacement Therapy on osteoporosis with minimum side effects. Many edible plants contain phytoestrogens that are believed to promote bone health. Abelmoschus manihot (L.) Medik has been known as a plant that is empirically used in the traditional medicine and has potency to prevent osteoporosis. The aim of this research is to determine whether the Abelmoschus manihot (L.) Medik leaves have the potential to increase bone formation in an in vitro assays using preosteoblast cell line MC3T3-E1. The results showed an increasing activity of Alkaline phosphatase using confocal laser scanning microscopy technique.

Co-Authors Abdul Malik Guhir Agnis Pondineka Ria Aditama Alif Firman Firdausy Anisa Eka Riyanti Anita Joeliantina Anita Joeliantina Annisa, Rahmi Arief Suryadinata Arijanto Jonosewojo Artabah Atik Kurniawati Bambang Wirjatmadi Begum Fauziyah Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma’arif Burhan Ma’arif Burhan Ma’arif Burhan Ma’arif Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu, Damaranie Denis Denis Mery Mirza Destiya A. P. Fihuda Destiya Argo Pamuji Fihuda Dewi Sinta Megawati, Dewi Sinta Dilla Amalia Edith Frederika Puruhito Ema Qurnianingsih Faisal A. Muslikh Faisal Akhmal Muslikh Hening Laswati Hening Laswati Putra Herra Studiawan Husnul Khotimah Imam Subadi, Imam J. A. Pangkahila Jatmiko, Ricky Arie Kusnanto Kusnanto Kusnanto Kusnanto M. Artabah Muchlisin M. Bagus Qomaruddin M. Bagus Qomaruddin Ma'arif, Burhan Marta Ika Riyana Meilina Ratna Dianti Menara Muslim Merryana Adriyani Nabila Rosa Ni Made Mertaniasih Nisfatul L. Saidah Nisfatul Lailatus Saidah Nyimas Yusma Aemi Oedojo Soedirham Purbosari, Ira Purwitasari, Neny Rakhmawati Rakhmawati Resti Perslami Retno Widyowati Ria Ramadhani Dwi Atmaja Sadli Syarifuddin Sari, Dewi Perwito Siti Maimunah Sugihantoro, Hajar Suko Hardjono Supriyadi Supriyadi Tutik Sri Wahyuni Widji Soeratri Wirda Anggraini Yunita Satya Pratiwi

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