This research aimed to determine the effect of Jigsawlearning model to students' teamwork skills and learning outcomes of cognitive aspects which the design was pretest posttest for non equivalent groups. The samples were students of XI IPA2 and XI IPA3 which were selected by purposive sampling. The qualitative data was the average score of students' teamwork skills that were analyzed descriptively. The quantitative data were obtained from average score of pretest, posttest, and N-gain then analyzed using t-test and U test. The results showed that the students had an average score of teamwork skills with good criteria (75.00). Students learning outcomes increased with an average N-gain (60.43). Thus, Jigsaw learning model influence in improving students teamwork skills and learning outcomesat human immune system subject matter.Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran tipe Jigsaw terhadap kemampuan kerjasama dan hasil belajar aspek kognitif siswa dengan desain pretes-postes kelompok tak ekuivalen. Sampel penelitian adalah siswa kelas XI IPA2 dan XI IPA3 yang dipilih secara purposive sampling. Data kualitatif berupa rata-rata nilai kemampuan kerjasama siswa yang dianalisis secara deskriptif. Data kuantitatif diperoleh dari rata-rata nilai pretes, postes dan N-gain, kemudian dianalisis secara statistik menggunakan uji-t dan uji U. Hasil penelitian menunjukkan rata-rata siswa memiliki kemampuan kerjasama dengan kriteria baik (75.00). Hasil belajar siswa mengalami peningkatan, dengan rata-rata N-gain (60.43). Dengan demikian, model pembelajaran tipe Jigsaw berpengaruh dalam meningkatkan kemampuan kerjasama dan hasil belajar siswa pada materi Sistem Pertahanan Tubuh Manusia.Kata kunci :hasil belajar siswa, kemampuan kerjasamasiswa, model Jigsaw, sistem pertahanan tubuh manusia