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Budi Untari
Pharmaceutical Program, Faculty of Sciences, University of Sriwijaya, Palembang 30662, South Sumatra
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Materials Science & Nanotechnology Physics

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Physical Interaction Of Chitosan-Alginate Entrapping Extract Of Papaya Leaf And Formation Of Submicron Particles Dosage Form Untari, Budi; Wijaya, Dina Permata; Mardiyanto, Mardiyanto; Herlina, Herlina; Angraeni, Via; Firana, Ario
Science and Technology Indonesia Vol 4 No 3 (2019): July
Publisher : ARTS Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1814 KB) | DOI: 10.26554/sti.2019.4.3.64-69

Abstract

Research on physical interaction of chitosan-alginate entrapping extract of papaya leaf (Carica papaya L) into submicron particles formation has been performed. Preparation of papaya leaf extract into submicron particle dosage form of chitosan and sodium alginate polymer using ionic gelation method aimed to increase the solubility of extract. Submicron particles consisting of papaya leaf extract, chitosan, sodium alginate and CaCl2 were combined using variation of stirrer speed of 500, 750, and 1000 RPM. The optimum formula obtained has a speed of 1000 RPM with the percent EE value of 71.90%. The results of submicron particles characterization such as diameter and particle size distribution (PDI) using particle size analyzer (PSA) tools were 189.2 nm and 0.330. The results of XRD revealed the changes of type of crystalinity form to amorphous on submicron particles. The results of FTIR revealed the physical interaction without shifting of wave number of carbonyl, amine, and hydroxyl group which indicated that there were no chemical interactions occurred. These data indicated that papaya extract can be formulated into submicron particles of chitosan-alginate polymer.
The submicron particles FORMULATION OF IONIC-GELATION SUBMICRON PARTICLES LOADING EXTRACT PAPAYA LEAVES (Carica papaya L.) WITH LACTIC ACID ISOLATES Mardiyanto, Mardiyanto; Untari, Budi; Fithri, Najma Annuria; Sandi, Sofia; Mawaddah, Zahrul
Science and Technology Indonesia Vol 4 No 3 (2019): July
Publisher : ARTS Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1762.875 KB) | DOI: 10.26554/sti.2019.4.3.77-81

Abstract

A study regarding ionic-gelation submicron particle of papaya leaves (Carica papaya L.) extract with lactic acid of weeds potentially for antidiarrhea has been conducted. Preparation of papaya leaves ethanolic extract and lactic acid isolate into particles was done by ionic gelation method. This study aimed to determine: the major compound of extract, the total quercertine of extract, the percent value of encapsulation efficiency of the optimum formula which was varied by (CaOH)2 of the three formulas, and physical properties of particles. Formula 1 was using (CaOH)2 of 12.5 gram; formula 2 (CaOH)2 of 17,5 gram; formula 3 (CaOH)2 of 22.5 gram. The results showed formula 1 as the optimum formula that has the highest %EE. The average %EE values ??of F1; F2; F3 respectively were 80,82%; 80,41%; 80,31%. The results of particle characterization using the PSA in the optimum formula produced particle size values ??with an average of 253.6 nm, PDI of 0.218, and zeta potential +8 mV respectively.
Co-Authors Angraeni, Via Dina Permata Wijaya Erra Kartika, Erra Firana, Ario fitra yosi, fitra Herlina Herlina Mardiyanto Mardiyanto Mawaddah, Zahrul Meisji Liana Sari Najma Annuria Fithri, Najma Annuria NUNI GOFAR Sofia Sandi