Article Per Year (5 Year)
p-Index From 2019 - 2024
2.155
P-Index
This Author published in this journals
All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Kesehatan Jurnal Kesehatan Tambusai Journal of Fundamental and Applied Pharmaceutical Science BAKTIMU : Jurnal Pengabdian Kepada Masyarakat Medimuh : Jurnal Kesehatan Muhammadiyah Jurnal Ilmiah Bakti Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian CERATA Dedikasi : Jurnal Pengabdian Lentera
Ismanurrahman Hadi
Prodi Sarjana Farmasi, STIKES Muhammadiyah Cirebon
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : Jurnal Ilmu Kesehatan

 1 
Potential of Several Phytochemicals of Mangrove Species (Rhizopora stylosa) as Inhibitor of Both Viral Gene Expression and Bacterial Nucleic Acid Synthesis Ismanurrahman Hadi; Ade Irawan; Mariam Ulfah; Teguh Adiyas Putra; Like Efriani; Mailatul Ilal Haq; Muhamad Rifki Purnama
Jurnal Ilmu Kesehatan Vol 10 No 1 (2022): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v10i1.3278

Abstract

The mangrove family (Rhizophora stylosa) has been used as traditional medicine. Due to the habitat of mangroves, they develop unique phytochemicals. Thus, they have the potential to become a source of plant-based therapeutic agents. However, many of the them remain uninvestigated. The purpose of this study was to predict the potential of some phytochemicals of the mangrove family as an inhibitor of both viral gene expression and bacterial nucleic acid. Some bioactive compounds of mangrove (taraxerol, pyrethrin, 2-Furancarboxaldehyde, and avicequinone A) were used as subject of this study. The main protease (Mpro) of SARS-Cov-2 virus (PDB ID: 6y2e), the staphylococcus aureus's proteins: topoisomerase II DNA gyrase (PDB id: 2XCT), and tyrosyl-tRNA synthetase (PDB id: 1JIJ) were used as targeted protein. The drug-likeness of compounds were analyzed using Swiss ADME based on the Lipinsky rule of five. Meanwhile, the affinity value between proteins and ligands was predicted using Autodock Vina. The root means square distance (RMSD) value (<2 A) and the binding cavity of drugs (ivermectin and ciprofloxacin) were used as validation parameters. This study resulted that only taraxerol compounds have a violation of Lipinsky's rule. Even so, out of the phytochemical compound of mangrove, the taraxerol has the highest affinity in Mpro and topoisomerase II DNA gyrase protein, although still lesser than ivermectin against Mpro; while avicequinone A has the highest affinity against tyrosyl-tRNA synthetase. This concludes that some phytochemicals of the mangrove family could be developed as an antibacterial and antiviral agents of therapy.
Description of Mother’s Knowledge and Adherence to Use of Helminthic Drugs in Kuwaluhan Village, Magelang Regency, Central Java Shalma Risqi Amanda; Perdana Priya Haresmita; Arief Kusuma Wardani; Ismanurrahman Hadi
Jurnal Ilmu Kesehatan Vol 11 No 1 (2023): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v11i1.3626

Abstract

Worm infection has become public health issue with the highest prevalence in children under the age of five and elementary school-aged children. The children have difficulty maintaining the hygienist, especially when they are playing. This study aims to describe the level of knowledge and mothers’ adherence to the use of helminthic drugs in Kuwaluhan Village, Magelang Regency. This research used a descriptive study with both a survey method and a cross-sectional approach. The purposive sampling technique was used, while the questionnaire was distributed to mothers with children under the age of five and elementary school-age children in Kuwaluhan Village RW 2, Magelang Regency, in December 2022. The results showed that the level of knowledge of mothers in Kuwaluhan Village RW 2, Magelang Regency, regarding the use of helminthic drugs out of a total of 74 mothers indicated that 33 respondents (44.59%) had good knowledge, 29 respondents (39.19%) had sufficient knowledge, and as many as 12 respondents (16.22%) had less knowledge. Meanwhile, at the adherence level, respondents were categorized as having high adherence by 1 respondent (1.35%), medium adherence by 73 respondents (98.65%), and low adherence by 0 respondents (0%). Based on these results, most of the mothers in Kuwaluhan RW 2, Magelang Regency have good knowledge and have a medium level of adherence to using helminthic drugs for children.
Co-Authors Ade Irawan Alvia Nuraeni Amelia Zannah Antika Mardhotillah Meilian Arief Kusuma Wardani Asya Nurfazera Ayu Zakkiyah Dadan Hidayattullah Deby Nurlutfiana Edy Meiyanto Erawati Erawati Flori Sindi Agwiana Hilda Nurul Fauzia Like Efriani Mahfud Anwar Mailatul Ilal Haq MARIAM ULFAH MARIAM ULFAH ULFAH Muhamad Rifki Purnama Nirma Rohmatika Perdana Priya Haresmita Putri Wulan Dari Riris Istighfari Jenie Samsudin Azhari Shalma Risqi Amanda Teguh Adiyas Putra Tonasih Tonasih