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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmascience Jurnal Ilmu Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Analit: Analytical and Environmental Chemistry
Perdana Priya Haresmita
Universitas Muhammadiyah Magelang, Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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DETERMINATION OF TOTAL FLAVONOID IN JAMU “X” WITH UV-VISIBLE SPECTROPHOTOMETRIC METHODS Perdana Priya Haresmita; Missya Putri Kurnia Pradani
Jurnal Farmasi Sains dan Praktis Vol 8 No 2 (May-August 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i2.6864

Abstract

Jamu is still the choice of Indonesian people as an alternative to modern medicine until now. As a cultural heritage of the Indonesian, jamu is still very popular from the west to the east of Indonesia. The enthusiasm of the Indonesian in consuming jamu has encouraged many traditional medicine industries to produce jamu with many kinds of claim. Jamu "X" is claimed to help maintain body health. This research was conducted to determine the total flavonoid content in jamu "X" calculated as rutin by UV-spectrophotometric method with aluminum chloride (AlCl3) reagent. Jamu "X" is a product with new formula that is expected to be marketed soon. The determination of the maximum absorbance wavelength of rutin was carried out at a wavelength of 400-800 nm and the resulting maximum absorbance wavelength of rutin was 416.5 nm. The determination of total flavonoid calculated as rutin determined using a linear regression equation from the rutin standard. The linear regression equation was determined from a rutin standard curve series with 10; 12.5; 15; 17.5 and 20 g/ml, respectively and the linear regression equation obtained y = 0.0275x + 0.093. The results of the determination of rutin in the jamu "X" were 1.474%; 1.474% and 1.469% with an average value of 1.472%.
Analisis Kualitatif Bahan Kimia Obat dalam Jamu Pegal Linu di Wilayah Magelang Novita Putri Dewita Sari; Perdana Priya Haresmita
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 20, No 1 (2023): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v20i1.8273

Abstract

Jamu pegal linu merupakan obat tradisional yang banyak dikonsumsi oleh masyarakat karena memiliki banyak manfaat. Bahan Kimia Obat (BKO) sering ditambahkan pada jamu pegal linu untuk menambah khasiatnya. BKO yang banyak ditambahkan dalam sediaan jamu adalah ibuprofen, natrium diklofenak dan fenilbutazon. Tujuan dari penelitian ini adalah mengidentifikasi kandungan bahan kimia obat pada jamu pegal linu di wilayah Magelang sehingga menjadi referensi keamanan jamu. Sampel adalah 6 (A, B, C, D, E, F) jamu pegal linu yang diperoleh dari toko jamu di wilayah Magelang. Identifikasi BKO dilakukan dengan Kromatografi Lapis Tipis (KLT) menggunakan fase diam silika gel 60 F254, fase gerak kloroform:etanol (8:1), etil asetat:n-heksan (3:2), etanol:kloroform:aseton (6:4:1) dan dideteksi sinar UV 254 nm. Hasil uji organoleptis menunjukkan bentuk dari semua jamu yaitu serbuk halus dan semuanya memiliki rasa yang pahit, mempunyai bau khas jamu. Sampel C memiliki aroma khas cengkeh. Hasil KLT tidak ditemukan kandungan fenilbutazon dan natrium diklofenak pada seluruh sampel. Sampel E dan F positif mengandung ibuprofen.
Description of Mother’s Knowledge and Adherence to Use of Helminthic Drugs in Kuwaluhan Village, Magelang Regency, Central Java Shalma Risqi Amanda; Perdana Priya Haresmita; Arief Kusuma Wardani; Ismanurrahman Hadi
Jurnal Ilmu Kesehatan Vol 11 No 1 (2023): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v11i1.3626

Abstract

Worm infection has become public health issue with the highest prevalence in children under the age of five and elementary school-aged children. The children have difficulty maintaining the hygienist, especially when they are playing. This study aims to describe the level of knowledge and mothers’ adherence to the use of helminthic drugs in Kuwaluhan Village, Magelang Regency. This research used a descriptive study with both a survey method and a cross-sectional approach. The purposive sampling technique was used, while the questionnaire was distributed to mothers with children under the age of five and elementary school-age children in Kuwaluhan Village RW 2, Magelang Regency, in December 2022. The results showed that the level of knowledge of mothers in Kuwaluhan Village RW 2, Magelang Regency, regarding the use of helminthic drugs out of a total of 74 mothers indicated that 33 respondents (44.59%) had good knowledge, 29 respondents (39.19%) had sufficient knowledge, and as many as 12 respondents (16.22%) had less knowledge. Meanwhile, at the adherence level, respondents were categorized as having high adherence by 1 respondent (1.35%), medium adherence by 73 respondents (98.65%), and low adherence by 0 respondents (0%). Based on these results, most of the mothers in Kuwaluhan RW 2, Magelang Regency have good knowledge and have a medium level of adherence to using helminthic drugs for children.
QUALITATIVE ANALYSIS OF DRUG SUBSTANCES IN RHEUMATIC JAMU SAMPLES USING THIN LAYER CHROMATOGRAPHY Resma Dwi Putri Fitrianasari; Perdana Priya Haresmita; Herma Fanani Agusta
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.862

Abstract

Since ancient times, jamu have been used to treat various diseases. Recently, the number of jamu has increasing and this has led several manufacturers to commit fraud. They added drug substances (DS) into jamu for gaining the effect of jamu so that can raise the sales of jamu in market . The addition of DS into herbal medicine is a violation of the regulation issued by The Ministry of Health. Such practices can cause side effects that are very dangerous for health. The purpose of this research is to analyze the presence of DS in jamu samples that are frequently consumed and circulated in Kranggan, Temanggung and Magelang city. Thin-Layer Chromatography (TLC) was employed to detect the presence of prednisone, paracetamol, and mefenamic acid. The working principle of the separation of compounds with TLC is to separate samples based on the partition difference between samples and the solvent used. In this case, the stationary phase used is the silica gel plate GF254 with the mobile phase for prednisone using ethyl acetate:chloroform (4:1), mefenamic acid using chloroform:methanol (9:1),and paracetamol using chloroform:ethanol (8:1). As a result of qualitative analysis, jamu samples in those areas do not contain any drug substances that were suspected to be present. Keywords: jamu, prednisone, paracetamol, mefenamic acid
Identifikasi Bahan Kimia Obat (BKO) dalam Sediaan Jamu Pegal Linu dari Kota Wonosobo Alvisnayna Aida Maharani; Perdana Priya Haresmita; Arief Kusuma Wardani; Khusnul Fadhilah; Indra Yudhawan
Jurnal Pharmascience Vol 10, No 2 (2023): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i2.15783

Abstract

Obat tradisional adalah ramuan atau bahan berupa tumbuhan, hewan, mineral, sediaan sarian (galenik), atau campuran dari bahan tersebut yang secara turun-temurun telah digunakan untuk pengobatan. Obat tradisional yang banyak diminati masyarakat salah satunya adalah jamu pegal linu. Meningkatnya permintaan pasar akan jamu membuat adanya produsen yang secara langsung menambahkan Bahan Kimia Obat (BKO) pada produknya. Tujuan penelitian ini untuk mengidentifikasi apakah terdapat kandungan BKO pada produk jamu pegal linu yang beredar di Kota Wonosobo. Metode yang digunakan adalah Kromatografi Lapis Tipis (KLT) dengan fase diam silika gel 60 F254, fase gerak etil asetat:kloroform (4:1), etil asetat:kloroform (1:1) dan etil asetat:n- heksan (3:2) dengan deteksi sinar UV254 nm. Pada penelitian ini digunakan 6 sampel jamu dengan baku pembanding parasetamol, asam mefenamat, prednison dan natrium diklofenak. Berdasarkan hasil penelitian ini, sampel yang positif mengandung BKO adalah sampel A dan E, yaitu positif mengandung prednison dengan nilai Rf 0,275. Kata Kunci: Obat Tradisional, Parasetamol, Asam Mefenamat, Prednison, Natrium Diklofenak Traditional medicines are mixtures or concoctions made from substances such as plants, animals, minerals, herbal preparations, or combinations of these substances that have been utilized for therapeutic purposes for many years. Herbal remedies for stiff and aching muscles are one of the ancient treatments that are in high demand by the general public. Producers have been forced to directly add Medicinal Chemicals to their products as a result of the rising market demand for herbal medicine. The goal of this study was to determine whether herbal products used to treat rheumatic pain in Wonosobo City included any medicinal chemicals. Thin Layer Chromatography (TLC) was the technique employed, with silica gel 60 F254 serving as the stationary phase and the mobile phases being ethylacetate:chloroform (4:1), ethyl acetate:chloroform (1:1), and ethyl acetate:n-hexane (3:2). using UV254 nm light detection. Six herbal medicine samples were employed in this trial, along with industry-standard doses of paracetamol, mefenamic acid, prednisone, and diclofenac sodium. According to the study's findings, samples A and E tested positive for the presence of pharmaceutical compounds because they contained prednisone, which had an Rf value of 0.275. 
Validation of Medicinal Chemicals Analysis Methods in Pegel Linu and Rheumatic Herbs using the TLC-UV-Visible Spectrophotometry method Perdana Priya Haresmita; Arief Kusuma Wardani; Diva Laila Ramadhani; Dwibara Bayuaji; Anna Sa'dia Azri; Nindya Yunia Putri; Mayla Eka Nadia
Analit: Analytical and Environmental Chemistry Vol 8, No 2 (2023): ANALIT: ANALYTICAL AND ENVIRONMENTAL CHEMISTRY
Publisher : Universitas Lampung Jl. Prof. Dr. Sumatri Brojonegoro No.1 Bandar Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/aec.v8i2.2023.p63-74

Abstract

Jamu is a traditional Indonesian medicine. Herbal medicine for rheumatism and “pegal linu” is one of the most widely consumed types of traditional medicinal products by the public, so it is a type of traditional medicinal preparation that is prone to the addition of chemical drugs (BKO). All types of traditional medicines are prohibited from containing isolated or synthetic chemicals with medicinal properties. Samples of rheumatism and “pegal linu” jamu were purchased from Grobogan, Central Java, and Gunungkidul, Yogyakarta. Two samples were purchased from Grobogan, while four samples were purchased from Gunungkidul. The standards used were mefenamic acid, phenylbutazone, and diclofenac sodium. Qualitative analysis was carried out using thin-layer chromatography and quantitative analysis using UV-visible spectrophotometry. Validation of the analytical method is carried out by setting four parameters: linearity, precision, limit of detection, and limit of quantitation. Information about the content of BKO in traditional medicines circulating in the Grobogan and Gunungkidul areas, as well as references to valid analytical methods, will greatly assist the government and academics in educating the public about the dangers of long-term consumption of traditional medicine with BKO. The results showed that three of the six samples contained BKO, and the analytical method was valid.
Co-Authors Alvisnayna Aida Maharani Anna Sa'dia Azri Arief Kusuma Wardani Arief Kusuma Wardani Diva Laila Ramadhani Dwibara Bayuaji Herma Fanani Agusta Indra Yudhawan Ismanurrahman Hadi Khusnul Fadhilah Mayla Eka Nadia Missya Putri Kurnia Pradani Nindya Yunia Putri Novita Putri Dewita Sari Resma Dwi Putri Fitrianasari Shalma Risqi Amanda