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All Journal Majalah Kedokteran Gigi Indonesia Dental Journal (Majalah Kedokteran Gigi) Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Indonesian Journal of Dental Medicine Jurnal Pengabdian Masyarakat Indonesia
Sri Wigati Mardi Mulyani
Department Of Dentomaxillofacial Radiology, Faculty Of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia, 60132
Humanities Dentistry Education Energy Engineering Health Professions Medicine & Pharmacology Physics Public Health Social Sciences

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The role of heat shock protein (HSP ) as inhibitor apoptosis in hypoxic conditions of bone marrow stem cell culture Sri Wigati Mardi Mulyani; Ernie Maduratna Setiawati; Erma Safitri; Eha Renwi Astuti
Dental Journal (Majalah Kedokteran Gigi) Vol. 47 No. 1 (2014): March 2014
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (535.11 KB) | DOI: 10.20473/j.djmkg.v47.i1.p41-44

Abstract

Background: The concept of stem cell therapy is one of the new hope as a medical therapy on salivary gland defect. However, the lack of viability of the transplanted stem cells survival rate led to the decrease of effectiveness of stem cell therapy. The underlying assumption in the decrease of viability and function of stem cells is an increase of apoptosis incidence. It suggests that the microenvironment in the area of damaged tissues is not conducive to support stem cell viability. One of the microenvironment is the hypoxia condition. Several scientific journals revealed that the administration of hypoxic cell culture can result in stress cells but on the other hand the stress condition of the cells also stimulates heat shock protein 27 (HSP 27) as antiapoptosis through inhibition of caspase 9. Purpose: The purpose of this study was to examine the role of heat shock protein 27 as inhibitor apoptosis in hypoxic conditions of bone marrow stem cell culture. Methods: Stem cell culture was performed in hypoxic conditions (O2 1%) and measured the resistance to apoptosis through HSP 27 and caspase 9 expression of bone marrow mesenchymal stem cells by using immunoflorecence and real time PCR. Results: The result of study showed that preconditioning hypoxia could inhibit apoptosis through increasing HSP 27 and decreasing level of caspase 9. Conclusion: The study suggested that hypoxic precondition could reduce apoptosis by increasing amount of heat shock protein 27 and decreasing caspase 9.Latar belakang: Konsep terapi stem cell merupakan salah satu harapan baru sebagai terapi medis kelainan kelenjar ludah. Namun, rendahnya viabilitas stem cell yang ditransplantasikan menyebabkan penurunan efektivitas terapi. Asumsi yang mendasari rendahnya viabilitas dan fungsi stem cell adalah tingginya kejadian apoptosis. Hal ini menunjukkan bahwa lingkungan mikro di daerah jaringan yang rusak tidak kondusif untuk mendukung viabilitas stem cell. Salah satu lingkungan mikro adalah kondisi hipoksia. Beberapa jurnal ilmiah mengungkapkan bahwa kondisi hipoksia pada kultur sel dapat menyebabkan sel-sel stres, namun di sisi lain kondisi stres sel juga merangsang heat shock protein 27 (HSP 27) sebagai antiapoptosis dengan menghambat ekspresi caspase 9. Tujuan: Tujuan penelitian ini adalah untuk meneliti peran protein heat shock 27 sebagai inhibitor apoptosis dalam kondisi hipoksia kultur stem cell sumsum tulang. Metode: Kultur stem sel dilakukan dalam kondisi hipoksia (O2 1%) dan mengukur resistensi terhadap apoptosis melalui ekspresi HSP 27 dan caspase 9 stem cell mesenchymal sumsum tulang dengan menggunakan immunoflorecence dan PCR real time. Hasil: Hasil penelitian menunjukkan bahwa prakondisi hipoksia dapat menghambat apoptosis melalui peningkatan HSP 27 dan penurunan tingkat Caspase 9. Simpulan: Studi ini menunjukkan bahwa prakondisi hipoksia dapat mengurangi apoptosis dengan meningkatkan jumlah protein heat shock 27 dan penurunan caspase 9.
Alternative tools as a guide for measuring the vertical dimensions of teeth on periapical radiographs Deny Saputra; Yunita Savitri; Sri Wigati Mardi Mulyani; Aga Satria Nurrachman; Nastiti Faradilla Ramadhani; Syenia Ramandha; Marselina Sesaria Pratiknjo
Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Vol 6 No 1 (2022): Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI)
Publisher : Ikatan Radiologi Kedokteran Gigi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jrdi.v6i1.753

Abstract

Objectives: This research is aimed to find out the advantages of alternative tools as a guide for measuring the vertical dimensions of teeth on periapical radiographs and comparing the lengths of vertical dimensions of teeth on periapical radiographs with the actual lengths. Materials and Methods: This research is using analytical observational study with a cross-sectional study design. The research data were primary data from 30 periapical radiographs of two maxillary central incisors, which were photographed using a periapical projection with bisecting technique and a periapical film that had been attached with wire on the outer layer of the film wrap. The data were analyzed by a paired T-Test using SPSS software. Results: The p-value of ALT (Actual Length of the Tooth) for tooth 11 was 0.53 and for tooth 21 was 0.140. These results show a p-value > 0.05. Conclusion: There is no statistically significant difference between the calculation of tooth length on periapical radiographs using alternative tools and the calculation of actual tooth length so that alternative tools can be used as a guide for measuring the vertical dimensions of teeth on periapical radiographs.
Pelatihan Object Localization Teknik Radiografi Intra Oral Pada Anggota Perhimpunan Ahli Radiografer Indonesia (PARI) Cabang Jawa Timur Eha Renwi Astuti; Otty Ratna Wahyuni; Sri Wigati Mardi Mulyani
Jurnal Pengabdian Masyarakat Indonesia Vol 2 No 3 (2022): JPMI - Juni 2022
Publisher : CV Infinite Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52436/1.jpmi.482

Abstract

Radiologi Kedokteran Gigi merupakan salah satu bidang ilmu yang memiliki peran penting di bidang kedokteran gigi. Salah satu teknik radiografi yang sering digunakan adalah radiografi periapical. Untuk pembuatan radiografi periapikal guna perawatan saluran akar atau kondisi lain yang memerlukan kondisi tanpa superimposisi maka radiografi periapikal dengan gambaran dua dimensi tidak selalu dapat memenuhi tujuan pemeriksaan yang diinginkan oleh dokter gigi. Saluran akar bukal dan lingual seringkali tampak superimposisi (tumpang tindih) satu sama lain pada radiografi periapikal dan memerlukan pemisahan agar dapat diidentifikasi secara tepat. Salah satu metode yang dapat digunakan adalah adalah Buccal Object Rule atau Clark’s Rule. Banyak permintaan dokter gigi untuk memperoleh radiograf yang gambarannya tidak tumpang tindih, namun belum banyak radiografer yang menguasai teknik atau metode ini. Metode dari kegiatan ini yaitu dengan pemberian materi dilanjutkan dengan pelatihan melalui video tutorial secara daring. Hasil yang dicapai meningkatnya kemampuan peserta di buktikan dengan rerata hasil post test (8,05) meningkat dari hasil pre test (5,72).
Distribution of dense bone island in the jaw based on the classification of radiopaque areas and their location on panoramic radiographs Yunita Savitri; Eha Renwi Astuti; Aga Satria Nurrachman; Sri Wigati Mardi Mulyani; Dina Karimah Putri; Diana Lilik Zainiyyah; Hilda Majidah
Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Vol 6 No 2 (2022): Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI)
Publisher : Ikatan Radiologi Kedokteran Gigi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jrdi.v6i2.874

Abstract

Objectives: This study is aimed to find out the distribution of DBI in the jaw based on the classification of radiopaque areas and their location using panoramic radiographs at RSKGMP Universitas Airlangga Surabaya. Materials and Methods: This research was a descriptive observational study with total sampling method. The study used secondary data from panoramic radiographs at the RSKGMP Airlangga University Surabaya during 2018–2021, which had a DBI appearance, and analyzed them based on the classification of radiopaque areas and locations. The results of the analysis are then presented in the form of tables and pie charts. Results: Classification of DBI based on radiopaque areas was found in type 5 separate (47.81%), type 4 apical (29.82%), type 3 apical and interradicular (17.54%), type 1 interradicular (3.07%), and the least in type 2 interradicular and separate (1.75%). The most common locations of the lesions were in the premolar region (42.54%), the molar region (27.63%), the canine region (12.28%), the canine-premolar region (8.33%), the premolar-molar region (6.58%), and the least common location in the incisor and incisor-canine regions (1,32%). Conclusion: Classification of DBI based on the most common radiopaque area was found to be type 5 separate, with the most lesion locations in the premolar region. While the least classification was found in type 2 interradicular and separate, the incisive and incisive-canine regions had the fewest lesion locations.
Distribution of dense bone island in the jaw through panoramic radiography based on gender and age Otty Ratna Wahyuni; Yunita Savitri; Sri Wigati Mardi Mulyani; Deny Saputra; Ramadhan Hardani Putra; Rasendriya Chandramurti; Alquira Emalda Hardiva
Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Vol 6 No 3 (2022): Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI)
Publisher : Ikatan Radiologi Kedokteran Gigi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jrdi.v6i3.932

Abstract

Objectives: Panoramic radiographs are used as a diagnostic tool adjunctive to oral examinations, treatment plans, and evaluation of treatment outcomes. This study was aimed to determine the distribution of Dense Bone Island (DBI) in the jaws through panoramic radiography based on gender and age. Materials and Methods: The method used for this research is descriptive-observational. The research data used is secondary data with a total of 422 panoramic radiographic data of RSKGMP Airlangga University patients. Results: From a study of 422 secondary data found 253 (60%) patients with Dense Bone Island in the jaw, more commonly found in female, which is 162 (38.4%) in female patients and 91 (21.5%) in male patients. It was also found mostly in the age range of 17–25 years. Conclusion: Dense Bone Island was found more in female than in male. It was also found to be more common in patients aged 17–25 years.
Variation of normal condyle shape based on gender in panoramic radiographs Sri Wigati Mardi Mulyani; Eha Renwi Astuti; Otty Ratna Wahyuni; Ramadhan Hardani Putra; Aga Satria Nurrachman; Nastiti Faradilla Ramadhani; Farah Tariza Harlens; Lailatul Hikmah Mazlan
Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Vol 7 No 1 (2023): Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI)
Publisher : Ikatan Radiologi Kedokteran Gigi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jrdi.v7i1.1007

Abstract

Objectives: To find out information about variations in the normal shape of the condyles based on gender using panoramic radiographic observations and to find out the frequency data for variations in the normal shape of the condyles. Materials and Methods: This is a descriptive observational research using 122 panoramic radiographs as secondary data. The panoramic image consisted of 61 male samples and 61 female samples. The condyles were observed by describing the condyle shapes on the right and left sides. Observation of the shape of the condyle was carried out by three observers. Then, the data were tested for reliability by using the Intraclass Correlation Coefficient to equalize the perceptions of the three observers. Results: The reliability test using ICC obtained a score > 0.9 which means very good reliability. The most commonly found condyles shape is round and there are differences in shape between the right and left condyles in both males and females. Conclusion: The most common variation of the normal shape of the condyle found in both males and females is round on the right and left sides.
Molecular docking of noni fruit extract (M. citrifolia L.) active compound as a radiation protection agent: a bioinformatic approach Saputra, Deny; Mulyani, Sri Wigati Mardi; Ramadhani, Nastiti Faradilla; Margareth, Jane Evelyn; Putri, Regita Maharani Kharisma; Harlens, Farah Tariza; Nugraha, Alexander Patera
Majalah Kedokteran Gigi Indonesia Vol 10, No 2 (2024): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.97890

Abstract

Noni fruit (M. citrifolia L.) is a medicinal plant known for its antioxidant bioactive compounds, which have potential use as radiation protection agents. Despite their traditional use, the specific bioactive compounds and their efficacy as radiation protectants have not been thoroughly investigated. This study aims to address this research gap by evaluating the potential of noni fruit extract as a candidate for radiation protection using in-silico methods. Databases consulted include PubChem, PASS Online, and ProTox-II. The results identified nine bioactive compounds in noni fruit extract: quercetin, kaempferol, morindin, morindone, alizarin, nicotinamide, beta-sitosterol, squalene, and n-hexadecanoic acid. Among these, kaempferol, squalene, and n-hexadecanoic acid were found to be the most potent antioxidants. Kaempferol exhibited a low toxicity level (grade 5) with significant activity as an antioxidant (Pa ≥ 0.7), free radical scavenger (Pa ≥ 0.7), and radioprotector (Pa 0.3 – 0.7). Squalene, a triterpene with low toxicity (class 5), showed antioxidant activity (Pa 0.3 – 0.7), free radical scavenger activity (Pa 0.3 – 0.7), and radioprotection (Pa 0.3 – 0.7). n-Hexadecanoic acid, a metabolite with moderate toxicity (class 4), demonstrated lower antioxidant activity (Pa ≤ 0.3), while morindin exhibited free radical scavenging and radioprotective properties. The findings suggest that kaempferol, squalene, and n-hexadecanoic acid in noni fruit extract hold promise as candidates for radiation protection, as evidenced by in-silico analysis.
Age-related mandibular condyle morphological variations: a panoramic radiography study at RSGMP Universitas Airlangga Mulyani, Sri Wigati Mardi; Astuti, Eha Renwi; Wahyuni, Otty Ratna; Savitri, Yunita; Nurrachman, Aga Satria; Ramadhani, Nastiti Faradilla; Putri, Kharisma Gaprila; Jihan, Jihan
Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Vol 7 No 3 (2023): Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI)
Publisher : Ikatan Radiologi Kedokteran Gigi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jrdi.v7i3.1081

Abstract

Objectives: This research aims to find out the variations of the mandibular condyle shape based on age on panoramic radiography. Materials and Methods: This study uses secondary data from 200 digital panoramic radiographs of patients at the dental hospital (RSGM) of Universitas Airlangga aged 20-65 years in 2019, 2020, and 2021, which have met the inclusion and exclusion criteria. Data is presented in the form of tables and graphs with simple statistical calculations, and reliability tests were carried out with intraclass correlation (ICC) methods using SPSS. Results: There are variations of the condyle shape in five age groups, the age I (20-25 Years), age II (26-35 years), age III (36-45 years), age IV (46-55 years), age V (56-65 years). Conclusion: There are condyle shape variabilities in several age groups. In age I (20-25 years), age II (26-35 years), age III (36-45 years), and age IV (46-55 years) the most variation of the condyle shape is rounded, at age V (56-65 years) the most variation of the condyle shape is rounded and pointed. Furthermore, the morphology of the condylar structures may exhibit variances and are not consistently uniform.
Distribution of dental anomalies in panoramic radiography at RSGMP Universitas Airlangga Wahyuni, Otty Ratna; Saputra, Deny; Savitri, Yunita; Mulyani, Sri Wigati Mardi; Nurrachman, Aga Satria; Asymal, Alhidayati; Fandani, Fany
Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Vol 8 No 1 (2024): Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI)
Publisher : Ikatan Radiologi Kedokteran Gigi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jrdi.v8i1.1133

Abstract

Objectives: This research was aimed to determine the distribution of dental anomaly cases on panoramic radiographs at Universitas Airlangga Dental Hospital (RSGMP). Materials and Methods: This research used a descriptive observational design with a total sampling technique from panoramic radiographic data at the Radiology Clinic of RSGMP Universitas Airlangga during 2018–2020, which had cases of dental anomalies. Results: The result showed 116 cases of dental anomalies, with more incidence in female (64%) than in male (36%). The most common dental anomaly category was the number of teeth anomalies (47.41%), followed by tooth size anomalies (29.31%), tooth shape anomalies (23.28%), and there were no cases of anomalies in tooth structure and position. The most common types of dental anomalies were microdontia (27.59%), missing teeth/agenesis (25%), supernumerary teeth (22.41%), dilaceration (16.38%), talon cusp (3.45%), taurodontism (2.59%), macrodontia (1.72%), gemination (0.86%). Conclusion: The most common cases of dental anomalies were based on their categories, namely anomalies in the number of teeth, followed by tooth size, and tooth shape.
Utilizing a Film Holder to Enhance Radiographic Imaging in Maxillary Molar Trifurcation Savitri, Yunita; Wahjuni, Otty Ratna; Bosawer, Ellyonord Diana; Astuti, Eha Renwi; Mulyani, Sri Wigati Mardi; Saputra, Deny; Putra, Ramadhan Hardani; Asymal, Alhidayati; Nurrachman, Aga Satria; Ramadhani, Nastiti Faradilla; Lashari, Dur Muhammad
Indonesian Journal of Dental Medicine Vol. 6 No. 2 (2023): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v6i2.2023.74-78

Abstract

Background: The parallel technique stands as a prominent method for radiographic examinations aiming to identify furcation involvement. Nevertheless, an inherent limitation lies in the frequent superimposition of the trifurcation region with tooth roots, potentially leading to inaccurate diagnoses. The Same Lingual Opposite Buccal (SLOB) technique was devised to yield radiographic images that alleviate superimposition at the trifurcation of the maxillary first molar. Purpose: to observe and compare the radiographic images of the trifurcation region of the maxillary first molar generated through the SLOB technique with the film holder modification set at a mesial and distal angulation of 20Ëš with the parallel technique. Methods: This observational analytic research encompassed a sample size of 24 instances. Each individual sample underwent three separate exposures: the SLOB technique with a horizontal angulation of 20Ëš towards both mesial and distal directions, and the parallel technique (serving as the control). Results: a significant difference in radiographic images of the trifurcation region of the maxillary first molar obtained through the SLOB technique, employing the film holder modification with a mesial angulation of 20Ëš and a distal angulation of 20Ëš, as opposed to the parallel technique (control). Conclusion: A radiographic image capturing the trifurcation of the maxillary first molar, devoid of superimposition, was successfully generated through the SLOB technique incorporating a horizontal angulation of 20Ëš towards the distal direction.
Co-Authors Aga Satria Nurrachman Aga Satria Nurrachman Alexander Patera Nugraha Alhidayati Asymal Alquira Emalda Hardiva Bosawer, Ellyonord Diana Deny Saputra Deny Saputra Deny Saputra Diana Lilik Zainiyyah Dina Karimah Putri Eha Renwi Astuti Eha Renwi Astuti Erma Safitri Ernie Maduratna Setiawati Fandani, Fany Farah Tariza Harlens Harlens, Farah Tariza Hilda Majidah Jihan Jihan, Jihan Lailatul Hikmah Mazlan Lashari, Dur Muhammad Margareth, Jane Evelyn Marselina Sesaria Pratiknjo Nastiti Faradilla Ramadhani Nastiti Faradilla Ramadhani Otty Ratna Wahyuni Putra, Ramadhan Hardani Putri, Kharisma Gaprila Putri, Regita Maharani Kharisma Ramadhan Hardani Putra Rasendriya Chandramurti Savitri, Yunita Syenia Ramandha Wahjuni, Otty Ratna Wahyuni, Otty Ratna Yunita Savitri Yunita Savitri