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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal At-Tarbiyat (Jurnal Pendidikan Islam) Jurnal Kesehatan Terpadu (Integrated Health Journal) To Maega: Jurnal Pengabdian Masyarakat Indian Journal of Forensic Medicine & Toxicology Poltekita: Jurnal Pengabdian Masyarakat Jurnal Keperawatan Indonesia Timur (East Indonesian Nursing Journal) Borneo Journal of Pharmacy
Saidah Rauf
Poltekkes Kemenkes Maluku
Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Moderate-intensity interval exercise but not high-intensity interval exercise improves the spatial memory of ovariectomized rats Kaidah, Siti; Rauf, Saidah; Soesatyo, Marsetyawan HNE; Agustiningsih, Denny; Partadiredja, Ginus
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (518.401 KB) | DOI: 10.19106/JMedScie/005003201804

Abstract

Physical exercise exerts beneficial effects on the spatial learning and memory. High-intensity interval exercise (HIIE) has been proposed as a time-efficient physical exercise regimen. On the other hand, there were evidences that HIIE increased oxidative stress biomarkers and reduced antioxidant capacity, which resulted in oxidative damage. The present study aimed to investigate the effects of high-intensity interval exercise and moderate-intensity interval exercise on oxidative stress biomarkers and oxidative enzymes activity in the hippocampus and the spatial memory of ovariectomized rats. A total of 16 female Sprague Dawley rats aged 12 weeks were randomly assigned into 4 groups, i.e. the sham-operated (SO), ovariectomized without exercise (O), ovariectomized with high-intensity interval exercise (HIIE), and ovariectomized with moderate-intensity interval exercise (MIIE) groups. Rats of the exercise groups (HIIE & MIIE groups) performed 6 sessions of interval exercise per week for 6 weeks. The spatial memory of rats was measured using the Morris water maze procedure. The malondialdehyde (MDA) levels and activity of catalase (Cat) as well as glutathione peroxidase (GPx) in hippocampus were determined using spectrophotometry method. The spatial learning and memory retention of the moderate-intensity interval exercise group was significantly better than that of the high-intensity interval exercise group. The GPx activity of MIIE group was higher than any other groups. The SO group had the lowest hippocampal MDA level and highest Cat activity among groups. Moderate-intensity interval exercise reduces the ovariectomy induced-oxidative stress in the hippocampus and improves spatial learning and memory retention of ovariectomized rats.
Co-Authors Agustiningsih, Denny Bustanul Arifin Dyah Aryani Perwitasari Epi Dusra Evi Sarfina Ode Ginus Partadiredja M. Rifqi Rokhman Marice Benga Olla Marsetyawan HNE Soesatyo Nunung Dwi Setyawati Rigoan Malawat Sakina Auliya Tehuayo Santi Aprilian Lestaluhu Siti Kaidah Zulkarnain Zulkarnain