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Adeanne Wullur
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Medicine & Pharmacology

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Uji Ekstrak Daun Binahong ( Anredera cordifolia Steen.) Terhadap kadar Gula Darah Pada Tikus Putih Jantan Galur Wistar ( Rattus norvegicus) yang Diinduksi Sukrosa Makalalag, Indri Wirasuasty; Wullur, Adeanne; wiyono, Weny
PHARMACON Vol 2, No 1 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.883

Abstract

ABSTRACT The objective of this research were tostudy the effect of Binahong leaf extract (Anredera cordifolia Steen.) on blood glucose content of white male Wistar rats (Rattus norvegicus) induced with sucrose.  This research using Randomized Controlled Group Design (RAL).The subjects in these research were 15 mices which divided into 3 groups, namely a negative control group (aquadest), a positive control group (Glucobay4,5 mg/KgBB) and treatments groupusing crude extract of Binahong leaf 1,8 g/KgBB.  Data were obtained after blood glucose examination at 15, 30, 60, and 120 minutes treatment. Data were analyzed using ANOVA and LSD to compare the effect of treatment. Statistical analysis shows that there are significant effect between a negative control group and treatment group, a negative control group and a positive control group, but did not show differences between treatment group and a positive control group.  The conclusion is Binahong leaf extract possess activity to decrease blood glucose content of white male wistar induced with sucrose.   Keywords: Anredera cordifolia Steen.,Extract, blood glucose content
ISOLASI DAN IDENTIFIKASI SENYAWA FLAVANOID PADA DAUN ADAM HAWA (Rhoe discolor) Sitorus, Risma Meidy Hardina; Wullur, Adeanne; Yamlean, Paulina
PHARMACON Vol 1, No 1 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.446

Abstract

One of the plants can be used as a drug crop is Adam Hawa (Rhoe discolor) are thought to containflavanoid compounds, it is seen from the purple on the leaf. This study aims to determine the presenceor absence of flavonoids and other types of flavanoid compounds are contained in the leaf AdamHawa (Rhoe discolor). Isolation of flavonoids is done by maceration. Flavanoid compoundidentification is done by preparative Thin Layer Chromatography (KLTP) using the eluent n-butanol:acetic acid: water (BAA) with a ratio of 4:1:5. Identification of flavanoid compounds made with UVVisspectrophotometer. The results showed the leaf extract of Adam Hawa (Rhoe discolor) containsflavanoid compounds. Seen from the results of preparative thin layer chromatography to yield threespots with Rf value of 0.09; 0.36, and 0.71. Based on the analysis of UV-Vis spectrophotometer, threeisolates with Rf value of 0.71 has a maximum wavelength of 275 nm.Keyword : Adam Eve leaf (Rhoe discolor), Flavanoid, Preparative Thin Layer Chromatography(KLTP), UV-Vis spectrophotometer.
UJI EFEK ANTIINFLAMASI EKSTRAK ETANOL KULIT BATANG JAMBU BIJI (PSIDIUM GUAJAVA) TERHADAP EDEMA KAKI TIKUS JANTAN GALUR WISTAR Lanti, Deliyana; Fatimawali, Fatimawali; Wullur, Adeanne
PHARMACON Vol 1, No 2 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.508

Abstract

Inflamation is a protective response of body from injury of cell. Edema is one ofinflammation sign. Guava stem leather contains of flavonoid which has potency to inhibitedema. The aims of this research were to study antiinflamation effect of ethanolic extractofguava stem leather (Psidium guajava L.) on edema of white mice strain wistar legs.Thesubjects in this research were 25 wistar male which divided into 5 groups, namely negativecontrol (aquades), positive control (indometasin) and extract group with concentration 1%,2% and 4%. Every group consists of five mices. Aquades, indometasin and extractsupplementation were done per oral, followed with 5% of white egg induction on mice leftleglead to edema formation.Measurement of edema volume was done using plestimometer,and observation of edema were made every hour during 7 hours. Data which obtained wereanalyzed with ANOVA, if there is a differences between treatment, analysis continue to LSDtest. The result shows that supplementation of ethanolic extract of guava stem leatherconcentration 1% and 2 % decrease edema significantly with percent of inhibition 37,37 and32,59%, but supplementation of ethanolic extract of guava stem leather concentration 1% didnot shows inhibition effect .Keywords: guava stem leather, antiinflamation, edema
UJI TOKSISITAS AKUT (LETHAL DOSE50) EKSTRAK ETANOL DAUN GEDI MERAH (Abelmoschus manihot L.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.) Assagaf, Fadhila; Wullur, Adeanne; Yudistira, Adithya
PHARMACON Vol 2, No 1 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.882

Abstract

ABSTRACT This study aimed to determine the acute toxicity Lethal Dose50 of red aibika (Abelmoschus Manihot L.) leaves extract against white males rats (Rattus norvegicus L.) wistar strain. The method used was controlled group post-test only design. Subject were white male white rats with a total of 20 and divided into 5 groups: namely group 1 as a positive control, group 2 was treated 40% red aibeka leaf extract, g, group 3 was treated 60% red aibeka leaf extract, , group 4 was treated 80% red aibeka leaf extract, and , group 5 was treated 100% red aibeka leaf extract,. Data was recorded when there was a death in rats after a given treatment. LD50 calculation formula according to Thomson and Weil Method to calculate the LD50 value of red aibeka leaf extract. The results showed that mortality in the entire group 4 and 5 of tested animal occurred after treatment with LD50 values of 6,25 g/KgBB. It can be concluded that the leaf extracts of red aibika slightly toxic to the male white rat wistar strain. Keywords: Abelmoschus Manihot L., Red aibika, Acute Toxicity Test, Lethal Dose 50 (LD50).
Co-Authors Adithya Yudistira Deliyana Lanti Fadhila Assagaf Fatimawali . Indri Wirasuasty Makalalag Paulina yamlean Risma Meidy Hardina Sitorus Weny Wiyono