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All Journal Journal of Stem Cell Research and Tissue Engineering IJOIS: Indonesian Journal of Islamic Studies Nabatia E-JRM
saiful arifin
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Desensitization with Self-Antigen dsDNA Inhibits B and T-cell Functions by Modulating Treg as Regulator Immune System in Pristane-induced Lupus Mice Model saiful arifin
Journal of Stem Cell Research and Tissue Engineering Vol. 3 No. 1 (2019): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (563.869 KB) | DOI: 10.20473/jscrte.v3i1.16325

Abstract

The aim of this study was to develop a novel therapeutic method for improving immune system regulation in SLE using escalating dose self-antigen dsDNA immunotherapy. Methods: Female Balb/c mice were given a single intraperitoneal injection of  0.5 ml pristane.. Starting at 12 weeks after injection,. the mice were evaluated for clinical and serological manifestations. Mice with lupus signs (PIL mice) were divided into four groups; positive control group, PIL A (0.01 μg/ml, 0.1 μg/ml, 1 μg/ml ) EDI dsDNA, PIL B (0.1 μg/ml, 1 μg/ml, 10 μg/ml ) EDI dsDNA, and PIL C(1 μg/ml, 10 μg/ml, 100 μg/ml). EDI dsDNA were administered once every week in consecutively. The doses would increase every week. dsDNA were complexed with the cationic polyethylenimine (PEI) before injection. Samples  were analyzed for autoantibodies levels (dsDNA, ANA) and ,TGF-β cytokine  from serum using ELISA and T-Reg, mature dendritic cells  from spleen using flowcytometry.. Results: Escalating dose antigen spesific immunotherapy with self-antigen dsDNA significantly decreased ANA (p=0.02), anti-dsDNA (p=0.03), dendritic cell mature  (p=0.02) compare to positive control, and not significantly decreases Th17 cells (p=0,18) but the result tend to get lower. Desensitization using self-antigen dsDNA was increased T-reg proliferation (p=0.00) and level of TGF-β (p=0.03) significantly compare to positive control. Conclusion: Desensitization using self-antigen dsDNA coupled to PEI was able to modulate T-Reg as a regulator immune respon and inhibit B and T cell functions in lupus mice model.
The Effect of Arbuscular Mycorrhizae and the Percentage of Lapindo Mud Media on the Growth and Production of Kangkung Darat (Ipomoea Sp.) Abdul Hakim; Saiful Arifin
Nabatia Vol 2 No 1 (2014): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (197.805 KB) | DOI: 10.21070/nabatia.v11i1.1590

Abstract

Lapindomud has been being a problem, especially in agriculture area. Special treatments are needed in using Lapindo mud, one of them is mixed Lapindo mud with soil.Not only supports plant growth, but also mycorrhiza form a mutualistic relationship with plant on critical and damaged land. This research aimed to study about interactions and effect ofLapindo mud and arbuscular mycorrhizal on kangkung(Ipomoea sp) yield. The experiment was conducted on May to June 2014. Factorial design was arranged as Randomized Block Design with each treatment using Lapindo mud 0%, 20%, 30% and without the addition of mycorrhizal and repeated 3 times. Variable were plant length, number of leaves, stem diameter, root length, stover fresh and dry weight, yield of fresh components and dry weight.Data obtained in this research were analyzed by ANOVA, then followed by HSD 5%. The results data of administration of mycorrhiza and percentages Lapindo mud showed that real interaction to the number of leaves (M1L1) with results of 9.22. In the provision of mycorrhiza was significantly different at the plant lenght (27.22), stem diameter (0.47) and dry weight (1.27) plant that is on the media by giving mycorrhiza (M1). While the media Lapindo mud percentage was significantly different to the length of the plant (30.63), number of leaves (14.39), stem diameter (0.48), the weight of the wet stover (7.87), dry weight (1.27), root fresh weight (2.87), and root length (22.64) plant on media Lapindo mud percentage of 0% (L0).
ANALISIS PENGENDALIAN MUTU PRODUKSI MELALUI PENDEKATAN STATISTIC QUALITY CONTROL DALAM RANGKA MENJAGA KUALITAS PRODUK (Studi kasus pada PG. Kebon Agung Malang) Saiful Arifin; M. Hufron; M. Khoirul ABS
E-JRM : Elektronik Jurnal Riset Manajemen ejrm Vol. 7 No. 8 Agustus 2018
Publisher : UNIVERSITAS ISLAM MALANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (499.303 KB)

Abstract

ABSTRACT            This research was done on PG. Kebon Agung, Malang. The purpose of this research is to analyze the Statistics of production quality control approach through quality control to maintain the quality of the production. This variable uses the production quality control and Statistical approach to quality control. Method of data collection using the study of library science and documentary films. The sample used is the amount of production and the amount of production declined to 12 years 2017. The analysis in this study is a descriptive qualitative analysis by processing raw data using a percentage of rendering, compute the line Centre (Central line), the lower control limit (the limit control), calculate the upper limit control (control over the limit), and map control P by using Microsoft excel 2010 help software.The research found that the percentage of damage production at any period of grinding are very low i.e. under 4%, then in the center line of the calculation can be (CL) of 0.02127, and later in the calculation of the limit control top (UCL) or can be called a maximum extent of damage boundary line of 0.147, as well as on the final stages of the calculation of the 3 sigma i.e. calculation of the lower limit (LCL) in can be the result of 0.10373-in other words the lower boundary line is 0 (zero) because if the limits under control less than 0 (zero) then the down control limits deem 0 (zero). So it can be inferred that the quality control of the production of PG. Kebon Agung in the year 2017 during the milling period 12 has been running very well without any slightest deviation.Keywords: Quality, Seven Tools, Statistical Quality Control.
Konsep Pendidikan Karakter Menurut KH. Abdurrahman Wahid Sri Wargiani; Zulfa Khoirun Nissa; Ilhami Nurisfa Pratami; Putut Ardianto; Saiful Arifin; Muhammad Sholihin
IJoIS: Indonesian Journal of Islamic Studies Vol. 4 No. 1 (2023): Indonesian Journal of Islamic Studies
Publisher : Civiliza Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59525/ijois.v4i1.202

Abstract

This study aims to determine Gus Dur's views on character education. This research is a research with library research method. The analysis technique used to solve a problem is based on some relevant literature or has anything to do with the problem under study. The results of the study show that Gus Dur has a concept of character education that promotes morality in the administration of education. Character education in question is oriented towards the formation of personality and noble character based on the Al-Qur'an and al-Hadith, as well as to seek the values ​​of tolerance. Gus Dur's Islamic education is centered on guiding students to become individuals who are free, self-aware, independent, and free from barriers that impede human rights. Islamic education from Gus Dur's perspective must also be able to face the challenges of the globalization era and not be limited to conventional methods. In addition, Gus Dur paid attention to pluralism education. He wanted to reform public schools and Islamic boarding schools to empower Muslims.
Co-Authors Abdul Hakim ABS, M Khoirul Ilhami Nurisfa Pratami M. Hufron Muhammad Sholihin Putut Ardianto Sri Wargiani Zulfa Khoirun Nissa