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All Journal Indonesian Journal of Biotechnology Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Journal Orthopaedi and Traumatology Surabaya (JOINTS) Indian Journal of Forensic Medicine & Toxicology Indonesian Andrology and Biomedical Journal
Heri Suroto
Department Of Orthopaedic And Traumatology, Faculty Of Medicine, Universitas Airlangga/ Dr. Soetomo General Hospital, Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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The Clinical Function Comparison of Post Operative Nerve Grafting and Nerve Transfer in Patients with Brachial Plexus Injury Agung Tristyanto1, Heri Suroto2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3234

Abstract

Background: Brachial plexus injury is most commonly caused by motorcycle accidents and leads to a deficit of motor strength, pain and disability of the upper limb. The main purpose of reconstructive action of brachial plexus injury is to restore the function of the shoulder and elbow. Aim: This study aimed to compare the clinical function of post-operative nerve grafting with nerve transfer in patients with brachial plexus injury. Methods: This study enrolled a sample of patients who had surgery and evaluated the range of active movement of shoulder abduction and elbow flexion; motor strength using the scale of the British Medical Research Council (BMRC); neuropathic pain using Visual Analog Scale (VAS); and upper extremity disability using the Quick Disability of the Arm, Shoulder, and Hand (Quick DASH) questionnaire. Results: 30 patients were divided into groups of nerve grafting and nerve transfer with each group consisting of 15 patients. 13 patients (87%) of each group had motor strength of functional shoulder abduction (>M3) (p = 0.874). 13 patients (87%) had better functional elbow flexion motor strength (>M3) in the nerve transfer group than 11 patients (73%) of the nerve grafting group (p = 0.036). Conclusion: The postoperative nerve transfered clinical function showed a better elbow flexion function with a lower severity of upper limb disability.
Role of Preconditioning Adipose Mesenchymal Stem Cells in Regeneration Disk: a Review Article Romaniyanto; Hari Basuki Notobroto; Cita Rosita Sigit Prakoeswa; Fedik Abdul Rantam; Dwikora Novembri Utomo; Heri Suroto; Ferdiansyah
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14892

Abstract

Intervertebral disk (IVD) degeneration (IDD) is a degenerative disease and often found in daily practice.The managements that were used so far are only symptomatic and have not been able to solve the diseasecompletely. The use of mesenchymal stem cells (MSCs) has been widely tested as a solution for theregeneration of IVD in IDD. Adipose-derived mesenchymal stem cells (ASCs) are one of the sources ofMSCs which were widely studied as an alternative. One of the factors that can influence the efficiency andcapacity of ASCs in IDD cases is preconditioning. Generally, there were three pre-conditioning strategies ofASCs before being used as therapy, (1) modifying the environment, (2) using Growth Factors, Cytokines,Chemokines, Hormones, (3) using pharmacological and chemical agents. Preconditioning on ASCs canchange its function in various ways. We tried to link all these things together so that we could know the roleof pre-conditioning ASCs in the regeneration disk.
Comparison of clinical evaluation of post-operation patients of open reduction internal fixation (ORIF) plating proximal humerus using conventional methods and minimally invasive plate osteosynthesis (MIPO) in Surabaya Musa Arafah; Heri Suroto; Erwin Ramawan
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.3119

Abstract

ABSTRACT There are several kinds of approaches in the installation of implants for proximal humerus therapy. At present, minimally invasive surgery is gaining in popularity; this is supported by increasingly good technological developments to optimal the postoperative outcome is more optimal than conventional methods. This study used an analytic retrospective design with samples of post-ORIF Plating MIPO and posted ORIF due to proximal humeral fracture. Evaluation using the instrument of VAS Score, ASES Score, and measurement of range of motion. Statistical tests showed that there was a significant difference in the VAS score at the first evaluation (p = 0.002); the last review was not significant. In ASES Score, abduction, flexion, and external rotation, there were significant differences during the first and last evaluations. Adduction, extension, and internal rotation have no significance. The method of minimally invasive plate osteosynthesis (MIPO) on proximal humeral operative fracture therapy had a better clinical outcome and operating time than post-ORIF plating with conventional methods. As well, the MIPO method on proximal humeral fracture operative therapy based on radiological features has the same union rates compared to post ORIF plating with conventional methods. The method of minimally invasive plate osteosynthesis (MIPO) in operative therapy of neer 2 and 3 proximal humeral fracture has a better clinical outcome than conventional methods.Keywords: proximal humeral fracture, Minimal Invasive Plate Osteosynthesis (MIPO), Open Reduction Internal Fixation (ORIF)Correspondence to: musa_shi911@yahoo.com   
Uji Biokompabilitas pada Implan Orthopedi Antara Implan Impor, Implan Lokal dari Material Impor, dan Prototipe Stainless Steel 316L dari Material Lokal Ferdiansyah Mahyudin; Heppy Chandra Waskita; Dwikora Novembri Utomo; Heri Suroto; Tri Wahyu Martanto
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 3, No 1 (2019)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (597.99 KB) | DOI: 10.30651/jqm.v3i1.1612

Abstract

ABSTRACT  Demands of orthopedic implants are increasing in Indonesia, but its production are limited and still imported. Stainless steel, especially 316L is one of metal that is used commonly. This research evaluates biocompatibility of stainless steel 316L implant prototype, local implant manufactured using imported stainless steel, and imported stainless steel implant. Cytotoxicity test used mesenchymal human cell with MTT assay. Irritation test, acute toxicity/pyrogenicity test, and implantation test used 24 Wistar rats respectively which were assigned to 4 groups. We evaluate Draize score, weight and rectal temperature changes, and fibrous capsule ring thickness. Cytotoxicity test shows viable cell percentage in stainless steel 316L implant prototype, local implant, and imported implant are 83.7%, 87.5%, and 83.7% respectively. Comparison test using One Way ANOVA shows no significant difference between 3 groups (p>0.05). Iritation test results in 3 groups are grade 0 (no edema and no erythema). Acute toxicity/pyrogenicity test shows no statistically significant difference (p>0.05) among all groups. There is also no significant difference (p>0.05) of fibrous capsule ring thickness on 1 and 4 weeks after implantation. Based on ISO for medical test guide, stainless steel 316L implant prototype is safe and has similar biocompatibility test result compared to local and imported implant.Keywords                   : stainless steel 316L, biocompatibility, orthopaedic implantCorrespondence to    : ferdiansyah@fk.unair.ac.id ABSTRAKKebutuhan implan orthopedi terus meningkat di Indonesia, namun produksinya terbatas dan sebagian besar masih impor dari luar negeri. Stainless steel, utama 316L adalah salah satu metal yang sering digunakan. Penelitian ini mengevaluasi biokompatibilitas dari prototipe implan stainless steel 316L, implan lokal yang diproduksi menggunakan stainless steel impor, dan implan stainless steel impor. Uji sitotoksisitas menggunakan sel mesenkim human dengan MTT assay. Uji iritasi, uji pirogenositas, dan uji implantasi menggunakan 24 tikus Wistar yang terbagi dalam 4 grup. Kami mengevaluasi skor Draize, perubahan berat dan temperatur rektal, dan ketebalan fibrous capsule ring. Uji sitotoksisitas menunjukkan persentase viabilitas sel pada prototipe stainless steel 316L, implan lokal, dan implan impor berturut-turut adalah 83,7%; 87,5%; dan 83,7%. Uji komparasi dengan One Way Anova tidak menunjukkan perbedaan signifikan diantara 3 grup (p>0,05). Hasil uji iritasi 3 grup menunjukkan grade 0 (tidak ada edema dan eritema). Uji pirogenositas tidak menunjukkan perbedaan signifikan pada semua grup (p>0,05). Tidak ada perbedaan signifikan (p>0,05) pula pada ketebalan fibrous capsule ring di minggu ke 1 dan 4 setelah implantasi. Berdasarkan ISO untuk pedoman uji di bidang medis, prototipe stainless steel 316L aman dan memiliki kesamaan hasil uji biokompatibilitas bila dibandingkan dengan implan lokal dan impor.Kata kunci              : stainless steel 316L, uji biokompatibilitas, implan orthopaediKorespondensi       : ferdiansyah@fk.unair.ac.id
The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review article Romaniyanto Romaniyanto; Cita Rosita Sigit Prakoeswa; Damayanti Tinduh; Hari Basuki Notobroto; Fedik Abdul Rantam; Dwikora Novembri Utomo; Heri Suroto; Ferdiansyah Ferdiansyah
Indonesian Journal of Biotechnology Vol 26, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.63318

Abstract

Low back pain is a crucial public health problem that is commonly associated with intervertebral disc de‐ generation and has vast socio‐economic impact worldwide. Current treatments for disc degeneration are conservative, non‐surgical, or surgical interventions, and there is no current clinical therapy aimed at directly reversing the degeneration. Given the limited capacity of intervertebral disc (IVD) cells to self‐repair, treatment aiming to regenerate IVDs is a topic of interest and mesenchymal stem cells (MSCs) have been identified as having potential in this regeneration. Recent studies have revealed that the benefits of MSC therapy could result from the molecules the cells secrete and that play principal roles in regulating essential biologic processes, rather than from the implanted cells themselves. Therefore, the objective of this study is to review the potential use of the MSC secretome to regenerate IVDs. Current evidence shows that the secretome may regenerate IVDs by modulating the gene expressions of nucleus pulposus cells (upregulation of keratin 19 and downregulation of matrix metalloproteinase 12 and matrix Gla protein) and stimulating IVD progenitor cells to repair the degenerated disc.
The Effect of MST 1 Inhibition through Hippo Pathway on Diabetes Mellitus (DM) Induced Osteoporosis Kintan Adelia Farahannisa; Gadis Meinar Sari; Heri Suroto
Indonesian Andrology and Biomedical Journal Vol. 3 No. 1 (2022): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (409.348 KB) | DOI: 10.20473/iabj.v3i1.35874

Abstract

Osteoporosis is a chronic metabolic disorder of the musculoskeletal system associated with reduced bone strength. One of the causes of secondary osteoporosis is diabetes mellitus (DM). The prevalence of both disorders keeps increasing with time. Therefore, this review is conducted to find a possible solution to prevent DM-induced osteoporosis. Diabetes mellitus mainly affects the bone through glucose uptake during the bone remodeling process. Glucose uptake through GLUT 1 is regulated by MST 1, which is an upstream kinase of the Hippo signaling pathway. MST 1 is responsible for regulating cell growth, proliferation, and apoptosis. In the bone remodeling process, MST 1 plays a role by regulating actin ring structures and the integrin signaling pathway. Moreover, DM is also associated with increased oxidative stress. Increased oxidative stress will activate Hippo signaling pathway. This will trigger cellular apoptosis as the Hippo signaling pathway plays a role mainly as a tumor suppressor. Increased cellular apoptosis will cause an imbalance in the bone remodeling process, disrupting bone quality. Inhibition of MST 1 through the Hippo signaling pathway will increase cell growth and reduce cellular apoptosis. Increased cell growth might increase osteogenesis during the bone remodeling process, thus resulting in better bone quality in DM-induced osteoporosis.
REPAIR OF SCIATIC NERVE LESION AUGMENTED WITH AMNION MEMBRANE COMPOSITE AND MESENCHYMAL STEM CELL Heri Suroto; R. Taufan Mulyo Wibisono
Journal Orthopaedi and Traumatology Surabaya Vol. 9 No. 1 (2020): April 2020
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v9i1.2020.29-33

Abstract

Background: Peripheral nerve injuries (PNI) are quite common, with an incidence of 13.9% per 100,000 people per year. The most cause is direct penetrating trauma. PNI will cause a significant decrease in the quality of life of patients. Case: A 21-years-old woman complained of the inability to move her right leg and numbness. She had been injured in the of the right thigh due to broken glass. The patient underwent emergency surgery to repair the right Femoral artery and the Sciatic nerve. Discussion: After six months since the first operation, flail foot and anesthesia were persisting with a FADI score of 47.1. We decided to perform re-exploration, from the exploration we found neuroma on the sciatic nerve. Excision was performed on the Neuroma then an end-to-end anastomosis was performed on both sciatic nerve components (tibial and peroneal) and augmented using amniotic membrane composites and mesenchymal stem cells. After 6 months since the second surgery, the patient could perform ankle dorsal flexion. After 12 months postoperatively, the patient could move his right leg functionally, sensory function also improved. Patients can undergo daily activities without difficulty, with a FADI score of 96.2. Conclusion: There is a significant improvement in the patient's foot function after surgery using the method we used, more research is needed to optimize the use of amniotic membrane and mesenchymal stem cells as augmentation in nerve repair.
DOUBLE FREE FUNCTIONING MUSCLE TRANSFERS FOR BRACHIAL PLEXUS INJURIES: A CASE REPORT Heri Suroto; Teddy Heri Wardhana; Farindra Ridhalhi
Journal Orthopaedi and Traumatology Surabaya Vol. 8 No. 1 (2019): April 2019
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v8i1.2019.19-24

Abstract

Free functional muscle transfer for brachial plexus injury is one of the alternatives to repair the upper extremity function, where usually one type of muscle is used, the gracillis. The method of using two donor muscles to restore the motor function is worth considering for a better improvement of the quality. A 36 years old man with a complete left brachial plexus injury from C5-T1 due to motorcycle accident. A double free functional muscle transfer was performed using the gracillis muscle and the adductor longus muscle with the arterial source from the thoraco-acromial artery with the phrenic and accessory nerves. The gracillis muscle is used to flex the fingers while the adductor is used for flexing the elbow. A one year post-operative evaluation showed the patient was already capable of flexing his elbow with the muscle score of 3 and also the fingers with the muscle score of 1. The double free functional muscle transfer procedure is effective in achieving the moving function of both the elbow and the hand.
CONSTANT MURLEY SCORE ON PATIENTS POST SUPRASPINATUS RECONSTRUCTION WITH MEMBRANE AMNION COMPOSITE AND FAT TISSUE ALLOGENIC MESENCHYMAL STEM CELL AUGMENTATION Heri Suroto; Bayu Antara Hadi; Goklas Ridwan Ricardo Gultom
Journal Orthopaedi and Traumatology Surabaya Vol. 8 No. 2 (2019): October 2019
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v8i2.2019.77-85

Abstract

Background: Rotator cuff tears are the most common cases in nontrauma upper extremities in group patient more than 50 years old. Incidence on rotator cuff can’t show the real population. New Approaches healing rotator cuff syndrome is tendon regeneration like mesenchymal stem cell injection and growth factor or tissue engineering that has been developed.Methods: Retrospective comparation study of 15 postsupraspinatus reparation patients who has been treated for more than 4 months at the Dr. Soetomo general hospital. Patients is divided into group undergone supraspinatus reparation and patient supraspinatus reparation with augmented by membrane amnion composite and mesenchymal stem cell. Its’ functional results were evaluated using constant murley score.Results: Pain score average on supraspinatus reparation patients which augmented by membrane amnion and mesenchymal stem cell and those without augmentation is 15 and 13.7 (p=0.036). Daily activity score average on patients with and without augmentation are 20 and 17 (p=0.037). Flexion score average on patients with and without augmentation are 10 and 8.6 (p=0.114). External rotation score average on patients with and without augmentation are 9.6 and 7.2 (p=0.004). Internal rotation score average on patients with and without augmentation are 9.2 and 7.2 (p=0.012).Conclusion: The constant murley score pain score, ADL score, external rotation score, and internal rotation score in the group with the addition of amniotic membrane and mesenchymal stem cells were significantly better than the group with supraspinatus repair only, but not significantly on the flexion score and lateral elevation score components.
Co-Authors Bayu Antara Hadi Cita Rosita Sigit Prakoeswa Damayanti Tinduh Dwikora Novembri Utomo Erwin Ramawan Farindra Ridhalhi Fedik Abdul Rantam Ferdiansyah Ferdiansyah Mahyudin Gadis Meinar Sari Goklas Ridwan Ricardo Gultom Hari Basuki Notobroto Heppy Chandra Waskita Kintan Adelia Farahannisa Musa Arafah R. Taufan Mulyo Wibisono Romaniyanto Romaniyanto Romaniyanto Teddy Heri Wardhana Tri Wahyu Martanto