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All Journal Indonesian Journal of Biotechnology Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Journal Orthopaedi and Traumatology Surabaya (JOINTS) Indian Journal of Forensic Medicine & Toxicology Indonesian Andrology and Biomedical Journal
Heri Suroto
Department Of Orthopaedic And Traumatology, Faculty Of Medicine, Universitas Airlangga/ Dr. Soetomo General Hospital, Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Indonesian Andrology and Biomedical Journal

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The Effect of MST 1 Inhibition through Hippo Pathway on Diabetes Mellitus (DM) Induced Osteoporosis Kintan Adelia Farahannisa; Gadis Meinar Sari; Heri Suroto
Indonesian Andrology and Biomedical Journal Vol. 3 No. 1 (2022): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (409.348 KB) | DOI: 10.20473/iabj.v3i1.35874

Abstract

Osteoporosis is a chronic metabolic disorder of the musculoskeletal system associated with reduced bone strength. One of the causes of secondary osteoporosis is diabetes mellitus (DM). The prevalence of both disorders keeps increasing with time. Therefore, this review is conducted to find a possible solution to prevent DM-induced osteoporosis. Diabetes mellitus mainly affects the bone through glucose uptake during the bone remodeling process. Glucose uptake through GLUT 1 is regulated by MST 1, which is an upstream kinase of the Hippo signaling pathway. MST 1 is responsible for regulating cell growth, proliferation, and apoptosis. In the bone remodeling process, MST 1 plays a role by regulating actin ring structures and the integrin signaling pathway. Moreover, DM is also associated with increased oxidative stress. Increased oxidative stress will activate Hippo signaling pathway. This will trigger cellular apoptosis as the Hippo signaling pathway plays a role mainly as a tumor suppressor. Increased cellular apoptosis will cause an imbalance in the bone remodeling process, disrupting bone quality. Inhibition of MST 1 through the Hippo signaling pathway will increase cell growth and reduce cellular apoptosis. Increased cell growth might increase osteogenesis during the bone remodeling process, thus resulting in better bone quality in DM-induced osteoporosis.
Co-Authors Bayu Antara Hadi Cita Rosita Sigit Prakoeswa Damayanti Tinduh Dwikora Novembri Utomo Erwin Ramawan Farindra Ridhalhi Fedik Abdul Rantam Ferdiansyah Ferdiansyah Mahyudin Gadis Meinar Sari Goklas Ridwan Ricardo Gultom Hari Basuki Notobroto Heppy Chandra Waskita Kintan Adelia Farahannisa Musa Arafah R. Taufan Mulyo Wibisono Romaniyanto Romaniyanto Romaniyanto Teddy Heri Wardhana Tri Wahyu Martanto