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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Biotechnology Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan)
Enny Nugraheni
Universitas Bengkulu
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Telekonsultasi Dalam Rangka Pemutusan Rantai Penularan Covid-19 di Kota Bengkulu Dessy Triana, M. Biomed; Hardiansyah Hardiansyah; Sri Yunita; Miftahul Haniyah; Enny Nugraheni Sulistiyorini; Riry Ambarsarie; Rizkianti Anggraini; Elvira Yunita; Mardhatillah Sariyanti
DHARMA RAFLESIA Vol 19, No 2 (2021): DESEMBER (ACCREDITED SINTA 5)
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/dr.v19i2.18373

Abstract

Coronavirus Disease-19 (Covid-19) is a disease that has become a global epidemic.  The World Health Organization (WHO) has declared Covid-19 a pandemic. Indonesia declared the status of the Covid-19 disease to be an Emergency Response. Supporting the social distancing, the right strategy is needed to continue implementing health services amid the Covid-19 pandemic. This activity aimed to provide knowledge related to Covid-19 to the community and health consultations and medical advice through applications (teleconsultation) to minimize patients queuing at Health Service Facilities directly. The activity partners were the Indonesian Medical Association (IDI) Bengkulu City Branch, Bengkulu City Health Office, and the Indonesian Red Crescent (BSMI) Bengkulu City Region. The method of this activity was to provide socialization, health consultation and medical advice through applications (teleconsultation) regarding the spread, transmission and prevention of Covid-19 from May 1 to August 31 2020. The number of participants was 41 people from Bengkulu City. The highest number of diseases consulted were acute respiratory infections (38.7%.) and Covid-19 independent protocol consultation (31.58%.) Teleconsultation can be continued and developed into a patentable application. Application development is indispensable in responding to the challenges of the health world in the digital era.
Association between Body Mass Index and Type of Infection on the Severity of Dengue Infection in Bengkulu City, Indonesia Annelin Kurniati; Dessy Triana; Enny Nugraheni Sulistiyorini; Mardhatillah Sariyanti; Gayatri Ghea Wirastari
JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Vol 6, No 3 (2021)
Publisher : Prodi Kesehatan Masyarakat Fakultas Kesehatan Masyarakat UIN Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (115.542 KB) | DOI: 10.30829/jumantik.v6i3.9177

Abstract

Background: Dengue virus infection is a serious global health problem. The incidence has increased rapidly within the last 50 years. The clinical manifestations vary from Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF), to Dengue Shock Syndrome (SSD). Some of the influencing factors are the Body Mass Index (BMI) and the type of dengue infection. The study aimed to determine the association between BMI and type of infection on the severity of dengue infection in adulthood.Methods: The study used a cross-sectional design with a total sample of 39 patients diagnosed with dengue infection and fulfilling the inclusion criteria. The sampling technique was consecutive sampling. The data analysis used was the Spearman correlation test. Data collection was conducted by distributing research form which cover sample characteristics, BMI values, clinical manifestations, types of infection and the severity of dengue infection.Results: The total of subject obtained was 37 respondents (23 male and 14 female). The average BMI value was 24.65 ± 5.08. The most common clinical manifestations were fever (100%), nausea/vomiting (91.8%), headache (89.1%), myalgia (89.1%), and arthralgia (72.9%). Most cases of dengue infection were in the normal BMI group and the highest degree of severity was DD. There was a significant relationship with a fairly strong correlation value between BMI and dengue severity (p=0.003; r=0.478). However, there was no significant relationship between the type of infection (p=0.987; r=0.03) with the level of dengue severity.Conclusion: Knowing the risk factors as predictors of dengue severity is very necessary in order to handle dengue infection quickly and accurately.
Potential of marine sponge Jaspis sp.‐associated bacteria as an antimicrobial producer in Enggano Island Sipriyadi Sipriyadi; Riziq Ilham Nurfahmi; Uci Cahlia; Risky Hadi Wibowo; Welly Darwis; Enny Nugraheni
Indonesian Journal of Biotechnology Vol 27, No 3 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.65943

Abstract

Sponges, a group of marine multicellular animals with a porous body structure, show potential for the production of bioactive compounds. Sponge‐associated bacteria are an alternative antimicrobial producer due to their high content of bioactive compounds. This study aimed to identify the highest‐potential antimicrobial‐producing bacteria isolate associated with Jaspis sp. sponges from Enggano island. The isolated bacteria were screened for antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans using cultures, supernatants, pellets, and crude extracts. The study also conducted genetic identification to determine the identity of the isolate with the greatest potency and its closest relationship using the 16S rRNA gene. The antimicrobial activity was determined by monitoring and measuring the diameter of the formed clear zones. The results of the observations of morphological characteristics revealed nine isolates from Jaspis sp. that each consisting of 6 JABS isolates and 3 JABB isolates. Based on isolates that had antimicrobial activity, JABS6 isolates had the best antimicrobial activity, with the diameter of inhibition zones of 24.7, 8.2, 4.6, and 33.7 mm for E. coli, P. aeruginosa, S. aureus and C. albicans, respectively. The genome sequencing of the JABS6 isolate confirmed that it was identical to Bacillus thuringiensis strain USS‐CAP‐1. The study concludes that this finding shows promise for the further development of future antimicrobial agents.
CASE REPORT : LOW LEVEL IMMUNOGLOBULING (IGG) IN REINFECTION COVID-19 CASE Enny Nugraheni; Debbie Rizqoh; Annelin Kurniati; Lusiana Astuti; Mulya Sundari; Etty Febrianti
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 3 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I3.18828

Abstract

Million people have infected the SARS-CoV-2 epidemic, which is currently spreading. We describe a confirmed COVID-19 patient whose oropharyngeal swab test for SARS-CoV-2 RNA and have positive PCR test results after 8 weeks proclaim negative result of PCR test for SARS-COV-2. ImmunoglobulinG was not detected during the initial illness. In this study, we discuss the potential role of low IgG in cases of reinfection.
MANIFESTASI KLINIS DEMAM BERDARAH DENGUE (DBD) Enny Nugraheni; Debie Rizqoh; Mulya Sundari
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I3.21425

Abstract

Abstrak Demam Berdarah Dengue ada penyakit infeksi yang disebabkan virus dengue. Manusia akan terinfeksi setelah diinfeksi oleh nyamuk Aedes Aegypti yang membawa virus DENV. Virus dengue terdiri dari 4 serotipe yaitu DENV-1, 2, 3 dan 4. Virus dengue dapat menyebabkan dua tipe infeksi yaitu infeksi primer dan infeksi sekunder. Infeksi primer dapat muncul sebagai demam akut atau disebut demam dengue yang akan dinetralisir dalam tujuh hari oleh respon imun. Sedangkan infeksi sekunder cenderung akan lebih berat dan akan mengakibatkan demam berdarah dengue (DBD) atau sindrom renjatan dengue (SRD).Manifestasi klinis DBD dapat diklasifikasikan berdasarkan kondisi klinis pasien dan hasil pemeriksaan penunjang. Kasus simptomatik dapat dibedakan menjadi beberapa klasifikasi diantaranya adalah undifferentiated febrile illness (UF), Demam Dengue (DD), Demam Berdarah Dengue (DBD), sindrom renjatan dengue (SRD) dan unusual dengue (UD). Manifestasi klinis dapat berdampak pada organ dan sistem yang ada di seluruh tubuh. Manifestasi klinis dengue bervariasi dari yang ringan sampai dengan berat. Manifestasi utama berupa adanya plasma leakage yang digambarkan pada fase awal adanya pendarahan ringan sampai berat. Tanda plasma leakage juga dapat ditemukan pada multiple organ Klasifikasi DBD dapat dilakukan berdasarkan WHO 1997 dan WHO 2009. Manifestasi klinis ini penting diketahui dan dipahami untuk menegakkan diagnosis yang cepat sehingga dapat melakukan penatalaksanaan DBD dengan baik sehingga mengurangi angka morbiditas dan mortalitas. Kata kunci: Syok, Infeksi, Gejala AbstractDengue Hemorrhagic Fever is an infectious disease caused by the dengue virus. Humans will become infected after being infected by the Aedes Aegypti mosquito that carries the DENV virus. Dengue virus consists of 4 serotypes namely DENV-1, 2, 3 and 4. Dengue virus can cause two types of infection, namely primary infection and secondary infection. Primary infection may appear as acute fever or called dengue fever which will be neutralized within seven days by the immune response. While secondary infections tend to be more severe and will result in dengue hemorrhagic fever (DHF) or dengue shock syndrome (SRD). The clinical manifestations of DHF can be classified based on the patient's clinical condition and the results of investigations. Symptomatic cases can be divided into several classifications including undifferentiated febrile illness (UF), Dengue Fever (DD), Dengue Hemorrhagic Fever (DHF), Dengue shock syndrome (SRD) and unusual dengue (UD). Clinical manifestations can impact organs and systems throughout the body. Dengue clinical manifestations vary from mild to severe. The main manifestation is the presence of plasma leakage which is described in the initial phase of light to heavy bleeding. Plasma leakage signs can also be found in multiple organs. Classification of DHF can be done based on WHO 1997 and WHO 2009. . It is important to know and understand these clinical manifestations in order to make a quick diagnosis so that DHF can be managed properly, thereby reducing morbidity and mortality.Keywords: Shock, infection, symptom
Case Report : Definisi dan Faktor Prediktor Thrombosis Stent Jusup Endang; Enny Nugraheni
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 9 No. 1 (2022): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universi
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I1.14515

Abstract

Implantasi stent telah menjadi kemajuan besar dalam intervensi koroner perkutan (PCI), mengurangi frekuensi penutupan akut dan restenosis dari stent. Stent, bagaimanapun juga merupakan bahan logam, dan implantasi mereka dalam arteri koroner memicu aktivasi platelet, yang dapat menyebabkan pembentukan trombus dan trombosis stent berikutnya. Kejadian trombosis stent telah dilaporkan dalam sejumlah studi yang sebagian besar telah menemukan angka kejadiannya sebesar 0,5-2% dan kematian akibat trombosis stent telah dilaporkan setinggi 45%. Laporan kasus ini bertujuan untuk menggambarkan riwayat klinis dan analisis kasus sub akut stent trombosis yang terjadi setelah penggunaan NSAID dan untuk meninjau prediktor yang menyebabkan stent thrombosis ini. Pasien usia 57 tahun dilakukan PTCA dengan menggunakan 2 stent DES overlapped pada daerah LAD. Paska tindakan pasien mengkonsumsi NSAID ibuprofen dan na diklofenak. Dalam 3 hari pasien masuk ke ruang gawat darurat RS PJNHK dengan diagnosa akut anterior STEMI onset 2 jam killip 1 TIMI 4/14 e.c dd/ sub akut stent thrombosis. Pasien dilakukan tindakan primary PCI. Selama perawatan pasien dengan klinis dan haemodinamik stabil dilakukan ekokardiografi didapatkan fungsi ventrikel kiri 30%.
Co-Authors Annelin Kurniati Annelin Kurniati Debbie Rizqoh Debie Rizqoh Dessy Triana Elvira Yunita Etty Febrianti Gayatri Ghea Wirastari Hardiansyah Hardiansyah Jusup Endang Lusiana Astuti Mardhatillah Sariyanti Miftahul Haniyah Mulya Sundari Mulya Sundari Riry Ambarsarie Risky Hadi Wibowo Riziq Ilham Nurfahmi Rizkianti Anggraini Sipriyadi Sipriyadi Sri Yunita Uci Cahlia Welly Darwis