Dewi Sumaryani Soemarko
Occupational Medicine Division, Departement Of Community Medicine, Faculty Of Medicine, Universitas Indonesia

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Journal : Medical Journal of Indonesia

Past antihypertensive drugs, obesity, daily light working load and risk of hypertension: An Indonesian 2001 rural study Basuki, Bastaman; Soemarko, Dewi S.; Amri, Zarni; Ibrahim, Ermita I.
Medical Journal of Indonesia Vol 10, No 4 (2001): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (725.11 KB) | DOI: 10.13181/mji.v10i4.38

Abstract

This study aims to identify some risk factors related to hypeertension in rural areas. The data for this study is a part af the result of the field study done by the second year medical students of the Faculty of Medicine, University of Indonesia, Jakarta, on June 27h , 2001, at Cijeruk subdistrict in Bogor regency. The subjects were seleccted randomly using neighborhood cluster which was diffirent from the previous study in 2000. Interviews and blood pressure were taken at the houses of the subjects from 1:00 PM to 4:00 PM. The results of this study showed that people aged 40 years or over had an increase risk to suffer hypertension compared to the 18-39 year old group, and the risk was most prominent among the 55-59 year group [adjusted odds ratio (OR)= 17.7; 95% confidence intervals (CI)=6.26-59.2). Compared to the subjects with normal body posture,those who were obese had more than two-fold increase in the risk to be hypertensive (adjusted OR= 0.87; 95% CI= 0.87-4.17; P= 0.109). In addition, those who discontinued antihypertensive drugs had almost 14-fold increase in the risk to be hypertensive relative to subjects who never take antihypertensive drugs (adjusted OR= 14.16; 95% CI= 7.14- 28.05). In general, the results of this study is similar with our last year study which used different subjects. This study concluded that special attention should be taken to the elderly aged 40 years and over, to some one who discontinued antihypertensive drugs; andwhom had light daily working load to prevent hypertension. (Med J Indones 2001; 10: 224-9)Keywords: hypertensive, risk factor, adjusted odds ratio, elderly.
Lymphocyte chromosome breakage in low benzene exposure among Indonesian workers Soemarko, Dewi S.; Mansyur, Muchtaruddin
Medical Journal of Indonesia Vol 23, No 4 (2014): November
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (394.206 KB) | DOI: 10.13181/mji.v23i4.740

Abstract

Background: Benzene has been used in industry since long time and its level in environment should be controled. Although environmental benzene level has been controlled to less than 1 ppm, negative effect of benzene exposure is still observed, such as chromosome breakage. This study aimed to know the prevalence of lymphocyte chromosome breakage and the influencing factors among workers in low level benzene exposure.Methods: This was a cross sectional study in oil & gas industry T, conducted between September 2007 and April 2010. The study subjects consisted of 115 workers from production section and head office. Data on type of work, duration of benzene exposure, and antioxidant consumption were collected by interview as well as observation of working process. Lymphocyte chromosome breakage was examined by banding method. Analysis of relationship between chromosome breakage and risk factors was performed by chi-square and odd ratio, whereas the role of determinant risk factors was analyzed by multivariate forward stepwise.Results: Overall lymphocyte chromosome breakage was experieced by 72 out of 115 subjects (62.61%). The prevalence among workers at production section was 68.9%, while among administration workers was 40% (p > 0.05). Low antioxidant intake increases the risk of chromosome breakage (p = 0.035; ORadjusted = 2.90; 95%CI 1.08-7.78). Other influencing factors are: type of work (p = 0,10; ORcrude = 3.32; 95% CI 1.33-8.3) and chronic benzene exposure at workplace (p = 0.014; ORcrude = 2.61; 95% CI 1.2-5.67), while the work practice-behavior decreases the lymphocyte chromosome breakage (p = 0.007; ORadjusted = 0.30; 95% CI 0.15-0.76).Conclusion: The prevalence of lymphocyte chromosome breakage in the environment with low benzene exposure is quite high especially in production workers. Chronic benzene exposure in the workplace, type of work, and low antioxidant consumption is related to lymphocyte chromosome breakage. Thus, benzene in the workplace should be controlled to less than 1 ppm, and the habit of high antioxidant consumption is recommended.