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All Journal Pediatric Sciences Journal
Eko Sulistijono
Department of Child Health, Faculty of Medicine, Brawijaya University, Saiful Anwar Hospital, Malang, Indonesia
Health Professions Public Health

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The levels of Human Beta Defensin-2 (HBD-2) in premature neonates’ feces at Saiful Anwar Hospital, Malang, Indonesia Eko Sulistijono; Putri Primawardani; Krisni Subandiyah; Anik Puryatni
Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Available online 1 June 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (552.505 KB) | DOI: 10.51559/pedscij.v1i1.2

Abstract

Background: Clinical evidence shows that the etiology of neonatal sepsis is translocation of the digestive tract of premature neonates. Human ß-defensor 2 has a protective effect during inflammation and apoptosis. This study aimed to determine the levels of fecal human ß-defensus-2 (HBD-2) as an inflammatory biomarker in premature neonates related to nutrition consumption. Methods: A cohort study design used in thirty-nine premature neonates according to inclusion criteria were collected in January to March 2019 in the neonatology room of RSUD Dr. Saiful Anwar Malang. The levels of premature neonatal feces HBD-2 were taken from all three sample groups on the seventh and fourteenth days and measured by the ELISA method. Data were analyzed using SPSS version 20 for Windows. Results: The mean levels of HBD-2 premature neonatal feces consuming formula milk alone were higher than other groups (349.16 + 67.66 vs 330.24 + 44.08 vs 215.65 + 51.34). There is a relationship between levels of HBD-2 premature neonatal feces with only breastfeeding (p=0,005; r=0.731), breast milk (p=0,005; r=0,727) and, formula milk only (p=0,003; r=0,761). Conclusion: The levels of HBD-2 in premature neonatal stools who consuming formula milk alone were significantly higher than levels of human HBD-2 premature neonatal stools that consumed only breast milk.
Fecal secretory immunoglobulin a, human ß defensin-2, and calprotectin levels in preterm neonates who consumes breast milk only, formula milk only, and combination Eko Sulistijono; Putri Primawardani; Rusdian N. Ningsih; Bernardinus P.A. Pradipta
Pediatric Sciences Journal Vol. 1 No. 2 (2020): (Available online 1 December 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (753.063 KB) | DOI: 10.51559/pedscij.v1i2.16

Abstract

Background: Secretory immunoglobulin A, human ß-defensin2 and calprotectin play an essential role in digestive system defense. This study aims to assess fecal SIgA, hBD-2, and calprotectin in preterm neonates (as inflammation marker) with different feeding patterns. Method: This study was cohort designed included 39 preterm neonates, which were categorized into breast milk only, formula milk only, and combination. Fecal SIgA, hBD-2, and calprotectin measured by ELISA. Results: Fecal SIga in the breast milk only group were significantly higher (p<0.005). Fecal HBD-2 and calprotectin in the formula milk only group were highest but not significantly different (p=0.463) with the combination group. Conclusion: Fecal SIgA levels that consumed breast milk only were significantly higher. Fecal HBD-2 and calprotectin levels that consumed formula milk only were highest but not significantly different from the combination group.
Co-Authors Anik Puryatni Bernardinus P.A. Pradipta Krisni Subandiyah Putri Primawardani Rusdian N. Ningsih