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All Journal Oceana Biomedicina Journal Hang Tuah Medical Journal Surabaya Biomedical Journal
R. Varidianto Yudo Tjahjono
Fakultas Kedokteran Universitas Hang Tuah
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Effects of Morning’s Prayer Routines in The Congregation on Random Blood Sugar Levels of Elderly at Al Wahyu Mosque Rungkut Surabaya Indri Ngesti Rahayu; Lani Diana; R. Varidianto Yudo Tjahjono
Denta Journal Kedokteran Gigi Vol 4 No 2 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 2
Publisher : Universitas Hang Tuah

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Background: Increased health problems in the elderly occur because of the aging process that causes many changes in their body. One of the changes istheincrease in blood glucose more than normal and at risk of diabetes mellitus. Morning prayer can be a religious coping and regular physical activity that lowers blood sugar levels. Objective: to analyze the effect of the morning prayer routines in the congregation on random blood sugar levels of the elderly at Al-Wahyu Mosque Rungkut Surabaya. Method:This study was an observational analytic study with a cross-sectional design using 30 respondents. The group studied was the congregation of the morning prayers of the Al Wahyu MosqueRungkut Surabaya which was over 45-year-old which undergoes random blood sugar levels measurement. Results:The Independent t-testmethodshowedthat the value of signification was 0,000 (p<0,05) which means that there is the influence of the morning prayer’s routines in the congregation on random blood sugar levels of the elderly at Al-Wahyu Mosque Rungkut Surabaya. Conclusion:Elderly people who routinely carry out the morning prayer routines in the congregation have lower blood sugar levels than elderly people who are not routine.
Comparison of Cerebral Malaria Mice Models Infected by P. berghei ANKA Prawesty Diah Utami; R. Varidianto Yudo Tjahjono; Indi Jazilah; Ismy Azizah Sisnawati
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

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The high morbidity and mortality due to malaria infection makes it a global health problem. The pathogenesis and pathophysiology of cerebral malaria has not been fully understood. The use of cerebral malaria model mice is one alternative to understand its pathogenesis and pathophysiology. The purpose of this study was to compare Swiss mice and C57BL / 6 mice inoculated by P.berghei ANKA as a model of cerebral malaria mice. Methods: The study design was a randomized Post Test Control Only Group Design using 12 Swiss mice and 12 C57BL / 6 mice divided into 2 groups each: the treatment group inoculated by P. berghei ANKA and the control group without inoculation. Observation of clinical manifestations and parasitemia level was carried out from day 1 to day -10. The study results showed that K2 group showed a significant increase in the degree of parasitemia compared to K4. K4 group showed clinical manifestations of cerebral malaria while K2 did not show clinical manifestations of cerebral malaria. Conclusion: C57BL / 6 mice inoculated by PbA can be used as cerebral malaria animal models.
PENGARUH HbA1c TERHADAP SINDROMA MATA KERING PADA PASIEN DIABETES MELLITUS DI SURABAYA NI WAYAN WIWIN OKTORI; VARIDIANTO YUDO TJAHJONO; SRI ARIANI
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background: Diabetes mellitus is a public health problem experienced by many countries and becomes a serious problem, affecting health in the world. Various complications of DM related to the surface of the eye is dry eye syndrome. Dry eye syndrome is an eye disorder with symptoms of discomfort, pain, dryness and foreign body sensation in the eye. The level of glycosylated hemoglobin (HbA1c) is one indicator of DM and it is stated that the prevalence of dry eye syndrome is significantly higher in DM sufferers than in healthy individuals. The Aim of this study to know the effect of HbA1c on dry eye syndrome in patients with diabetes mellitus Method :. This study used a cross sectional method and the sampling method used was purposive sampling. Samples taken as many as 34 people are patients with diabetes mellitus aged 18-55 years who have HbA1c results seen from medical records at the Public Health Center Jagir Surabaya. The research data was taken using the Dry Eye Questionnaire (DEQ), interviews and Schirmer Test I. The research data was then analyzed using a contingency test. Result: The significance value of the HbA1c test with the Schirmer I Test showed p = 0.026; that’s means a significant effect between HbA1c levels on dry eye syndrome with the Schirmer I Test and the significance value of the HbA1c test with the DEQ questionnaire shows p <0.001; that’s means a significant effect between HbA1c levels on dry eye syndrome and DEQ questionnaire, performed on patients with diabetes mellitus in Jagir Health Center, Surabaya City Conclusion: There is an influence of HbA1c levels on dry eye syndrome
Efek Pemberian Oksigen Hiperbarik Pada Efektivitas Ekstrak Cacing Tanah (Lumbricus terrestris) Terhadap Pertumbuhan Salmonella Typhi Secara In Vitro VARIDIANTO YUDO TJAHJONO; RETNO BUDIARTI; PRAWESTY DIAH UTAMI
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v20i1.341

Abstract

Background: Typhoid fever is an infectious disease of the small intestine caused by the bacterium Salmonella typhi, and causes a fairly high mortality rate. These bacteria have developed resistance to many antibiotics. Earthworm extract (ECT) has been widely used as an alternative to treat typhoid fever. Hyperbaric oxygen therapy (OHB) has been used to treat various diseases and can suppress the growth of bacteria. Objective: To determine the effect of hyperbaric oxygen (OHB) 3 ATA on the effectiveness of earthworm (Lumbricus terrestris) extract on the growth of Salmonella typhi in vitro. Methods: This experimental study used the post-test only control group design method. Thirty-six samples of S.typhi bacteria in liquid medium (broth) were divided into four groups. The first group (K-) was not given any treatment, the second group (P1) was given earthworm extract, the third group (P2) was given hyperbaric oxygen 3 ATA, and the fourth group (P3) was given a combination of earthworm extract and hyperbaric oxygen 3 ATA. The results of bacterial growth in each group were calculated in colony forming units (CFU) / ml and analyzed statistically. Results: The growth of S.typhi bacteria in the first group (K-) was 108.51 x 106 CFU/ml, the second group (P1) was 483 CFU/ml, the third group was 1.4 x 106 CFU/ml, and the fourth group (P3) was 215 CFU/ml. The fourth group (P3) had the smallest number of bacterial growth and had a significant difference compared to the first (P1) and third (P3) groups (p = 0.001; p < α ; α = 0.05), but the difference was not significant compared to the second group (P1 ) (p = 0.308; p > α; α = 0.05). Conclusion: Giving earthworm extract (ECT) with hyperbaric oxygen (OHB) 3 ATA (combination) was most effective in inhibiting the growth of Salmonella typhi bacteria compared to giving earthworm extract (ECT) alone or giving hyperbaric oxygen (OHB) 3 ATA alone.
STUDI EKSPERIMENTAL: PENURUNAN PROFIL NETROFIL DAN TNF-α SETELAH PEMBERIAN EKSTRAK TERIPANG EMAS (STICHOPUS HERMANNI) R. Varidianto Yudo Tjahjono; Prawesty Diah Utami; Herin Setianingsih
Surabaya Biomedical Journal Vol 1 No 2 (2022): Januari
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i2.23

Abstract

Latar Belakang: Vaginitis candida adalah penyakit infeksi jamur yang diderita hampir setiap wanita di dunia. Meningkatnya jumlah netrofil dan kadar faktor nekrosis tumor alfa (TNF-α) merupakan ciri khas dari penyakit ini. Ekstrak teripang emas (Stichopus hermanni) telah banyak diteliti terutama untuk anti jamur dan bakteri, anti peradangan , anti oksidan dan lain-lain. Tujuan: Membandingkan profil netrofil dan TNF-α antara kelompok kontrol dengan kelompok studi lain yang mendapatkan ekstrak teripang emas (S.hermanni) melalui studi eksperimental menggunakan mencit coba. Metode: Penelitian eksperimental dengan desain “post-test only control group design”. Unit eksperimentalnya terdiri dari 24 mencit BALB/c yang diinokulasi C.albicans per vaginam dan dibagi menjadi empat grup terdiri dari : (K-) kelompok yang tidak mendapatkan perlakuan; (P1)kelompok yang mendapatkan ekstrak S.hermanni dosis 8,5mg/kgBB; (P2) kelompok dengan dosis ekstrak 17mg/kgBB; dan (P3) kelompok dengan dosis ektrak 34 mg/kgBB. Jumlah netrofil dilihat dari pemeriksaan mikroskopis jaringan mukosa vagina. Kadar sitokin TNF-α dilihat dari pemeriksaan ELISA sampel darah. Hasil: Hasil pengamatan profil netrofil pada jaringan mukosa vagina mencit coba menunjukkan bahwa kelompok P2 mengalami penurunan netrofil tertinggi namun secara statistic tidak signifikan penurunannya (p=0,156; p>α). Pengamatan profil TNF-α padai serum darah mencit pada kelompok P2 menunukkan penurunan yang signifikan dibanding kelompk lain (p=0,001; p< α). Perbedaan ini terutama bila dibandingkan kelompok K- (p=0,004; p< α) dan kelompok P1(p=0,004; p< α) Kesimpulan: Pemberian ekstrak S.hermanni terbukti mampu menurunkan profil netrofil dan kadar TNF-α pada mencit coba, dengan dosis efektifnya sebesar 17 mg/kgBB.
Co-Authors Indi Jazilah Ismy Azizah Sisnawati Lani Diana NI WAYAN WIWIN OKTORI Prawesty Diah Utami Retno Budiarti Setianingsih, Herin SRI ARIANI