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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Indonesia Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Hari Susanti
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics

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DOCKING MOLEKULER SENYAWA B-KAROTEN DALAM TANAMAN KELOR (Moringa Oleifera L.) SEBAGAI PENGHAMBAT ENZIM TIROSINASE DENGAN AUTODOCK – VINA Bayu Herdi Al Huda; Nining Sugihartini; Hari Susanti; Dwi Utami
Jurnal Insan Farmasi Indonesia Vol 3 No 2 (2020): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v3i2.540

Abstract

Hydroquinone has been used in cosmetics because of its whitening activity. In previous studies, B-carotene in Moringa plants was also known as an inhibitor of the tyrosinase enzyme. It is necessary to know how the interaction mechanism of B-carotene with tyrosinase (5M8N) and which compounds between hydroquinone and B-carotene provide computationally better activity as whitening. Tyrosinase was prepared using Discovery Studio Visualizer. Ligands were prepared using Autodock 4.2. Autodock-Vina is used for ligand docking between proteins. The result is the binding affinity (kcal/mol) of the ligand to protein. Visualization of docking between ligands and proteins using the Ligplot + Program with a 1 year license. Media used for the docking process is a computer with an Intel Core i7-3770 CPU with a speed of 3.40 GHz 8 cores, 1920x1080p resolution, VGA NVIDIA GeForce GTX 750, 8 GB RAM, Windows 8 64-bit. The docking results showed that the binding affinity of B-carotene to tyrosinase was -11.2 while hydroquinone with tyrosinase was -5.4 with RMSD 0. The results of visualization showed that B-carotene binds more amino acid receptors than hydroquinone. B-carotene in moringa has been shown to be active not only in wet laboratories, but also in dry laboratories.
PENETAPAN KADAR ß-KAROTEN PADA BEBERAPA JENIS CABE (Genus Capsicum) DENGAN METODE SPEKTROFOTOMETRI TAMPAK Tri Octaviani; Any Guntarti; Hari Susanti
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.451 KB) | DOI: 10.12928/pharmaciana.v4i2.1566

Abstract

Beta carotene is provitamin essential role for vitamin A formation. Most of vitamin Asources are ß-carotene. In the body, ß-carotene will be converted into vitamin A. Chilies areconsidered as one of the essential food. Chillies are known as very good sources of ß-carotene.Therefore, it is important to conduct a research in order to observe the content of ß-carotene inthe chillies using visible spectrophotometry. Fresh chillies were extracted with a mixture ofhexane:acetone:ethanol (2:1:1) v/v using a maceration method. After the extraction process wascomplete, aquabidest was added. The extraction result was non-polar phase. It was separatedand evaporated. The residue was further subjected to qualitative and quantitative analysis102 Pharmaҫiana, Vol. 4, No. 2, 2014: 101-109obtained. Qualitative analysis by using Carr-Price method. Determination of ß-carotene wasconducted using visible spectrophotometry method at 452,4 nm. The qualitative test resultsshowed that the Capsicum annuum L. Var. abreviatum Fingerhuth, Capsicum annuum L. Var.Longum sendt) and Capsicum frutescens L. contain ß-carotene. From the research, it wasobtained that the average levels of ß-carotene on the Capsicum annuum L. Var. abreviatumFingerhuth was (10,54±0,07) mg/100g, Capsicum annuum L. Var. Longum sendt was(5,57±0,13) mg/100g and Capsicum frutescens L. was about (0,36±0,01) mg/100g. Statisticalanalysis using LSD test of ß-carotene levels in the Capsicum annuum L. Var. abreviatumFingerhuth, Capsicum annuum L. Var. Longum sendt) and Capsicum frutescens L. weresignificantly different at P of 0.05.
PENETAPAN KADAR FENOLIK TOTAL DAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN KOPI KAWA DENGAN METODE DPPH Aprilia Kusbandari; Dwi Yogo Prasetyo; Hari Susanti
Media Farmasi: Jurnal Ilmu Farmasi Vol 15, No 2: September 2018
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.456 KB) | DOI: 10.12928/mf.v15i2.12658

Abstract

Antioksidan merupakan senyawa yang mampu menghambat laju oksidasi dalamtubuh. Antioksidan sintetik dapat menimbulkan efek samping pada kesehatantubuh sehingga penggunaan antioksidan alami sebagai pengganti semakindiminati masyarakat karena dipercaya lebih aman. Salah satu golongan senyawaalami yang bersifat sebagai antioksidan adalah golongan fenolik. Daun kopi kawamengandung flavonoid, alkaloid, saponin, kafein, dan polifenol. Penelitian inibertujuan untuk mengetahui kadar fenol total dan harga Effective Scavenging(ES)50 ekstrak etanol daun kopi kawa. Daun kopi kawa diekstraksi menggunakanmetode maserasi. Ekstrak kental diuji kandungan fenoliknya dengan reagen Folin-Ciocalteu dan standar asam galat. Hasil uji kandungan fenolik total dinyatakandengan kesetaraan asam galat per gram ekstrak (GAE/g ekstrak). Hasil penelitianmenunjukkan ekstrak etanol daun kopi kawa memiliki kandungan senyawafenolik total sebesar 55,87 mg GAE/g ekstrak. Ekstrak etanol daun kopi kawamemiliki aktivitas antioksidan dengan nilai ES50 sebesar 57,79 μg/mL sedangkanuntuk standar asam galat memiliki nilai ES50 sebesar 1,54 μg/mL. Hasil tersebutmenunjukkan ekstrak etanol daun kopi kawa memiliki aktivitas yang kuat sebagaiantioksidan.
REVIEW : KARAKTERISTIK FISIK DAN DAYA IRITASI MINYAK ATSIRI BUNGA CENGKEH (Syzygium aromaticum) DALAM BEBERAPA TIPE BASIS SEBAGAI ANTI-INFLAMASI Amraini Amelia; Nining Sugihartini; Hari Susanti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 5 No 2 (2020): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.846 KB) | DOI: 10.36387/jiis.v5i2.527

Abstract

ABSTRACT This review aims to determine the types of bases that can be used every day, which are effective and efficient as anti-inflammatory drugs. The research method used was to review the development of clove essential oil formulations that have been carried out using various concentrations of various types of bases including M / A type cream, A / M type cream, water soluble base, lotion, emulgel, hydrocarbons, hydrogels and absorbents. The recommended formulation is type M / A cream with a concentration of 5% clove flower essential oil. The types of bases studied were M / A cream, type A / M cream, water soluble base, lotion, emulgel, hydrocarbons, hydrogels and absorption properties which had good physical properties and did not irritate the skin of the test animals. This review refers to several national and international journals released in the last ten years, from 2010 to 2020.
The Purification effect on Organoleptic Profile, Yield, Total Phenol and Total Flavonoids from 96% Ethanol Extract of Moringa (Moringa oleifera. L) leaves. Bayu Herdi Al Huda; Hari Susanti; Nining Sugihartini
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.983

Abstract

Purification extract ethanol 96% of Moringa dry leaves was carried out to increase the active substance content and to obtain a more attractive color. The purpose of this study was to determine the type of solvent in the fractionation which provides a higher active substance content than the extract. This research begins with maceration of dried Moringa leaves with 96% ethanol. The filtrate that has been dried then purified. Purification begins with dissolving the extract in hot distilled water with a ratio of 1:10, after that ethyl acetate or n-hexane is added to the same amount as hot distilled water in a separating funnel, shaking it. The ethyl acetate or n-hexane phase is taken then the filtrate obtained is combined. The 96% ethanol extract (E1), ethyl acetate (E2) and n-hexane (E3) were then evaluated with parameters of organoleptic, % yield, total phenol, and total flavonoids. Data were analyzed statistically one way ANOVA with confidence level of 95%. The measurement results for E1, E2, and E3 in the yield were 15.81%;22.18%;20%, the total phenol was 28.94±0.54mgGAE/g; 29.44±0.93mgGAE/g; 11,41±0,12mgGAE/g, and total flavonoids 3,19±0.13%; 9,92±0.06%; 5.81±0.18% respectively. The consistency, smell and taste, all are identical, while in color, E2 is more yellowish green and brighter, making it more attractive. Statistically, there were significant differences between E1, E2, and E3 in total phenols and flavonoids. Thus it can be concluded that E2 significantly higher total phenol and flavonoids than E1 and E3.
Pengaruh Purifikasi Terhadap Kandungan Zat Aktif dan Aktivitas Antioksidan Ekstrak Etanol 50% Daun Kelor (Moringa oleifera L.) Diyan Sakti Purwanto; Hari Susanti; Nining Sugihartini
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.1232

Abstract

Purification extract ethanol 50% of Moringa dry leaves was carried out to increase the active substance content of flavonoids, β-carotene, saponins and tannins which have antioxidant activity. The purpose of this study was to determine the optimal solvent between ethyl acetate and n-hexane in the ethanol extract fractionation of 50% Moringa leaves. The viscous extract obtained was then purified by fractionation. Fractionation was carried out by dissolving the viscous ethanol extract of 50% Moringa leaves (E1) in aquadest of 70ºC and then adding ethyl acetate to a separating funnel to obtain ethyl acetate (E2) fraction. In addition, the viscous ethanol extract of 50 % Moringa leaves (E1) was fractured with n-hexane (E3). The extract and fraction were evaluated for the parameters including the water level of the extract with gravimetry, levels the β-carotene by HPLC and the antioxidant activity with DPPH . Data were analyzed statistically with a confidence level of 95%. The results the water level of the ethanol extract of 50% Moringa leaves is 4.16 with a CV of 4.62%. The β-carotene level on fractured with n-hexane (E3) then ethyl acetate fraction (E2) and ethanol extract 50 % (E1) that is 1.48 ± 0.01%, 1.19 ± 005% and 0.73 ± 0.01%. While antioxidant activity (IC50) were the most optimal in the n-hexane fraction(E3) then ethanol extract 50 % (E1) and ethyl acetate fraction (E2) that is 40.83 ± 0.04 ug/ml, 47.75 ± 0.09 ug/ml and 58.79 ± 0.10ug/ml. The ethanol extract of 50% Moringa leaves and n-hexane fraction were included in the very strong category while the ethyl acetate fraction was included in the strong category so that it has the potential to be an antioxidant.
Co-Authors Amraini Amelia Any Guntarti Aprilia Kusbandari, Aprilia Bayu Herdi Al Huda Diyan Sakti Purwanto DWI UTAMI Dwi Yogo Prasetyo Nining Sugihartini Tri Octaviani