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All Journal Majalah Kedokteran Andalas JIDAN (Jurnal Ilmiah Bidan) Stikes Pelita Ilmu Depok
Andani Eka Putra
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Health Professions Medicine & Pharmacology Nursing Public Health

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The Enhancement of COVID-19 Severity on Coagulation Markers: a Cross-sectional Study in West Sumatra, Indonesia Ika Kurnia Febrianti; Andani Eka Putra; Raveinal Raveinal; Aisyah Elliyanti
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1712-1723.2024

Abstract

Objective: This study aimed to determine the description of the coagulation marker and how it implicates COVID-19 patients based on clinical outcomes in the form of enhancement severity and death. Method: The subjects were collected from patients with positive COVID-19 RT-PCR with medical records including demographic data, and laboratory results such as hemoglobin, hematocrit, leukocytes, platelets, coagulation markers (D-dimer, PT, and APTT), and patients outcomes post-treatment. Statistical analysis is performed by using chi-square and Mann-Whitney tests were considered statistically difference level of significant between variables. Result: The COVID-19 patients is classified into mild group with 27 subjects  (44.2%) and moderate-severe group 34 subjects (55.8%). Leukocytes, D-dimer, and PT levels significantly differed between mild and moderate-severe groups. All coagulation markers had a symptomatic effect on Covid-19 patients, increased D-dimer and prolonged prothrombin time in adult COVID-19 patients tend to be followed by the enhancement of severe symptoms and death
Distribusi Mutasi Asp614Gly pada Spike Protein SARS-CoV-2 di Sumatera Barat Dede Rahman Agustian; Andani Eka Putra; Dessy Arisanty
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1724-1733.2024

Abstract

Objective: This study aims to map the distribution of the Aspartate 614 to Glycine (Asp614Gly) mutation in the spike protein of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) circulating in West Sumatra, to understand the extent of its spread within the local population. Methods: RNA samples were taken from 98 confirmed COVID-19 cases across various area in West Sumatra. Genetic amplification and next-generation sequencing (NGS) were performed to identify the presence of the Asp614Gly mutation. The frequency of mutations was analyzed using bioinformatics software. Results: Out of the 98 samples analyzed, approximately 97% exhibited the Asp614Gly mutation. The geographic distribution of this mutation showed significant variation among the districts of West Sumatra, with the highest prevalence in urban areas. Conclusion: These findings indicate that the Asp614Gly mutation is highly prevalent in West Sumatra. Associated with increased virus transmissibility, this mutation dominates the circulating virus strains in the region, highlighting the need for ongoing genetic surveillance to guide public health interventions and vaccination strategies.
HUBUNGAN UMUR DAN PENDIDIKAN DENGAN KEJADIAN INFERTILITAS PADA WANITA PASANGAN USIA SUBUR (PUS) Silvia Yolanda; Arni Amir; Andani Eka Putra
JIDAN : Jurnal Ilmiah Bidan Vol. 5 No. 1 (2021): JIDAN : Jurnal Ilmiah Bidan
Publisher : STIKES Pelita Ilmu Depok

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69935/jidan.v5i1.25

Abstract

Infertilitas adalah sebuah permasalahan sistem reproduksi yang digambarkan dengan kegagalan untuk memperoleh kehamilan setelah 12 bulan atau lebih melakukan hubungan seksual 2-3 kali seminggu secara teratur tanpa menggunakan alat kontrasepsi. Salah satu faktor yang mempengaruhi infertilitas yakni umur dan pendidikan. Penelitian ini bertujuan untuk mengetahui hubungan umur dan pendidikan dengan infertilitas pada wanita pasangan usia subur. Penelitian ini merupakan penelitian studi analitik dengan pendekatan case control dilakukan di labor mikrobiologi Fakultas Kedokteran Universitas Andalas pada bulan Juni hingga November 2019. Sampel pada penelitian ini yakni wanita pasangan usia subur infertilitas dan fertilitas yang berkunjung ke labor mikrobiologi serta dibagi menjadi kelompok kasus dan kontrol sesuai kriteria inklusi sebanyak 33 sampel diambil secara consecutive sampling. Data dikumpulkan menggunakan kuesioner dan hasil pemeriksaan. Hasil penelitian menunjukkan bahwa hubungan umur dan pendidikan dengan kejadian infertilitas pada wanita pasangan usia subur(PUS).
Co-Authors Aisyah Elliyanti Arni Amir Dede Rahman Agustian Dessy Arisanty Ika Kurnia Febrianti RAVEINAL RAVEINAL Silvia Yolanda