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All Journal JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Farmasi Higea

Maria Dona Octavia

Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang

Author-ID : 481191

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Formulasi Krim Griseofulvin Dan Uji Penetrasi Menggunakan Sel Difusi Franz Auzal Halim; Iin Indah Sari; Maria Dona Octavia
Jurnal Farmasi Higea Vol 4, No 1 (2012)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v4i1.62

Griseofulvin cream formulation and it’s penetration test using Franzs difusion cell has been done. This cream formulation was using two different types of base cream, such as water/oil (w/o) and oil/water (o/w) base cream type. The vertical type cells of Franz difusion cells, was used for the penetration test and it’s quantity determination was done by using spectrophotometry methods. The result showed, that griseofulvin cream with water/oil (w/o) base has the highest of the griseofulvin penetration quantity. The griseofulvin penetration quantity and it’s capacity of penetrating toward water/oil (w/o) and oil/water (o/w) base are 7,447 µg/mL and 18,54%, then 5,724 µg/mL and 14,39% respectively for 90 minutes periods time. It showed that the cream type can influence the griseofulvin penetration from it’s base. From both cream types, water/oil (w/o) type gives better penetration than oil/water (o/w) cream.

Pengaruh Cara Pengeringan Oven Dan Microwave Terhadap Perolehan Kadar Senyawa Fenolat Dan Daya Antioksidan Dari Daun Jambu Biji (Psidii folium) Maria Dona Octavia; Stephany Stephany; Harrizul Rivai
Jurnal Farmasi Higea Vol 2, No 1 (2010)
Publisher : STIFARM Padang

Effects of drying methods in gaining of extracted material, phenolic content, and antioxidant activity in Psidii folium leaves have been investigated. The drying methods tested were air-drying, microwave oven-drying, and oven-drying at 60ºC. The determination of extracted material compound showed that the air-drying, microwave oven-drying, and oven-drying at 60ºC contained 184,767; 333,767; and 208,533 mg/g, phenolic of these sample were 46,0474; 53,8402; and 51,4532 mg/g, and IC50 of these sample were 0,529; 0,477; and 0,505 mg/mL. Among the drying methods tested, the highest extracted material, phenolic concentration, and antioxidant activity were by microwave oven-drying.

Karakterisasi Alginat Dari Ganggang Coklat ( Sargassum crassifolium, Mont ) Dengan Menggunakan CaCl2 14 % Auzal Halim; Yeni Novita Sari; Maria Dona Octavia
Jurnal Farmasi Higea Vol 3, No 1 (2011)
Publisher : STIFARM Padang

Analysis of the synthetic sweetener sodium saccharin and sodium cyclamate in tea packaging has been done. The content of synthetic sweeteners are identified by color reactions and test microcrystals. The results obtained were compared with the reference standard material. Of the four samples tested, obtained three samples containing sodium cyclamate, while the other samples did not contain sodium cyclamate and sodium saccharin. Levels are determined by sodium cyclamate spektrofoto, ether UV-Vis. Levels of sodium cyclamate were obtained not exceed the maximum limit allowed by the Ministry of Health of the Republic of Indonesia is 0.3% for soft drinks.

Uji Sistem Dispersi Padat Kofein Dengan Menggunakan Polivinil Pirolidon (PVP) K-30 Maria Dona Octavia; Auzal Halim; Sari Kartika
Jurnal Farmasi Higea Vol 5, No 2 (2013)
Publisher : STIFARM Padang

The research about solid dispersion test of coffein used Polvinil pyrrolidone (PVP) K-30. In the current study using solid dispersion coffein using Polyvinyl pyrrolidone (PVP) K-30 and a mixture of physics. coffein manufacture solid dispersion using Polyvinyl pyrrolidone (PVP) K-30's, using the method of dissolution. The parameters tested were melting range, lift angle, specific gravity, Hausner factor, compressibility, porosity, water content, particle size distribution, the absorption of water, microscopic analysis and dissolution. Result of research coffein solid dispersion system using Polyvinyl pyrrolidone (PVP) K-30 can increase the solubility Kofein compared with the mixed form of physics. The percent of dissolution of the best in the 35th minute was the solid dispersion formula 4: 6, amounting to 79.34% compared with other formula.

Uji Disolusi Beberapa Tablet Parasetamol yang Ada di Perdagangan Maria Dona Octavia; Resita Sandra; Auzal Halim
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

The dissolution test four generic tablets and one branded name of parasetamol tablets has been undertaken. Method applied was in the paddle method as required by Pharmacopea of Indonesian ed. IV. Paracetamol concentration measured spectrophotometrically at maximum wave length of 243 nm in dissolution medium pH 5.8 phosphate buffer solution. The result dissolution test to comply with tolerance is not less than 80% of the labeled amount of paracetamol is dissolved in tweenty minutes. The dissolution about drown from the plot between percentage of paracetamol dissolved versus time.The percentage of paracetamol dissolved at T30 analyzed by using ANOVA test. Result showed in the dissolution rates between generic 1,2,3,4 and branded name were significant different take. Then continued to DUNNET test , only generic 2 tablets was not significantly difference whereas the other generic tablets were significant differences.

Studi Sistem Dispersi Padat Meloksikam Menggunakan Hiroksipropil Metilselulosa (HPMC) 6 Centipoise (CPS) Erizal Zaini; Maria Dona Octavia; Kiki Rizky Wirza
Jurnal Farmasi Higea Vol 4, No 2 (2012)
Publisher : STIFARM Padang

The solid dispersion system of meloxicam-hydroxypropyl methylcelluloce (HPMC) 6 centipoise (cps) had been studied. The solid dispersion system was prepared by solvation method with several combination of meloxicam and HPMC were 1:1, 1:3 and 1:5. The physical mixture of meloxicam and HPMC with similar composition were used as standard. The powder of solid dispersion system and physical mixture were evaluated by X-ray powder diffraction, thermal (DTA), SEM and FT-IR spectroscopy analysis. The dissolution studies were carried out in USP type II apparatus. The result of X-ray powder diffraction analysis showed that the solid dispersion of meloxicam with HPMC decreased the drug crystallinity. The endothermic peak of meloxicam from solid dispersion products shifted to lower temperature and peak intensity decreased significantly. X-ray powder diffraction and DTA indicated transformation of crystalline state of meloxicam to amorphous one by solid dispersion with HPMC. SEM results showed the solid dispersion of meloxicam and HPMC has agglomerates form. FT-IR spectra indicated no chemical interaction between meloxicam and HPMC in the solid dispersion. The highest in dissolution rate was observed with solid dispersion products of meloxicam and HPMC with ratio 1:5 (94,083 %) compared to pure meloxicam and its physical mixture.

Pengaruh Dimetil Sulfoksida Terhadap Penetrasi Ketokonazol Melalui Membran Sel Difusi Franz Auzal Halim; Maizel Fitri; Maria Dona Octavia
Jurnal Farmasi Higea Vol 5, No 1 (2013)
Publisher : STIFARM Padang

Evaluation about the effect of dimethyl sulfoxide in ketoconazole gel formulation and its penetration using Franz diffusion cell membrane has been done. This gel formulation was using base are dimethyl sulfoxide and tragacant. The vertical type cell of Franz diffusion cell, was used for the penetration test and its quantity determination was done by using spectrophotometry method. The ketoconazole penetration quantity and its capacity of penetrating from dimethyl sulfoxide and tragacanth base are F1: 8.34µg/mL and 21.275%, F2: 10.36µg/mL and 13.705% F3: 6.56 µg/mL and 16.318% then F4: 10.36µg/mL and 26.030%.

Pengaruh Besar Ukuran Partikel Terhadap Sifat – Sifat Tablet Metronidazol Maria Dona Octavia; Auzal Halim; Rika Indriyani
Jurnal Farmasi Higea Vol 4, No 2 (2012)
Publisher : STIFARM Padang

The influence of particle size toward the characteristics of Metronidazole tablets has been studied. Metronidazole that is used for first formua is not crushed, for the second formula is used Metronidazole powder cruhed for 30 minutes, and for the third formula is used Metronidazole powder that is crushed for 3 hours. The crushing process of the powder is done by using Ball mill. The result is analysed by SEM, DTA, FT IR, and particle distribution. DTA data (mettler Toledo) shows the changing of thermodynamic characteristics that occurs when the sample is given heat energy in form of melting shown by endoterm. From the three formula are made Metronidazole tablets by using wet granulation. The formulations of Metronidazole use mucilago gelatin as a binder, lactose as excipients, amylum as desintegrant and aerosil as a lubricant. Tablet evaluation involves the same size, same weight, the strength determining of level and dissolution. Dissolution test is done by using basket method and the level determined by the method of UV Spectrophotometer at the maximum absorption wavelength of 276.5 nm in HCl 0,1 N. The result of the assay formula 1 is 82,6248%, the formula 2 is 87.3086% and the formula 3 is 95.7037%. Result of dissolution measurement at 60 minutes showed that the average dissolution is 47.902%, 68,584% and 69.320%. The dissolution profile test uses HCl 0,1 N. The analysis of dissolution profile is done by the equality orde 0, orde 1, Higuchi and Korsmeyer peppas. Dissolution profile of Metronidazole tablets approach to Korsmeyer peppas.

Pengaruh Bahan Pelincir terhadap Sifat-Sifat Tablet Parasetamol Sistem Dispersi Padat dengan PEG 6000 Maria Dona Octavia; Yuliana Yuliana; Auzal Halim
Jurnal Farmasi Higea Vol 1, No 2 (2009)
Publisher : STIFARM Padang

A research has been performed on the effect of lubricant to a solid dispersion system of paracetamol tablet with polyetilenglicol 6000, the solid dispersion system of paracetamol-polyetilenglicol 6000 is prepared through the dissolution method with 7 : 3 comparison. Then physiochemical characteristics and dissolution profile evalution is ferformed to three lubricant materials, which is aerosol, stearate magnesium, and talcum.

Peningkatan Laju Disolusi Dispersi Padat Amorf Genistein dengan PVP K-30 Erizal Zaini; Vike Zulia Putri; Maria Dona Octavia; Friardi Ismed
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

Amorphous solid dispersions of a poorly water-soluble drug genistein in PVP K-30 were prepared by solvent co-evaporation technique using organic solvent methanol. Solid dispersions system was prepared with several variations of drug to polymer 2:1, 1:1 dan 1:2 w/w. Solid state properties of solid dispersion system were evaluated by powder X-ray diffraction, Fourier transform infrared spectroscopy, and differential scanning calorimetry, and microscopic SEM. Dissolution rate profile were conducted in distilled water medium by using dissolution tester apparatus type II USP. Base on X-ray diffractometry analysis, differential scanning calorimetry and microscopic SEM, crystalline phase of genistein decreased in crystallinity index and formation of amophous state. Dissolution rate profile showed that genistein in amorphous solid dispersion had a faster dissolution rate in comparison to intact genistein. This study proved that preparation of solid dispersion of genistein in PVP K-30 is an effective approach to improve dissolution rate of genistein.

Co-Authors Auzal Halim Auzal Halim Auzal Halim Erizal Zaini Firmansyah Firmansyah Fitriani Fitriani Friardi Ismed Harrizul Rivai Iin Indah Sari Kiki Rizky Wirza Maizel Fitri Marlani Marlani Monica Afrinda Netty Novitasari Novi Rini Novita Resita Sandra Rika Indriyani Riri Hariyani Sari Kartika Sri Kartika Ayu Stephany Stephany Syofyan Syofyan Tri Yanuarto Vike Zulia Putri Vina Oktavia Yeni Novita Sari Yuliana Yuliana Zilfia Zilfia

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